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Bethany Kerr PhD

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentCancer Biology
Address
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    Other Positions
    TitleAssistant Professor
    InstitutionWake Forest School of Medicine
    DepartmentBiomedical Engineering

    TitleAssistant Professor
    InstitutionWake Forest School of Medicine
    DepartmentOrthopedic Surgery

    TitleAssistant Professor
    InstitutionWake Forest School of Medicine
    DepartmentUrology


    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    F32CA142133     (KERR, BETHANY AMBER)Jan 1, 2011 - Dec 31, 2013
    NIH
    Molecular Mechanisms of Prostate Cancer Induced Bone Remodeling
    Role: Principal Investigator
    K99CA175291     (KERR, BETHANY AMBER)Feb 1, 2014 - Jan 31, 2016
    NIH
    CD117 Signaling as a Mechanism of Prostate Cancer Metastasis
    Role: Principal Investigator
    R00CA175291     (KERR, BETHANY AMBER)Dec 1, 2015 - Nov 30, 2019
    NIH
    CD117 Signaling as a Mechanism of Prostate Cancer Metastasis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Foster BM, Shi L, Harris KS, Patel C, Surratt VE, Langsten KL, Kerr BA. Bone Marrow-Derived Stem Cell Factor Regulates Prostate Cancer-Induced Shifts in Pre-Metastatic Niche Composition. Front Oncol. 2022; 12:855188. PMID: 35515124.
      Citations:    
    2. Ramirez MU, Clear KYJ, Cornelius Z, Bawaneh A, Feliz-Mosquea YR, Wilson AS, Ruggiero AD, Cruz-Diaz N, Shi L, Kerr BA, Soto-Pantoja DR, Cook KL. Diet impacts triple-negative breast cancer growth, metastatic potential, chemotherapy responsiveness, and doxorubicin-mediated cardiac dysfunction. Physiol Rep. 2022 04; 10(8):e15192. PMID: 35439354.
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    3. Patel C, Shi L, Whitesides JF, Foster BM, Fajardo RJ, Quillen EE, Kerr BA. A New Method of Bone Stromal Cell Characterization by Flow Cytometry. Curr Protoc. 2022 Mar; 2(3):e400. PMID: 35349226.
      Citations:    
    4. Foster BM, Langsten KL, Mansour A, Shi L, Kerr BA. Tissue distribution of stem cell factor in adults. Exp Mol Pathol. 2021 10; 122:104678. PMID: 34450114.
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    5. Kwok AT, Mohamed NS, Plate JF, Yammani RR, Rosas S, Bateman TA, Livingston E, Moore JE, Kerr BA, Lee J, Furdui CM, Tan L, Bouxsein ML, Ferguson VL, Stodieck LS, Zawieja DC, Delp MD, Mao XW, Willey JS. Spaceflight and hind limb unloading induces an arthritic phenotype in knee articular cartilage and menisci of rodents. Sci Rep. 2021 May 18; 11(1):10469. PMID: 34006989.
      Citations:    
    6. Kerr BA, Harris KS, Shi L, Willey JS, Soto-Pantoja DR, Byzova TV. Platelet TSP-1 controls prostate cancer-induced osteoclast differentiation and bone marrow-derived cell mobilization through TGFß-1. Am J Clin Exp Urol. 2021; 9(1):18-31. PMID: 33816691.
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    7. Harris KS, Shi L, Foster BM, Mobley ME, Elliott PL, Song CJ, Watabe K, Langefeld CD, Kerr BA. CD117/c-kit defines a prostate CSC-like subpopulation driving progression and TKI resistance. Sci Rep. 2021 Jan 14; 11(1):1465. PMID: 33446896.
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    8. Kerr BA, Shi L, Jinnah AH, Harris KS, Willey JS, Lennon DP, Caplan AI, Byzova TV. Kindlin-3 mutation in mesenchymal stem cells results in enhanced chondrogenesis. Exp Cell Res. 2021 02 15; 399(2):112456. PMID: 33417921.
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    9. Jinnah AH, Whitlock P, Willey JS, Danelson K, Kerr BA, Hassan OA, Emory CL, Smith TL, Bracey DN. Improved osseointegration using porcine xenograft compared to demineralized bone matrix for the treatment of critical defects in a small animal model. Xenotransplantation. 2021 Mar; 28(2):e12662. PMID: 33242920.
      Citations:    
    10. Ghassemi P, Harris KS, Ren X, Foster BM, Langefeld CD, Kerr BA, Agah M. Comparative Study of Prostate Cancer Biophysical and Migratory Characteristics via Iterative Mechanoelectrical Properties (iMEP) and Standard Migration Assays. Sens Actuators B Chem. 2020 Oct 15; 321. PMID: 32863589.
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    11. Kikkeri K, Kerr BA, Bertke AS, Strobl JS, Agah M. Passivated-electrode insulator-based dielectrophoretic separation of heterogeneous cell mixtures. J Sep Sci. 2020 Apr; 43(8):1576-1585. PMID: 31991043.
      Citations:    
    12. Ghassemi P, Ren X, Foster BM, Kerr BA, Agah M. Post-enrichment circulating tumor cell detection and enumeration via deformability impedance cytometry. Biosens Bioelectron. 2020 Feb 15; 150:111868. PMID: 31767345.
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    13. Peak TC, Panigrahi GK, Praharaj PP, Su Y, Shi L, Chyr J, Rivera-Chávez J, Flores-Bocanegra L, Singh R, Vander Griend DJ, Oberlies NH, Kerr BA, Hemal A, Bitting RL, Deep G. Syntaxin 6-mediated exosome secretion regulates enzalutamide resistance in prostate cancer. Mol Carcinog. 2020 01; 59(1):62-72. PMID: 31674708.
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    14. Bracey DN, Jinnah AH, Willey JS, Seyler TM, Hutchinson ID, Whitlock PW, Smith TL, Danelson KA, Emory CL, Kerr BA. Investigating the Osteoinductive Potential of a Decellularized Xenograft Bone Substitute. Cells Tissues Organs. 2019; 207(2):97-113. PMID: 31655811.
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    15. Rosas S, Tipton S, Luo TD, Kerr BA, Plate JF, Willey JS, Emory CL. A History of Past Prostate Cancer Still Carries Risk After Total Knee Arthroplasty. J Knee Surg. 2021 Feb; 34(3):293-297. PMID: 31461758.
      Citations:    
    16. Rosas S, Hughes RT, Farris M, Lee H, McTyre ER, Plate JF, Shi L, Emory CL, Blackstock AW, Kerr BA, Willey JS. Cartilage oligomeric matrix protein in patients with osteoarthritis is independently associated with metastatic disease in prostate cancer. Oncotarget. 2019 Jul 30; 10(46):4776-4785. PMID: 31413818.
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    17. Kwok AT, Moore JE, Rosas S, Kerr BA, Andrews RN, Nguyen CM, Lee J, Furdui CM, Collins BE, Munley MT, Willey JS. Knee and Hip Joint Cartilage Damage from Combined Spaceflight Hazards of Low-Dose Radiation Less than 1 Gy and Prolonged Hindlimb Unloading. Radiat Res. 2019 06; 191(6):497-506. PMID: 30925135.
      Citations:    
    18. Kerr, Bethany A. Science Translational Medicine. Age Is Just a State of Marrow. 2019; 11(504):eaay7698.
    19. Kerr, Bethany A. Science Translational Medicine. A Workout Plan to Prevent Metastasis. 2019; 11(496):eaax9564.
    20. Kerr, Bethany A. Science Translational Medicine. An Aspirin a Day Keeps the Metastasis at Bay. 2019; 11(488):eaax1728.
    21. Rosas, Samuel, Ryan T. Hughes, Michael Farris, Hwajin Lee, Emory R. McTyre, Johannes F. Plate, Lihong Shi, Cynthia L. Emory, A. William Blackstock, Bethany A. Kerr, and Jeffrey S. Willey. Oncotarget. Cartilage Oligo-metric Matrix Protein in Patients with Osteoarthritis is Independently Associated with Metastatic Disease in Prostate Cancer. 2019.
    22. Ren X, Foster BM, Ghassemi P, Strobl JS, Kerr BA, Agah M. Entrapment of Prostate Cancer Circulating Tumor Cells with a Sequential Size-Based Microfluidic Chip. Anal Chem. 2018 06 19; 90(12):7526-7534. PMID: 29790741.
      Citations:    
    23. Jinnah AH, Zacks BC, Gwam CU, Kerr BA. Emerging and Established Models of Bone Metastasis. Cancers (Basel). 2018 Jun 01; 10(6). PMID: 29865211.
      Citations:    
    24. Foster BM, Zaidi D, Young TR, Mobley ME, Kerr BA. CD117/c-kit in Cancer Stem Cell-Mediated Progression and Therapeutic Resistance. Biomedicines. 2018 Mar 08; 6(1). PMID: 29518044.
      Citations:    
    25. Harris KS, Kerr BA. Prostate Cancer Stem Cell Markers Drive Progression, Therapeutic Resistance, and Bone Metastasis. Stem Cells Int. 2017; 2017:8629234. PMID: 28690641.
      Citations:    
    26. Kerr BA, West XZ, Kim YW, Zhao Y, Tischenko M, Cull RM, Phares TW, Peng XD, Bernier-Latmani J, Petrova TV, Adams RH, Hay N, Naga Prasad SV, Byzova TV. Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium. Nat Commun. 2016 Mar 14; 7:10960. PMID: 26971877.
      Citations:    
    27. Kerr BA, Miocinovic R, Smith AK, West XZ, Watts KE, Alzayed AW, Klink JC, Mir MC, Sturey T, Hansel DE, Heston WD, Stephenson AJ, Klein EA, Byzova TV. CD117? cells in the circulation are predictive of advanced prostate cancer. Oncotarget. 2015 Jan 30; 6(3):1889-97. PMID: 25595903.
      Citations:    
    28. Ma L, Kerr BA, Naga Prasad SV, Byzova TV, Somanath PR. Differential effects of Akt1 signaling on short- versus long-term consequences of myocardial infarction and reperfusion injury. Lab Invest. 2014 Oct; 94(10):1083-91. PMID: 25046438.
      Citations:    
    29. Kerr BA, McCabe NP, Feng W, Byzova TV. Platelets govern pre-metastatic tumor communication to bone. Oncogene. 2013 Sep 05; 32(36):4319-24. PMID: 23069656.
      Citations:    
    30. Kerr BA, Ma L, West XZ, Ding L, Malinin NL, Weber ME, Tischenko M, Goc A, Somanath PR, Penn MS, Podrez EA, Byzova TV. Interference with akt signaling protects against myocardial infarction and death by limiting the consequences of oxidative stress. Sci Signal. 2013 Aug 06; 6(287):ra67. PMID: 23921086.
      Citations:    
    31. Kerr BA, Byzova TV. The dark side of the oxidative force in angiogenesis. Nat Med. 2012 Aug; 18(8):1184-5. PMID: 22869186.
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    32. West XZ, Meller N, Malinin NL, Deshmukh L, Meller J, Mahabeleshwar GH, Weber ME, Kerr BA, Vinogradova O, Byzova TV. Integrin ß3 crosstalk with VEGFR accommodating tyrosine phosphorylation as a regulatory switch. PLoS One. 2012; 7(2):e31071. PMID: 22363548.
      Citations:    
    33. Feng W, Madajka M, Kerr BA, Mahabeleshwar GH, Whiteheart SW, Byzova TV. A novel role for platelet secretion in angiogenesis: mediating bone marrow-derived cell mobilization and homing. Blood. 2011 Apr 07; 117(14):3893-902. PMID: 21224474.
      Citations:    
    34. McCabe NP, Kerr BA, Madajka M, Vasanji A, Byzova TV. Augmented osteolysis in SPARC-deficient mice with bone-residing prostate cancer. Neoplasia. 2011 Jan; 13(1):31-9. PMID: 21245938.
      Citations:    
    35. West XZ, Malinin NL, Merkulova AA, Tischenko M, Kerr BA, Borden EC, Podrez EA, Salomon RG, Byzova TV. Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands. Nature. 2010 Oct 21; 467(7318):972-6. PMID: 20927103.
      Citations:    
    36. Kerr BA, Miocinovic R, Smith AK, Klein EA, Byzova TV. Comparison of tumor and microenvironment secretomes in plasma and in platelets during prostate cancer growth in a xenograft model. Neoplasia. 2010 May; 12(5):388-96. PMID: 20454510.
      Citations:    
    37. Kerr BA, Byzova TV. alphaB-crystallin: a novel VEGF chaperone. Blood. 2010 Apr 22; 115(16):3181-3. PMID: 20413662.
      Citations:    
    38. Kerr BA, Otani T, Koyama E, Freeman TA, Enomoto-Iwamoto M. Small GTPase protein Rac-1 is activated with maturation and regulates cell morphology and function in chondrocytes. Exp Cell Res. 2008 Apr 01; 314(6):1301-12. PMID: 18261726.
      Citations:    
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