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Che-Ping Cheng MD, PhD

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Cardiovascular Medicine
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentPhysiology & Pharmacology


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    R29HL045258     (CHENG, CHE-PING)Jan 1, 1991 - Dec 31, 1996
    NIH
    DIASTOLIC FILLING DYNAMICS OF EXERCISE AND HEART FAILURE
    Role: Principal Investigator
    R01AA012335     (CHENG, CHE-PING)Mar 1, 2000 - Feb 28, 2006
    NIH
    MECHANISM OF CHRONIC ALCOHOL INDUCED CARDIOMYOPATHY
    Role: Principal Investigator
    R01HL074318     (CHENG, CHE-PING)Jul 1, 2003 - Jun 30, 2008
    NIH
    Beta3-Adrenergic Receptor &Progression to Heart Failure
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhang X, Li T, Cheng HJ, Wang H, Ferrario CM, Groban L, Cheng CP. Chronic GPR30 agonist therapy causes restoration of normal cardiac functional performance in a male mouse model of progressive heart failure: Insights into cellular mechanisms. Life Sci. 2021 Sep 11; 119955. PMID: 34520767.
      Citations:    
    2. Liu Y, Shao Q, Cheng HJ, Li T, Zhang X, Callahan MF, Herrington D, Kitzman D, Zhao D, Cheng CP. Chronic Ca2+/Calmodulin-Dependent Protein Kinase II Inhibition Rescues Advanced Heart Failure. J Pharmacol Exp Ther. 2021 Jun; 377(3):316-325. PMID: 33722881.
      Citations:    
    3. Heng Jie Cheng, Jing Cao, Xiaoqiang Sun, Yixi Liu, Zhe Chen, Dalane Kitzman, David Herrington, David Zhao, Che Ping Cheng. Circulation. Abstract 13451: Upregulation of CaMKII and Contrast Changes of Cardiac ß1- and ß3-Adrenergic Signaling Pathways in a Humanized Angiotensinogen Model of Hypertension. 2020; 142(Suppl_3):A13451. View Publication.
    4. Heng Jie Cheng, Xiaoqiang Sun, Jing Cao, Zhe Chen, Yixi Liu, David Zhao, Dalane Kitzman, Che Ping Cheng. Circulation. Abstract 13385: Protective Effect of Beta3-Adrenergic Receptor Deficiency on Diabetic Cardiomyopathy: Reversal of Type 2 Diabetes-Induced Contrast Changes of Cardiac SERCA 2a and Inducible Nitric Oxide Synthase. 2020; 142(Suppl_3):A13385. View Publication.
    5. Xiaoqiang Sun, Jing Cao, Heng-Jie Cheng, Yixi Liu, Zhe Chen, Donald A McClain, Dalane Kitzman, David Zhao, Che Ping Cheng. Circulation. Abstract 13035: Beta3-Adrenergic-Receptor-Deficient Mice Protected From Diabetic Cardiomyopathy in Type 2 Diabetic Murine Model: Beneficial Effects on Cardiomyocyte Contractile Function, [Ca2+]i Regulation and Beta-Adrenergic Modulation. 2020; 142(Suppl_3):A13035. View Publication.
    6. Xiaoqiang Sun, Jing Cao, Heng-Jie Cheng, Yixi Liu, Zhe Chen, Dalane Kitzman, David Zhao, Donald A McClain, Che Ping Cheng. Circulation. Abstract 12808: Mechanism of Chronic Ranolazine Caused Regression of Cardiac Dysfunction in a Murine of Diabetic Cardiomyopathy: Beneficial Effects on Cardiomyocyte Contractile Function, [Ca2+]i Regulation and Beta-Adrenergic Modulation. 2020; 142(Suppl_3):A12808. View Publication.
    7. Xiaoqiang Sun, Jing Cao, Qun Shao, Heng Jie Cheng, Yixi Liu, Zhe Chen, Jessica VonCannon, Carlos M Ferrario, Che Ping Cheng. Circulation. Abstract 12731: Acute Calcium/Calmodulin-Dependent Protein Kinase II Inhibition Augments Cardiomyocyte Contractility and Improves ß-Adrenergic Regulation in Experimental Hypertension of Transgenic Rats Expressing Human Angiotensinogen Gene. 2020; 142(Suppl_3):A12731. View Publication.
    8. Xiaoqiang Sun, Che Ping Cheng, Jing Cao, Zhi Zhang, Tiankai Li, Xiaowei Zhang, Heng Jie Cheng. Circulation. Abstract 13438: The Role and Mechanism of Chronic Beta3-Adrenergic Receptor Blockade on the Progression of Heart Failure in a Rat Model. 2020; 142(Suppl_3):A13438. View Publication.
    9. Yixi Liu, Heng Jie Cheng, Xiaoqiang Sun, Jing Cao, Zhe Chen, Jessica L VonCannon, Sarfaraz Ahmad, Carlos M Ferrario, Che Ping Cheng. Circulation. Abstract 12677: Impaired Cardiomyocyte Contractility to Angiotensin-(1-12) in a Humanized Angiotensinogen Model of Hypertension. 2020; 142(Suppl_3):A12677. View Publication.
    10. Yixi Liu, Che Ping Cheng, Xiaoqiang Sun, Jing Cao, Peng Zhou, David Herrington, Dalane Kitzman, David Zhao, Heng Jie Cheng. Circulation. Abstract 12692: Overexpression of Myocardial Inducible Nitric Oxide Synthase Exacerbates Cardiac Dysfunction and Beta-Adrenergic Desensitization in Streptozotocin-Induced Diabetic Mice. 2020; 142(Suppl_3):A12692. View Publication.
    11. Jing Cao, Xiaoqiang Sun, Heng Jie Cheng, Yixi Liu, Dalane Kitzman, David Zhao, Donald A McClain, Che Ping Cheng. Circulation. Abstract 13045: Chronic Beta3-Adrenergic Receptor Antagonist Therapy Rescues Diabetic Cardiomyopathy in a Mouse Model With Type 2 Diabetes: Insights into Cellular Mechanism. 2020; 142(Suppl_3):A13045. View Publication.
    12. Jing Cao, Xiaoqiang Sun, Heng Jie Cheng, Tiankai Li, Yixi Liu, Jessica L VonCannon, Carlos M Ferrario, Che Ping Cheng. Circulation. Abstract 12717: Enhance Negative Modulation of Beta3-Adrenergic Stimulation on Cardiomyocyte Functional Performance, [Ca2+]i Regulation and ß-Adrenergic Reserve in Rats Expressing Human Angiotensinogen Gene. 2020; 142(Suppl_3):A12717. View Publication.
    13. Zhi Zhang, Che Ping Cheng, Satoshi Masutani, Tiankai Li, Xiaowei Zhang, Xiaoqiang Sun, Jing Cao, David M Herrington, Heng Jie Cheng. Circulation. Abstract 13050: Acute Alcohol-Induced Enhanced Cardiac Depression in a Canine Model of Chronic Alcohol Consumption: Adverse Effects on Left Ventricle and Myocyte Contraction, [Ca2+]i Transient and Ca2+ Current. 2020; 142(Suppl_3):A13050. View Publication.
    14. Che Ping Cheng, Zhi Zhang, Tiankai Li, Xiaowei Zhang, Xiaoqiang Sun, Jing Cao, David M Herrington, David X Zhao, Heng Jie Cheng. Circulation. Abstract 13027: Differential Direct Effects of Equal Hypotensive Natriuretic Peptides (NPs) of ANP, BNP and CNP on Left Ventricular Contractile Performance in Heart Failure: Assessment by Left Ventricular Pressure-Volume Analysis. 2020; 142(Suppl_3):A13027. View Publication.
    15. Che Ping Cheng, Xiaoqiang Sun, Jing Cao, Yixi Liu, Zhe Chen, Peng Zhou, Satoshi Masutani, Dalane Kitzman, David Zhao, Heng Jie Cheng. Circulation. Abstract 13100: Rescue Myocardial Aging Caused a Progressive Decline in Cardiac Function and ß-Adrenergic Reserve With a Selective Beta3-Adrenergic Receptor Antagonist, but Not Beta1-Adrenergic Receptor Blocker in a Murine Model. 2020; 142(Suppl_3):A13100. View Publication.
    16. Ferrario CM, VonCannon J, Ahmad S, Wright KN, Roberts DJ, Wang H, Yamashita T, Groban L, Cheng CP, Collawn JF, Dell'Italia LJ, Varagic J. Activation of the Human Angiotensin-(1-12)-Chymase Pathway in Rats With Human Angiotensinogen Gene Transcripts. Front Cardiovasc Med. 2019; 6:163. PMID: 31803758.
      Citations:    
    17. Heng-Jie Cheng, Yixi Liu, Zhe Chen, Alexei V Mikhailov, Jen-Jar Lin, Dalane Kitzman, Donald A McClain, Che Ping Cheng. Circulation. Abstract 9831: Molecular Mechanism of Chronic Beta3-Adrenergic Receptor Blockade-Caused Regression of Cardiac Dysfunction in a Diabetic Mouse Model: Effects on the Express of Cardiac SR Ca2+-ATPase, Subtypes of Beta-Adrenergic Receptors and Nitric Oxide Synthase Isoforms and Nitrotyrosine. 2019; 140(Suppl_1). View Publication.
    18. Heng-Jie Cheng, Zhe Chen, Yixi Liu, Xiaowei Zhang, Donald A McClain, Dalane Kitzman, Che Ping Cheng. Circulation. Abstract 9995: Beta3-Adrenergic-Receptor-Deficient Mice Protected From Diabetes-Induced Cardiomyopathy: Pivotal Role of the Prevention of Cardiac CaMKII Upregulation. 2019; 140(Suppl_1). View Publication.
    19. Heng-Jie Cheng, Yixi Liu, Zhe Chen, Xiaowei Zhang, Dalane Kitzman, Donald A McClain, Che Ping Cheng. Abstract 10246: Chronic Beta3-Adrenergic Receptor Antagonist Therapy Rescues Diabetic Cardiomyopathy Through Ca2+/Calmodulin-Dependent Protein Kinase II Inhibition. 2019; 140(Suppl_1). View Publication.
    20. Heng-Jie Cheng, Yixi Liu, Xiaoqiang Sun, Jen-Jar Lin, Alexei V Mikhailov, David Zhao, Dalane Kitzman, Che Ping Cheng. Circulation. Abstract 10275: The Role and Mechanism of Chronic Ca2+/Calmodulin-Dependent Protein Kinase II Inhibition in a Mouse Model of Diabetic Cardiomyopathy. 2019; 140(Suppl_1). View Publication.
    21. Yixi Liu, Heng-Jie Cheng, Alexei V Mikhailov, Jen-Jar Lin, Peng Zhou, David Zhao, David Herrington, Dalane Kitzman, Che Ping Cheng. Circulation. Abstract 9924: Acute Inhibition of CaMKII Over-Activation Augments Cardiomyocyte Contractility and Improves ß-Adrenergic Regulation in Experimental Diabetic Cardiomyopathy. 2019; 140(Suppl_1). View Publication.
    22. Yixi Liu, Heng-Jie Cheng, Zhe Chen, Leanne Groban, Dalane Kitzman, Donald A McClain, Che Ping Cheng. Circulation. Abstract 10565: Effective Treatment of Diabetic Cardiomyopathy With a Selective Beta3-Adrenergic Receptor Antagonist, but Not Beta1-Adrenergic Receptor Blocker in a Murine Model. 2019; 140(Suppl_1). View Publication.
    23. Xiaowei Zhang, Che Ping Cheng, Tiankai Li, Zhe Chen, Yixi Liu, Peng Zhou, Heng-Jie Cheng. Circulation. Abstract 9664: Importance of Early Initiation of Anti-Tumor Necrosis Factor-a With Etanercept for Slowing the Progression of Heart Failure: Insights into the Underlying Cellular and Molecular Mechanisms. 2019; 140(Suppl_1). View Publication.
    24. Xiaowei Zhang, Che Ping Cheng, Peng Zhou, Zhi Zhang, Satoshi Masutani, Michael F Callahan, Dalane Kitzman, David Herrington, Heng-Jie Cheng. Circulation. Abstract 10297: Altered Cardiac Response of Nitric Oxide and cGMP After Heart Failure--Assessment by Pressure-Volume Analysis. 2019; 140(Suppl_1). View Publication.
    25. Zhi Zhang, Che Ping Cheng, Satoshi Masutani, Tiankai Li, Heng-Jie Cheng. Circulation. Abstract 9759: Mechanism of the Protective Effects of L-carnitine on Left Ventricular Dysfunction after Short-term Oral Alcohol Administration in Rats. 2019; 140(Suppl_1). View Publication.
    26. Zhi Zhang, Heng-Jie Cheng, Satoshi Masutani, Michael F Callahan, David Zhao, Dalane Kitzman, Che Ping Cheng. Circulation. Abstract 10126: Chronic Anthrax-Lethal-Toxin Causes Progressive Cardiac Depression in Mice: Insights into Cellular Mechanism. 2019; 140(Suppl_1). View Publication.
    27. Che Ping Cheng, Peng Zhou, Atsushi Morimoto, Xiaowei Zhang, David Zhao, David Herrington, Dalane Kitzman, Heng-Jie Cheng. Circulation. Abstract 9805: Chronic Beta3-Adrenergic Receptor Blockade Restores Beta-Adrenergic Positive Modulation on Cardiomyocyte L-Type Ca2+ Current in Rats With Advanced Heart Failure. 2019; 140(Suppl_1). View Publication.
    28. Che Ping Cheng, Peng Zhou, Zhe Chen, Xiaowei Zhang, Xiaoqiang Sun, Dalane Kitzman, Michael Callahan, Heng-Jie Cheng. Circulation. Abstract 10711: Upregulation Cardiac Beta3-Adrenergic Receptor-Activated Inducible Nitric Oxide Synthase Uncoupling Promotes Cardiac Aging. 2019; 140(Suppl_1). View Publication.
    29. Zhe Chen, Che Ping Cheng, Peng Zhou, Yixi Liu, Zhi Zhang, Satoshi Masutani, Michael F Callahan, Dalane Kitzman, Heng-Jie Cheng. Circulation. Abstract 10094: Upregulation of Cardiac Beta3-Adrenergic Signaling Promotes Cardiac Aging: Evidence from Chronic Beta3-Adrenoceptor Deficiency Mice. 2019; 140(Suppl_1). View Publication.
    30. Zhe Chen, Yixi Liu, Heng-Jie Cheng, Jessica VonCannon, Sarfaraz Ahmad, Jasmina Varagic, Carlos M Ferrario, Che Ping Cheng. Circulation. Abstract 9651: Angiotensin-(1-12) Modulation of Cardiomyocyte Functional Performance in Wistar-Kyoto and Spontaneously Hypertensive Rats. 2019; 140(Suppl_1). View Publication.
    31. Tiankai Li, Heng-Jie Cheng, Zhi Zhang, Satoshi Masutani, Xiaowei Zhang, David Herrington, Che Ping Cheng. Circulation. Abstract 10438: Effects of Prostaglandin E1 on Left Ventricular Systolic and Diastolic Performance in Conscious Dogs With Pacing-Induced Heart Failure - Assessment by Pressure-Volume Analysis. 2019; 140(Suppl_1). View Publication.
    32. Tiankai Li, Hideo Tachibana, Tomohiko Ukai, Zhi Zhang, Xiaowei Zhang, Nobuyuki Ohte, Heng-Jie Cheng, David Herrington, David Zhao, Che Ping Cheng. Circulation. Abstract 9685: Positive Modulation of Exogenous L-carnosine on Left Ventricular Systolic and Diastolic Performance in Conscious, Chronically-Instrumented Dogs With Pacing-Induced Heart Failure: Assessment by Left Ventricular Pressure-Volume Analysis. 2019; 140(Suppl_1). View Publication.
    33. Alexei V Mikhailov, Jen-Jar Lin, Yixi Liu, Heng-Jie Cheng, David Herrington, David Zhao, Che Ping Cheng. Circulation. Abstract 11388: Calmodulin-Dependent Protein Kinase II Activation Promotes Cardiac Structural Remolding and Kidney Mesangial Expansion in Streptozotocin-Induced Diabetic Mice. 2019; 140(Suppl_1). View Publication.
    34. Reyes S, Cheng CP, Roberts DJ, Yamashita T, Ahmad S, VonCannon JL, Wright KN, Dell'Italia LJ, Varagic J, Ferrario CM. Angiotensin-(1-12)/chymase axis modulates cardiomyocyte L-type calcium currents in rats expressing human angiotensinogen. Int J Cardiol. 2019 12 15; 297:104-110. PMID: 31629566.
      Citations:    
    35. Li T, Zhang Z, Zhang X, Chen Z, Cheng HJ, Ahmad S, Ferrario CM, Cheng CP. Reversal of angiotensin-(1-12)-caused positive modulation on left ventricular contractile performance in heart failure: Assessment by pressure-volume analysis. Int J Cardiol. 2020 02 15; 301:135-141. PMID: 31521437.
      Citations:    
    36. Zhao H, Li T, Liu G, Zhang L, Li G, Yu J, Lou Q, He R, Zhan C, Li L, Yang W, Zang Y, Cheng C, Li W. Chronic B-Type Natriuretic Peptide Therapy Prevents Atrial Electrical Remodeling in a Rabbit Model of Atrial Fibrillation. J Cardiovasc Pharmacol Ther. 2019 11; 24(6):575-585. PMID: 31159577.
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    37. Carlos M Ferrario, Cheng CP, Jasmina Varagic. . Angiotensin-(1-7), Springer Science, Robson Augusto Souza Santos (Editor). Angiotensin-(1-7) and the Heart. 2019; 83-104.
    38. Heng-Jie Cheng, Xiaowei Zhang, Tiankai Li, Zhi Zhang, Dwight D Deal, James E Jordan, Zhe Chen, David Herrington, John Adams, Che Ping Cheng. Circulation. Abstract 10477: Adverse Functional Significance of Cardiac Beta3-Adrenergic Receptor Activation on Left Ventricular Contractile Performance in Conscious, Chronically-Instrumented Dogs with Pacing-Induced Heart Failure. 2018; 138(Suppl_1). View Publication.
    39. Yixi Liu, Qun Shao, Heng-Jie Cheng, Tiankai Li, Michael F Callahan, and Che Ping Cheng. Abstract 10519: Mechanism of Chronic CaMKII Inhibition-Caused Regression of Advanced Heart Failure: Beneficial Effects on Neurohormonal Activation, Cardiomyocyte Contractile Function, [Ca2+]i Regulation and Beta-Adrenergic Modulation. 2018; 138(Suppl_1). View Publication.
    40. Zhe Chen, Zhi Zhang, Heng-Jie Cheng, Peng Zhou, and Che Ping Cheng. Circulation. Abstract 10520: Cellular Basis of Beta2-Adrenergic Receptor Activation Produced Enhanced Positive Modulation on Left Ventricular Systolic and Diastolic Functional Performance in Heart Failure. 2018; 138(Suppl_1). View Publication.
    41. Xiaowei Zhang, Zhi Zhang, Tiankai Li, Heng-Jie Cheng, Dwight D Deal, James E Jordan, John Adams, and Che Ping Cheng. Circulation. Abstract 10553: APD418, A Selective Beta3-Adrenergic Receptor Antagonist Enhances Cardiac Positive Inotropic and Lusitropic Responses to Dobutamine in Conscious, Chronically-Instrumented Dogs With Pacing-Induced Heart Failure: Assessment by Pressure-Volume Analysis. 2018; 138(Suppl_1). View Publication.
    42. Xiaowei Zhang, Tiankai Li, Peng Zhou, Michael F Callahan, Che Ping Cheng, and Heng-Jie Cheng. Circulation. Abstract 10608: Cellular Basis of Urotensin II Produced Enhanced Inhibition on Left Ventricular Contractile Functional Performance in Diabetes Mellitus. 2018; 138(Suppl_1). View Publication.
    43. Zhe Chen, Che Ping Cheng, Yixi Liu, Peng Zhou, Zhi Zhang, Tiankai Li, Xiaowei Zhang, Dalane Kitzman, and Heng-Jie Cheng. Circulation. Abstract 10630: Is Beta3-Adrenergic-Receptor (AR) a Target for Diabetic Cardiomyopathy Therapy? Evidence From Beta3-AR Knockout Mice. 2018; 138(Suppl_1). View Publication.
    44. Zhe Chen, Yixi Liu, Heng-Jie Cheng, Peng Zhou, XiaoWei Zhang, Tiankai Li, Zhi Zhang, Michael F Callahan, Delane Kitzman, and Che Ping Cheng. Circulation. Abstract 10774: Restoration of Normal Cardiomyocyte Basal and Beta-Adrenergic Receptor (AR) Subtype Modulation in Heart Failure by Chronic Beta3-AR Deficiency. 2018; 138(Suppl_1). View Publication.
    45. Yixi Liu, Che Ping Cheng, Peng Zhou, Zhe Chen, Satoshi Masutani, Nobuyuki Ohte, Michael F Callanhan, David Zhao, and Heng-Jie Cheng. Circulation. Abstract 10893: Mechanism of Chronic Urotensin II Receptor Blockade Causes Regression in Murine Heart Failure: Beneficial Effects on Neurohormonal Activation, Cardiomyocyte Contractile Function, [Ca2+]i Regulation and Beta-Adrenergic Modulation. 2018; 138(Suppl_1). View Publication.
    46. Zhe Chen, Nadeem Wajih, Heng-Jie Cheng, Tiankai Li, Qun Shao, Michael F Callahan, and Che Ping Cheng. Circulation. Abstract 11078: Molecular Basis of Obesity Cardiomyopathy in a High-Fat-Diet Rat Model: Contrasting Changes Between Cardiac Beta1-Adrenergic Receptors, SERCA2a and Cardiac Beta3-Adrenergic Receptors. 2018; 138(Suppl_1). View Publication.
    47. Heng-Jie Cheng, Zhe Chen, Yixi Liu, Michael F Callahan, David Herrington, Dalane Kitzman, and Che Ping Cheng. Circulation. Abstract 11100: Molecular Basis of the Protective Effect of Beta3-Adrenergic Receptor Deficiency on Diabetic Cardiomyopathy in a Mouse Model: Effects on the Express of Cardiac SR Ca2+-ATPase, Subtypes of Beta-Adrenergic Receptors, Nitric Oxide Synthase Isoforms and Nitrotyrosine. 2018; 138(Suppl_1). View Publication.
    48. Che Ping Cheng, Nadeen Wajih, Heng-Jie Cheng, Qun Shao, David Friedman, James B Daunais, and Kathleen A Grant. Circulation. Abstract 11199: Downregulation of SR Ca2+-ATPase in Monkeys With Chronic Heavy Alcohol Consumption: A Key Molecular Mechanism of Alcoholic Cardiomyopathy. 2018; 138(Suppl_1). View Publication.
    49. Zhi Zhang, Heng-Jie Cheng, Xiaowei Zhang, Tiankai Li, Tomohiko Ukai, Nobuyuki Ohte, David Herrington, and Che-Ping Cheng. Circulation. Abstract 11225: Chronic Beta3-Adrenergic Receptor Blockade Causes Regression of Cardiac Dysfunction in Chronically-Instrumented Conscious Dogs With Pacing-Induced Heart Failure. 2018; 138(Suppl_1). View Publication.
    50. Xiaowei Zhang, Heng-Jie Cheng, Tomohiko Ukai, Hideo Tachibana, Zhi Zhang, Tiankai Li, and Che-Ping Cheng. Circulation. Abstract 11242: Enhanced Cardiac and Vascular Responses of L-Carnitine in Heart Failure: Assessment by Left Ventricular Pressure-Volume Analysis . 2018; 138(Suppl_1). View Publication.
    51. Heng-Jie Cheng, Peng Zhou, Chad D Markert, Qun Shao, Dalane Kitzman, David Zhao, Martin K Childers, and Che Ping Cheng. Circulation. Abstract 11246: Cellular Basis of Progressive Left Ventricle Dysfunction in a Canine Model of Duchenne Muscular Dystrophy: Effects of Cardiomyocyte Contractile Functional Performance, L-Type Calcium Current Response and Beta-Adrenergic Modulation. 2018; 138(Suppl_1). View Publication.
    52. Yixi Liu, Zhe Chen, Heng-Jie Cheng, Peng Zhou, Satoshi Masutani, Nobuyuki Ohte, and Che Ping Cheng. Circulation. Abstract 11350: Is Up-Regulation of Beta3-Adrenergic Receptor (AR) in the Diabetes Myocardium Detrimental or Beneficial?--Effects of Chronic Beta3-Adrenergic Receptors Blockade on Diabetic Cardiomyopathy in a Murine Model. 2018; 138(Suppl_1). View Publication.
    53. Che Ping Cheng, Zhe Chen, Yixi Liu, Michael F Callahan, Satoshi Masutani, Peng Zhou, Zhi Zhang, Dalane Kitzman, David Zhao, and Heng-Jie Cheng. Circulation. Abstract 11375: Chronic ß3-Adrenergic Receptor Blockade Improves Cardiovascular Functional and Structural Responses in Aging Murine Model. 2018; 138(Suppl_1). View Publication.
    54. Che Ping Cheng, Heng-Jie Cheng, Qun Shao, Li Zhang, Michael F Callahan, Dalane Kitzman, David Zhao, and Janice D Wagner. Circulation. Abstract 11401: Upregulation of Cardiac Beta3-Adrenergic Receptor-Activated Inducible Nitric Oxide Synthase (iNOS)-Coupled Pathway Promotes Diabetic Cardiomyopathy in Spontaneous Diabetic Cynomolgus Monkeys: Role of Oxidant Stress. 2018; 138(Suppl_1). View Publication.
    55. Yixi Liu, Heng-Jie Cheng, Zhe Chen, Zhi Zhang, Dalane Kitzman, David Herring, David Zhao, and Che Ping Cheng. Circulation. Abstract 11399: Chronic Ca2+/Calmodulin-Dependent Protein Kinase II Inhibition Causes Regression in a Mouse Model of Diabetic Cardiomyopathy: Insights Into Molecular and Cellular Mechanisms. 2018; 138(Suppl_1). View Publication.
    56. Li T, Zhang X, Cheng HJ, Zhang Z, Ahmad S, Varagic J, Li W, Cheng CP, Ferrario CM. Critical role of the chymase/angiotensin-(1-12) axis in modulating cardiomyocyte contractility. Int J Cardiol. 2018 08 01; 264:137-144. PMID: 29685688.
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    57. Reyes S, Varagic J, Ahmad S, VonCannon J, Kon ND, Wang H, Groban L, Cheng CP, Dell'Italia LJ, Ferrario CM. Novel Cardiac Intracrine Mechanisms Based on Ang-(1-12)/Chymase Axis Require a Revision of Therapeutic Approaches in Human Heart Disease. Curr Hypertens Rep. 2017 Feb; 19(2):16. PMID: 28233239.
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    58. Zhang X, Cheng HJ, Zhou P, Kitzman DW, Ferrario CM, Li WM, Cheng CP. Cellular basis of angiotensin-(1-7)-induced augmentation of left ventricular functional performance in heart failure. Int J Cardiol. 2017 Jun 01; 236:405-412. PMID: 28096047.
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    59. Ferrario CM, Ahmad S, Varagic J, Cheng CP, Groban L, Wang H, Collawn JF, Dell Italia LJ. Intracrine angiotensin II functions originate from noncanonical pathways in the human heart. . 2016 08 01; 311(2):H404-14. PMID: 27233763.
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    60. Li T, Cheng HJ, Ohte N, Hasegawa H, Morimoto A, Herrington DM, Little WC, Li W, Cheng CP. C-Type Natriuretic Peptide Improves Left Ventricular Functional Performance at Rest and Restores Normal Exercise Responses after Heart Failure. J Pharmacol Exp Ther. 2016 06; 357(3):545-53. PMID: 27026682.
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    61. Shao Q, Cheng HJ, Callahan MF, Kitzman DW, Li WM, Cheng CP. Overexpression myocardial inducible nitric oxide synthase exacerbates cardiac dysfunction and beta-adrenergic desensitization in experimental hypothyroidism. Int J Cardiol. 2016 Feb 01; 204:229-41. PMID: 26681542.
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    62. Zhou P, Cheng CP, Li T, Ferrario CM, Cheng HJ. Modulation of cardiac L-type Ca2+ current by angiotensin-(1-7): normal versus heart failure. Ther Adv Cardiovasc Dis. 2015 Dec; 9(6):342-53. PMID: 26082338.
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    63. Upadhya B, Taffet GE, Cheng CP, Kitzman DW. Heart failure with preserved ejection fraction in the elderly: scope of the problem. J Mol Cell Cardiol. 2015 Jun; 83:73-87. PMID: 25754674.
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    64. Masutani S, Cheng HJ, Morimoto A, Hasegawa H, Han QH, Little WC, Cheng CP. ß3-Adrenergic receptor antagonist improves exercise performance in pacing-induced heart failure. . 2013 Sep 15; 305(6):H923-30. PMID: 23873794.
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    65. Masutani S, Cheng HJ, Tachibana H, Little WC, Cheng CP. Levosimendan restores the positive force-frequency relation in heart failure. . 2011 Aug; 301(2):H488-96. PMID: 21572004.
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    66. Cheng HJ, Grant KA, Han QH, Daunais JB, Friedman DP, Masutani S, Little WC, Cheng CP. Up-regulation and functional effect of cardiac ß3-adrenoreceptors in alcoholic monkeys. Alcohol Clin Exp Res. 2010 Jul; 34(7):1171-81. PMID: 20477780.
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    67. Frankel AE, Kuo SR, Dostal D, Watson L, Duesbery NS, Cheng CP, Cheng HJ, Leppla SH. Pathophysiology of anthrax. Front Biosci (Landmark Ed). 2009 Jan 01; 14:4516-24. PMID: 19273366.
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    68. Masutani S, Little WC, Hasegawa H, Cheng HJ, Cheng CP. Restrictive left ventricular filling pattern does not result from increased left atrial pressure alone. Circulation. 2008 Mar 25; 117(12):1550-4. PMID: 18332265.
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    69. Masutani S, Cheng HJ, Hyttilä-Hopponen M, Levijoki J, Heikkilä A, Vuorela A, Little WC, Cheng CP. Orally available levosimendan dose-related positive inotropic and lusitropic effect in conscious chronically instrumented normal and heart failure dogs. J Pharmacol Exp Ther. 2008 Apr; 325(1):236-47. PMID: 18174383.
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    70. Cheng CP, Cheng HJ, Cunningham C, Shihabi ZK, Sane DC, Wannenburg T, Little WC. Angiotensin II type 1 receptor blockade prevents alcoholic cardiomyopathy. Circulation. 2006 Jul 18; 114(3):226-36. PMID: 16831986.
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    71. Zhang ZS, Cheng HJ, Onishi K, Ohte N, Wannenburg T, Cheng CP. Enhanced inhibition of L-type Ca2+ current by beta3-adrenergic stimulation in failing rat heart. J Pharmacol Exp Ther. 2005 Dec; 315(3):1203-11. PMID: 16135702.
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    72. Tachibana H, Cheng HJ, Ukai T, Igawa A, Zhang ZS, Little WC, Cheng CP. Levosimendan improves LV systolic and diastolic performance at rest and during exercise after heart failure. . 2005 Feb; 288(2):H914-22. PMID: 15486041.
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    73. Morimoto A, Hasegawa H, Cheng HJ, Little WC, Cheng CP. Endogenous beta3-adrenoreceptor activation contributes to left ventricular and cardiomyocyte dysfunction in heart failure. . 2004 Jun; 286(6):H2425-33. PMID: 14962832.
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    74. Little WC, Wesley-Farrington DJ, Hoyle J, Brucks S, Robertson S, Kitzman DW, Cheng CP. Effect of candesartan and verapamil on exercise tolerance in diastolic dysfunction. J Cardiovasc Pharmacol. 2004 Feb; 43(2):288-93. PMID: 14716219.
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    75. Ohte N, Cheng CP, Little WC. Tachycardia exacerbates abnormal left ventricular-arterial coupling in heart failure. Heart Vessels. 2003 Jul; 18(3):136-41. PMID: 12955429.
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    76. Hasegawa H, Little WC, Ohno M, Brucks S, Morimoto A, Cheng HJ, Cheng CP. Diastolic mitral annular velocity during the development of heart failure. J Am Coll Cardiol. 2003 May 07; 41(9):1590-7. PMID: 12742302.
      Citations:    
    77. Cheng HJ, Zhang ZS, Onishi K, Ukai T, Sane DC, Cheng CP. Upregulation of functional beta(3)-adrenergic receptor in the failing canine myocardium. Circ Res. 2001 Sep 28; 89(7):599-606. PMID: 11577025.
      Citations:    
    78. Shihabi ZK, Hinsdale ME, Cheng CP. Analysis of glutathione by capillary electrophoresis based on sample stacking. Electrophoresis. 2001 Jul; 22(11):2351-3. PMID: 11504072.
      Citations:    
    79. Zhang ZS, Cheng HJ, Ukai T, Tachibana H, Cheng CP. Enhanced cardiac L-type calcium current response to beta2-adrenergic stimulation in heart failure. J Pharmacol Exp Ther. 2001 Jul; 298(1):188-96. PMID: 11408541.
      Citations:    
    80. Cheng CP, Ukai T, Onishi K, Ohte N, Suzuki M, Zhang ZS, Cheng HJ, Tachibana H, Igawa A, Little WC. The role of ANG II and endothelin-1 in exercise-induced diastolic dysfunction in heart failure. . 2001 Apr; 280(4):H1853-60. PMID: 11247801.
      Citations:    
    81. Ukai T, Cheng CP, Tachibana H, Igawa A, Zhang ZS, Cheng HJ, Little WC. Allopurinol enhances the contractile response to dobutamine and exercise in dogs with pacing-induced heart failure. Circulation. 2001 Feb 06; 103(5):750-5. PMID: 11156889.
      Citations:    
    82. Little WC, Kitzman DW, Cheng CP. Diastolic dysfunction as a cause of exercise intolerance. Heart Fail Rev. 2000 Dec; 5(4):301-6. PMID: 11498643.
      Citations:    
    83. Ohte N, Cheng CP, Suzuki M, Little WC. Effects of atrial natriuretic peptide on left ventricular performance in conscious dogs before and after pacing-induced heart failure. J Pharmacol Exp Ther. 1999 Nov; 291(2):589-95. PMID: 10525076.
      Citations:    
    84. Onishi K, Ohno M, Little WC, Cheng CP. Endogenous endothelin-1 depresses left ventricular systolic and diastolic performance in congestive heart failure. J Pharmacol Exp Ther. 1999 Mar; 288(3):1214-22. PMID: 10027861.
      Citations:    
    85. Suzuki M, Ohte N, Wang ZM, Williams DL, Little WC, Cheng CP. Altered inotropic response of endothelin-1 in cardiomyocytes from rats with isoproterenol-induced cardiomyopathy. Cardiovasc Res. 1998 Sep; 39(3):589-99. PMID: 9861301.
      Citations:    
    86. Little WC, Cheng CP. Diastolic Dysfunction. Cardiol Rev. 1998 Jul; 6(4):231-239. PMID: 10348945.
      Citations:    
    87. Cheng CP, Onishi K, Ohte N, Suzuki M, Little WC. Functional effects of endogenous bradykinin in congestive heart failure. J Am Coll Cardiol. 1998 Jun; 31(7):1679-86. PMID: 9626851.
      Citations:    
    88. Little WC, Warner JG, Rankin KM, Kitzman DW, Cheng CP. Evaluation of left ventricular diastolic function from the pattern of left ventricular filling. Clin Cardiol. 1998 Jan; 21(1):5-9. PMID: 9474459.
      Citations:    
    89. Suzuki M, Cheng CP, Ohte N, Little WC. Left ventricular spherical dilation and regional contractile dysfunction in dogs with heart failure. Am J Physiol. 1997 Sep; 273(3 Pt 2):H1058-67. PMID: 9321789.
      Citations:    
    90. Ohte N, Cheng CP, Suzuki M, Little WC. The cardiac effects of pimobendan (but not amrinone) are preserved at rest and during exercise in conscious dogs with pacing-induced heart failure. J Pharmacol Exp Ther. 1997 Jul; 282(1):23-31. PMID: 9223536.
      Citations:    
    91. Cheng CP, Suzuki M, Ohte N, Ohno M, Wang ZM, Little WC. Altered ventricular and myocyte response to angiotensin II in pacing-induced heart failure. Circ Res. 1996 May; 78(5):880-92. PMID: 8620609.
      Citations:    
    92. Little WC, Cheng CP, Elvelin L, Nordlander M. Vascular selective calcium entry blockers in the treatment of cardiovascular disorders: focus on felodipine. Cardiovasc Drugs Ther. 1995 Oct; 9(5):657-63. PMID: 8573548.
      Citations:    
    93. Little WC, Ohno M, Kitzman DW, Thomas JD, Cheng CP. Determination of left ventricular chamber stiffness from the time for deceleration of early left ventricular filling. Circulation. 1995 Oct 01; 92(7):1933-9. PMID: 7671378.
      Citations:    
    94. Cheng CP, Pettersson K, Little WC. Effects of felodipine on left ventricular systolic and diastolic performance in congestive heart failure. J Pharmacol Exp Ther. 1994 Dec; 271(3):1409-17. PMID: 7996453.
      Citations:    
    95. Nozawa T, Cheng CP, Noda T, Little WC. Effect of exercise on left ventricular mechanical efficiency in conscious dogs. Circulation. 1994 Dec; 90(6):3047-54. PMID: 7994853.
      Citations:    
    96. Ohno M, Cheng CP, Little WC. Mechanism of altered patterns of left ventricular filling during the development of congestive heart failure. Circulation. 1994 May; 89(5):2241-50. PMID: 8181149.
      Citations:    
    97. Cheng CP, Noda T, Nordlander M, Ohno M, Little WC. Comparison of effects of dihydropyridine calcium antagonists on left ventricular systolic and diastolic performance. J Pharmacol Exp Ther. 1994 Mar; 268(3):1232-41. PMID: 8138936.
      Citations:    
    98. Little WC, Cheng CP. Coupling of the left ventricular and arterial system. Med Biol Eng Comput. 1994 Mar; 32(2):205-9. PMID: 8022218.
      Citations:    
    99. Nozawa T, Cheng CP, Noda T, Little WC. Relation between left ventricular oxygen consumption and pressure-volume area in conscious dogs. Circulation. 1994 Feb; 89(2):810-7. PMID: 8313570.
      Citations:    
    100. Little WC, Cheng CP. Vascular versus myocardial effects of calcium antagonists. Drugs. 1994; 47 Suppl 4:41-5; discussion 45-6. PMID: 7523061.
      Citations:    
    101. Noda T, Cheng CP, De Tombe PP, Little WC. Curvilinearity of LV end-systolic pressure-volume and dP/dtmax-end-diastolic volume relations. Am J Physiol. 1993 Sep; 265(3 Pt 2):H910-7. PMID: 8214126.
      Citations:    
    102. Nakamoto T, Cheng CP, Santamore WP, Iizuka M. Estimation of left ventricular elastance without altering preload or afterload in the conscious dog. Cardiovasc Res. 1993 May; 27(5):868-73. PMID: 8348586.
      Citations:    
    103. Little WC, Cheng CP. Effect of exercise on left ventricular-arterial coupling assessed in the pressure-volume plane. Am J Physiol. 1993 May; 264(5 Pt 2):H1629-33. PMID: 8098914.
      Citations:    
    104. Cheng CP, Noda T, Nozawa T, Little WC. Effect of heart failure on the mechanism of exercise-induced augmentation of mitral valve flow. Circ Res. 1993 Apr; 72(4):795-806. PMID: 8095187.
      Citations:    
    105. Cheng CP, Igarashi Y, Klopfenstein HS, Applegate RJ, Shihabi Z, Little WC. Effect of vasopressin on left ventricular performance. Am J Physiol. 1993 Jan; 264(1 Pt 2):H53-60. PMID: 8430861.
      Citations:    
    106. Cheng CP, Igarashi Y, Little WC. Mechanism of augmented rate of left ventricular filling during exercise. Circ Res. 1992 Jan; 70(1):9-19. PMID: 1345778.
      Citations:    
    107. Little WC, Cheng CP. Left ventricular-arterial coupling in conscious dogs. Am J Physiol. 1991 Jul; 261(1 Pt 2):H70-6. PMID: 1858932.
      Citations:    
    108. Igarashi Y, Cheng CP, Little WC. Left ventricular ejection activation in the in situ heart. Am J Physiol. 1991 May; 260(5 Pt 2):H1495-500. PMID: 2035671.
      Citations:    
    109. Cheng CP, Freeman GL, Santamore WP, Constantinescu MS, Little WC. Effect of loading conditions, contractile state, and heart rate on early diastolic left ventricular filling in conscious dogs. Circ Res. 1990 Mar; 66(3):814-23. PMID: 1689618.
      Citations:    
    110. Applegate RJ, Cheng CP, Little WC. Simultaneous conductance catheter and dimension assessment of left ventricle volume in the intact animal. Circulation. 1990 Feb; 81(2):638-48. PMID: 2404634.
      Citations:    
    111. Little WC, Cheng CP, Mumma M, Igarashi Y, Vinten-Johansen J, Johnston WE. Comparison of measures of left ventricular contractile performance derived from pressure-volume loops in conscious dogs. Circulation. 1989 Nov; 80(5):1378-87. PMID: 2805273.
      Citations:    
    112. Little WC, Cheng CP, Peterson T, Vinten-Johansen J. Response of the left ventricular end-systolic pressure-volume relation in conscious dogs to a wide range of contractile states. Circulation. 1988 Sep; 78(3):736-45. PMID: 3409508.
      Citations:    
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