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Bruce A. Lessey MD, PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Gastroenterology
Address
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    R29HD029448     (LESSEY, BRUCE A.)Jul 1, 1992 - Jun 30, 1998
    NIH
    ENDOMETRIAL INTEGRINS: A ROLE IN UTERINE RECEPTIVITY
    Role: Principal Investigator
    R01HD030476     (LESSEY, BRUCE A.)Sep 30, 1992 - Aug 31, 1997
    NIH
    ENDOMETRIOSIS, INTEGRINS AND INFERTILITY
    Role: Principal Investigator
    U01HD034824     (LESSEY, BRUCE A.)Dec 1, 1996 - Nov 30, 2001
    NIH
    ENDOMETRIAL INTEGRINS AS MARKERS OF UTERINE RECEPTIVITY
    Role: Principal Investigator
    U54HD035041     (FRENCH, FRANK S)Apr 7, 1997 - Mar 31, 2014
    NIH
    Molecular regulation in reproduction
    Role: Co-Principal Investigator
    R01HD102170     (JEONG, JAE-WOOK)Apr 15, 2021 - Jan 31, 2026
    NIH
    Epigenetic regulation of receptive endometrium
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lessey BA. Extracellular vesicles: a new understanding of endometrial receptivity? Fertil Steril. 2020 08; 114(2):287. PMID: 32622658.
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    2. Song Y, Joshi NR, Vegter E, Hrbek S, Lessey BA, Fazleabas AT. Establishment of an Immortalized Endometriotic Stromal Cell Line from Human Ovarian Endometrioma. Reprod Sci. 2020 11; 27(11):2082-2091. PMID: 32542539.
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    3. Overholt TL, Evans RJ, Lessey BA, Matthews CA, Hines KN, Badlani G, Walker SJ. Non-bladder centric interstitial cystitis/bladder pain syndrome phenotype is significantly associated with co-occurring endometriosis. Can J Urol. 2020 06; 27(3):10257-10262. PMID: 32544050.
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    4. Song Y, Su RW, Joshi NR, Kim TH, Lessey BA, Jeong JW, Fazleabas AT. Interleukin-6 (IL-6) Activates the NOTCH1 Signaling Pathway Through E-Proteins in Endometriotic Lesions. J Clin Endocrinol Metab. 2020 05 01; 105(5). PMID: 32119078.
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    5. Hisrich BV, Young RB, Sansone AM, Bowens Z, Green LJ, Lessey BA, Blenda AV. Role of Human Galectins in Inflammation and Cancers Associated with Endometriosis. Biomolecules. 2020 02 04; 10(2). PMID: 32033052.
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    6. Teasley HE, Beesley A, Kim TH, Risinger J, Young SL, Jeong JW, Schammel DP, Lessey BA, Elder JW, Puls L. Differential Expression of KRAS and SIRT1 in Ovarian Cancers with and Without Endometriosis. Reprod Sci. 2020 01; 27(1):145-151. PMID: 32046380.
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    7. Symons LK, Miller JE, Tyryshkin K, Monsanto SP, Marks RM, Lingegowda H, Vanderbeck K, Childs T, Young SL, Lessey BA, Koti M, Tayade C. Neutrophil recruitment and function in endometriosis patients and a syngeneic murine model. FASEB J. 2020 01; 34(1):1558-1575. PMID: 31914688.
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    8. Khalaj K, Miller JE, Lingegowda H, Fazleabas AT, Young SL, Lessey BA, Koti M, Tayade C. Extracellular vesicles from endometriosis patients are characterized by a unique miRNA-lncRNA signature. JCI Insight. 2019 09 19; 4(18). PMID: 31534048.
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    9. Lessey BA, Young SL. What exactly is endometrial receptivity? Fertil Steril. 2019 04; 111(4):611-617. PMID: 30929718.
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    10. Kim TH, Yoo JY, Choi KC, Shin JH, Leach RE, Fazleabas AT, Young SL, Lessey BA, Yoon HG, Jeong JW. Loss of HDAC3 results in nonreceptive endometrium and female infertility. Sci Transl Med. 2019 01 09; 11(474). PMID: 30626716.
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    11. Likes CE, Cooper LJ, Efird J, Forstein DA, Miller PB, Savaris R, Lessey BA. Medical or surgical treatment before embryo transfer improves outcomes in women with abnormal endometrial BCL6 expression. J Assist Reprod Genet. 2019 Mar; 36(3):483-490. PMID: 30610661.
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    12. Lessey BA, Gordts S, Donnez O, Somigliana E, Chapron C, Garcia-Velasco JA, Donnez J. Ovarian endometriosis and infertility: in vitro fertilization (IVF) or surgery as the first approach? Fertil Steril. 2018 12; 110(7):1218-1226. PMID: 30503109.
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    13. Vasquez YM, Wang X, Wetendorf M, Franco HL, Mo Q, Wang T, Lanz RB, Young SL, Lessey BA, Spencer TE, Lydon JP, DeMayo FJ. FOXO1 regulates uterine epithelial integrity and progesterone receptor expression critical for embryo implantation. PLoS Genet. 2018 11; 14(11):e1007787. PMID: 30452456.
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    14. Wang X, Li X, Wang T, Wu SP, Jeong JW, Kim TH, Young SL, Lessey BA, Lanz RB, Lydon JP, DeMayo FJ. SOX17 regulates uterine epithelial-stromal cross-talk acting via a distal enhancer upstream of Ihh. Nat Commun. 2018 10 24; 9(1):4421. PMID: 30356064.
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    15. Colón-Caraballo M, Torres-Reverón A, Soto-Vargas JL, Young SL, Lessey B, Mendoza A, Urrutia R, Flores I. Effects of histone methyltransferase inhibition in endometriosis. Biol Reprod. 2018 08 01; 99(2):293-307. PMID: 29408993.
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    16. Surrey E, Taylor HS, Giudice L, Lessey BA, Abrao MS, Archer DF, Diamond MP, Johnson NP, Watts NB, Gallagher JC, Simon JA, Carr BR, Dmowski WP, Leyland N, Singh SS, Rechberger T, Agarwal SK, Duan WR, Schwefel B, Thomas JW, Peloso PM, Ng J, Soliman AM, Chwalisz K. Long-Term Outcomes of Elagolix in Women With Endometriosis: Results From Two Extension Studies. Obstet Gynecol. 2018 07; 132(1):147-160. PMID: 29889764.
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    17. Matson BC, Quinn KE, Lessey BA, Young SL, Caron KM. Elevated levels of adrenomedullin in eutopic endometrium and plasma from women with endometriosis. Fertil Steril. 2018 06; 109(6):1072-1078. PMID: 29871794.
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    18. Hill AM, Lessey B, Flores VA, Taylor HS. Bazedoxifene/conjugated estrogens in combination with leuprolide for the treatment of endometriosis. Clin Case Rep. 2018 Jun; 6(6):990-994. PMID: 29881549.
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    19. Zhang T, Zhou J, Man GCW, Leung KT, Liang B, Xiao B, Ma X, Huang S, Huang H, Hegde VL, Zhong Y, Li Y, Kong GWS, Yiu AKW, Kwong J, Ng PC, Lessey BA, Nagarkatti PS, Nagarkatti M, Wang CC. MDSCs drive the process of endometriosis by enhancing angiogenesis and are a new potential therapeutic target. Eur J Immunol. 2018 06; 48(6):1059-1073. PMID: 29460338.
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    20. Snyder BM, Beets JW, Lessey BA, Horton SRW, Abrams GA. Postmenopausal Deep Infiltrating Endometriosis of the Colon: Rare Location and Novel Medical Therapy. Case Rep Gastrointest Med. 2018; 2018:9587536. PMID: 29666722.
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    21. Strug MR, Su RW, Kim TH, Mauriello A, Ticconi C, Lessey BA, Young SL, Lim JM, Jeong JW, Fazleabas AT. RBPJ mediates uterine repair in the mouse and is reduced in women with recurrent pregnancy loss. FASEB J. 2018 05; 32(5):2452-2466. PMID: 29242273.
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    22. Miller JE, Monsanto SP, Ahn SH, Khalaj K, Fazleabas AT, Young SL, Lessey BA, Koti M, Tayade C. Interleukin-33 modulates inflammation in endometriosis. Sci Rep. 2017 12 20; 7(1):17903. PMID: 29263351.
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    23. Lessey BA. Detection of the smaller window of maximal receptivity: timing isn't everything. Fertil Steril. 2018 01; 109(1):73-74. PMID: 29246555.
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    24. Almquist LD, Likes CE, Stone B, Brown KR, Savaris R, Forstein DA, Miller PB, Lessey BA. Endometrial BCL6 testing for the prediction of in vitro fertilization outcomes: a cohort study. Fertil Steril. 2017 12; 108(6):1063-1069. PMID: 29126613.
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    25. Palomino WA, Tayade C, Argandoña F, Devoto L, Young SL, Lessey BA. The endometria of women with endometriosis exhibit dysfunctional expression of complement regulatory proteins during the mid secretory phase. J Reprod Immunol. 2018 02; 125:1-7. PMID: 29153978.
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    26. Young SL, Savaris RF, Lessey BA, Sharkey AM, Balthazar U, Zaino RJ, Sherwin RA, Fritz MA. Effect of randomized serum progesterone concentration on secretory endometrial histologic development and gene expression. Hum Reprod. 2017 09 01; 32(9):1903-1914. PMID: 28854727.
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    27. Yoo JY, Kim TH, Fazleabas AT, Palomino WA, Ahn SH, Tayade C, Schammel DP, Young SL, Jeong JW, Lessey BA. KRAS Activation and over-expression of SIRT1/BCL6 Contributes to the Pathogenesis of Endometriosis and Progesterone Resistance. Sci Rep. 2017 07 28; 7(1):6765. PMID: 28754906.
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    28. Khalaj K, Ahn SH, Bidarimath M, Nasirzadeh Y, Singh SS, Fazleabas AT, Young SL, Lessey BA, Koti M, Tayade C. A balancing act: RNA binding protein HuR/TTP axis in endometriosis patients. Sci Rep. 2017 07 19; 7(1):5883. PMID: 28724967.
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    29. Chang HJ, Yoo JY, Kim TH, Fazleabas AT, Young SL, Lessey BA, Jeong JW. Overexpression of Four Joint Box-1 Protein (FJX1) in Eutopic Endometrium From Women With Endometriosis. Reprod Sci. 2018 02; 25(2):207-213. PMID: 28673206.
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    30. Lessey BA, Kim JJ. Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why. Fertil Steril. 2017 07; 108(1):19-27. PMID: 28602477.
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    31. Taylor HS, Giudice LC, Lessey BA, Abrao MS, Kotarski J, Archer DF, Diamond MP, Surrey E, Johnson NP, Watts NB, Gallagher JC, Simon JA, Carr BR, Dmowski WP, Leyland N, Rowan JP, Duan WR, Ng J, Schwefel B, Thomas JW, Jain RI, Chwalisz K. Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist. N Engl J Med. 2017 07 06; 377(1):28-40. PMID: 28525302.
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    32. Mendes da Silva D, Gross LA, Neto EPG, Lessey BA, Savaris RF. The Use of Resveratrol as an Adjuvant Treatment of Pain in Endometriosis: A Randomized Clinical Trial. J Endocr Soc. 2017 Apr 01; 1(4):359-369. PMID: 29264492.
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    33. Joshi NR, Miyadahira EH, Afshar Y, Jeong JW, Young SL, Lessey BA, Serafini PC, Fazleabas AT. Progesterone Resistance in Endometriosis Is Modulated by the Altered Expression of MicroRNA-29c and FKBP4. J Clin Endocrinol Metab. 2017 01 01; 102(1):141-149. PMID: 27778641.
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    34. Fox C, Azores-Gococo D, Swart L, Holoch K, Savaris RF, Likes CE, Miller PB, Forstein DA, Lessey BA. Luteal phase HCG support for unexplained recurrent pregnancy loss - a low hanging fruit? Reprod Biomed Online. 2017 Mar; 34(3):319-324. PMID: 28041830.
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    35. Ahn SH, Khalaj K, Young SL, Lessey BA, Koti M, Tayade C. Immune-inflammation gene signatures in endometriosis patients. Fertil Steril. 2016 Nov; 106(6):1420-1431.e7. PMID: 27475412.
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    36. Yoo JY, Jeong JW, Fazleabas AT, Tayade C, Young SL, Lessey BA. Protein Inhibitor of Activated STAT3 (PIAS3) Is Down-Regulated in Eutopic Endometrium of Women with Endometriosis. Biol Reprod. 2016 07; 95(1):11. PMID: 27226311.
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    37. Evans-Hoeker E, Lessey BA, Jeong JW, Savaris RF, Palomino WA, Yuan L, Schammel DP, Young SL. Endometrial BCL6 Overexpression in Eutopic Endometrium of Women With Endometriosis. Reprod Sci. 2016 09; 23(9):1234-41. PMID: 27222232.
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    38. Strug MR, Su R, Young JE, Dodds WG, Shavell VI, Díaz-Gimeno P, Ruíz-Alonso M, Simón C, Lessey BA, Leach RE, Fazleabas AT. Intrauterine human chorionic gonadotropin infusion in oocyte donors promotes endometrial synchrony and induction of early decidual markers for stromal survival: a randomized clinical trial. Hum Reprod. 2016 07; 31(7):1552-61. PMID: 27122490.
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    39. Fox C, Morin S, Jeong JW, Scott RT, Lessey BA. Local and systemic factors and implantation: what is the evidence? Fertil Steril. 2016 Apr; 105(4):873-84. PMID: 26945096.
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    40. Monsanto SP, Edwards AK, Zhou J, Nagarkatti P, Nagarkatti M, Young SL, Lessey BA, Tayade C. Surgical removal of endometriotic lesions alters local and systemic proinflammatory cytokines in endometriosis patients. Fertil Steril. 2016 Apr; 105(4):968-977.e5. PMID: 26698677.
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    41. Chapela PJ, Broaddus RR, Hawkins SM, Lessey BA, Carson DD. Cytokine stimulation of MUC4 expression in human female reproductive tissue carcinoma cell lines and endometrial cancer. J Cell Biochem. 2015 Nov; 116(11):2649-57. PMID: 25923310.
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    42. Kim TH, Yoo JY, Wang Z, Lydon JP, Khatri S, Hawkins SM, Leach RE, Fazleabas AT, Young SL, Lessey BA, Ku BJ, Jeong JW. ARID1A Is Essential for Endometrial Function during Early Pregnancy. PLoS Genet. 2015 Sep; 11(9):e1005537. PMID: 26378916.
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    43. Ahn SH, Edwards AK, Singh SS, Young SL, Lessey BA, Tayade C. IL-17A Contributes to the Pathogenesis of Endometriosis by Triggering Proinflammatory Cytokines and Angiogenic Growth Factors. J Immunol. 2015 Sep 15; 195(6):2591-600. PMID: 26259585.
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    44. Kim BG, Yoo JY, Kim TH, Shin JH, Langenheim JF, Ferguson SD, Fazleabas AT, Young SL, Lessey BA, Jeong JW. Aberrant activation of signal transducer and activator of transcription-3 (STAT3) signaling in endometriosis. Hum Reprod. 2015 May; 30(5):1069-78. PMID: 25750101.
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    45. Hood BL, Liu B, Alkhas A, Shoji Y, Challa R, Wang G, Ferguson S, Oliver J, Mitchell D, Bateman NW, Zahn CM, Hamilton CA, Payson M, Lessey B, Fazleabas AT, Maxwell GL, Conrads TP, Risinger JI. Proteomics of the human endometrial glandular epithelium and stroma from the proliferative and secretory phases of the menstrual cycle. Biol Reprod. 2015 Apr; 92(4):106. PMID: 25695723.
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    46. Su RW, Strug MR, Joshi NR, Jeong JW, Miele L, Lessey BA, Young SL, Fazleabas AT. Decreased Notch pathway signaling in the endometrium of women with endometriosis impairs decidualization. J Clin Endocrinol Metab. 2015 Mar; 100(3):E433-42. PMID: 25546156.
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    47. Szwarc MM, Kommagani R, Lessey BA, Lydon JP. The p160/steroid receptor coactivator family: potent arbiters of uterine physiology and dysfunction. Biol Reprod. 2014 Nov; 91(5):122. PMID: 25297546.
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    48. Franasiak JM, Burns KA, Slayden O, Yuan L, Fritz MA, Korach KS, Lessey BA, Young SL. Endometrial CXCL13 expression is cycle regulated in humans and aberrantly expressed in humans and Rhesus macaques with endometriosis. Reprod Sci. 2015 Apr; 22(4):442-51. PMID: 25031316.
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    49. Lessey BA, Young SL. Homeostasis imbalance in the endometrium of women with implantation defects: the role of estrogen and progesterone. Semin Reprod Med. 2014 Sep; 32(5):365-75. PMID: 24959818.
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    50. Yoo JY, Shin H, Kim TH, Choi WS, Ferguson SD, Fazleabas AT, Young SL, Lessey BA, Ha UH, Jeong JW. CRISPLD2 is a target of progesterone receptor and its expression is decreased in women with endometriosis. PLoS One. 2014; 9(6):e100481. PMID: 24955763.
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    51. Germeyer A, Savaris RF, Jauckus J, Lessey B. Endometrial beta3 integrin profile reflects endometrial receptivity defects in women with unexplained recurrent pregnancy loss. Reprod Biol Endocrinol. 2014 Jun 20; 12:53. PMID: 24950982.
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    52. Giuliani E, Parkin KL, Lessey BA, Young SL, Fazleabas AT. Characterization of uterine NK cells in women with infertility or recurrent pregnancy loss and associated endometriosis. Am J Reprod Immunol. 2014 Sep; 72(3):262-9. PMID: 24807109.
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    53. Franasiak JM, Holoch KJ, Yuan L, Schammel DP, Young SL, Lessey BA. Prospective assessment of midsecretory endometrial leukemia inhibitor factor expression versus a?ß3 testing in women with unexplained infertility. Fertil Steril. 2014 Jun; 101(6):1724-31. PMID: 24690239.
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    54. Li X, Large MJ, Creighton CJ, Lanz RB, Jeong JW, Young SL, Lessey BA, Palomino WA, Tsai SY, Demayo FJ. COUP-TFII regulates human endometrial stromal genes involved in inflammation. Mol Endocrinol. 2013 Dec; 27(12):2041-54. PMID: 24176914.
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    55. Oh SJ, Shin JH, Kim TH, Lee HS, Yoo JY, Ahn JY, Broaddus RR, Taketo MM, Lydon JP, Leach RE, Lessey BA, Fazleabas AT, Lim JM, Jeong JW. ß-Catenin activation contributes to the pathogenesis of adenomyosis through epithelial-mesenchymal transition. J Pathol. 2013 Oct; 231(2):210-22. PMID: 23784889.
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    56. Altmäe S, Esteban FJ, Stavreus-Evers A, Simón C, Giudice L, Lessey BA, Horcajadas JA, Macklon NS, D'Hooghe T, Campoy C, Fauser BC, Salamonsen LA, Salumets A. Guidelines for the design, analysis and interpretation of 'omics' data: focus on human endometrium. Hum Reprod Update. 2014 Jan-Feb; 20(1):12-28. PMID: 24082038.
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    57. Lessey BA. Endometrial assessment: a clinical guide. Womens Health (Lond). 2013 Sep; 9(5):415-7. PMID: 24007244.
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    58. Fuhrich DG, Lessey BA, Savaris RF. Comparison of HSCORE assessment of endometrial beta3 integrin subunit expression with digital HSCORE using computerized image analysis (ImageJ). Anal Quant Cytopathol Histpathol. 2013 Aug; 35(4):210-6. PMID: 24341124.
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    59. Lessey BA, Lebovic DI, Taylor RN. Eutopic endometrium in women with endometriosis: ground zero for the study of implantation defects. Semin Reprod Med. 2013 Mar; 31(2):109-24. PMID: 23446858.
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    60. Lessey BA, Higdon HL, Miller SE, Price TA. Intraoperative detection of subtle endometriosis: a novel paradigm for detection and treatment of pelvic pain associated with the loss of peritoneal integrity. J Vis Exp. 2012 Dec 21; (70). PMID: 23288271.
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    61. Lessey BA. The pathologists are free to go, or are they? Fertil Steril. 2013 Feb; 99(2):350-1. PMID: 23246452.
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    62. Korch C, Spillman MA, Jackson TA, Jacobsen BM, Murphy SK, Lessey BA, Jordan VC, Bradford AP. DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination. Gynecol Oncol. 2012 Oct; 127(1):241-8. PMID: 22710073.
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    63. Plante BJ, Lessey BA, Taylor RN, Wang W, Bagchi MK, Yuan L, Scotchie J, Fritz MA, Young SL. G protein-coupled estrogen receptor (GPER) expression in normal and abnormal endometrium. Reprod Sci. 2012 Jul; 19(7):684-93. PMID: 22378861.
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    64. Miller PB, Parnell BA, Bushnell G, Tallman N, Forstein DA, Higdon HL, Kitawaki J, Lessey BA. Endometrial receptivity defects during IVF cycles with and without letrozole. Hum Reprod. 2012 Mar; 27(3):881-8. PMID: 22246449.
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    65. Patel BG, Lessey BA. Clinical assessment and management of the endometrium in recurrent early pregnancy loss. Semin Reprod Med. 2011 Nov; 29(6):491-506. PMID: 22161462.
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    66. Lessey BA. Assessment of endometrial receptivity. Fertil Steril. 2011 Sep; 96(3):522-9. PMID: 21880273.
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    67. de Paula Guedes Neto E, Savaris RF, von Eye Corleta H, de Moraes GS, do Amaral Cristovam R, Lessey BA. Prospective, randomized comparison between raloxifene and clomiphene citrate for ovulation induction in polycystic ovary syndrome. Fertil Steril. 2011 Sep; 96(3):769-73. PMID: 21782166.
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    68. Savaris RF, Groll JM, Young SL, DeMayo FJ, Jeong JW, Hamilton AE, Giudice LC, Lessey BA. Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles. J Clin Endocrinol Metab. 2011 Jun; 96(6):1737-46. PMID: 21411543.
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    69. Holoch KJ, Lessey BA. Endometriosis and infertility. Clin Obstet Gynecol. 2010 Jun; 53(2):429-38. PMID: 20436320.
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    70. Lessey BA. Fine tuning of endometrial function by estrogen and progesterone through microRNAs. Biol Reprod. 2010 Apr; 82(4):653-5. PMID: 20130265.
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    71. Young SL, Lessey BA. Progesterone function in human endometrium: clinical perspectives. Semin Reprod Med. 2010 Jan; 28(1):5-16. PMID: 20104424.
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    72. Brosens JJ, Hodgetts A, Feroze-Zaidi F, Sherwin JR, Fusi L, Salker MS, Higham J, Rose GL, Kajihara T, Young SL, Lessey BA, Henriet P, Langford PR, Fazleabas AT. Proteomic analysis of endometrium from fertile and infertile patients suggests a role for apolipoprotein A-I in embryo implantation failure and endometriosis. Mol Hum Reprod. 2010 Apr; 16(4):273-85. PMID: 20008415.
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    73. Fassbender A, D'Hooghe T, Mihalyi A, Kyama C, Simsa P, Lessey BA. Plasma C3a-des-Arg levels in women with and without endometriosis. Am J Reprod Immunol. 2009 Sep; 62(3):187-95. PMID: 19694644.
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    74. Groll JM, Usadi RS, Lessey BA, Lininger R, Young SL, Fritz MA. Effects of variations in serum estradiol concentrations on secretory endometrial development and function in experimentally induced cycles in normal women. Fertil Steril. 2009 Dec; 92(6):2058-61. PMID: 19608171.
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    75. Scotchie JG, Fritz MA, Mocanu M, Lessey BA, Young SL. Proteomic analysis of the luteal endometrial secretome. Reprod Sci. 2009 Sep; 16(9):883-93. PMID: 19494364.
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    76. Jeong JW, Lee HS, Lee KY, White LD, Broaddus RR, Zhang YW, Vande Woude GF, Giudice LC, Young SL, Lessey BA, Tsai SY, Lydon JP, DeMayo FJ. Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease. Proc Natl Acad Sci U S A. 2009 May 26; 106(21):8677-82. PMID: 19439667.
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    77. Collins NH, Lessey EC, DuSell CD, McDonnell DP, Fowler L, Palomino WA, Illera MJ, Yu X, Mo B, Houwing AM, Lessey BA. Characterization of antiestrogenic activity of the Chinese herb, prunella vulgaris, using in vitro and in vivo (Mouse Xenograft) models. Biol Reprod. 2009 Feb; 80(2):375-83. PMID: 18923163.
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    78. Usadi RS, Groll JM, Lessey BA, Lininger RA, Zaino RJ, Fritz MA, Young SL. Endometrial development and function in experimentally induced luteal phase deficiency. J Clin Endocrinol Metab. 2008 Oct; 93(10):4058-64. PMID: 18647810.
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    79. Savaris RF, Hamilton AE, Lessey BA, Giudice LC. Endometrial gene expression in early pregnancy: lessons from human ectopic pregnancy. Reprod Sci. 2008 Oct; 15(8):797-816. PMID: 18591649.
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    80. Sugihara K, Kabir-Salmani M, Byrne J, Wolf DP, Lessey B, Iwashita M, Aoki D, Nakayama J, Fukuda MN. Induction of trophinin in human endometrial surface epithelia by CGbeta and IL-1beta. FEBS Lett. 2008 Jan 23; 582(2):197-202. PMID: 18078818.
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    81. Bai S, Grossman G, Yuan L, Lessey BA, French FS, Young SL, Wilson EM. Hormone control and expression of androgen receptor coregulator MAGE-11 in human endometrium during the window of receptivity to embryo implantation. Mol Hum Reprod. 2008 Feb; 14(2):107-16. PMID: 18048459.
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    82. Donaghay M, Lessey BA. Uterine receptivity: alterations associated with benign gynecological disease. Semin Reprod Med. 2007 Nov; 25(6):461-75. PMID: 17960531.
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    83. Bohler HC, Gercel-Taylor C, Lessey BA, Taylor DD. Endometriosis markers: immunologic alterations as diagnostic indicators for endometriosis. Reprod Sci. 2007 Sep; 14(6):595-604. PMID: 17959888.
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    84. MacLaughlan SD, Palomino WA, Mo B, Lewis TD, Lininger RA, Lessey BA. Endometrial expression of Cyr61: a marker of estrogenic activity in normal and abnormal endometrium. Obstet Gynecol. 2007 Jul; 110(1):146-54. PMID: 17601910.
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    85. Burney RO, Talbi S, Hamilton AE, Vo KC, Nyegaard M, Nezhat CR, Lessey BA, Giudice LC. Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis. Endocrinology. 2007 Aug; 148(8):3814-26. PMID: 17510236.
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    86. Carson DD, Julian J, Lessey BA, Prakobphol A, Fisher SJ. MUC1 is a scaffold for selectin ligands in the human uterus. Front Biosci. 2006 Sep 01; 11:2903-8. PMID: 16720361.
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    87. Mo B, Vendrov AE, Palomino WA, DuPont BR, Apparao KB, Lessey BA. ECC-1 cells: a well-differentiated steroid-responsive endometrial cell line with characteristics of luminal epithelium. Biol Reprod. 2006 Sep; 75(3):387-94. PMID: 16707768.
      Citations:    
    88. Lessey BA, Palomino WA, Apparao KB, Young SL, Lininger RA. Estrogen receptor-alpha (ER-alpha) and defects in uterine receptivity in women. Reprod Biol Endocrinol. 2006; 4 Suppl 1:S9. PMID: 17118173.
      Citations:    
    89. Miller PB, Forstein DA, Usadi RS, Lessey BA, Higdon HL, Boone WR. Assisted reproductive technology (ART) in the upstate: reducing the risks of multiple births. J S C Med Assoc. 2005 Dec; 101(11):373-7. PMID: 16711617.
      Citations:    
    90. Igarashi TM, Bruner-Tran KL, Yeaman GR, Lessey BA, Edwards DP, Eisenberg E, Osteen KG. Reduced expression of progesterone receptor-B in the endometrium of women with endometriosis and in cocultures of endometrial cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fertil Steril. 2005 Jul; 84(1):67-74. PMID: 16009159.
      Citations:    
    91. Lessey BA, Chetkowski RJ. Detecting differences in endometrial maturation? Fertil Steril. 2005 Feb; 83(2):519; author reply 519-20. PMID: 15705412.
      Citations:    
    92. Lovely LP, Fazleabas AT, Fritz MA, McAdams DG, Lessey BA. Prevention of endometrial apoptosis: randomized prospective comparison of human chorionic gonadotropin versus progesterone treatment in the luteal phase. J Clin Endocrinol Metab. 2005 Apr; 90(4):2351-6. PMID: 15671112.
      Citations:    
    93. Haendler B, Yamanouchi H, Lessey BA, Chwalisz K, Hess-Stumpp H. Cycle-dependent endometrial expression and hormonal regulation of the fibulin-1 gene. Mol Reprod Dev. 2004 Jul; 68(3):279-87. PMID: 15112320.
      Citations:    
    94. Murray MJ, Meyer WR, Zaino RJ, Lessey BA, Novotny DB, Ireland K, Zeng D, Fritz MA. A critical analysis of the accuracy, reproducibility, and clinical utility of histologic endometrial dating in fertile women. Fertil Steril. 2004 May; 81(5):1333-43. PMID: 15136099.
      Citations:    
    95. Lessey BA. Endometrial responsiveness to steroid hormones: a moving target. J Soc Gynecol Investig. 2004 Feb; 11(2):61-2. PMID: 14980306.
      Citations:    
    96. Sagoskin AW, Lessey BA, Mottla GL, Richter KS, Chetkowski RJ, Chang AS, Levy MJ, Stillman RJ. Salpingectomy or proximal tubal occlusion of unilateral hydrosalpinx increases the potential for spontaneous pregnancy. Hum Reprod. 2003 Dec; 18(12):2634-7. PMID: 14645184.
      Citations:    
    97. Lessey BA. Two pathways of progesterone action in the human endometrium: implications for implantation and contraception. Steroids. 2003 Nov; 68(10-13):809-15. PMID: 14667972.
      Citations:    
    98. Murray MJ, Meyer WR, Lessey BA, Oi RH, DeWire RE, Fritz MA. Soy protein isolate with isoflavones does not prevent estradiol-induced endometrial hyperplasia in postmenopausal women: a pilot trial. Menopause. 2003 Sep-Oct; 10(5):456-64. PMID: 14501608.
      Citations:    
    99. Usadi RS, Murray MJ, Bagnell RC, Fritz MA, Kowalik AI, Meyer WR, Lessey BA. Temporal and morphologic characteristics of pinopod expression across the secretory phase of the endometrial cycle in normally cycling women with proven fertility. Fertil Steril. 2003 Apr; 79(4):970-4. PMID: 12749439.
      Citations:    
    100. Illera MJ, Lorenzo PL, Gui YT, Beyler SA, Apparao KB, Lessey BA. A role for alphavbeta3 integrin during implantation in the rabbit model. Biol Reprod. 2003 Mar; 68(3):766-71. PMID: 12604624.
      Citations:    
    101. Apparao KB, Illera MJ, Beyler SA, Olson GE, Osteen KG, Corjay MH, Boggess K, Lessey BA. Regulated expression of osteopontin in the peri-implantation rabbit uterus. Biol Reprod. 2003 May; 68(5):1484-90. PMID: 12606431.
      Citations:    
    102. Khorram O, Lessey BA. Alterations in expression of endometrial endothelial nitric oxide synthase and alpha(v)beta(3) integrin in women with endometriosis. Fertil Steril. 2002 Oct; 78(4):860-4. PMID: 12372469.
      Citations:    
    103. Carson DD, Lagow E, Thathiah A, Al-Shami R, Farach-Carson MC, Vernon M, Yuan L, Fritz MA, Lessey B. Changes in gene expression during the early to mid-luteal (receptive phase) transition in human endometrium detected by high-density microarray screening. Mol Hum Reprod. 2002 Sep; 8(9):871-9. PMID: 12200466.
      Citations:    
    104. Lessey BA, Gui Y, Apparao KB, Young SL, Mulholland J. Regulated expression of heparin-binding EGF-like growth factor (HB-EGF) in the human endometrium: a potential paracrine role during implantation. Mol Reprod Dev. 2002 Aug; 62(4):446-55. PMID: 12112577.
      Citations:    
    105. Gregory CW, Wilson EM, Apparao KB, Lininger RA, Meyer WR, Kowalik A, Fritz MA, Lessey BA. Steroid receptor coactivator expression throughout the menstrual cycle in normal and abnormal endometrium. J Clin Endocrinol Metab. 2002 Jun; 87(6):2960-6. PMID: 12050280.
      Citations:    
    106. Lessey BA. Adhesion molecules and implantation. J Reprod Immunol. 2002 May-Jun; 55(1-2):101-12. PMID: 12062825.
      Citations:    
    107. Lessey BA, Castelbaum AJ. Integrins and implantation in the human. Rev Endocr Metab Disord. 2002 May; 3(2):107-17. PMID: 12007287.
      Citations:    
    108. Young SL, Lessey BA, Fritz MA, Meyer WR, Murray MJ, Speckman PL, Nowicki BJ. In vivo and in vitro evidence suggest that HB-EGF regulates endometrial expression of human decay-accelerating factor. J Clin Endocrinol Metab. 2002 Mar; 87(3):1368-75. PMID: 11889210.
      Citations:    
    109. Lessey BA. Implantation defects in infertile women with endometriosis. Ann N Y Acad Sci. 2002 Mar; 955:265-80; discussion 293-5, 396-406. PMID: 11949954.
      Citations:    
    110. Apparao KB, Lovely LP, Gui Y, Lininger RA, Lessey BA. Elevated endometrial androgen receptor expression in women with polycystic ovarian syndrome. Biol Reprod. 2002 Feb; 66(2):297-304. PMID: 11804942.
      Citations:    
    111. Arnold JT, Lessey BA, Seppälä M, Kaufman DG. Effect of normal endometrial stroma on growth and differentiation in Ishikawa endometrial adenocarcinoma cells. Cancer Res. 2002 Jan 01; 62(1):79-88. PMID: 11782363.
      Citations:    
    112. Tabibzadeh S, Mason JM, Shea W, Cai Y, Murray MJ, Lessey B. Dysregulated expression of ebaf, a novel molecular defect in the endometria of patients with infertility. J Clin Endocrinol Metab. 2000 Jul; 85(7):2526-36. PMID: 10902804.
      Citations:    
    113. Tabibzadeh S, Lessey B, Satyaswaroop PG. Temporal and site-specific expression of transforming growth factor-beta4 in human endometrium. Mol Hum Reprod. 1998 Jun; 4(6):595-602. PMID: 9665343.
      Citations:    
    114. Ilesanmi A, Harris J, Lessey B. A simple and sensitive microtiter plate estrogen bioassay based on stimulation of alkaline phosphatase in an endometrial adenocarcinoma cell line (Ishikawa line). Afr J Med Med Sci. 1996 Dec; 25(4):381-4. PMID: 9532312.
      Citations:    
    115. Sayegh R, Awwad JT, Maxwell C, Lessey B, Isaacson K. Alpha 2-macroglobulin production by the human endometrium. J Clin Endocrinol Metab. 1995 Mar; 80(3):1021-6. PMID: 7533769.
      Citations:    
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