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Colleen A.Hanlon PhD

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentCancer Biology
Address
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentPhysiology & Pharmacology


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    Collapse Biography 
    Collapse education and training
    University of FloridaBS05/2001Interdisciplinary Studies
    Duke UniversityPh.D.05/2005Neurobiology
    Wake Forest School of MedicineFellowship09/2010Physiology & Pharmacology
    Collapse awards and honors
    2009Kavli Fellow, National Academy of Science
    2011Outstanding Early Career Investigator Award, National Institute of Drug Abuse

    Collapse Overview 
    Collapse overview
    I lead a clinical research program designed to develop and optimize non-invasive electromagnetic therapeutics. We have primarily focused on transcranial magnetic stimulation (TMS) as a tool to treat substance dependence (e.g. tobacco cessation, alcohol dependence), chronic pain, and other mood disorders – all of which are directly relevant to cancer prevention and survivorship outcomes. Our therapeutic discovery pipeline is divided into 5 themes: 1) Target Identification studies – often achieved through functional and structural MRI measurements in the population interest, 2) Target Engagement studies – typically multimodal imaging studies evaluating the effect of the intervention on cue-reactivity or pain, 3) NIH-supported Clinical Trials – larger, double-blind sham-controlled investigations of safety and efficacy, 4) Methods Refinement – utilizing computational modeling and variance observed in our clinical data, we are able to revisit dosing parameters and develop novel pulse sequences for subsequent testing, 5) Preclinical Translational Research – leveraging the strength of animal models we work closely with basic scientists to investigate novel electromagnetic therapeutics.

    Through this thematic approach we have made contributions to several areas of science:

    1. Evaluating individual differences in neural connectivity and cue-reactivity in substance dependent individuals.

    2. Leading National and International efforts to develop a Brain Stimulation based approach for drug and alcohol use disorders (including smoking cessation). Transcranial magnetic stimulation (TMS) is an FDA-approved treatment for depression which has been used for over a decade. In 2020, after demonstrating positive outcomes in a multisite double-blind sham-controlled investigation, a unique form of TMS (‘Deep TMS’) received FDA-clearance for use as a smoking cessation aid. It is now emerging as a promising new tool for the attenuation of craving among multiple substance dependent populations. I am happy to be playing an active part in shaping this emerging field- including recently serving as the senior author on a consensus paper:
    Ekhtiari,H et al. Transcranial Electrical and Magnetic Stimulation (tES and TMS) for Addiction Medicine: A consensus paper on the present state of the science and the road ahead. Neurosci Biobehav Rev. 2019 Jul 1. PMID: 31271802

    3. Methods Refinement. With a staff of engineers and biostatisticians we are continually investigating various aspects of these dosing parameters and attempting to develop open-source tools which can be used by the field of therapeutic brain stimulation at large.

    4. Translational/Collaborative research. I have actively collaborated with teams of clinician scientists in Psychiatry, Neurology, Radiology, and Pain Management on various research projects. I am also committed to translational research efforts – working closely with preclinical researchers in 2 NIH supported P50 centers at MUSC and looking forward to greater involvement in the NIAAA P50 and NIDA P50 at Wake Forest Health Sciences. In 2020, for example, our lab joined forces with Dr. Paul Czoty’s laboratory in Physiology & Pharmacology and performed some first-in-class research devoted to developing a non-human primate model for TMS studies. The fruits of these efforts were submitted for publication in August 2020.

    5. Mentorship, Teaching, and National Service. I participate in the research training and education community at both a local level (serving as a mentor to over 50 medical, graduate, post-graduate, and fellowship trainees since 2005 on a national and international scale) as well as leading an annual outreach event at the College of Problems on Drug Dependence (CPDD) meeting (2015-2018), serving on the Liaison Committee (2016-2019) and the Education and Training Committee (2019-present) for the American College of Neuropsychopharmacology, Grassroots Advocacy Team for the Society for Neuroscience (2017-2019), Chair of the Education Outreach and Public Policy Committee for CPDD (2017-2019), ad hoc participation in over 20 NIH study sections, and serving as a standing member of NIH NPAS study section (effective 10/2018)I also serve as a consultant and mentor on NIH grants led by several Assistant and Associate Professors whom I have mentored in TMS practices including Rebecca Price (Associate Professor, University of Pittsburg, “Evaluating TMS for OCD patients”, R21 consultant), Christine Sheffer (Assistant Professor, Roswell Park Cancer Institute, “Evaluating TMS for smoking cessation”, R01 consultant), Michael Wesley (Assistant Professor, University of Kentucky, K01 co-mentor), Andrada Neacsiu (Assistant Professor, Duke University), Eleanor Cole (Research fellow, Stanford), Claudia Padula (Assistant Professor, PaloAlto VA, Stanford, VA merit consultant). I am actively involved in mentoring all members of our laboratory as well as graduate students, medical students, and residents.

    Collapse Research 
    Collapse research activities and funding
    F32DA021456     (HANLON, COLLEEN A)May 1, 2006 - Apr 30, 2008
    NIH
    Neuroimaging of Motor Control in Chronic Cocaine Users
    Role: Principal Investigator

    K01DA027756     (HANLON, COLLEEN A)Jan 15, 2010 - Dec 31, 2014
    NIH
    Cortical Inhibition and Corpus Callosum Integrity in Cocaine Users
    Role: Principal Investigator

    R01DA036617     (HANLON, COLLEEN A)Jul 1, 2014 - May 31, 2021
    NIH
    Longitudinal study of functional connectivity among cocaine users in treatment
    Role: Principal Investigator

    R21DA041610     (HANLON, COLLEEN A)Jun 1, 2016 - May 31, 2018
    NIH
    Impact of vMPFC Brain Stimulation on Outcomes in Treatment-Engaged Cocaine Users
    Role: Principal Investigator

    R01DA044471     (HANLON, COLLEEN A)Apr 15, 2018 - Feb 28, 2022
    NIH
    Translational approaches to TMS treatment development for smoking
    Role: Principal Investigator

    R21DA044503     (BORCKARDT, JEFFREY J)Aug 15, 2018 - Jul 31, 2021
    NIH
    Developing brain stimulation as a treatment for pain in opiate dependent individuals
    Role: Principal Investigator

    P50DA046373     (KALIVAS, PETER W)Sep 15, 2019 - May 31, 2024
    NIH/NIDA
    Center for Opioid and Cocaine Addiction (COCA)
    Role: Co-Principal Investigator

    R01AA027705     (HANLON, COLLEEN A)Sep 20, 2019 - Aug 31, 2024
    NIH
    Longitudinal investigation of TMS as a tool to improve alcohol treatment outcomes
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. McCalley DM, Hanlon CA. Regionally specific gray matter volume is lower in alcohol use disorder: Implications for noninvasive brain stimulation treatment. Alcohol Clin Exp Res. 2021 Jun 12. PMID: 34120347.
      Citations:    
    2. Lench DH, DeVries W, Kearney-Ramos TE, Chesnutt A, Monsch ED, Embry AE, Doolittle JD, Kautz SA, Hanlon CA, Revuelta GJ. Paired inhibitory stimulation and gait training modulates supplemental motor area connectivity in freezing of gait. Parkinsonism Relat Disord. 2021 Jul; 88:28-33. PMID: 34102418.
      Citations:    
    3. Bergmann TO, Varatheeswaran R, Hanlon CA, Madsen KH, Thielscher A, Siebner HR. Concurrent TMS-fMRI for causal network perturbation and proof of target engagement. Neuroimage. 2021 Apr 30; 237:118093. PMID: 33940146.
      Citations:    
    4. McCalley DM, Lench DH, Doolittle JD, Imperatore JP, Hoffman M, Hanlon CA. Determining the optimal pulse number for theta burst induced change in cortical excitability. Sci Rep. 2021 Apr 22; 11(1):8726. PMID: 33888752.
      Citations:    
    5. Smith HR, Imperatore JP, Hanlon CA. The frontal pole as a target for transcranial magnetic stimulation: A retrospective analysis of feasibility and tolerability. Brain Stimul. 2021 May-Jun; 14(3):655-657. PMID: 33826932.
      Citations:    
    6. Imperatore JP, McCalley DM, Borckardt JJ, Brady KT, Hanlon CA. Non-invasive brain stimulation as a tool to decrease chronic pain in current opiate users: A parametric evaluation of two promising cortical targets. Drug Alcohol Depend. 2021 01 01; 218:108409. PMID: 33250384.
      Citations:    
    7. Doolittle JD, Downey RJ, Imperatore JP, Dowdle LT, Lench DH, McLeod J, McCalley DM, Gregory CM, Hanlon CA. Evaluating a novel MR-compatible foot pedal device for unipedal and bipedal motion: Test-retest reliability of evoked brain activity. Hum Brain Mapp. 2021 Jan; 42(1):128-138. PMID: 33089953.
      Citations:    
    8. Hanlon CA, Czoty PW, Smith HR, Epperly PM, Galbo LK. Cortical excitability in a nonhuman primate model of TMS. Brain Stimul. 2021 Jan-Feb; 14(1):19-21. PMID: 33099045.
      Citations:    
    9. Badran BW, Caulfield KA, Cox C, Lopez JW, Borckardt JJ, DeVries WH, Summers P, Kerns S, Hanlon CA, McTeague LM, George MS, Roberts DR. Brain stimulation in zero gravity: transcranial magnetic stimulation (TMS) motor threshold decreases during zero gravity induced by parabolic flight. NPJ Microgravity. 2020; 6:26. PMID: 33024819.
      Citations:    
    10. Mahoney JJ, Hanlon CA, Marshalek PJ, Rezai AR, Krinke L. Transcranial magnetic stimulation, deep brain stimulation, and other forms of neuromodulation for substance use disorders: Review of modalities and implications for treatment. J Neurol Sci. 2020 11 15; 418:117149. PMID: 33002757.
      Citations:    
    11. Milighetti S, Sterzi S, Fregni F, Hanlon CA, Hayley P, Murphy MD, Bundy DT, Nudo RJ, Guggenmos DJ. Effects of tDCS on spontaneous spike activity in a healthy ambulatory rat model. Brain Stimul. 2020 Nov - Dec; 13(6):1566-1576. PMID: 32927094.
      Citations:    
    12. Lench DH, Hutchinson S, Woodbury ML, Hanlon CA. Kinematic Measures of Bimanual Performance are Associated With Callosum White Matter Change in People With Chronic Stroke. Arch Rehabil Res Clin Transl. 2020 Dec; 2(4):100075. PMID: 33543100.
      Citations:    
    13. Bikson M, Hanlon CA, Woods AJ, Gillick BT, Charvet L, Lamm C, Madeo G, Holczer A, Almeida J, Antal A, Ay MR, Baeken C, Blumberger DM, Campanella S, Camprodon JA, Christiansen L, Loo C, Crinion JT, Fitzgerald P, Gallimberti L, Ghobadi-Azbari P, Ghodratitoostani I, Grabner RH, Hartwigsen G, Hirata A, Kirton A, Knotkova H, Krupitsky E, Marangolo P, Nakamura-Palacios EM, Potok W, Praharaj SK, Ruff CC, Schlaug G, Siebner HR, Stagg CJ, Thielscher A, Wenderoth N, Yuan TF, Zhang X, Ekhtiari H. Guidelines for TMS/tES clinical services and research through the COVID-19 pandemic. Brain Stimul. 2020 Jul - Aug; 13(4):1124-1149. PMID: 32413554.
      Citations:    
    14. Lench DH, Embry A, Hydar A, Hanlon CA, Revuelta G. Increased on-state cortico-mesencephalic functional connectivity in Parkinson disease with freezing of gait. Parkinsonism Relat Disord. 2020 03; 72:31-36. PMID: 32097881.
      Citations:    
    15. Philip NS, Sorensen DO, McCalley DM, Hanlon CA. Non-invasive Brain Stimulation for Alcohol Use Disorders: State of the Art and Future Directions. Neurotherapeutics. 2020 01; 17(1):116-126. PMID: 31452080.
      Citations:    
    16. Hanlon CA, Lench DH, Dowdle LT, Ramos TK. Neural Architecture Influences Repetitive Transcranial Magnetic Stimulation-Induced Functional Change: A Diffusion Tensor Imaging and Functional Magnetic Resonance Imaging Study of Cue-Reactivity Modulation in Alcohol Users. Clin Pharmacol Ther. 2019 10; 106(4):702-705. PMID: 31206172.
      Citations:    
    17. Ekhtiari H, Tavakoli H, Addolorato G, Baeken C, Bonci A, Campanella S, Castelo-Branco L, Challet-Bouju G, Clark VP, Claus E, Dannon PN, Del Felice A, den Uyl T, Diana M, di Giannantonio M, Fedota JR, Fitzgerald P, Gallimberti L, Grall-Bronnec M, Herremans SC, Herrmann MJ, Jamil A, Khedr E, Kouimtsidis C, Kozak K, Krupitsky E, Lamm C, Lechner WV, Madeo G, Malmir N, Martinotti G, McDonald WM, Montemitro C, Nakamura-Palacios EM, Nasehi M, Noël X, Nosratabadi M, Paulus M, Pettorruso M, Pradhan B, Praharaj SK, Rafferty H, Sahlem G, Salmeron BJ, Sauvaget A, Schluter RS, Sergiou C, Shahbabaie A, Sheffer C, Spagnolo PA, Steele VR, Yuan TF, van Dongen JDM, Van Waes V, Venkatasubramanian G, Verdejo-García A, Verveer I, Welsh JW, Wesley MJ, Witkiewitz K, Yavari F, Zarrindast MR, Zawertailo L, Zhang X, Cha YH, George TP, Frohlich F, Goudriaan AE, Fecteau S, Daughters SB, Stein EA, Fregni F, Nitsche MA, Zangen A, Bikson M, Hanlon CA. Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead. Neurosci Biobehav Rev. 2019 09; 104:118-140. PMID: 31271802.
      Citations:    
    18. Kearney-Ramos TE, Dowdle LT, Mithoefer OJ, Devries W, George MS, Hanlon CA. State-Dependent Effects of Ventromedial Prefrontal Cortex Continuous Thetaburst Stimulation on Cocaine Cue Reactivity in Chronic Cocaine Users. Front Psychiatry. 2019; 10:317. PMID: 31133897.
      Citations:    
    19. Dowdle LT, Borckardt JJ, Back SE, Morgan K, Adams D, Madan A, Balliet W, Hanlon CA. Sensitized brain response to acute pain in patients using prescription opiates for chronic pain: A pilot study. Drug Alcohol Depend. 2019 07 01; 200:6-13. PMID: 31071496.
      Citations:    
    20. Seo NJ, Lakshminarayanan K, Lauer AW, Ramakrishnan V, Schmit BD, Hanlon CA, George MS, Bonilha L, Downey RJ, DeVries W, Nagy T. Use of imperceptible wrist vibration to modulate sensorimotor cortical activity. Exp Brain Res. 2019 Mar; 237(3):805-816. PMID: 30607471.
      Citations:    
    21. Hanlon CA. Treating cue-reactivity with brain stimulation: a new (transdiagnostic) approach. Neuropsychopharmacology. 2019 01; 44(1):232-233. PMID: 30293999.
      Citations:    
    22. Adisetiyo V, McGill CE, DeVries WH, Jensen JH, Hanlon CA, Helpern JA. Elevated Brain Iron in Cocaine Use Disorder as Indexed by Magnetic Field Correlation Imaging. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 06; 4(6):579-588. PMID: 30581153.
      Citations:    
    23. Hanlon CA, Shannon EE, Porrino LJ. Brain activity associated with social exclusion overlaps with drug-related frontal-striatal circuitry in cocaine users: A pilot study. Neurobiol Stress. 2019 Feb; 10:100137. PMID: 30937344.
      Citations:    
    24. Hanlon CA, Dowdle LT, Gibson NB, Li X, Hamilton S, Canterberry M, Hoffman M. Cortical substrates of cue-reactivity in multiple substance dependent populations: transdiagnostic relevance of the medial prefrontal cortex. Transl Psychiatry. 2018 09 07; 8(1):186. PMID: 30194288.
      Citations:    
    25. Hanlon CA, Philip NS, Price RB, Bickel WK, Downar J. A Case for the Frontal Pole as an Empirically Derived Neuromodulation Treatment Target. Biol Psychiatry. 2019 02 01; 85(3):e13-e14. PMID: 30126608.
      Citations:    
    26. Bell SJ, Lauer A, Lench DH, Hanlon CA. Visual Attention Affects the Amplitude of the Transcranial Magnetic Stimulation-associated Motor-evoked Potential: A Preliminary Study With Clinical Utility. J Psychiatr Pract. 2018 07; 24(4):220-229. PMID: 30427805.
      Citations:    
    27. Hanlon CA, Dowdle LT, Henderson JS. Modulating Neural Circuits with Transcranial Magnetic Stimulation: Implications for Addiction Treatment Development. Pharmacol Rev. 2018 07; 70(3):661-683. PMID: 29945899.
      Citations:    
    28. Charalambous CC, Dean JC, Adkins DL, Hanlon CA, Bowden MG. Characterizing the corticomotor connectivity of the bilateral ankle muscles during rest and isometric contraction in healthy adults. J Electromyogr Kinesiol. 2018 Aug; 41:9-18. PMID: 29715530.
      Citations:    
    29. Kearney-Ramos TE, Lench DH, Hoffman M, Correia B, Dowdle LT, Hanlon CA. Author Correction: Gray and white matter integrity influence TMS signal propagation: a multimodal evaluation in cocaine-dependent individuals. Sci Rep. 2018 Apr 20; 8(1):6497. PMID: 29679040.
      Citations:    
    30. Kearney-Ramos TE, Dowdle LT, Lench DH, Mithoefer OJ, Devries WH, George MS, Anton RF, Hanlon CA. Transdiagnostic Effects of Ventromedial Prefrontal Cortex Transcranial Magnetic Stimulation on Cue Reactivity. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 07; 3(7):599-609. PMID: 29776789.
      Citations:    
    31. Dowdle LT, Brown TR, George MS, Hanlon CA. Single pulse TMS to the DLPFC, compared to a matched sham control, induces a direct, causal increase in caudate, cingulate, and thalamic BOLD signal. Brain Stimul. 2018 Jul - Aug; 11(4):789-796. PMID: 29530447.
      Citations:    
    32. Kearney-Ramos TE, Lench DH, Hoffman M, Correia B, Dowdle LT, Hanlon CA. Gray and white matter integrity influence TMS signal propagation: a multimodal evaluation in cocaine-dependent individuals. Sci Rep. 2018 02 19; 8(1):3253. PMID: 29459743.
      Citations:    
    33. Hanlon CA, Kearney-Ramos T, Dowdle LT, Hamilton S, DeVries W, Mithoefer O, Austelle C, Lench DH, Correia B, Canterberry M, Smith JP, Brady KT, George MS. Developing Repetitive Transcranial Magnetic Stimulation (rTMS) as a Treatment Tool for Cocaine Use Disorder: a Series of Six Translational Studies. Curr Behav Neurosci Rep. 2017 Dec; 4(4):341-352. PMID: 30009124.
      Citations:    
    34. Li X, Sahlem GL, Badran BW, McTeague LM, Hanlon CA, Hartwell KJ, Henderson S, George MS. Transcranial magnetic stimulation of the dorsal lateral prefrontal cortex inhibits medial orbitofrontal activity in smokers. Am J Addict. 2017 Dec; 26(8):788-794. PMID: 28898485.
      Citations:    
    35. Hanlon CA, Dowdle LT, Correia B, Mithoefer O, Kearney-Ramos T, Lench D, Griffin M, Anton RF, George MS. Left frontal pole theta burst stimulation decreases orbitofrontal and insula activity in cocaine users and alcohol users. Drug Alcohol Depend. 2017 09 01; 178:310-317. PMID: 28686990.
      Citations:    
    36. Summers PM, Hanlon CA. BrainRuler-a free, open-access tool for calculating scalp to cortex distance. Brain Stimul. 2017 Sep - Oct; 10(5):1009-1010. PMID: 28528737.
      Citations:    
    37. Lench DH, DeVries W, Hanlon CA. The effect of task difficulty on motor performance and frontal-striatal connectivity in cocaine users. Drug Alcohol Depend. 2017 Apr 01; 173:178-184. PMID: 28260681.
      Citations:    
    38. Hanlon CA, Dowdle LT, Jones JL. Biomarkers for Success: Using Neuroimaging to Predict Relapse and Develop Brain Stimulation Treatments for Cocaine-Dependent Individuals. Int Rev Neurobiol. 2016; 129:125-56. PMID: 27503451.
      Citations:    
    39. Canterberry M, Peltier MR, Brady KT, Hanlon CA. Attenuated neural response to emotional cues in cocaine-dependence: a preliminary analysis of gender differences. Am J Drug Alcohol Abuse. 2016 09; 42(5):577-586. PMID: 27441590.
      Citations:    
    40. Hanlon CA, Dowdle LT, Moss H, Canterberry M, George MS. Mobilization of Medial and Lateral Frontal-Striatal Circuits in Cocaine Users and Controls: An Interleaved TMS/BOLD Functional Connectivity Study. Neuropsychopharmacology. 2016 12; 41(13):3032-3041. PMID: 27374278.
      Citations:    
    41. Dunlop K, Hanlon CA, Downar J. Noninvasive brain stimulation treatments for addiction and major depression. Ann N Y Acad Sci. 2017 04; 1394(1):31-54. PMID: 26849183.
      Citations:    
    42. Mullins CR, Hanlon CA. MAVIN: An Open-Source Tool for Interactive Analysis and Visualization of EMG Data. Brain Stimul. 2016 Mar-Apr; 9(2):305-6. PMID: 26970384.
      Citations:    
    43. Hartwell KJ, Hanlon CA, Li X, Borckardt JJ, Canterberry M, Prisciandaro JJ, Moran-Santa Maria MM, LeMatty T, George MS, Brady KT. Individualized real-time fMRI neurofeedback to attenuate craving in nicotine-dependent smokers. J Psychiatry Neurosci. 2016 Jan; 41(1):48-55. PMID: 26505139.
      Citations:    
    44. Wesley MJ, Lile JA, Hanlon CA, Porrino LJ. Abnormal medial prefrontal cortex activity in heavy cannabis users during conscious emotional evaluation. Psychopharmacology (Berl). 2016 Mar; 233(6):1035-44. PMID: 26690589.
      Citations:    
    45. Bickel WK, Snider SE, Quisenberry AJ, Stein JS, Hanlon CA. Competing neurobehavioral decision systems theory of cocaine addiction: From mechanisms to therapeutic opportunities. Prog Brain Res. 2016; 223:269-93. PMID: 26806781.
      Citations:    
    46. Hanlon CA, DeVries W, Dowdle LT, West JA, Siekman B, Li X, George MS. A comprehensive study of sensorimotor cortex excitability in chronic cocaine users: Integrating TMS and functional MRI data. Drug Alcohol Depend. 2015 Dec 01; 157:28-35. PMID: 26541870.
      Citations:    
    47. Hanlon CA, Dowdle LT, Austelle CW, DeVries W, Mithoefer O, Badran BW, George MS. What goes up, can come down: Novel brain stimulation paradigms may attenuate craving and craving-related neural circuitry in substance dependent individuals. Brain Res. 2015 Dec 02; 1628(Pt A):199-209. PMID: 25770818.
      Citations:    
    48. Williams NR, Taylor JJ, Lamb K, Hanlon CA, Short EB, George MS. Role of functional imaging in the development and refinement of invasive neuromodulation for psychiatric disorders. World J Radiol. 2014 Oct 28; 6(10):756-78. PMID: 25349661.
      Citations:    
    49. Hanlon CA, Owens MM, Joseph JE, Zhu X, George MS, Brady KT, Hartwell KJ. Lower subcortical gray matter volume in both younger smokers and established smokers relative to non-smokers. Addict Biol. 2016 Jan; 21(1):185-95. PMID: 25125263.
      Citations:    
    50. Hanlon CA, Dowdle LT, Naselaris T, Canterberry M, Cortese BM. Visual cortex activation to drug cues: a meta-analysis of functional neuroimaging papers in addiction and substance abuse literature. Drug Alcohol Depend. 2014 Oct 01; 143:206-12. PMID: 25155889.
      Citations:    
    51. Stoeckel LE, Garrison KA, Ghosh S, Wighton P, Hanlon CA, Gilman JM, Greer S, Turk-Browne NB, deBettencourt MT, Scheinost D, Craddock C, Thompson T, Calderon V, Bauer CC, George M, Breiter HC, Whitfield-Gabrieli S, Gabrieli JD, LaConte SM, Hirshberg L, Brewer JA, Hampson M, Van Der Kouwe A, Mackey S, Evins AE. Optimizing real time fMRI neurofeedback for therapeutic discovery and development. Neuroimage Clin. 2014; 5:245-55. PMID: 25161891.
      Citations:    
    52. Moran-Santa Maria MM, Hartwell KJ, Hanlon CA, Canterberry M, Lematty T, Owens M, Brady KT, George MS. Right anterior insula connectivity is important for cue-induced craving in nicotine-dependent smokers. Addict Biol. 2015 Mar; 20(2):407-14. PMID: 24529072.
      Citations:    
    53. Goldman RL, Canterberry M, Borckardt JJ, Madan A, Byrne TK, George MS, O'Neil PM, Hanlon CA. Executive control circuitry differentiates degree of success in weight loss following gastric-bypass surgery. Obesity (Silver Spring). 2013 Nov; 21(11):2189-2196. PMID: 24136926.
      Citations:    
    54. Li X, Malcolm RJ, Huebner K, Hanlon CA, Taylor JJ, Brady KT, George MS, See RE. Low frequency repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex transiently increases cue-induced craving for methamphetamine: a preliminary study. Drug Alcohol Depend. 2013 Dec 01; 133(2):641-6. PMID: 24028801.
      Citations:    
    55. Canterberry M, Hanlon CA, Hartwell KJ, Li X, Owens M, LeMatty T, Prisciandaro JJ, Borckardt J, Saladin ME, Brady KT, George MS. Sustained reduction of nicotine craving with real-time neurofeedback: exploring the role of severity of dependence. Nicotine Tob Res. 2013 Dec; 15(12):2120-4. PMID: 23935182.
      Citations:    
    56. Hanlon CA, Canterberry M, Taylor JJ, DeVries W, Li X, Brown TR, George MS. Probing the frontostriatal loops involved in executive and limbic processing via interleaved TMS and functional MRI at two prefrontal locations: a pilot study. PLoS One. 2013; 8(7):e67917. PMID: 23874466.
      Citations:    
    57. Hanlon CA, Hartwell KJ, Canterberry M, Li X, Owens M, Lematty T, Prisciandaro JJ, Borckardt J, Brady KT, George MS. Reduction of cue-induced craving through realtime neurofeedback in nicotine users: the role of region of interest selection and multiple visits. Psychiatry Res. 2013 Jul 30; 213(1):79-81. PMID: 23683344.
      Citations:    
    58. Hanlon CA, Beveridge TJ, Porrino LJ. Recovering from cocaine: insights from clinical and preclinical investigations. Neurosci Biobehav Rev. 2013 Nov; 37(9 Pt A):2037-46. PMID: 23628740.
      Citations:    
    59. Li X, Hartwell KJ, Owens M, Lematty T, Borckardt JJ, Hanlon CA, Brady KT, George MS. Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex reduces nicotine cue craving. Biol Psychiatry. 2013 Apr 15; 73(8):714-20. PMID: 23485014.
      Citations:    
    60. Taylor JJ, Borckardt JJ, Canterberry M, Li X, Hanlon CA, Brown TR, George MS. Naloxone-reversible modulation of pain circuitry by left prefrontal rTMS. Neuropsychopharmacology. 2013 Jun; 38(7):1189-97. PMID: 23314221.
      Citations:    
    61. Hanlon CA, Canterberry M. The use of brain imaging to elucidate neural circuit changes in cocaine addiction. Subst Abuse Rehabil. 2012 Sep; 3(1):115-128. PMID: 23162375.
      Citations:    
    62. Hanlon CA, Jones EM, Li X, Hartwell KJ, Brady KT, George MS. Individual variability in the locus of prefrontal craving for nicotine: implications for brain stimulation studies and treatments. Drug Alcohol Depend. 2012 Oct 01; 125(3):239-43. PMID: 22459915.
      Citations:    
    63. Hanlon CA, Dufault DL, Wesley MJ, Porrino LJ. Elevated gray and white matter densities in cocaine abstainers compared to current users. Psychopharmacology (Berl). 2011 Dec; 218(4):681-92. PMID: 21691942.
      Citations:    
    64. Hanlon CA, Wesley MJ, Stapleton JR, Laurienti PJ, Porrino LJ. The association between frontal-striatal connectivity and sensorimotor control in cocaine users. Drug Alcohol Depend. 2011 Jun 01; 115(3):240-3. PMID: 21193273.
      Citations:    
    65. Wesley MJ, Hanlon CA, Porrino LJ. Poor decision-making by chronic marijuana users is associated with decreased functional responsiveness to negative consequences. Psychiatry Res. 2011 Jan 30; 191(1):51-9. PMID: 21145211.
      Citations:    
    66. Hanlon CA, Wesley MJ, Roth AJ, Miller MD, Porrino LJ. Loss of laterality in chronic cocaine users: an fMRI investigation of sensorimotor control. Psychiatry Res. 2010 Jan 30; 181(1):15-23. PMID: 19959345.
      Citations:    
    67. Hanlon CA, Wesley MJ, Porrino LJ. Loss of functional specificity in the dorsal striatum of chronic cocaine users. Drug Alcohol Depend. 2009 Jun 01; 102(1-3):88-94. PMID: 19264428.
      Citations:    
    68. Beveridge TJ, Gill KE, Hanlon CA, Porrino LJ. Review. Parallel studies of cocaine-related neural and cognitive impairment in humans and monkeys. Philos Trans R Soc Lond B Biol Sci. 2008 Oct 12; 363(1507):3257-66. PMID: 18640916.
      Citations:    
    69. Hanlon CA, Buffington AL, McKeown MJ. New brain networks are active after right MCA stroke when moving the ipsilesional arm. Neurology. 2005 Jan 11; 64(1):114-20. PMID: 15642913.
      Citations:    
    70. Buffington AL, Hanlon CA, McKeown MJ. Acute and persistent pain modulation of attention-related anterior cingulate fMRI activations. Pain. 2005 Jan; 113(1-2):172-84. PMID: 15621378.
      Citations:    
    71. McKeown MJ, Hanlon CA. A post-processing/region of interest (ROI) method for discriminating patterns of activity in statistical maps of fMRI data. J Neurosci Methods. 2004 May 30; 135(1-2):137-47. PMID: 15020098.
      Citations:    
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