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Carlos M. Ferrario MD

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentSurgery, General Administration
Address
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    T32HL007242     (FERRARIO, CARLOS M)Jul 1, 1977 - Jun 30, 1990
    NIH
    STUDIES IN CARDIOVASCULAR DISEASES
    Role: Principal Investigator
    P01HL006835     (BARNES, KAREN)Dec 1, 1978 - Nov 30, 1993
    NIH
    NEUROHORMONAL MECHANISMS IN HYPERTENSION
    Role: Co-Principal Investigator
    R01HL031256     (FERRARIO, CARLOS M)Dec 1, 1983 - Nov 30, 1986
    NIH
    NEUROGENIC HYPERTENSION
    Role: Principal Investigator
    R01HL050066     (FERRARIO, CARLOS M)Aug 1, 1992 - Jul 31, 2002
    NIH
    ANGIOTENSIN 1-7 IN THE SPONTANEOUSLY HYPERTENSIVE
    Role: Principal Investigator
    P01HL051952     (FERRARIO, CARLOS M)Apr 1, 1994 - Mar 31, 2021
    NIH
    Vaso-Hormonal Mechanisms in Hypertension
    Role: Principal Investigator
    T32HL007868     (FERRARIO, CARLOS M)May 1, 1997 - Apr 30, 2003
    NIH
    PATHOBIOLOGY OF VASCULAR DISEASE
    Role: Principal Investigator
    R01HL068258     (FERRARIO, CARLOS M)Sep 1, 2001 - Aug 31, 2006
    NIH
    ATHEROGENESIS AND THE BONE MARROW ANGIOTENSIN SYSTEM
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. da Silva JS, Sun X, Ahmad S, Wang H, Sudo RT, Varagic J, Ferrario CM, Zapata-Sudo G, Groban L. G-Protein-Coupled Estrogen Receptor Agonist G1 Improves Diastolic Function and Attenuates Cardiac Renin-Angiotensin System Activation in Estrogen-Deficient Hypertensive Rats. J Cardiovasc Pharmacol. 2019 11; 74(5):443-452. PMID: 31361702.
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    2. Wang H, Sun X, Hodge HS, Ferrario CM, Groban L. NLRP3 inhibition improves heart function in GPER knockout mice. Biochem Biophys Res Commun. 2019 06 30; 514(3):998-1003. PMID: 31092335.
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    3. Wang H, Sun X, Ahmad S, Su J, Ferrario CM, Groban L. Estrogen modulates the differential expression of cardiac myocyte chymase isoforms and diastolic function. Mol Cell Biochem. 2019 Jun; 456(1-2):85-93. PMID: 30712071.
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    4. Ahmad S, Ferrario CM. Chymase inhibitors for the treatment of cardiac diseases: a patent review (2010-2018). Expert Opin Ther Pat. 2018 11; 28(11):755-764. PMID: 30278800.
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    5. Wang H, Sun X, Lin MS, Ferrario CM, Van Remmen H, Groban L. G protein-coupled estrogen receptor (GPER) deficiency induces cardiac remodeling through oxidative stress. Transl Res. 2018 09; 199:39-51. PMID: 29758174.
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    6. Li T, Zhang X, Cheng HJ, Zhang Z, Ahmad S, Varagic J, Li W, Cheng CP, Ferrario CM. Critical role of the chymase/angiotensin-(1-12) axis in modulating cardiomyocyte contractility. Int J Cardiol. 2018 08 01; 264:137-144. PMID: 29685688.
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    7. Dell'Italia LJ, Collawn JF, Ferrario CM. Multifunctional Role of Chymase in Acute and Chronic Tissue Injury and Remodeling. Circ Res. 2018 01 19; 122(2):319-336. PMID: 29348253.
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    8. Butts B, Goeddel LA, George DJ, Steele C, Davies JE, Wei CC, Varagic J, George JF, Ferrario CM, Melby SJ, Dell'Italia LJ. Increased Inflammation in Pericardial Fluid Persists 48 Hours After Cardiac Surgery. Circulation. 2017 12 05; 136(23):2284-2286. PMID: 29203568.
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    9. Ahmad S, Sun X, Lin M, Varagic J, Zapata-Sudo G, Ferrario CM, Groban L, Wang H. Blunting of estrogen modulation of cardiac cellular chymase/RAS activity and function in SHR. J Cell Physiol. 2018 04; 233(4):3330-3342. PMID: 28888034.
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    10. da Silva JS, Gabriel-Costa D, Wang H, Ahmad S, Sun X, Varagic J, Sudo RT, Ferrario CM, Dell Italia LJ, Sudo GZ, Groban L. Blunting of cardioprotective actions of estrogen in female rodent heart linked to altered expression of cardiac tissue chymase and ACE2. J Renin Angiotensin Aldosterone Syst. 2017 Jul-Sep; 18(3):1470320317722270. PMID: 28748720.
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    11. Ferrario CM, Mullick AE. Renin angiotensin aldosterone inhibition in the treatment of cardiovascular disease. Pharmacol Res. 2017 Nov; 125(Pt A):57-71. PMID: 28571891.
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    12. Ferrario CM, Frohlich ED, Gerena Y. Walmor C. De Mello: "Your Heart Is Still With Us". Hypertension. 2017 06; 69(6):992-993. PMID: 28396538.
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    13. Reyes S, Varagic J, Ahmad S, VonCannon J, Kon ND, Wang H, Groban L, Cheng CP, Dell'Italia LJ, Ferrario CM. Novel Cardiac Intracrine Mechanisms Based on Ang-(1-12)/Chymase Axis Require a Revision of Therapeutic Approaches in Human Heart Disease. Curr Hypertens Rep. 2017 Feb; 19(2):16. PMID: 28233239.
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    14. Zhang X, Cheng HJ, Zhou P, Kitzman DW, Ferrario CM, Li WM, Cheng CP. Cellular basis of angiotensin-(1-7)-induced augmentation of left ventricular functional performance in heart failure. Int J Cardiol. 2017 Jun 01; 236:405-412. PMID: 28096047.
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    15. Ola MS, Alhomida AS, Ferrario CM, Ahmad S. Role of Tissue Renin-angiotensin System and the Chymase/angiotensin-( 1-12) Axis in the Pathogenesis of Diabetic Retinopathy. Curr Med Chem. 2017; 24(28):3104-3114. PMID: 28403787.
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    16. Wang H, Sun X, Chou J, Lin M, Ferrario CM, Zapata-Sudo G, Groban L. Inflammatory and mitochondrial gene expression data in GPER-deficient cardiomyocytes from male and female mice. Data Brief. 2017 Feb; 10:465-473. PMID: 28054009.
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    17. Wang H, Sun X, Chou J, Lin M, Ferrario CM, Zapata-Sudo G, Groban L. Cardiomyocyte-specific deletion of the G protein-coupled estrogen receptor (GPER) leads to left ventricular dysfunction and adverse remodeling: A sex-specific gene profiling analysis. Biochim Biophys Acta Mol Basis Dis. 2017 08; 1863(8):1870-1882. PMID: 27725247.
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    18. Ahmad S, Varagic J, VonCannon JL, Groban L, Collawn JF, Dell'Italia LJ, Ferrario CM. Primacy of cardiac chymase over angiotensin converting enzyme as an angiotensin-(1-12) metabolizing enzyme. Biochem Biophys Res Commun. 2016 09 16; 478(2):559-64. PMID: 27465904.
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    19. Wang H, da Silva J, Alencar A, Zapata-Sudo G, Lin MR, Sun X, Ahmad S, Ferrario CM, Groban L. Mast Cell Inhibition Attenuates Cardiac Remodeling and Diastolic Dysfunction in Middle-aged, Ovariectomized Fischer 344 × Brown Norway Rats. J Cardiovasc Pharmacol. 2016 Jul; 68(1):49-57. PMID: 26981683.
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    20. Ferrario CM, Wang JG. Preface. Ther Adv Cardiovasc Dis. 2016 Jun; 10(3):116-7. PMID: 27271311.
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    21. Ferrario CM, Ahmad S, Varagic J, Cheng CP, Groban L, Wang H, Collawn JF, Dell Italia LJ. Intracrine angiotensin II functions originate from noncanonical pathways in the human heart. . 2016 08 01; 311(2):H404-14. PMID: 27233763.
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    22. Ferrario CM. Cardiac remodelling and RAS inhibition. Ther Adv Cardiovasc Dis. 2016 Jun; 10(3):162-71. PMID: 27105891.
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    23. Alencar AK, da Silva JS, Lin M, Silva AM, Sun X, Ferrario CM, Cheng C, Sudo RT, Zapata-Sudo G, Wang H, Groban L. Effect of Age, Estrogen Status, and Late-Life GPER Activation on Cardiac Structure and Function in the Fischer344×Brown Norway Female Rat. J Gerontol A Biol Sci Med Sci. 2017 02; 72(2):152-162. PMID: 27006078.
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    24. Ferrario CM, VonCannon J, Jiao Y, Ahmad S, Bader M, Dell'Italia LJ, Groban L, Varagic J. Cardiac angiotensin-(1-12) expression and systemic hypertension in rats expressing the human angiotensinogen gene. . 2016 Apr 15; 310(8):H995-1002. PMID: 26873967.
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    25. Sunwook K, Nussbaum MA, Quandt SA, Laurienti PJ, Arcury TA. Effects of Lifetime Occupational Pesticide Exposure on Postural Control Among Farmworkers and Non-Farmworkers. J Occup Environ Med. 2016 Feb; 58(2):133-9. PMID: 18456730.
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    26. Fu L, Wei CC, Powell PC, Bradley WE, Ahmad S, Ferrario CM, Collawn JF, Dell'Italia LJ. Increased fibroblast chymase production mediates procollagen autophagic digestion in volume overload. J Mol Cell Cardiol. 2016 Mar; 92:1-9. PMID: 26807691.
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    27. Irigoyen M, Thorne M, Ferrario CM. Therapeutic Advances in Cardiovascular Disease. Editorial. Ther Adv Cardiovasc Dis. 2015 Aug; 9(4):113-4. PMID: 26335584.
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    28. Zhou P, Cheng CP, Li T, Ferrario CM, Cheng HJ. Modulation of cardiac L-type Ca2+ current by angiotensin-(1-7): normal versus heart failure. Ther Adv Cardiovasc Dis. 2015 Dec; 9(6):342-53. PMID: 26082338.
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    29. Nagata S, Varagic J, Kon ND, Wang H, Groban L, Simington SW, Ahmad S, Dell'Italia LJ, VonCannon JL, Deal D, Ferrario CM. Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue. Ther Adv Cardiovasc Dis. 2015 Aug; 9(4):168-80. PMID: 26082339.
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    30. Ferrario CM, Schiffrin EL. Role of mineralocorticoid receptor antagonists in cardiovascular disease. Circ Res. 2015 Jan 02; 116(1):206-13. PMID: 25552697.
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    31. Varagic J, Punzi H, Ferrario CM. Clinical utility of fixed-dose combinations in hypertension: evidence for the potential of nebivolol/valsartan. Integr Blood Press Control. 2014; 7:61-70. PMID: 25473311.
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    32. Schindler C, Guenther K, Hermann C, Ferrario CM, Schroeder C, Haufe S, Jordan J, Kirch W. Statin treatment in hypercholesterolemic men does not attenuate angiotensin II-induced venoconstriction. PLoS One. 2014; 9(9):e103909. PMID: 25264877.
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    33. Flores-Monroy J, Ferrario CM, Valencia-Hernández I, Hernández-Campos ME, Martínez-Aguilar L. Comparative effects of a novel angiotensin-converting enzyme inhibitor versus captopril on plasma angiotensins after myocardial infarction. Pharmacology. 2014; 94(1-2):21-8. PMID: 25171296.
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    34. Ahmad S, Varagic J, Groban L, Dell'Italia LJ, Nagata S, Kon ND, Ferrario CM. Angiotensin-(1-12): a chymase-mediated cellular angiotensin II substrate. Curr Hypertens Rep. 2014 May; 16(5):429. PMID: 24633843.
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    35. Zheng J, Wei CC, Hase N, Shi K, Killingsworth CR, Litovsky SH, Powell PC, Kobayashi T, Ferrario CM, Rab A, Aban I, Collawn JF, Dell'Italia LJ. Chymase mediates injury and mitochondrial damage in cardiomyocytes during acute ischemia/reperfusion in the dog. PLoS One. 2014; 9(4):e94732. PMID: 24733352.
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    36. Ferrario CM, Ahmad S, Nagata S, Simington SW, Varagic J, Kon N, Dell'italia LJ. An evolving story of angiotensin-II-forming pathways in rodents and humans. Clin Sci (Lond). 2014 Apr; 126(7):461-9. PMID: 24329563.
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    37. Habibi J, Hayden MR, Ferrario CM, Sowers JR, Whaley-Connell AT. Salt Loading Promotes Kidney Injury via Fibrosis in Young Female Ren2 Rats. Cardiorenal Med. 2014 Apr; 4(1):43-52. PMID: 24847333.
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    38. Varagic J, Ahmad S, Nagata S, Ferrario CM. ACE2: angiotensin II/angiotensin-(1-7) balance in cardiac and renal injury. Curr Hypertens Rep. 2014 Mar; 16(3):420. PMID: 24510672.
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    39. Cohall DH, Scantlebury-Manning T, James S, Hall K, Ferrario CM. Renin-angiotensin-aldosterone system gender differences in an Afro-Caribbean population. J Renin Angiotensin Aldosterone Syst. 2015 Sep; 16(3):539-46. PMID: 24532825.
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    40. Joyner J, Cline DM, Simmons DR, Ferrario CM, Mount DL. Self-reported cardiovascular disease risk factors and associated hopelessness in African American participants of a church-placed health screening program. Ethn Dis. 2014; 24(1):60-6. PMID: 24620450.
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    41. Joyner J, Moore MA, Simmons DR, Forrest B, Yu-Isenberg K, Piccione R, Caton K, Lackland DT, Ferrario CM. Impact of performance improvement continuing medical education on cardiometabolic risk factor control: the COSEHC initiative. J Contin Educ Health Prof. 2014; 34(1):25-36. PMID: 24648361.
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    42. Ferrario CM, Jessup JA, Smith RD. Hemodynamic and hormonal patterns of untreated essential hypertension in men and women. Ther Adv Cardiovasc Dis. 2013 Dec; 7(6):293-305. PMID: 24280597.
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    43. Wang H, Jessup JA, Zhao Z, Da Silva J, Lin M, MacNamara LM, Ahmad S, Chappell MC, Ferrario CM, Groban L. Characterization of the cardiac renin angiotensin system in oophorectomized and estrogen-replete mRen2.Lewis rats. PLoS One. 2013; 8(10):e76992. PMID: 24204720.
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    44. Whaley-Connell AT, Habibi J, Aroor A, Ma L, Hayden MR, Ferrario CM, Demarco VG, Sowers JR. Salt loading exacerbates diastolic dysfunction and cardiac remodeling in young female Ren2 rats. Metabolism. 2013 Dec; 62(12):1761-71. PMID: 24075738.
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    45. Varagic J, Ferrario CM. Response to "Angiotensin-(1-7) in the central regulation of blood pressure and renin-angiotensin system". Am J Hypertens. 2013 Sep; 26(9):1175. PMID: 23939419.
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    46. Ferrario CM, Joyner J, Colby C, Exuzides A, Moore M, Simmons D, Bestermann W, Frech-Tamas F. The COSEHC™ Global Vascular Risk Management quality improvement program: first follow-up report. Vasc Health Risk Manag. 2013; 9:391-400. PMID: 23901282.
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    47. Moniwa N, Varagic J, Simington SW, Ahmad S, Nagata S, Voncannon JL, Ferrario CM. Primacy of angiotensin converting enzyme in angiotensin-(1-12) metabolism. . 2013 Sep 01; 305(5):H644-50. PMID: 23812388.
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    48. Dell'Italia LJ, Ferrario CM. The never-ending story of angiotensin peptides: beyond angiotensin I and II. Circ Res. 2013 Apr 12; 112(8):1086-7. PMID: 23580768.
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    49. Varagic J, Ahmad S, VonCannon JL, Moniwa N, Brosnihan KB, Wysocki J, Batlle D, Ferrario CM. Predominance of AT(1) blockade over mas-mediated angiotensin-(1-7) mechanisms in the regulation of blood pressure and renin-angiotensin system in mRen2.Lewis rats. Am J Hypertens. 2013 May; 26(5):583-90. PMID: 23459599.
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    50. Whaley-Connell A, Habibi J, Rehmer N, Ardhanari S, Hayden MR, Pulakat L, Krueger C, Ferrario CM, DeMarco VG, Sowers JR. Renin inhibition and AT(1)R blockade improve metabolic signaling, oxidant stress and myocardial tissue remodeling. Metabolism. 2013 Jun; 62(6):861-72. PMID: 23352204.
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    51. Ferrario CM, Panjabi S, Buzinec P, Swindle JP. Clinical and economic outcomes associated with amlodipine/renin-angiotensin system blocker combinations. Ther Adv Cardiovasc Dis. 2013 Feb; 7(1):27-39. PMID: 23328188.
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    52. Ahmad S, Wei CC, Tallaj J, Dell'Italia LJ, Moniwa N, Varagic J, Ferrario CM. Chymase mediates angiotensin-(1-12) metabolism in normal human hearts. J Am Soc Hypertens. 2013 Mar-Apr; 7(2):128-36. PMID: 23312967.
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    53. Moniwa N, Varagic J, Ahmad S, VonCannon JL, Simington SW, Wang H, Groban L, Brosnihan KB, Nagata S, Kato J, Kitamura K, Gomez RA, Lopez ML, Ferrario CM. Hemodynamic and hormonal changes to dual renin-angiotensin system inhibition in experimental hypertension. Hypertension. 2013 Feb; 61(2):417-24. PMID: 23232645.
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    54. Varagic J, Ahmad S, Voncannon JL, Moniwa N, Simington SW, Brosnihan BK, Gallagher PE, Habibi J, Sowers JR, Ferrario CM. Nebivolol reduces cardiac angiotensin II, associated oxidative stress and fibrosis but not arterial pressure in salt-loaded spontaneously hypertensive rats. J Hypertens. 2012 Sep; 30(9):1766-74. PMID: 22895019.
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    55. Groban L, Wang H, Machado FS, Trask AJ, Kritchevsky SB, Ferrario CM, Diz DI. Low glial angiotensinogen improves body habitus, diastolic function, and exercise tolerance in aging male rats. Cardiovasc Endocrinol. 2012 Sep 01; 1(3):49-58. PMID: 23795309.
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    56. Joyner J, Moore AR, Mount DL, Simmons DR, Ferrario CM, Cline DM. Emergency department patients self-report higher patient inertia, hopelessness, and harmful lifestyle choices than community counterparts. J Clin Hypertens (Greenwich). 2012 Dec; 14(12):828-35. PMID: 23205749.
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    57. Wei CC, Chen Y, Powell LC, Zheng J, Shi K, Bradley WE, Powell PC, Ahmad S, Ferrario CM, Dell'Italia LJ. Cardiac kallikrein-kinin system is upregulated in chronic volume overload and mediates an inflammatory induced collagen loss. PLoS One. 2012; 7(6):e40110. PMID: 22768235.
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    58. Whaley-Connell A, Habibi J, Nistala R, Hayden MR, Pulakat L, Sinak C, Locher B, Ferrario CM, Sowers JR. Combination of direct renin inhibition with angiotensin type 1 receptor blockade improves aldosterone but does not improve kidney injury in the transgenic Ren2 rat. Regul Pept. 2012 Jun 10; 176(1-3):36-44. PMID: 22465166.
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    59. Ma L, Gul R, Habibi J, Yang M, Pulakat L, Whaley-Connell A, Ferrario CM, Sowers JR. Nebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the transgenic (mRen2) rat. . 2012 Jun 01; 302(11):H2341-51. PMID: 22447938.
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    60. Moniwa N, Varagic J, Ahmad S, VonCannon JL, Ferrario CM. Restoration of the blood pressure circadian rhythm by direct renin inhibition and blockade of angiotensin II receptors in mRen2.Lewis hypertensive rats. Ther Adv Cardiovasc Dis. 2012 Feb; 6(1):15-29. PMID: 22222314.
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    61. Whaley-Connell AT, Habibi J, Nistala R, DeMarco VG, Pulakat L, Hayden MR, Joginpally T, Ferrario CM, Parrish AR, Sowers JR. Mineralocorticoid receptor-dependent proximal tubule injury is mediated by a redox-sensitive mTOR/S6K1 pathway. Am J Nephrol. 2012; 35(1):90-100. PMID: 22205374.
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    62. Ahmad S, Simmons T, Varagic J, Moniwa N, Chappell MC, Ferrario CM. Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue. PLoS One. 2011; 6(12):e28501. PMID: 22180785.
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    63. Igase M, Yokoyama H, Ferrario CM. Attenuation of hypertension-mediated glomerulosclerosis in conjunction with increased angiotensin (1-7). Ther Adv Cardiovasc Dis. 2011 Dec; 5(6):297-304. PMID: 22089474.
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    64. Johnson MS, DeMarco VG, Heesch CM, Whaley-Connell AT, Schneider RI, Rehmer NT, Tilmon RD, Ferrario CM, Sowers JR. Sex differences in baroreflex sensitivity, heart rate variability, and end organ damage in the TGR(mRen2)27 rat. . 2011 Oct; 301(4):H1540-50. PMID: 21821781.
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    65. Whaley-Connell A, Habibi J, Panfili Z, Hayden MR, Bagree S, Nistala R, Hyder S, Krueger B, Demarco V, Pulakat L, Ferrario CM, Parrish A, Sowers JR. Angiotensin II activation of mTOR results in tubulointerstitial fibrosis through loss of N-cadherin. Am J Nephrol. 2011; 34(2):115-25. PMID: 21720156.
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    66. Manrique C, Lastra G, Habibi J, Pulakat L, Schneider R, Durante W, Tilmon R, Rehmer J, Hayden MR, Ferrario CM, Whaley-Connell A, Sowers JR. Nebivolol improves insulin sensitivity in the TGR(Ren2)27 rat. Metabolism. 2011 Dec; 60(12):1757-66. PMID: 21640361.
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    67. Ahmad S, Varagic J, Westwood BM, Chappell MC, Ferrario CM. Uptake and metabolism of the novel peptide angiotensin-(1-12) by neonatal cardiac myocytes. PLoS One. 2011 Jan 10; 6(1):e15759. PMID: 21249217.
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    68. Ferrario CM. ACE2: more of Ang-(1-7) or less Ang II? Curr Opin Nephrol Hypertens. 2011 Jan; 20(1):1-6. PMID: 21045683.
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    69. Ferrario CM, Moore MA, Bestermann W, Colby C, Exuzides A, Simmons D, Panjabi S. COSEHC global vascular risk management quality improvement program: rationale and design. Vasc Health Risk Manag. 2010; 6:1135-45. PMID: 21931496.
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    70. Varagic J, Ahmad S, Brosnihan KB, Habibi J, Tilmon RD, Sowers JR, Ferrario CM. Salt-induced renal injury in spontaneously hypertensive rats: effects of nebivolol. Am J Nephrol. 2010; 32(6):557-66. PMID: 21042014.
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    71. Ferrario CM, Smith RD. Role of olmesartan in combination therapy in blood pressure control and vascular function. Vasc Health Risk Manag. 2010 Sep 07; 6:701-9. PMID: 20859541.
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    72. Arnold AC, Isa K, Shaltout HA, Nautiyal M, Ferrario CM, Chappell MC, Diz DI. Angiotensin-(1-12) requires angiotensin converting enzyme and AT1 receptors for cardiovascular actions within the solitary tract nucleus. . 2010 Sep; 299(3):H763-71. PMID: 20562338.
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    73. Ferrario CM, Varagic J. The ANG-(1-7)/ACE2/mas axis in the regulation of nephron function. Am J Physiol Renal Physiol. 2010 Jun; 298(6):F1297-305. PMID: 20375118.
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    74. Ferrario CM. ARBITER 6-HALTS. Does it have the power to settle all matters? Ther Adv Cardiovasc Dis. 2010 Apr; 4(2):77-81. PMID: 20360390.
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    75. Trask AJ, Groban L, Westwood BM, Varagic J, Ganten D, Gallagher PE, Chappell MC, Ferrario CM. Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats. Am J Hypertens. 2010 Jun; 23(6):687-93. PMID: 20300067.
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    76. Joyner-Grantham J, Simmons DR, Moore MA, Ferrario CM. The impact of changing ICD code on hypertension-related mortality in the southeastern United States from 1994-2005. J Clin Hypertens (Greenwich). 2010 Mar; 12(3):213-22. PMID: 20433540.
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    77. Hayden MR, Habibi J, Whaley-Connell A, Sowers D, Johnson M, Tilmon R, Jain D, Ferrario C, Sowers JR. Nebivolol attenuates maladaptive proximal tubule remodeling in transgenic rats. Am J Nephrol. 2010; 31(3):262-72. PMID: 20110666.
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    78. Ferrario CM, Ahmad S, Joyner J, Varagic J. Advances in the renin angiotensin system focus on angiotensin-converting enzyme 2 and angiotensin-(1-7). Adv Pharmacol. 2010; 59:197-233. PMID: 20933203.
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    79. Ferrario CM, Flack JM, Strobeck JE, Smits G, Peters C. Individualizing hypertension treatment with impedance cardiography: a meta-analysis of published trials. Ther Adv Cardiovasc Dis. 2010 Feb; 4(1):5-16. PMID: 20042450.
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    80. Ferrario CM. New physiological concepts of the renin-angiotensin system from the investigation of precursors and products of angiotensin I metabolism. Hypertension. 2010 Feb; 55(2):445-52. PMID: 20026757.
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    81. Whaley-Connell A, Nistala R, Habibi J, Hayden MR, Schneider RI, Johnson MS, Tilmon R, Rehmer N, Ferrario CM, Sowers JR. Comparative effect of direct renin inhibition and AT1R blockade on glomerular filtration barrier injury in the transgenic Ren2 rat. Am J Physiol Renal Physiol. 2010 Mar; 298(3):F655-61. PMID: 20007350.
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    82. Ferrario CM. Addressing the theoretical and clinical advantages of combination therapy with inhibitors of the renin-angiotensin-aldosterone system: antihypertensive effects and benefits beyond BP control. Life Sci. 2010 Feb 27; 86(9-10):289-99. PMID: 19958778.
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    83. Wysocki J, Ye M, Rodriguez E, González-Pacheco FR, Barrios C, Evora K, Schuster M, Loibner H, Brosnihan KB, Ferrario CM, Penninger JM, Batlle D. Targeting the degradation of angiotensin II with recombinant angiotensin-converting enzyme 2: prevention of angiotensin II-dependent hypertension. Hypertension. 2010 Jan; 55(1):90-8. PMID: 19948988.
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    84. Varagic J, Ahmad S, Brosnihan KB, Groban L, Chappell MC, Tallant EA, Gallagher PE, Ferrario CM. Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction. Ther Adv Cardiovasc Dis. 2010 Feb; 4(1):17-25. PMID: 19946038.
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    85. Joyner-Grantham J, Mount DL, McCorkle OD, Simmons DR, Ferrario CM, Cline DM. Self-reported influences of hopelessness, health literacy, lifestyle action, and patient inertia on blood pressure control in a hypertensive emergency department population. Am J Med Sci. 2009 Nov; 338(5):368-72. PMID: 19838100.
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    86. DeMarco VG, Habibi J, Whaley-Connell AT, Schneider RI, Sowers JR, Andresen BT, Gutweiler AA, Ma L, Johnson MS, Ferrario CM, Dellsperger KC. Rosuvastatin ameliorates the development of pulmonary arterial hypertension in the transgenic (mRen2)27 rat. . 2009 Sep; 297(3):H1128-39. PMID: 19633211.
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    87. Whaley-Connell A, Habibi J, Johnson M, Tilmon R, Rehmer N, Rehmer J, Wiedmeyer C, Ferrario CM, Sowers JR. Nebivolol reduces proteinuria and renal NADPH oxidase-generated reactive oxygen species in the transgenic Ren2 rat. Am J Nephrol. 2009; 30(4):354-60. PMID: 19609077.
      Citations:    
    88. Ferrario CM, Moore MA, Copeland L. The economic challenges in healthcare: the effect on quality. Am J Med Sci. 2009 Jun; 337(6):391-3. PMID: 19525657.
      Citations:    
    89. Isa K, García-Espinosa MA, Arnold AC, Pirro NT, Tommasi EN, Ganten D, Chappell MC, Ferrario CM, Diz DI. Chronic immunoneutralization of brain angiotensin-(1-12) lowers blood pressure in transgenic (mRen2)27 hypertensive rats. . 2009 Jul; 297(1):R111-5. PMID: 19403863.
      Citations:    
    90. Ferrario C. Effect of angiotensin receptor blockade on endothelial function: focus on olmesartan medoxomil. Vasc Health Risk Manag. 2009; 5(1):301-14. PMID: 19436655.
      Citations:    
    91. Ferrario CM. Memorial. Ther Adv Cardiovasc Dis. 2009 Apr; 3(2):101. PMID: 19299426.
      Citations:    
    92. Whaley-Connell A, Habibi J, Wei Y, Gutweiler A, Jellison J, Wiedmeyer CE, Ferrario CM, Sowers JR. Mineralocorticoid receptor antagonism attenuates glomerular filtration barrier remodeling in the transgenic Ren2 rat. Am J Physiol Renal Physiol. 2009 May; 296(5):F1013-22. PMID: 19261739.
      Citations:    
    93. Wei Y, Clark SE, Thyfault JP, Uptergrove GM, Li W, Whaley-Connell AT, Ferrario CM, Sowers JR, Ibdah JA. Oxidative stress-mediated mitochondrial dysfunction contributes to angiotensin II-induced nonalcoholic fatty liver disease in transgenic Ren2 rats. Am J Pathol. 2009 04; 174(4):1329-37. PMID: 19246643.
      Citations:    
    94. Lastra G, Habibi J, Whaley-Connell AT, Manrique C, Hayden MR, Rehmer J, Patel K, Ferrario C, Sowers JR. Direct renin inhibition improves systemic insulin resistance and skeletal muscle glucose transport in a transgenic rodent model of tissue renin overexpression. Endocrinology. 2009 Jun; 150(6):2561-8. PMID: 19246535.
      Citations:    
    95. Ferrario CM, Varagic J, Habibi J, Nagata S, Kato J, Chappell MC, Trask AJ, Kitamura K, Whaley-Connell A, Sowers JR. Differential regulation of angiotensin-(1-12) in plasma and cardiac tissue in response to bilateral nephrectomy. . 2009 Apr; 296(4):H1184-92. PMID: 19218503.
      Citations:    
    96. Ferrario CM. Editorial: journal accomplishments in just one short year. Ther Adv Cardiovasc Dis. 2009 Feb; 3(1):5. PMID: 19144666.
      Citations:    
    97. Wei Y, Whaley-Connell AT, Habibi J, Rehmer J, Rehmer N, Patel K, Hayden M, DeMarco V, Ferrario CM, Ibdah JA, Sowers JR. Mineralocorticoid receptor antagonism attenuates vascular apoptosis and injury via rescuing protein kinase B activation. Hypertension. 2009 Feb; 53(2):158-65. PMID: 19114643.
      Citations:    
    98. Ferrario CM. Questions to ponder. Ther Adv Cardiovasc Dis. 2008 Dec; 2(6):417-8. PMID: 19124437.
      Citations:    
    99. Gallagher PE, Ferrario CM, Tallant EA. Regulation of ACE2 in cardiac myocytes and fibroblasts. . 2008 Dec; 295(6):H2373-9. PMID: 18849338.
      Citations:    
    100. Gallagher PE, Ferrario CM, Tallant EA. MAP kinase/phosphatase pathway mediates the regulation of ACE2 by angiotensin peptides. . 2008 Nov; 295(5):C1169-74. PMID: 18768926.
      Citations:    
    101. Habibi J, Whaley-Connell A, Hayden MR, DeMarco VG, Schneider R, Sowers SD, Karuparthi P, Ferrario CM, Sowers JR. Renin inhibition attenuates insulin resistance, oxidative stress, and pancreatic remodeling in the transgenic Ren2 rat. Endocrinology. 2008 Nov; 149(11):5643-53. PMID: 18653711.
      Citations:    
    102. Schindler C, Ferrario CM. Olmesartan for the treatment of arterial hypertension. Future Cardiol. 2008 Jul; 4(4):357-72. PMID: 19804316.
      Citations:    
    103. Diz DI, Garcia-Espinosa MA, Gallagher PE, Ganten D, Ferrario CM, Averill DB. Angiotensin-(1-7) and baroreflex function in nucleus tractus solitarii of (mRen2)27 transgenic rats. J Cardiovasc Pharmacol. 2008 Jun; 51(6):542-8. PMID: 18475201.
      Citations:    
    104. Whaley-Connell A, Habibi J, Cooper SA, Demarco VG, Hayden MR, Stump CS, Link D, Ferrario CM, Sowers JR. Effect of renin inhibition and AT1R blockade on myocardial remodeling in the transgenic Ren2 rat. Am J Physiol Endocrinol Metab. 2008 Jul; 295(1):E103-9. PMID: 18460596.
      Citations:    
    105. Smith RD, Yokoyama H, Averill DB, Schiffrin EL, Ferrario CM. Reversal of vascular hypertrophy in hypertensive patients through blockade of angiotensin II receptors. J Am Soc Hypertens. 2008 May-Jun; 2(3):165-72. PMID: 20409899.
      Citations:    
    106. Lastra G, Whaley-Connell A, Manrique C, Habibi J, Gutweiler AA, Appesh L, Hayden MR, Wei Y, Ferrario C, Sowers JR. Low-dose spironolactone reduces reactive oxygen species generation and improves insulin-stimulated glucose transport in skeletal muscle in the TG(mRen2)27 rat. Am J Physiol Endocrinol Metab. 2008 Jul; 295(1):E110-6. PMID: 18445755.
      Citations:    
    107. Varagic J, Trask AJ, Jessup JA, Chappell MC, Ferrario CM. New angiotensins. J Mol Med (Berl). 2008 Jun; 86(6):663-71. PMID: 18437333.
      Citations:    
    108. Wei Y, Clark SE, Morris EM, Thyfault JP, Uptergrove GM, Whaley-Connell AT, Ferrario CM, Sowers JR, Ibdah JA. Angiotensin II-induced non-alcoholic fatty liver disease is mediated by oxidative stress in transgenic TG(mRen2)27(Ren2) rats. J Hepatol. 2008 Sep; 49(3):417-28. PMID: 18486983.
      Citations:    
    109. Jessup JA, Trask AJ, Chappell MC, Nagata S, Kato J, Kitamura K, Ferrario CM. Localization of the novel angiotensin peptide, angiotensin-(1-12), in heart and kidney of hypertensive and normotensive rats. . 2008 Jun; 294(6):H2614-8. PMID: 18408132.
      Citations:    
    110. Ferrario CM. On the selective inhibitors of Cyclooxygenase-2: do we have a last word? Ther Adv Cardiovasc Dis. 2008 Apr; 2(2):75-8. PMID: 19124410.
      Citations:    
    111. Ferrario CM. Of gender, statins, and coronary artery interventions. Ther Adv Cardiovasc Dis. 2008 Apr; 2(2):73-4. PMID: 19124409.
      Citations:    
    112. Trask AJ, Jessup JA, Chappell MC, Ferrario CM. Angiotensin-(1-12) is an alternate substrate for angiotensin peptide production in the heart. . 2008 May; 294(5):H2242-7. PMID: 18359898.
      Citations:    
    113. Diz DI, Garcia-Espinosa MA, Gegick S, Tommasi EN, Ferrario CM, Ann Tallant E, Chappell MC, Gallagher PE. Injections of angiotensin-converting enzyme 2 inhibitor MLN4760 into nucleus tractus solitarii reduce baroreceptor reflex sensitivity for heart rate control in rats. Exp Physiol. 2008 May; 93(5):694-700. PMID: 18356558.
      Citations:    
    114. Garabelli PJ, Modrall JG, Penninger JM, Ferrario CM, Chappell MC. Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heart. Exp Physiol. 2008 May; 93(5):613-21. PMID: 18356559.
      Citations:    
    115. Arnold AC, Sakima A, Ganten D, Ferrario CM, Diz DI. Modulation of reflex function by endogenous angiotensins in older transgenic rats with low glial angiotensinogen. Hypertension. 2008 May; 51(5):1326-31. PMID: 18347230.
      Citations:    
    116. Brosnihan KB, Li P, Figueroa JP, Ganten D, Ferrario CM. Estrogen, nitric oxide, and hypertension differentially modulate agonist-induced contractile responses in female transgenic (mRen2)27 hypertensive rats. . 2008 May; 294(5):H1995-2001. PMID: 18344376.
      Citations:    
    117. Jessup JA, Brosnihan KB, Gallagher PE, Chappell MC, Ferrario CM. Differential effect of low dose thiazides on the Renin Angiotensin system in genetically hypertensive and normotensive rats. J Am Soc Hypertens. 2008 Mar-Apr; 2(2):106-15. PMID: 19343087.
      Citations:    
    118. Igase M, Kohara K, Nagai T, Miki T, Ferrario CM. Increased expression of angiotensin converting enzyme 2 in conjunction with reduction of neointima by angiotensin II type 1 receptor blockade. Hypertens Res. 2008 Mar; 31(3):553-9. PMID: 18497476.
      Citations:    
    119. Anton L, Merrill DC, Neves LA, Stovall K, Gallagher PE, Diz DI, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. Activation of local chorionic villi angiotensin II levels but not angiotensin (1-7) in preeclampsia. Hypertension. 2008 Apr; 51(4):1066-72. PMID: 18259034.
      Citations:    
    120. Whaley-Connell A, Habibi J, Nistala R, Cooper SA, Karuparthi PR, Hayden MR, Rehmer N, DeMarco VG, Andresen BT, Wei Y, Ferrario C, Sowers JR. Attenuation of NADPH oxidase activation and glomerular filtration barrier remodeling with statin treatment. Hypertension. 2008 Feb; 51(2):474-80. PMID: 18172055.
      Citations:    
    121. Wei Y, Sowers JR, Clark SE, Li W, Ferrario CM, Stump CS. Angiotensin II-induced skeletal muscle insulin resistance mediated by NF-kappaB activation via NADPH oxidase. Am J Physiol Endocrinol Metab. 2008 Feb; 294(2):E345-51. PMID: 18073321.
      Citations:    
    122. Ferrario CM, Basile J, Bestermann W, Frohlich E, Houston M, Lackland DT, Smith RD, Wise DL. The role of noninvasive hemodynamic monitoring in the evaluation and treatment of hypertension. Ther Adv Cardiovasc Dis. 2007 Dec; 1(2):113-8. PMID: 19124400.
      Citations:    
    123. Morris RT, Fine DM, Lees SJ, Booth FW, Link CD, Ferrario CM, Stump CS, Sowers JR. Exercise training prevents development of cardiac contractile dysfunction in hypertensive TG (mREN-2)27 rats. J Am Soc Hypertens. 2007 Nov-Dec; 1(6):393-9. PMID: 19050745.
      Citations:    
    124. Neves LA, Stovall K, Joyner J, Valdés G, Gallagher PE, Ferrario CM, Merrill DC, Brosnihan KB. ACE2 and ANG-(1-7) in the rat uterus during early and late gestation. . 2008 Jan; 294(1):R151-61. PMID: 17977916.
      Citations:    
    125. Strawn WB, Ferrario CM. Angiotensin II AT1 receptor blockade normalizes CD11b+ monocyte production in bone marrow of hypercholesterolemic monkeys. Atherosclerosis. 2008 Feb; 196(2):624-32. PMID: 17692319.
      Citations:    
    126. Gironacci MM, Brosnihan KB, Ferrario CM, Gorzalczany S, Verrilli MA, Pascual M, Taira C, Peña C. Increased hypothalamic angiotensin-(1-7) levels in rats with aortic coarctation-induced hypertension. Peptides. 2007 Aug; 28(8):1580-5. PMID: 17646033.
      Citations:    
    127. De Mello WC, Ferrario CM, Jessup JA. Beneficial versus harmful effects of Angiotensin (1-7) on impulse propagation and cardiac arrhythmias in the failing heart. J Renin Angiotensin Aldosterone Syst. 2007 Jun; 8(2):74-80. PMID: 17703433.
      Citations:    
    128. Wei Y, Whaley-Connell AT, Chen K, Habibi J, Uptergrove GM, Clark SE, Stump CS, Ferrario CM, Sowers JR. NADPH oxidase contributes to vascular inflammation, insulin resistance, and remodeling in the transgenic (mRen2) rat. Hypertension. 2007 Aug; 50(2):384-91. PMID: 17533199.
      Citations:    
    129. Stas S, Whaley-Connell A, Habibi J, Appesh L, Hayden MR, Karuparthi PR, Qazi M, Morris EM, Cooper SA, Link CD, Stump C, Hay M, Ferrario C, Sowers JR. Mineralocorticoid receptor blockade attenuates chronic overexpression of the renin-angiotensin-aldosterone system stimulation of reduced nicotinamide adenine dinucleotide phosphate oxidase and cardiac remodeling. Endocrinology. 2007 Aug; 148(8):3773-80. PMID: 17494996.
      Citations:    
    130. Whaley-Connell A, Govindarajan G, Habibi J, Hayden MR, Cooper SA, Wei Y, Ma L, Qazi M, Link D, Karuparthi PR, Stump C, Ferrario C, Sowers JR. Angiotensin II-mediated oxidative stress promotes myocardial tissue remodeling in the transgenic (mRen2) 27 Ren2 rat. Am J Physiol Endocrinol Metab. 2007 Jul; 293(1):E355-63. PMID: 17440033.
      Citations:    
    131. Menon J, Soto-Pantoja DR, Callahan MF, Cline JM, Ferrario CM, Tallant EA, Gallagher PE. Angiotensin-(1-7) inhibits growth of human lung adenocarcinoma xenografts in nude mice through a reduction in cyclooxygenase-2. Cancer Res. 2007 Mar 15; 67(6):2809-15. PMID: 17363603.
      Citations:    
    132. Pignone A, Rosso AD, Brosnihan KB, Perfetto F, Livi R, Fiori G, Guiducci S, Cinelli M, Rogai V, Tempestini A, Bartoli F, Generini S, Ferrario CM, Cerinic MM. Reduced circulating levels of angiotensin-(1--7) in systemic sclerosis: a new pathway in the dysregulation of endothelial-dependent vascular tone control. Ann Rheum Dis. 2007 Oct; 66(10):1305-10. PMID: 17360781.
      Citations:    
    133. Habibi J, Whaley-Connell A, Qazi MA, Hayden MR, Cooper SA, Tramontano A, Thyfault J, Stump C, Ferrario C, Muniyappa R, Sowers JR. Rosuvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, decreases cardiac oxidative stress and remodeling in Ren2 transgenic rats. Endocrinology. 2007 May; 148(5):2181-8. PMID: 17317778.
      Citations:    
    134. Trask AJ, Averill DB, Ganten D, Chappell MC, Ferrario CM. Primary role of angiotensin-converting enzyme-2 in cardiac production of angiotensin-(1-7) in transgenic Ren-2 hypertensive rats. . 2007 Jun; 292(6):H3019-24. PMID: 17308000.
      Citations:    
    135. Diz DI, Kasper SO, Sakima A, Ferrario CM. Aging and the brain renin-angiotensin system: insights from studies in transgenic rats. Cleve Clin J Med. 2007 Feb; 74 Suppl 1:S95-8. PMID: 17455554.
      Citations:    
    136. Schindler C, Brosnihan KB, Ferrario CM, Bramlage P, Maywald U, Koch R, Oertel R, Kirch W. Comparison of inhibitory effects of irbesartan and atorvastatin treatment on the renin angiotensin system (RAS) in veins: a randomized double-blind crossover trial in healthy subjects. J Clin Pharmacol. 2007 Jan; 47(1):112-20. PMID: 17192509.
      Citations:    
    137. Schindler C, Bramlage P, Kirch W, Ferrario CM. Role of the vasodilator peptide angiotensin-(1-7) in cardiovascular drug therapy. Vasc Health Risk Manag. 2007; 3(1):125-37. PMID: 17583183.
      Citations:    
    138. Trask AJ, Ferrario CM. Angiotensin-(1-7): pharmacology and new perspectives in cardiovascular treatments. Cardiovasc Drug Rev. 2007; 25(2):162-74. PMID: 17614938.
      Citations:    
    139. Sakima A, Averill DB, Kasper SO, Jackson L, Ganten D, Ferrario CM, Gallagher PE, Diz DI. Baroreceptor reflex regulation in anesthetized transgenic rats with low glia-derived angiotensinogen. . 2007 Mar; 292(3):H1412-9. PMID: 17085537.
      Citations:    
    140. Hayden MR, Chowdhury NA, Cooper SA, Whaley-Connell A, Habibi J, Witte L, Wiedmeyer C, Manrique CM, Lastra G, Ferrario C, Stump C, Sowers JR. Proximal tubule microvilli remodeling and albuminuria in the Ren2 transgenic rat. Am J Physiol Renal Physiol. 2007 Feb; 292(2):F861-7. PMID: 17032939.
      Citations:    
    141. Basile J, Houston M, Ferrario C. Incremental risk-factor reduction improves overall cardiovascular benefit: is it time to abandon the silos? J Clin Hypertens (Greenwich). 2006 Oct; 8(10):686-8. PMID: 17028480.
      Citations:    
    142. Kasper SO, Ferrario CM, Ganten D, Diz DI. Rats with low brain angiotensinogen do not exhibit insulin resistance during early aging. Endocrine. 2006 Oct; 30(2):167-74. PMID: 17322575.
      Citations:    
    143. Shaltout HA, Westwood BM, Averill DB, Ferrario CM, Figueroa JP, Diz DI, Rose JC, Chappell MC. Angiotensin metabolism in renal proximal tubules, urine, and serum of sheep: evidence for ACE2-dependent processing of angiotensin II. Am J Physiol Renal Physiol. 2007 Jan; 292(1):F82-91. PMID: 16896185.
      Citations:    
    144. Whaley-Connell AT, Chowdhury NA, Hayden MR, Stump CS, Habibi J, Wiedmeyer CE, Gallagher PE, Tallant EA, Cooper SA, Link CD, Ferrario C, Sowers JR. Oxidative stress and glomerular filtration barrier injury: role of the renin-angiotensin system in the Ren2 transgenic rat. Am J Physiol Renal Physiol. 2006 Dec; 291(6):F1308-14. PMID: 16788142.
      Citations:    
    145. Jessup JA, Gallagher PE, Averill DB, Brosnihan KB, Tallant EA, Chappell MC, Ferrario CM. Effect of angiotensin II blockade on a new congenic model of hypertension derived from transgenic Ren-2 rats. . 2006 Nov; 291(5):H2166-72. PMID: 16766648.
      Citations:    
    146. Reyes-Engel A, Morcillo L, Aranda FJ, Ruiz M, Gaitan MJ, Mayor-Olea A, Aranda P, Ferrario CM. Influence of gender and genetic variability on plasma angiotensin peptides. J Renin Angiotensin Aldosterone Syst. 2006 Jun; 7(2):92-7. PMID: 17083063.
      Citations:    
    147. Ferrario CM, Strawn WB. Role of the renin-angiotensin-aldosterone system and proinflammatory mediators in cardiovascular disease. Am J Cardiol. 2006 Jul 01; 98(1):121-8. PMID: 16784934.
      Citations:    
    148. Tallant EA, Ferrario CM, Gallagher PE. Cardioprotective role for angiotensin-(1-7) and angiotensin converting enzyme 2 in the heart. Future Cardiol. 2006 May; 2(3):335-42. PMID: 19804091.
      Citations:    
    149. Smith RD, Levy P, Ferrario CM. Value of noninvasive hemodynamics to achieve blood pressure control in hypertensive subjects. Hypertension. 2006 Apr; 47(4):771-7. PMID: 16520405.
      Citations:    
    150. Ferrario CM. Role of angiotensin II in cardiovascular disease therapeutic implications of more than a century of research. J Renin Angiotensin Aldosterone Syst. 2006 Mar; 7(1):3-14. PMID: 17083068.
      Citations:    
    151. Ferrario CM. Highlights of the Twelfth Annual COSEHC National Scientific Session. Am J Med Sci. 2006 Feb; 331(2):59. PMID: 16479176.
      Citations:    
    152. Hertz RP, Unger AN, Ferrario CM. Diabetes, hypertension, and dyslipidemia in Mexican Americans and non-Hispanic whites. Am J Prev Med. 2006 Feb; 30(2):103-10. PMID: 16459207.
      Citations:    
    153. Pendergrass KD, Averill DB, Ferrario CM, Diz DI, Chappell MC. Differential expression of nuclear AT1 receptors and angiotensin II within the kidney of the male congenic mRen2. Lewis rat. Am J Physiol Renal Physiol. 2006 Jun; 290(6):F1497-506. PMID: 16403834.
      Citations:    
    154. Ferrario CM, Smith RD. Cost-effectiveness of impedance cardiography testing in uncontrolled hypertension. Am Heart Hosp J. 2006; 4(4):279-89. PMID: 17086009.
      Citations:    
    155. Basile J, Houston M, Ferrario CM. Treating the cardiometabolic syndrome: an opportunity to provide comprehensive cardiovascular risk reduction. J Cardiometab Syndr. 2006; 1(5):358-61. PMID: 17679795.
      Citations:    
    156. Smith RD, Yokoyama H, Averill DB, Cooke L, Brosnihan KB, Schiffrin EL, Ferrario CM. The protective effects of angiotensin II blockade with olmesartan medoxomil on resistance vessel remodeling (The VIOS study): rationale and baseline characteristics. Am J Cardiovasc Drugs. 2006; 6(5):335-42. PMID: 17083268.
      Citations:    
    157. Ferrario CM. Angiotensin-converting enzyme 2 and angiotensin-(1-7): an evolving story in cardiovascular regulation. Hypertension. 2006 Mar; 47(3):515-21. PMID: 16365192.
      Citations:    
    158. Ferrario CM, Jessup J, Gallagher PE, Averill DB, Brosnihan KB, Ann Tallant E, Smith RD, Chappell MC. Effects of renin-angiotensin system blockade on renal angiotensin-(1-7) forming enzymes and receptors. Kidney Int. 2005 Nov; 68(5):2189-96. PMID: 16221218.
      Citations:    
    159. Gallagher PE, Chappell MC, Ferrario CM, Tallant EA. Distinct roles for ANG II and ANG-(1-7) in the regulation of angiotensin-converting enzyme 2 in rat astrocytes. . 2006 Feb; 290(2):C420-6. PMID: 16176966.
      Citations:    
    160. Kasper SO, Carter CS, Ferrario CM, Ganten D, Ferder LF, Sonntag WE, Gallagher PE, Diz DI. Growth, metabolism, and blood pressure disturbances during aging in transgenic rats with altered brain renin-angiotensin systems. Physiol Genomics. 2005 Nov 17; 23(3):311-7. PMID: 16131528.
      Citations:    
    161. Ferrario CM, Trask AJ, Jessup JA. Advances in biochemical and functional roles of angiotensin-converting enzyme 2 and angiotensin-(1-7) in regulation of cardiovascular function. . 2005 Dec; 289(6):H2281-90. PMID: 16055515.
      Citations:    
    162. Huentelman MJ, Grobe JL, Vazquez J, Stewart JM, Mecca AP, Katovich MJ, Ferrario CM, Raizada MK. Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats. Exp Physiol. 2005 Sep; 90(5):783-90. PMID: 16049057.
      Citations:    
    163. Sakima A, Averill DB, Gallagher PE, Kasper SO, Tommasi EN, Ferrario CM, Diz DI. Impaired heart rate baroreflex in older rats: role of endogenous angiotensin-(1-7) at the nucleus tractus solitarii. Hypertension. 2005 Aug; 46(2):333-40. PMID: 16009784.
      Citations:    
    164. Yokoyama H, Averill DB, Brosnihan KB, Smith RD, Schiffrin EL, Ferrario CM. Role of blood pressure reduction in prevention of cardiac and vascular hypertrophy. Am J Hypertens. 2005 Jul; 18(7):922-9. PMID: 16053988.
      Citations:    
    165. Kasper SO, Basso N, Kurnjek ML, Paglia N, Ferrario CM, Ferder LF, Diz DI. Divergent regulation of circulating and intrarenal renin-angiotensin systems in response to long-term blockade. Am J Nephrol. 2005 Jul-Aug; 25(4):335-41. PMID: 15976496.
      Citations:    
    166. Tallant EA, Ferrario CM, Gallagher PE. Angiotensin-(1-7) inhibits growth of cardiac myocytes through activation of the mas receptor. . 2005 Oct; 289(4):H1560-6. PMID: 15951342.
      Citations:    
    167. Bestermann W, Houston MC, Basile J, Egan B, Ferrario CM, Lackland D, Hawkins RG, Reed J, Rogers P, Wise D, Moore MA. Addressing the global cardiovascular risk of hypertension, dyslipidemia, diabetes mellitus, and the metabolic syndrome in the southeastern United States, part II: treatment recommendations for management of the global cardiovascular risk of hypertension, dyslipidemia, diabetes mellitus, and the metabolic syndrome. Am J Med Sci. 2005 Jun; 329(6):292-305. PMID: 15958871.
      Citations:    
    168. Luque M, Martell N, Egocheaga I, Fernandez-Pinilla C, Zamorano J, Almeria C, Fernandez-Cruz A, Ferrario CM. Left ventricular geometric patterns after 1 year of antihypertensive treatment. J Clin Hypertens (Greenwich). 2005 Jun; 7(6):333-8. PMID: 16088296.
      Citations:    
    169. Houston MC, Basile J, Bestermann WH, Egan B, Lackland D, Hawkins RG, Moore MA, Reed J, Rogers P, Wise D, Ferrario CM. Addressing the global cardiovascular risk of hypertension, dyslipidemia, and insulin resistance in the southeastern United States. Am J Med Sci. 2005 Jun; 329(6):276-91. PMID: 15958870.
      Citations:    
    170. Ferrario CM, Jessup J, Chappell MC, Averill DB, Brosnihan KB, Tallant EA, Diz DI, Gallagher PE. Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2. Circulation. 2005 May 24; 111(20):2605-10. PMID: 15897343.
      Citations:    
    171. Ferrario CM. Myocardial infarction increases ACE2 expression in rat and humans. Eur Heart J. 2005 Jun; 26(11):1141; author reply 1141-3. PMID: 15833761.
      Citations:    
    172. Igase M, Strawn WB, Gallagher PE, Geary RL, Ferrario CM. Angiotensin II AT1 receptors regulate ACE2 and angiotensin-(1-7) expression in the aorta of spontaneously hypertensive rats. . 2005 Sep; 289(3):H1013-9. PMID: 15833808.
      Citations:    
    173. Ferrario CM. New approaches to hypertension management: always reasonable but now necessary. Am J Hypertens. 2005 Feb; 18(2 Pt 2):23S-25S. PMID: 15752930.
      Citations:    
    174. Abdelhammed AI, Smith RD, Levy P, Smits GJ, Ferrario CM. Noninvasive hemodynamic profiles in hypertensive subjects. Am J Hypertens. 2005 Feb; 18(2 Pt 2):51S-59S. PMID: 15752933.
      Citations:    
    175. Rodríguez-Esparragón F, Rodríguez-Pérez JC, Hernández-Trujillo Y, Macías-Reyes A, Medina A, Caballero A, Ferrario CM. Allelic variants of the human scavenger receptor class B type 1 and paraoxonase 1 on coronary heart disease: genotype-phenotype correlations. Arterioscler Thromb Vasc Biol. 2005 Apr; 25(4):854-60. PMID: 15681296.
      Citations:    
    176. Richmond RS, Tallant EA, Gallagher PE, Ferrario CM, Strawn WB. Angiotensin II stimulates arachidonic acid release from bone marrow stromal cells. J Renin Angiotensin Aldosterone Syst. 2004 Dec; 5(4):176-82. PMID: 15803435.
      Citations:    
    177. Ferrario CM. The role of angiotensin antagonism in stroke prevention in patients with hypertension: focus on losartan. Curr Med Res Opin. 2004 Nov; 20(11):1797-804. PMID: 15537480.
      Citations:    
    178. Blendea MC, Jacobs D, Stump CS, McFarlane SI, Ogrin C, Bahtyiar G, Stas S, Kumar P, Sha Q, Ferrario CM, Sowers JR. Abrogation of oxidative stress improves insulin sensitivity in the Ren-2 rat model of tissue angiotensin II overexpression. Am J Physiol Endocrinol Metab. 2005 Feb; 288(2):E353-9. PMID: 15494608.
      Citations:    
    179. Neves LA, Averill DB, Ferrario CM, Aschner JL, Brosnihan KB. Vascular responses to Angiotensin-(1-7) during the estrous cycle. Endocrine. 2004 Jul; 24(2):161-5. PMID: 15347843.
      Citations:    
    180. Strawn WB, Richmond RS, Ann Tallant E, Gallagher PE, Ferrario CM. Renin-angiotensin system expression in rat bone marrow haematopoietic and stromal cells. Br J Haematol. 2004 Jul; 126(1):120-6. PMID: 15198742.
      Citations:    
    181. Chen GJ, Smith RD, Ferrario CM. Association between antihypertensive agent use and hospital admissions in a managed care population. Am J Med Sci. 2004 Jun; 327(6):310-4. PMID: 15201642.
      Citations:    
    182. Ferrario CM. Highlights of the Tenth Annual COSEHC National Scientific Session. Am J Med Sci. 2004 May; 327(5):234-5. PMID: 15166740.
      Citations:    
    183. Ferrario CM. COSEHC overview. Am J Med Sci. 2004 May; 327(5):233. PMID: 15166739.
      Citations:    
    184. Ishiyama Y, Gallagher PE, Averill DB, Tallant EA, Brosnihan KB, Ferrario CM. Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors. Hypertension. 2004 May; 43(5):970-6. PMID: 15007027.
      Citations:    
    185. Ferrario C, Abdelhamed AI, Moore M. AII antagonists in hypertension, heart failure, and diabetic nephropathy: focus on losartan. Curr Med Res Opin. 2004 Mar; 20(3):279-93. PMID: 15025837.
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    186. Aileru AA, Logan E, Callahan M, Ferrario CM, Ganten D, Diz DI. Alterations in sympathetic ganglionic transmission in response to angiotensin II in (mRen2)27 transgenic rats. Hypertension. 2004 Feb; 43(2):270-5. PMID: 14732737.
      Citations:    
    187. Kasper SO, Ferrario CM, Ganten D, Diz DI. Central depletion of angiotensinogen is associated with elevated AT1 receptors in the SFO and PVN. Neurotox Res. 2004; 6(4):259-65. PMID: 15545009.
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    188. Chappell MC, Modrall JG, Diz DI, Ferrario CM. Novel aspects of the renal renin-angiotensin system: angiotensin-(1-7), ACE2 and blood pressure regulation. Contrib Nephrol. 2004; 143:77-89. PMID: 15248357.
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    189. Ferrario CM, Richmond RS, Smith R, Levy P, Strawn WB, Kivlighn S. Renin-angiotensin system as a therapeutic target in managing atherosclerosis. Am J Ther. 2004 Jan-Feb; 11(1):44-53. PMID: 14704595.
      Citations:    
    190. McBride W, Ferrario C, Lyle PA. Hypertension and medical informatics. J Natl Med Assoc. 2003 Nov; 95(11):1048-56. PMID: 14651371.
      Citations:    
    191. Averill DB, Ishiyama Y, Chappell MC, Ferrario CM. Cardiac angiotensin-(1-7) in ischemic cardiomyopathy. Circulation. 2003 Oct 28; 108(17):2141-6. PMID: 14517166.
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    192. Neves LA, Williams AF, Averill DB, Ferrario CM, Walkup MP, Brosnihan KB. Pregnancy enhances the angiotensin (Ang)-(1-7) vasodilator response in mesenteric arteries and increases the renal concentration and urinary excretion of Ang-(1-7). Endocrinology. 2003 Aug; 144(8):3338-43. PMID: 12865311.
      Citations:    
    193. Chappell MC, Gallagher PE, Averill DB, Ferrario CM, Brosnihan KB. Estrogen or the AT1 antagonist olmesartan reverses the development of profound hypertension in the congenic mRen2. Lewis rat. Hypertension. 2003 Oct; 42(4):781-6. PMID: 12874087.
      Citations:    
    194. Brosnihan KB, Neves LA, Joyner J, Averill DB, Chappell MC, Sarao R, Penninger J, Ferrario CM. Enhanced renal immunocytochemical expression of ANG-(1-7) and ACE2 during pregnancy. Hypertension. 2003 Oct; 42(4):749-53. PMID: 12874086.
      Citations:    
    195. Rodríguez-Esparragón F, Hernández-Perera O, Rodríguez-Pérez JC, Anábitarte A, Díaz-Cremades JM, Losada A, Fiuza D, Hernández E, Yunis C, Ferrario CM. The effect of methylenetetrahydrofolate reductase C677T common variant on hypertensive risk is not solely explained by increased plasma homocysteine values. Clin Exp Hypertens. 2003 May; 25(4):209-20. PMID: 12797595.
      Citations:    
    196. Ferrario CM. Contribution of angiotensin-(1-7) to cardiovascular physiology and pathology. Curr Hypertens Rep. 2003 Apr; 5(2):129-34. PMID: 12642012.
      Citations:    
    197. Douglas JG, Bakris GL, Epstein M, Ferdinand KC, Ferrario C, Flack JM, Jamerson KA, Jones WE, Haywood J, Maxey R, Ofili EO, Saunders E, Schiffrin EL, Sica DA, Sowers JR, Vidt DG. Management of high blood pressure in African Americans: consensus statement of the Hypertension in African Americans Working Group of the International Society on Hypertension in Blacks. Arch Intern Med. 2003 Mar 10; 163(5):525-41. PMID: 12622600.
      Citations:    
    198. Neves LA, Averill DB, Ferrario CM, Chappell MC, Aschner JL, Walkup MP, Brosnihan KB. Characterization of angiotensin-(1-7) receptor subtype in mesenteric arteries. Peptides. 2003 Mar; 24(3):455-62. PMID: 12732345.
      Citations:    
    199. Ferrario CM. Commentary on Tikellis et al: There is more to discover about angiotensin-converting enzyme. Hypertension. 2003 Mar; 41(3):390-1. PMID: 12623932.
      Citations:    
    200. Nakamura S, Averill DB, Chappell MC, Diz DI, Brosnihan KB, Ferrario CM. Angiotensin receptors contribute to blood pressure homeostasis in salt-depleted SHR. . 2003 Jan; 284(1):R164-73. PMID: 12482748.
      Citations:    
    201. Ferrario CM, Levy P. Sexual dysfunction in patients with hypertension: implications for therapy. J Clin Hypertens (Greenwich). 2002 Nov-Dec; 4(6):424-32. PMID: 12461307.
      Citations:    
    202. Yang H, Francis SC, Sellers K, DeBarros M, Sun C, Sumners C, Ferrario CM, Katovich MJ, Muro AF, Raizada MK. Hypertension-linked decrease in the expression of brain gamma-adducin. Circ Res. 2002 Oct 04; 91(7):633-9. PMID: 12364392.
      Citations:    
    203. Ferrario CM, Averill DB, Brosnihan KB, Chappell MC, Iskandar SS, Dean RH, Diz DI. Vasopeptidase inhibition and Ang-(1-7) in the spontaneously hypertensive rat. Kidney Int. 2002 Oct; 62(4):1349-57. PMID: 12234305.
      Citations:    
    204. Strawn WB, Ferrario CM. Mechanisms linking angiotensin II and atherogenesis. Curr Opin Lipidol. 2002 Oct; 13(5):505-12. PMID: 12352014.
      Citations:    
    205. Merrill DC, Karoly M, Chen K, Ferrario CM, Brosnihan KB. Angiotensin-(1-7) in normal and preeclamptic pregnancy. Endocrine. 2002 Aug; 18(3):239-45. PMID: 12450315.
      Citations:    
    206. Crackower MA, Sarao R, Oudit GY, Yagil C, Kozieradzki I, Scanga SE, Oliveira-dos-Santos AJ, da Costa J, Zhang L, Pei Y, Scholey J, Ferrario CM, Manoukian AS, Chappell MC, Backx PH, Yagil Y, Penninger JM. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature. 2002 Jun 20; 417(6891):822-8. PMID: 12075344.
      Citations:    
    207. Ferrario CM, Smith RD, Brosnihan B, Chappell MC, Campese VM, Vesterqvist O, Liao WC, Ruddy MC, Grim CE. Effects of omapatrilat on the renin-angiotensin system in salt-sensitive hypertension. Am J Hypertens. 2002 Jun; 15(6):557-64. PMID: 12074359.
      Citations:    
    208. Ferrario CM. Angiotensin I, angiotensin II and their biologically active peptides. J Hypertens. 2002 May; 20(5):805-7. PMID: 12011630.
      Citations:    
    209. Pachori AS, Numan MT, Ferrario CM, Diz DM, Raizada MK, Katovich MJ. Blood pressure-independent attenuation of cardiac hypertrophy by AT(1)R-AS gene therapy. Hypertension. 2002 May; 39(5):969-75. PMID: 12019278.
      Citations:    
    210. Ferrario CM. Does angiotensin-(1-7) contribute to cardiac adaptation and preservation of endothelial function in heart failure? Circulation. 2002 Apr 02; 105(13):1523-5. PMID: 11927512.
      Citations:    
    211. Ratanakorn D, Yunis C, Ferrario CM, McKinney WM. Noninvasive ultrasound evaluation of the vertebral artery in hypertension. J Neuroimaging. 2002 Apr; 12(2):158-63. PMID: 11977912.
      Citations:    
    212. Ferrario CM, Smith R, Levy P, Strawn W. The hypertension-lipid connection: insights into the relation between angiotensin II and cholesterol in atherogenesis. Am J Med Sci. 2002 Jan; 323(1):17-24. PMID: 11814137.
      Citations:    
    213. Wei CC, Ferrario CM, Brosnihan KB, Farrell DM, Bradley WE, Jaffa AA, Dell'Italia LJ. Angiotensin peptides modulate bradykinin levels in the interstitium of the dog heart in vivo. J Pharmacol Exp Ther. 2002 Jan; 300(1):324-9. PMID: 11752132.
      Citations:    
    214. Ferrario CM. Use of angiotensin II receptor blockers in animal models of atherosclerosis. Am J Hypertens. 2002 Jan; 15(1 Pt 2):9S-13S. PMID: 11824874.
      Citations:    
    215. Bloomfield RL, Novikov SV, Ferrario CM. Hypertension in the Elderly. Am J Geriatr Cardiol. 1994 Jul; 3(4):39-44. PMID: 11416314.
      Citations:    
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