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Bharathi Upadhya MD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Cardiovascular Medicine
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Upadhya B, Rocco MV, Pajewski NM, Morgan T, Blackshear J, Hundley WG, Oparil S, Soliman EZ, Cohen DL, Hamilton CA, Cho ME, Kostis WJ, Papademetriou V, Rodriguez CJ, Raj DS, Townsend R, Vasu S, Zamanian S, Kitzman DW. Effect of Intensive Blood Pressure Reduction on Left Ventricular Mass, Structure, Function, and Fibrosis in the SPRINT-HEART. Hypertension. 2019 Jul 01; HYPERTENSIONAHA11913073. PMID: 31256724.
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    2. Brooks JE, Soliman EZ, Upadhya B. Is Left Ventricular Hypertrophy a Valid Therapeutic Target? Curr Hypertens Rep. 2019 05 20; 21(6):47. PMID: 31111289.
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    3. Upadhya B, Stacey RB, Kitzman DW. Preventing Heart Failure by Treating Systolic Hypertension: What Does the SPRINT Add? Curr Hypertens Rep. 2019 01 18; 21(1):9. PMID: 30659372.
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    4. Warraich HJ, Kitzman DW, Whellan DJ, Duncan PW, Mentz RJ, Pastva AM, Nelson MB, Upadhya B, Reeves GR. Physical Function, Frailty, Cognition, Depression, and Quality of Life in Hospitalized Adults =60 Years With Acute Decompensated Heart Failure With Preserved Versus Reduced Ejection Fraction. Circ Heart Fail. 2018 11; 11(11):e005254. PMID: 30571197.
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    5. Upadhya B, Haykowsky MJ, Kitzman DW. Therapy for heart failure with preserved ejection fraction: current status, unique challenges, and future directions. Heart Fail Rev. 2018 09; 23(5):609-629. PMID: 29876843.
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    6. Haykowsky MJ, Nicklas BJ, Brubaker PH, Hundley WG, Brinkley TE, Upadhya B, Becton JT, Nelson MD, Chen H, Kitzman DW. Regional Adipose Distribution and its Relationship to Exercise Intolerance in Older Obese Patients Who Have Heart Failure With Preserved Ejection Fraction. JACC Heart Fail. 2018 08; 6(8):640-649. PMID: 30007558.
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    7. Upadhya B, Brubaker PH, Morgan TM, Eggebeen JD, Jao GT, Stewart KP, Kitzman DW. The effect of Aliskiren on exercise capacity in older patients with heart failure and preserved ejection fraction: A randomized, placebo-controlled, double-blind trial. Am Heart J. 2018 07; 201:164-167. PMID: 29910050.
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    8. Upadhya B, Pisani B, Kitzman DW. Evolution of a Geriatric Syndrome: Pathophysiology and Treatment of Heart Failure with Preserved Ejection Fraction. J Am Geriatr Soc. 2017 Nov; 65(11):2431-2440. PMID: 29124734.
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    9. Upadhya B, Kitzman DW. Management of Heart Failure with Preserved Ejection Fraction: Current Challenges and Future Directions. Am J Cardiovasc Drugs. 2017 Aug; 17(4):283-298. PMID: 28316006.
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    10. Upadhya B, Hundley WG, Brubaker PH, Morgan TM, Stewart KP, Kitzman DW. Effect of Spironolactone on Exercise Tolerance and Arterial Function in Older Adults with Heart Failure with Preserved Ejection Fraction. J Am Geriatr Soc. 2017 Nov; 65(11):2374-2382. PMID: 28542926.
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    11. Upadhya B, Kitzman DW. Heart Failure with Preserved Ejection Fraction in Older Adults. Heart Fail Clin. 2017 Jul; 13(3):485-502. PMID: 28602367.
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    12. Upadhya B, Rocco M, Lewis CE, Oparil S, Lovato LC, Cushman WC, Bates JT, Bello NA, Aurigemma G, Fine LJ, Johnson KC, Rodriguez CJ, Raj DS, Rastogi A, Tamariz L, Wiggers A, Kitzman DW. Effect of Intensive Blood Pressure Treatment on Heart Failure Events in the Systolic Blood Pressure Reduction Intervention Trial. Circ Heart Fail. 2017 Apr; 10(4). PMID: 28364091.
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    13. Kitzman DW, Upadhya B, Zhao D. New Concepts in an Old Disease: Exercise Intolerance in Moderate Mitral Stenosis. JACC Cardiovasc Imaging. 2017 06; 10(6):634-636. PMID: 27865721.
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    14. Brandon Stacey R, Meng M, Byrum Iii GV, Gilbert ON, Upadhya B, Rodriguez C, Zhao D, Pu M. Clinical Outcomes in Different Types of Aortic Stenosis as Assessed by Doppler Echocardiography. J Heart Valve Dis. 2016 11; 25(6):672-678. PMID: 28290165.
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    15. Stacey RB, Milks MW, Deutsch C, Upadhya B, Hundley WG, Thohan V. Clinical significance of intermediate left ventricular trabeculations in cardiac magnetic resonance. Acta Cardiol. 2015 Oct; 70(5):588-93. PMID: 26567819.
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    16. Ohara T, Iwano H, Thohan V, Kitzman DW, Upadhya B, Pu M, Little WC. Role of Diastolic Function in Preserved Exercise Capacity in Patients with Reduced Ejection Fractions. J Am Soc Echocardiogr. 2015 Oct; 28(10):1184-93. PMID: 26232892.
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    17. Upadhya B, Haykowsky MJ, Eggebeen J, Kitzman DW. Sarcopenic obesity and the pathogenesis of exercise intolerance in heart failure with preserved ejection fraction. Curr Heart Fail Rep. 2015 Jun; 12(3):205-14. PMID: 25750186.
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    18. Upadhya B, Haykowsky MJ, Eggebeen J, Kitzman DW. Exercise intolerance in heart failure with preserved ejection fraction: more than a heart problem. J Geriatr Cardiol. 2015 May; 12(3):294-304. PMID: 26089855.
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    19. Upadhya B, Taffet GE, Cheng CP, Kitzman DW. Heart failure with preserved ejection fraction in the elderly: scope of the problem. J Mol Cell Cardiol. 2015 Jun; 83:73-87. PMID: 25754674.
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    20. Milks MW, Upadhya B, Hall ME, Vasu S, Hundley WG, Stacey RB. Right ventricular stress-induced perfusion defects and late gadolinium enhancement in coronary artery disease. J Comput Assist Tomogr. 2015 Mar-Apr; 39(2):185-8. PMID: 25423554.
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    21. Kitzman DW, Upadhya B, Vasu S. What the dead can teach the living: systemic nature of heart failure with preserved ejection fraction. Circulation. 2015 Feb 10; 131(6):522-4. PMID: 25552355.
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    22. Lin T, Milks MW, Upadhya B, Hundley WG, Stacey RB. Improvement in systolic function in left ventricular non-compaction cardiomyopathy: A case report. J Cardiol Cases. 2014 Dec; 10(6):231-234. PMID: 30534250.
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    23. Stacey RB, Haag J, Hall ME, McLeod G, Upadhya B, Hundley WG, Thohan V. Mitral regurgitation in left ventricular noncompaction cardiomyopathy assessed by cardiac MRI. J Heart Valve Dis. 2014 Sep; 23(5):591-7. PMID: 25799708.
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    24. Gomadam PS, Stacey RB, Johnsen AE, Kitzman DW, Kon ND, Upadhya B. Papillary fibroelastoma of the mitral valve chordae with systemic embolization. J Cardiol Cases. 2014 Oct; 10(4):125-128. PMID: 30534222.
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    25. Iwano H, Pu M, Upadhya B, Meyers B, Vlachos P, Little WC. Delay of left ventricular longitudinal expansion with diastolic dysfunction: impact on load dependence of e' and longitudinal strain rate. Physiol Rep. 2014 Jul 01; 2(7). PMID: 25035279.
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    26. Upadhya B, Stacey RB, Ntim W, Knovich MA, Pu M. Echocardiography-derived tricuspid regurgitant jet velocity is an important marker for the progression of sickle-cell disease. Acta Haematol. 2014; 132(2):152-8. PMID: 24577318.
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    27. Stacey RB, Andersen M, Haag J, Hall ME, McLeod G, Upadhya B, Hundley WG, Thohan V. Right ventricular morphology and systolic function in left ventricular noncompaction cardiomyopathy. Am J Cardiol. 2014 Mar 15; 113(6):1018-23. PMID: 24462071.
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    28. Kitzman DW, Upadhya B. Heart failure with preserved ejection fraction: a heterogenous disorder with multifactorial pathophysiology. J Am Coll Cardiol. 2014 Feb 11; 63(5):457-9. PMID: 24184240.
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    29. Upadhya B, Ntim W, Brandon Stacey R, Henderson R, Leedy D, O'Brien FX, Knovich MA. Prolongation of QTc intervals and risk of death among patients with sickle cell disease. Eur J Haematol. 2013 Aug; 91(2):170-8. PMID: 23621844.
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    30. Wahla AS, Ruiz J, Noureddine N, Upadhya B, Sane DC, Owen J. Myocardial infarction in thrombotic thrombocytopenic purpura: a single-center experience and literature review. Eur J Haematol. 2008 Oct; 81(4):311-6. PMID: 18616514.
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    31. Ntim WO, Upadhya B, Cruz J. Diastolic dysfunction is an independent risk factor for death in patients with sickle cell disease. J Am Coll Cardiol. 2007 Jul 24; 50(4):378; author reply 378-9. PMID: 17659206.
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    32. Deliargyris EN, Upadhya B, Melton LG, Thompson C, Fisher M, Gabriel DA, Dehmer GJ, Sane DC. Unfractionated heparin reduces the anti-platelet effects of abciximab but not eptifibatide during PCI. Clin Appl Thromb Hemost. 2006 Oct; 12(4):458-64. PMID: 17000891.
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    33. Applegate RJ, Upadhya B, Little WC, Xenakis M, Gandhi SK, Baki TT, Kahl FR, Kutcher MA. Late outcomes after intervention of vein grafts in diabetics with abciximab use. Int J Cardiol. 2006 Jul 28; 111(1):136-41. PMID: 16226815.
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    34. Upadhya B, Applegate RJ, Sane DC, Deliargyris EN, Kutcher MA, Gandhi SK, Baki TT, Call JT, Little WC. Preprocedural white blood cell count and major adverse cardiac events late after percutaneous coronary intervention in saphenous vein grafts. Am J Cardiol. 2005 Aug 15; 96(4):515-8. PMID: 16098303.
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    35. Deliargyris EN, Upadhya B, Applegate RJ, Kontos JL, Kutcher MA, Riesmeyer JS, Sane DC. Safety of abciximab administration during PCI of patients with previous stroke. J Thromb Thrombolysis. 2005 Jun; 19(3):147-53. PMID: 16082601.
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    36. Upadhya B, Sane DC, Applegate RJ, Kutcher MA, Gandhi SK, Deliargyris EN. Differences in baseline characteristics and in-hospital outcomes in patients with or without prior stroke undergoing percutaneous coronary intervention. J Invasive Cardiol. 2005 May; 17(5):243-7. PMID: 15879602.
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    37. Deliargyris EN, Upadhya B, Sane DC, Dehmer GJ, Pye J, Smith SC, Boucher WS, Theoharides TC. Mast cell tryptase: a new biomarker in patients with stable coronary artery disease. Atherosclerosis. 2005 Feb; 178(2):381-6. PMID: 15694948.
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    38. Deliargyris EN, Upadhya B, Applegate RJ, Kutcher MA, Gandhi SK, Sane DC. Superior in-hospital and 30-day outcomes with abciximab versus eptifibatide: a contemporary analysis of 495 consecutive percutaneous coronary interventions. J Invasive Cardiol. 2004 Nov; 16(11):611-6. PMID: 15550727.
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    39. Brucks S, Little WC, Chao T, Rideman RL, Upadhya B, Wesley-Farrington D, Sane DC. Relation of anemia to diastolic heart failure and the effect on outcome. Am J Cardiol. 2004 Apr 15; 93(8):1055-7. PMID: 15081458.
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    40. Upadhya B, Kontos JL, Ardeshirpour F, Pye J, Boucher WS, Theoharides TC, Dehmer GJ, Deliargyris EN. Relation of serum levels of mast cell tryptase of left ventricular systolic function, left ventricular volume or congestive heart failure. J Card Fail. 2004 Feb; 10(1):31-5. PMID: 14966772.
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