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Che-Ping Cheng, M.D., Ph.D.

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentInt Med-Cardiovascular Med
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentPhysiology and Pharmacology


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    R29HL045258     (CHENG, CHE-PING)Jan 1, 1991 - Dec 31, 1996
    NIH/NHLBI
    DIASTOLIC FILLING DYNAMICS OF EXERCISE AND HEART FAILURE
    Role: Principal Investigator

    R01AA012335     (CHENG, CHE-PING)Mar 1, 2000 - Feb 28, 2006
    NIH/NIAAA
    MECHANISM OF CHRONIC ALCOHOL INDUCED CARDIOMYOPATHY
    Role: Principal Investigator

    R01HL074318     (CHENG, CHE-PING)Jul 1, 2003 - Jun 30, 2008
    NIH/NHLBI
    Beta3-Adrenergic Receptor &Progression to Heart Failure
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ferrario CM, VonCannon J, Ahmad S, Wright KN, Roberts DJ, Wang H, Yamashita T, Groban L, Cheng CP, Collawn JF, Dell'Italia LJ, Varagic J. Activation of the Human Angiotensin-(1-12)-Chymase Pathway in Rats With Human Angiotensinogen Gene Transcripts. Front Cardiovasc Med. 2019; 6:163. PMID: 31803758.
      View in: PubMed
    2. Heng-Jie Cheng, Yixi Liu, Zhe Chen, Alexei V Mikhailov, Jen-Jar Lin, Dalane Kitzman, Donald A McClain, Che Ping Cheng. Circulation. Abstract 9831: Molecular Mechanism of Chronic Beta3-Adrenergic Receptor Blockade-Caused Regression of Cardiac Dysfunction in a Diabetic Mouse Model: Effects on the Express of Cardiac SR Ca2+-ATPase, Subtypes of Beta-Adrenergic Receptors and Nitric Oxide Synthase Isoforms and Nitrotyrosine. 2019; 140(Suppl_1).
    3. Heng-Jie Cheng, Zhe Chen, Yixi Liu, Xiaowei Zhang, Donald A McClain, Dalane Kitzman, Che Ping Cheng. Circulation. Abstract 9995: Beta3-Adrenergic-Receptor-Deficient Mice Protected From Diabetes-Induced Cardiomyopathy: Pivotal Role of the Prevention of Cardiac CaMKII Upregulation. 2019; 140(Suppl_1).
    4. Heng-Jie Cheng, Yixi Liu, Zhe Chen, Xiaowei Zhang, Dalane Kitzman, Donald A McClain, Che Ping Cheng. Abstract 10246: Chronic Beta3-Adrenergic Receptor Antagonist Therapy Rescues Diabetic Cardiomyopathy Through Ca2+/Calmodulin-Dependent Protein Kinase II Inhibition. 2019; 140(Suppl_1).
    5. Heng-Jie Cheng, Yixi Liu, Xiaoqiang Sun, Jen-Jar Lin, Alexei V Mikhailov, David Zhao, Dalane Kitzman, Che Ping Cheng. Circulation. Abstract 10275: The Role and Mechanism of Chronic Ca2+/Calmodulin-Dependent Protein Kinase II Inhibition in a Mouse Model of Diabetic Cardiomyopathy. 2019; 140(Suppl_1).
    6. Yixi Liu, Heng-Jie Cheng, Alexei V Mikhailov, Jen-Jar Lin, Peng Zhou, David Zhao, David Herrington, Dalane Kitzman, Che Ping Cheng. Circulation. Abstract 9924: Acute Inhibition of CaMKII Over-Activation Augments Cardiomyocyte Contractility and Improves ß-Adrenergic Regulation in Experimental Diabetic Cardiomyopathy. 2019; 140(Suppl_1).
    7. Yixi Liu, Heng-Jie Cheng, Zhe Chen, Leanne Groban, Dalane Kitzman, Donald A McClain, Che Ping Cheng. Circulation. Abstract 10565: Effective Treatment of Diabetic Cardiomyopathy With a Selective Beta3-Adrenergic Receptor Antagonist, but Not Beta1-Adrenergic Receptor Blocker in a Murine Model. 2019; 140(Suppl_1).
    8. Xiaowei Zhang, Che Ping Cheng, Tiankai Li, Zhe Chen, Yixi Liu, Peng Zhou, Heng-Jie Cheng. Circulation. Abstract 9664: Importance of Early Initiation of Anti-Tumor Necrosis Factor-a With Etanercept for Slowing the Progression of Heart Failure: Insights into the Underlying Cellular and Molecular Mechanisms. 2019; 140(Suppl_1).
    9. Xiaowei Zhang, Che Ping Cheng, Peng Zhou, Zhi Zhang, Satoshi Masutani, Michael F Callahan, Dalane Kitzman, David Herrington, Heng-Jie Cheng. Circulation. Abstract 10297: Altered Cardiac Response of Nitric Oxide and cGMP After Heart Failure--Assessment by Pressure-Volume Analysis. 2019; 140(Suppl_1).
    10. Zhi Zhang, Che Ping Cheng, Satoshi Masutani, Tiankai Li, Heng-Jie Cheng. Circulation. Abstract 9759: Mechanism of the Protective Effects of L-carnitine on Left Ventricular Dysfunction after Short-term Oral Alcohol Administration in Rats. 2019; 140(Suppl_1).
    11. Zhi Zhang, Heng-Jie Cheng, Satoshi Masutani, Michael F Callahan, David Zhao, Dalane Kitzman, Che Ping Cheng. Circulation. Abstract 10126: Chronic Anthrax-Lethal-Toxin Causes Progressive Cardiac Depression in Mice: Insights into Cellular Mechanism. 2019; 140(Suppl_1).
    12. Che Ping Cheng, Peng Zhou, Atsushi Morimoto, Xiaowei Zhang, David Zhao, David Herrington, Dalane Kitzman, Heng-Jie Cheng. Circulation. Abstract 9805: Chronic Beta3-Adrenergic Receptor Blockade Restores Beta-Adrenergic Positive Modulation on Cardiomyocyte L-Type Ca2+ Current in Rats With Advanced Heart Failure. 2019; 140(Suppl_1).
    13. Che Ping Cheng, Peng Zhou, Zhe Chen, Xiaowei Zhang, Xiaoqiang Sun, Dalane Kitzman, Michael Callahan, Heng-Jie Cheng. Circulation. Abstract 10711: Upregulation Cardiac Beta3-Adrenergic Receptor-Activated Inducible Nitric Oxide Synthase Uncoupling Promotes Cardiac Aging. 2019; 140(Suppl_1).
    14. Zhe Chen, Che Ping Cheng, Peng Zhou, Yixi Liu, Zhi Zhang, Satoshi Masutani, Michael F Callahan, Dalane Kitzman, Heng-Jie Cheng. Circulation. Abstract 10094: Upregulation of Cardiac Beta3-Adrenergic Signaling Promotes Cardiac Aging: Evidence from Chronic Beta3-Adrenoceptor Deficiency Mice. 2019; 140(Suppl_1).
    15. Zhe Chen, Yixi Liu, Heng-Jie Cheng, Jessica VonCannon, Sarfaraz Ahmad, Jasmina Varagic, Carlos M Ferrario, Che Ping Cheng. Circulation. Abstract 9651: Angiotensin-(1-12) Modulation of Cardiomyocyte Functional Performance in Wistar-Kyoto and Spontaneously Hypertensive Rats. 2019; 140(Suppl_1).
    16. Tiankai Li, Heng-Jie Cheng, Zhi Zhang, Satoshi Masutani, Xiaowei Zhang, David Herrington, Che Ping Cheng. Circulation. Abstract 10438: Effects of Prostaglandin E1 on Left Ventricular Systolic and Diastolic Performance in Conscious Dogs With Pacing-Induced Heart Failure - Assessment by Pressure-Volume Analysis. 2019; 140(Suppl_1).
    17. Tiankai Li, Hideo Tachibana, Tomohiko Ukai, Zhi Zhang, Xiaowei Zhang, Nobuyuki Ohte, Heng-Jie Cheng, David Herrington, David Zhao, Che Ping Cheng. Circulation. Abstract 9685: Positive Modulation of Exogenous L-carnosine on Left Ventricular Systolic and Diastolic Performance in Conscious, Chronically-Instrumented Dogs With Pacing-Induced Heart Failure: Assessment by Left Ventricular Pressure-Volume Analysis. 2019; 140(Suppl_1).
    18. Alexei V Mikhailov, Jen-Jar Lin, Yixi Liu, Heng-Jie Cheng, David Herrington, David Zhao, Che Ping Cheng. Circulation. Abstract 11388: Calmodulin-Dependent Protein Kinase II Activation Promotes Cardiac Structural Remolding and Kidney Mesangial Expansion in Streptozotocin-Induced Diabetic Mice. 2019; 140(Suppl_1).
    19. Reyes S, Cheng CP, Roberts DJ, Yamashita T, Ahmad S, VonCannon JL, Wright KN, Dell'Italia LJ, Varagic J, Ferrario CM. Angiotensin-(1-12)/chymase axis modulates cardiomyocyte L-type calcium currents in rats expressing human angiotensinogen. Int J Cardiol. 2019 Oct 08. PMID: 31629566.
      View in: PubMed
    20. Li T, Zhang Z, Zhang X, Chen Z, Cheng HJ, Ahmad S, Ferrario CM, Cheng CP. Reversal of angiotensin-(1-12)-caused positive modulation on left ventricular contractile performance in heart failure: Assessment by pressure-volume analysis. Int J Cardiol. 2019 Sep 06. PMID: 31521437.
      View in: PubMed
    21. Zhao H, Li T, Liu G, Zhang L, Li G, Yu J, Lou Q, He R, Zhan C, Li L, Yang W, Zang Y, Cheng C, Li W. Chronic B-Type Natriuretic Peptide Therapy Prevents Atrial Electrical Remodeling in a Rabbit Model of Atrial Fibrillation. J Cardiovasc Pharmacol Ther. 2019 Nov; 24(6):575-585. PMID: 31159577.
      View in: PubMed
    22. Carlos M Ferrario, Cheng CP, Jasmina Varagic. . Angiotensin-(1-7), Springer Science, Robson Augusto Souza Santos (Editor). Angiotensin-(1-7) and the Heart. 2019; 83-104.
    23. Heng-Jie Cheng, Xiaowei Zhang, Tiankai Li, Zhi Zhang, Dwight D Deal, James E Jordan, Zhe Chen, David Herrington, John Adams, Che Ping Cheng. Circulation. Abstract 10477: Adverse Functional Significance of Cardiac Beta3-Adrenergic Receptor Activation on Left Ventricular Contractile Performance in Conscious, Chronically-Instrumented Dogs with Pacing-Induced Heart Failure. 2018; 138(Suppl_1).
    24. Yixi Liu, Qun Shao, Heng-Jie Cheng, Tiankai Li, Michael F Callahan, and Che Ping Cheng. Abstract 10519: Mechanism of Chronic CaMKII Inhibition-Caused Regression of Advanced Heart Failure: Beneficial Effects on Neurohormonal Activation, Cardiomyocyte Contractile Function, [Ca2+]i Regulation and Beta-Adrenergic Modulation. 2018; 138(Suppl_1).
    25. Zhe Chen, Zhi Zhang, Heng-Jie Cheng, Peng Zhou, and Che Ping Cheng. Circulation. Abstract 10520: Cellular Basis of Beta2-Adrenergic Receptor Activation Produced Enhanced Positive Modulation on Left Ventricular Systolic and Diastolic Functional Performance in Heart Failure. 2018; 138(Suppl_1).
    26. Xiaowei Zhang, Zhi Zhang, Tiankai Li, Heng-Jie Cheng, Dwight D Deal, James E Jordan, John Adams, and Che Ping Cheng. Circulation. Abstract 10553: APD418, A Selective Beta3-Adrenergic Receptor Antagonist Enhances Cardiac Positive Inotropic and Lusitropic Responses to Dobutamine in Conscious, Chronically-Instrumented Dogs With Pacing-Induced Heart Failure: Assessment by Pressure-Volume Analysis. 2018; 138(Suppl_1).
    27. Xiaowei Zhang, Tiankai Li, Peng Zhou, Michael F Callahan, Che Ping Cheng, and Heng-Jie Cheng. Circulation. Abstract 10608: Cellular Basis of Urotensin II Produced Enhanced Inhibition on Left Ventricular Contractile Functional Performance in Diabetes Mellitus. 2018; 138(Suppl_1).
    28. Zhe Chen, Che Ping Cheng, Yixi Liu, Peng Zhou, Zhi Zhang, Tiankai Li, Xiaowei Zhang, Dalane Kitzman, and Heng-Jie Cheng. Circulation. Abstract 10630: Is Beta3-Adrenergic-Receptor (AR) a Target for Diabetic Cardiomyopathy Therapy? Evidence From Beta3-AR Knockout Mice. 2018; 138(Suppl_1).
    29. Zhe Chen, Yixi Liu, Heng-Jie Cheng, Peng Zhou, XiaoWei Zhang, Tiankai Li, Zhi Zhang, Michael F Callahan, Delane Kitzman, and Che Ping Cheng. Circulation. Abstract 10774: Restoration of Normal Cardiomyocyte Basal and Beta-Adrenergic Receptor (AR) Subtype Modulation in Heart Failure by Chronic Beta3-AR Deficiency. 2018; 138(Suppl_1).
    30. Yixi Liu, Che Ping Cheng, Peng Zhou, Zhe Chen, Satoshi Masutani, Nobuyuki Ohte, Michael F Callanhan, David Zhao, and Heng-Jie Cheng. Circulation. Abstract 10893: Mechanism of Chronic Urotensin II Receptor Blockade Causes Regression in Murine Heart Failure: Beneficial Effects on Neurohormonal Activation, Cardiomyocyte Contractile Function, [Ca2+]i Regulation and Beta-Adrenergic Modulation. 2018; 138(Suppl_1).
    31. Zhe Chen, Nadeem Wajih, Heng-Jie Cheng, Tiankai Li, Qun Shao, Michael F Callahan, and Che Ping Cheng. Circulation. Abstract 11078: Molecular Basis of Obesity Cardiomyopathy in a High-Fat-Diet Rat Model: Contrasting Changes Between Cardiac Beta1-Adrenergic Receptors, SERCA2a and Cardiac Beta3-Adrenergic Receptors. 2018; 138(Suppl_1).
    32. Heng-Jie Cheng, Zhe Chen, Yixi Liu, Michael F Callahan, David Herrington, Dalane Kitzman, and Che Ping Cheng. Circulation. Abstract 11100: Molecular Basis of the Protective Effect of Beta3-Adrenergic Receptor Deficiency on Diabetic Cardiomyopathy in a Mouse Model: Effects on the Express of Cardiac SR Ca2+-ATPase, Subtypes of Beta-Adrenergic Receptors, Nitric Oxide Synthase Isoforms and Nitrotyrosine. 2018; 138(Suppl_1).
    33. Che Ping Cheng, Nadeen Wajih, Heng-Jie Cheng, Qun Shao, David Friedman, James B Daunais, and Kathleen A Grant. Circulation. Abstract 11199: Downregulation of SR Ca2+-ATPase in Monkeys With Chronic Heavy Alcohol Consumption: A Key Molecular Mechanism of Alcoholic Cardiomyopathy. 2018; 138(Suppl_1).
    34. Zhi Zhang, Heng-Jie Cheng, Xiaowei Zhang, Tiankai Li, Tomohiko Ukai, Nobuyuki Ohte, David Herrington, and Che-Ping Cheng. Circulation. Abstract 11225: Chronic Beta3-Adrenergic Receptor Blockade Causes Regression of Cardiac Dysfunction in Chronically-Instrumented Conscious Dogs With Pacing-Induced Heart Failure. 2018; 138(Suppl_1).
    35. Xiaowei Zhang, Heng-Jie Cheng, Tomohiko Ukai, Hideo Tachibana, Zhi Zhang, Tiankai Li, and Che-Ping Cheng. Circulation. Abstract 11242: Enhanced Cardiac and Vascular Responses of L-Carnitine in Heart Failure: Assessment by Left Ventricular Pressure-Volume Analysis . 2018; 138(Suppl_1).
    36. Heng-Jie Cheng, Peng Zhou, Chad D Markert, Qun Shao, Dalane Kitzman, David Zhao, Martin K Childers, and Che Ping Cheng. Circulation. Abstract 11246: Cellular Basis of Progressive Left Ventricle Dysfunction in a Canine Model of Duchenne Muscular Dystrophy: Effects of Cardiomyocyte Contractile Functional Performance, L-Type Calcium Current Response and Beta-Adrenergic Modulation. 2018; 138(Suppl_1).
    37. Yixi Liu, Zhe Chen, Heng-Jie Cheng, Peng Zhou, Satoshi Masutani, Nobuyuki Ohte, and Che Ping Cheng. Circulation. Abstract 11350: Is Up-Regulation of Beta3-Adrenergic Receptor (AR) in the Diabetes Myocardium Detrimental or Beneficial?--Effects of Chronic Beta3-Adrenergic Receptors Blockade on Diabetic Cardiomyopathy in a Murine Model. 2018; 138(Suppl_1).
    38. Che Ping Cheng, Zhe Chen, Yixi Liu, Michael F Callahan, Satoshi Masutani, Peng Zhou, Zhi Zhang, Dalane Kitzman, David Zhao, and Heng-Jie Cheng. Circulation. Abstract 11375: Chronic ß3-Adrenergic Receptor Blockade Improves Cardiovascular Functional and Structural Responses in Aging Murine Model. 2018; 138(Suppl_1).
    39. Che Ping Cheng, Heng-Jie Cheng, Qun Shao, Li Zhang, Michael F Callahan, Dalane Kitzman, David Zhao, and Janice D Wagner. Circulation. Abstract 11401: Upregulation of Cardiac Beta3-Adrenergic Receptor-Activated Inducible Nitric Oxide Synthase (iNOS)-Coupled Pathway Promotes Diabetic Cardiomyopathy in Spontaneous Diabetic Cynomolgus Monkeys: Role of Oxidant Stress. 2018; 138(Suppl_1).
    40. Yixi Liu, Heng-Jie Cheng, Zhe Chen, Zhi Zhang, Dalane Kitzman, David Herring, David Zhao, and Che Ping Cheng. Circulation. Abstract 11399: Chronic Ca2+/Calmodulin-Dependent Protein Kinase II Inhibition Causes Regression in a Mouse Model of Diabetic Cardiomyopathy: Insights Into Molecular and Cellular Mechanisms. 2018; 138(Suppl_1).
    41. Li T, Zhang X, Cheng HJ, Zhang Z, Ahmad S, Varagic J, Li W, Cheng CP, Ferrario CM. Critical role of the chymase/angiotensin-(1-12) axis in modulating cardiomyocyte contractility. Int J Cardiol. 2018 08 01; 264:137-144. PMID: 29685688.
      View in: PubMed
    42. Reyes S, Varagic J, Ahmad S, VonCannon J, Kon ND, Wang H, Groban L, Cheng CP, Dell'Italia LJ, Ferrario CM. Novel Cardiac Intracrine Mechanisms Based on Ang-(1-12)/Chymase Axis Require a Revision of Therapeutic Approaches in Human Heart Disease. Curr Hypertens Rep. 2017 Feb; 19(2):16. PMID: 28233239.
      View in: PubMed
    43. Zhang X, Cheng HJ, Zhou P, Kitzman DW, Ferrario CM, Li WM, Cheng CP. Cellular basis of angiotensin-(1-7)-induced augmentation of left ventricular functional performance in heart failure. Int J Cardiol. 2017 Jun 01; 236:405-412. PMID: 28096047.
      View in: PubMed
    44. Ferrario CM, Ahmad S, Varagic J, Cheng CP, Groban L, Wang H, Collawn JF, Dell Italia LJ. Intracrine angiotensin II functions originate from noncanonical pathways in the human heart. Am J Physiol Heart Circ Physiol. 2016 08 01; 311(2):H404-14. PMID: 27233763.
      View in: PubMed
    45. Li T, Cheng HJ, Ohte N, Hasegawa H, Morimoto A, Herrington DM, Little WC, Li W, Cheng CP. C-Type Natriuretic Peptide Improves Left Ventricular Functional Performance at Rest and Restores Normal Exercise Responses after Heart Failure. J Pharmacol Exp Ther. 2016 06; 357(3):545-53. PMID: 27026682.
      View in: PubMed
    46. Shao Q, Cheng HJ, Callahan MF, Kitzman DW, Li WM, Cheng CP. Overexpression myocardial inducible nitric oxide synthase exacerbates cardiac dysfunction and beta-adrenergic desensitization in experimental hypothyroidism. Int J Cardiol. 2016 Feb 01; 204:229-41. PMID: 26681542.
      View in: PubMed
    47. Zhou P, Cheng CP, Li T, Ferrario CM, Cheng HJ. Modulation of cardiac L-type Ca2+ current by angiotensin-(1-7): normal versus heart failure. Ther Adv Cardiovasc Dis. 2015 Dec; 9(6):342-53. PMID: 26082338.
      View in: PubMed
    48. Upadhya B, Taffet GE, Cheng CP, Kitzman DW. Heart failure with preserved ejection fraction in the elderly: scope of the problem. J Mol Cell Cardiol. 2015 Jun; 83:73-87. PMID: 25754674.
      View in: PubMed
    49. Masutani S, Cheng HJ, Morimoto A, Hasegawa H, Han QH, Little WC, Cheng CP. ß3-Adrenergic receptor antagonist improves exercise performance in pacing-induced heart failure. Am J Physiol Heart Circ Physiol. 2013 Sep 15; 305(6):H923-30. PMID: 23873794.
      View in: PubMed
    50. Masutani S, Cheng HJ, Tachibana H, Little WC, Cheng CP. Levosimendan restores the positive force-frequency relation in heart failure. Am J Physiol Heart Circ Physiol. 2011 Aug; 301(2):H488-96. PMID: 21572004.
      View in: PubMed
    51. Cheng HJ, Grant KA, Han QH, Daunais JB, Friedman DP, Masutani S, Little WC, Cheng CP. Up-regulation and functional effect of cardiac ß3-adrenoreceptors in alcoholic monkeys. Alcohol Clin Exp Res. 2010 Jul; 34(7):1171-81. PMID: 20477780.
      View in: PubMed
    52. Frankel AE, Kuo SR, Dostal D, Watson L, Duesbery NS, Cheng CP, Cheng HJ, Leppla SH. Pathophysiology of anthrax. Front Biosci (Landmark Ed). 2009 Jan 01; 14:4516-24. PMID: 19273366.
      View in: PubMed
    53. Masutani S, Little WC, Hasegawa H, Cheng HJ, Cheng CP. Restrictive left ventricular filling pattern does not result from increased left atrial pressure alone. Circulation. 2008 Mar 25; 117(12):1550-4. PMID: 18332265.
      View in: PubMed
    54. Masutani S, Cheng HJ, Hyttilä-Hopponen M, Levijoki J, Heikkilä A, Vuorela A, Little WC, Cheng CP. Orally available levosimendan dose-related positive inotropic and lusitropic effect in conscious chronically instrumented normal and heart failure dogs. J Pharmacol Exp Ther. 2008 Apr; 325(1):236-47. PMID: 18174383.
      View in: PubMed
    55. Cheng CP, Cheng HJ, Cunningham C, Shihabi ZK, Sane DC, Wannenburg T, Little WC. Angiotensin II type 1 receptor blockade prevents alcoholic cardiomyopathy. Circulation. 2006 Jul 18; 114(3):226-36. PMID: 16831986.
      View in: PubMed
    56. Zhang ZS, Cheng HJ, Onishi K, Ohte N, Wannenburg T, Cheng CP. Enhanced inhibition of L-type Ca2+ current by beta3-adrenergic stimulation in failing rat heart. J Pharmacol Exp Ther. 2005 Dec; 315(3):1203-11. PMID: 16135702.
      View in: PubMed
    57. Tachibana H, Cheng HJ, Ukai T, Igawa A, Zhang ZS, Little WC, Cheng CP. Levosimendan improves LV systolic and diastolic performance at rest and during exercise after heart failure. Am J Physiol Heart Circ Physiol. 2005 Feb; 288(2):H914-22. PMID: 15486041.
      View in: PubMed
    58. Morimoto A, Hasegawa H, Cheng HJ, Little WC, Cheng CP. Endogenous beta3-adrenoreceptor activation contributes to left ventricular and cardiomyocyte dysfunction in heart failure. Am J Physiol Heart Circ Physiol. 2004 Jun; 286(6):H2425-33. PMID: 14962832.
      View in: PubMed
    59. Little WC, Wesley-Farrington DJ, Hoyle J, Brucks S, Robertson S, Kitzman DW, Cheng CP. Effect of candesartan and verapamil on exercise tolerance in diastolic dysfunction. J Cardiovasc Pharmacol. 2004 Feb; 43(2):288-93. PMID: 14716219.
      View in: PubMed
    60. Ohte N, Cheng CP, Little WC. Tachycardia exacerbates abnormal left ventricular-arterial coupling in heart failure. Heart Vessels. 2003 Jul; 18(3):136-41. PMID: 12955429.
      View in: PubMed
    61. Hasegawa H, Little WC, Ohno M, Brucks S, Morimoto A, Cheng HJ, Cheng CP. Diastolic mitral annular velocity during the development of heart failure. J Am Coll Cardiol. 2003 May 07; 41(9):1590-7. PMID: 12742302.
      View in: PubMed
    62. Cheng HJ, Zhang ZS, Onishi K, Ukai T, Sane DC, Cheng CP. Upregulation of functional beta(3)-adrenergic receptor in the failing canine myocardium. Circ Res. 2001 Sep 28; 89(7):599-606. PMID: 11577025.
      View in: PubMed
    63. Shihabi ZK, Hinsdale ME, Cheng CP. Analysis of glutathione by capillary electrophoresis based on sample stacking. Electrophoresis. 2001 Jul; 22(11):2351-3. PMID: 11504072.
      View in: PubMed
    64. Zhang ZS, Cheng HJ, Ukai T, Tachibana H, Cheng CP. Enhanced cardiac L-type calcium current response to beta2-adrenergic stimulation in heart failure. J Pharmacol Exp Ther. 2001 Jul; 298(1):188-96. PMID: 11408541.
      View in: PubMed
    65. Cheng CP, Ukai T, Onishi K, Ohte N, Suzuki M, Zhang ZS, Cheng HJ, Tachibana H, Igawa A, Little WC. The role of ANG II and endothelin-1 in exercise-induced diastolic dysfunction in heart failure. Am J Physiol Heart Circ Physiol. 2001 Apr; 280(4):H1853-60. PMID: 11247801.
      View in: PubMed
    66. Ukai T, Cheng CP, Tachibana H, Igawa A, Zhang ZS, Cheng HJ, Little WC. Allopurinol enhances the contractile response to dobutamine and exercise in dogs with pacing-induced heart failure. Circulation. 2001 Feb 06; 103(5):750-5. PMID: 11156889.
      View in: PubMed
    67. Little WC, Kitzman DW, Cheng CP. Diastolic dysfunction as a cause of exercise intolerance. Heart Fail Rev. 2000 Dec; 5(4):301-6. PMID: 11498643.
      View in: PubMed
    68. Ohte N, Cheng CP, Suzuki M, Little WC. Effects of atrial natriuretic peptide on left ventricular performance in conscious dogs before and after pacing-induced heart failure. J Pharmacol Exp Ther. 1999 Nov; 291(2):589-95. PMID: 10525076.
      View in: PubMed
    69. Onishi K, Ohno M, Little WC, Cheng CP. Endogenous endothelin-1 depresses left ventricular systolic and diastolic performance in congestive heart failure. J Pharmacol Exp Ther. 1999 Mar; 288(3):1214-22. PMID: 10027861.
      View in: PubMed
    70. Suzuki M, Ohte N, Wang ZM, Williams DL, Little WC, Cheng CP. Altered inotropic response of endothelin-1 in cardiomyocytes from rats with isoproterenol-induced cardiomyopathy. Cardiovasc Res. 1998 Sep; 39(3):589-99. PMID: 9861301.
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    71. Little WC, Cheng CP. Diastolic Dysfunction. Cardiol Rev. 1998 Jul; 6(4):231-239. PMID: 10348945.
      View in: PubMed
    72. Cheng CP, Onishi K, Ohte N, Suzuki M, Little WC. Functional effects of endogenous bradykinin in congestive heart failure. J Am Coll Cardiol. 1998 Jun; 31(7):1679-86. PMID: 9626851.
      View in: PubMed
    73. Little WC, Warner JG, Rankin KM, Kitzman DW, Cheng CP. Evaluation of left ventricular diastolic function from the pattern of left ventricular filling. Clin Cardiol. 1998 Jan; 21(1):5-9. PMID: 9474459.
      View in: PubMed
    74. Suzuki M, Cheng CP, Ohte N, Little WC. Left ventricular spherical dilation and regional contractile dysfunction in dogs with heart failure. Am J Physiol. 1997 Sep; 273(3 Pt 2):H1058-67. PMID: 9321789.
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    75. Ohte N, Cheng CP, Suzuki M, Little WC. The cardiac effects of pimobendan (but not amrinone) are preserved at rest and during exercise in conscious dogs with pacing-induced heart failure. J Pharmacol Exp Ther. 1997 Jul; 282(1):23-31. PMID: 9223536.
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    76. Cheng CP, Suzuki M, Ohte N, Ohno M, Wang ZM, Little WC. Altered ventricular and myocyte response to angiotensin II in pacing-induced heart failure. Circ Res. 1996 May; 78(5):880-92. PMID: 8620609.
      View in: PubMed
    77. Little WC, Cheng CP, Elvelin L, Nordlander M. Vascular selective calcium entry blockers in the treatment of cardiovascular disorders: focus on felodipine. Cardiovasc Drugs Ther. 1995 Oct; 9(5):657-63. PMID: 8573548.
      View in: PubMed
    78. Little WC, Ohno M, Kitzman DW, Thomas JD, Cheng CP. Determination of left ventricular chamber stiffness from the time for deceleration of early left ventricular filling. Circulation. 1995 Oct 01; 92(7):1933-9. PMID: 7671378.
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    79. Cheng CP, Pettersson K, Little WC. Effects of felodipine on left ventricular systolic and diastolic performance in congestive heart failure. J Pharmacol Exp Ther. 1994 Dec; 271(3):1409-17. PMID: 7996453.
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    80. Nozawa T, Cheng CP, Noda T, Little WC. Effect of exercise on left ventricular mechanical efficiency in conscious dogs. Circulation. 1994 Dec; 90(6):3047-54. PMID: 7994853.
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    81. Ohno M, Cheng CP, Little WC. Mechanism of altered patterns of left ventricular filling during the development of congestive heart failure. Circulation. 1994 May; 89(5):2241-50. PMID: 8181149.
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    82. Cheng CP, Noda T, Nordlander M, Ohno M, Little WC. Comparison of effects of dihydropyridine calcium antagonists on left ventricular systolic and diastolic performance. J Pharmacol Exp Ther. 1994 Mar; 268(3):1232-41. PMID: 8138936.
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    83. Little WC, Cheng CP. Coupling of the left ventricular and arterial system. Med Biol Eng Comput. 1994 Mar; 32(2):205-9. PMID: 8022218.
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    84. Nozawa T, Cheng CP, Noda T, Little WC. Relation between left ventricular oxygen consumption and pressure-volume area in conscious dogs. Circulation. 1994 Feb; 89(2):810-7. PMID: 8313570.
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    85. Little WC, Cheng CP. Vascular versus myocardial effects of calcium antagonists. Drugs. 1994; 47 Suppl 4:41-5; discussion 45-6. PMID: 7523061.
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    86. Noda T, Cheng CP, De Tombe PP, Little WC. Curvilinearity of LV end-systolic pressure-volume and dP/dtmax-end-diastolic volume relations. Am J Physiol. 1993 Sep; 265(3 Pt 2):H910-7. PMID: 8214126.
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    87. Nakamoto T, Cheng CP, Santamore WP, Iizuka M. Estimation of left ventricular elastance without altering preload or afterload in the conscious dog. Cardiovasc Res. 1993 May; 27(5):868-73. PMID: 8348586.
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    88. Little WC, Cheng CP. Effect of exercise on left ventricular-arterial coupling assessed in the pressure-volume plane. Am J Physiol. 1993 May; 264(5 Pt 2):H1629-33. PMID: 8098914.
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    89. Cheng CP, Noda T, Nozawa T, Little WC. Effect of heart failure on the mechanism of exercise-induced augmentation of mitral valve flow. Circ Res. 1993 Apr; 72(4):795-806. PMID: 8095187.
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    90. Cheng CP, Igarashi Y, Klopfenstein HS, Applegate RJ, Shihabi Z, Little WC. Effect of vasopressin on left ventricular performance. Am J Physiol. 1993 Jan; 264(1 Pt 2):H53-60. PMID: 8430861.
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    91. Cheng CP, Igarashi Y, Little WC. Mechanism of augmented rate of left ventricular filling during exercise. Circ Res. 1992 Jan; 70(1):9-19. PMID: 1345778.
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    92. Little WC, Cheng CP. Left ventricular-arterial coupling in conscious dogs. Am J Physiol. 1991 Jul; 261(1 Pt 2):H70-6. PMID: 1858932.
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    93. Igarashi Y, Cheng CP, Little WC. Left ventricular ejection activation in the in situ heart. Am J Physiol. 1991 May; 260(5 Pt 2):H1495-500. PMID: 2035671.
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    94. Cheng CP, Freeman GL, Santamore WP, Constantinescu MS, Little WC. Effect of loading conditions, contractile state, and heart rate on early diastolic left ventricular filling in conscious dogs. Circ Res. 1990 Mar; 66(3):814-23. PMID: 1689618.
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    95. Applegate RJ, Cheng CP, Little WC. Simultaneous conductance catheter and dimension assessment of left ventricle volume in the intact animal. Circulation. 1990 Feb; 81(2):638-48. PMID: 2404634.
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    96. Little WC, Cheng CP, Mumma M, Igarashi Y, Vinten-Johansen J, Johnston WE. Comparison of measures of left ventricular contractile performance derived from pressure-volume loops in conscious dogs. Circulation. 1989 Nov; 80(5):1378-87. PMID: 2805273.
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    97. Little WC, Cheng CP, Peterson T, Vinten-Johansen J. Response of the left ventricular end-systolic pressure-volume relation in conscious dogs to a wide range of contractile states. Circulation. 1988 Sep; 78(3):736-45. PMID: 3409508.
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