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William H. Gmeiner PhD

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentCancer Biology
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentTranslational Neuroscience

    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentWake Forest Institute for Regenerative Medicine


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    R29CA060612     (GMEINER, WILLIAM H)Jul 16, 1993 - Jun 30, 1998
    NIH
    IMPACT OF 5-FU ON THE STRUCTURE OF THE U4-U6 COMPLEX
    Role: Principal Investigator
    R01CA060612     (GMEINER, WILLIAM H)Jul 16, 1993 - Jun 30, 2001
    NIH
    IMPACT OF 5FU ON THE STRUCTURE OF THE U4/U6 COMPLEX
    Role: Principal Investigator
    U01CA102532     (GMEINER, WILLIAM H)Aug 10, 2005 - Jul 31, 2011
    NIH
    DNA-DIRECTED EFFECTS OF FdUMP(N)
    Role: Principal Investigator
    R21CA218933     (GMEINER, WILLIAM H.)Feb 2, 2018 - Jan 31, 2021
    NIH
    Development of a CF10 Predictive Gene Signature in CRC Organoids.
    Role: Principal Investigator
    R21CA227709     (WADAS, THADDEUS J)Jul 1, 2019 - Jun 30, 2021
    NIH
    Aptamer-Based Radiopharmaceuticals for the Targeted Alpha Particle Therapy of Prostate Cancer
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gmeiner WH. Recent Advances in Our Knowledge of mCRC Tumor Biology and Genetics: A Focus on Targeted Therapy Development. Onco Targets Ther. 2021; 14:2121-2130. PMID: 33790575.
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    2. Haber AO, Jain A, Mani C, Nevler A, Agostini LC, Golan T, Palle K, Yeo CJ, Gmeiner WH, Brody JR. AraC-FdUMP[10] Is a Next-Generation Fluoropyrimidine with Potent Antitumor Activity in PDAC and Synergy with PARG Inhibition. Mol Cancer Res. 2021 Apr; 19(4):565-572. PMID: 33593942.
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    3. Gmeiner WH, Dominijanni A, Haber AO, Ghiraldeli LP, Caudell DL, D'Agostino R, Pasche BC, Smith TL, Deng Z, Kiren S, Mani C, Palle K, Brody JR. Improved Antitumor Activity of the Fluoropyrimidine Polymer CF10 in Preclinical Colorectal Cancer Models through Distinct Mechanistic and Pharmacologic Properties. Mol Cancer Ther. 2021 03; 20(3):553-563. PMID: 33361273.
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    4. Das U, Bhuniya A, Roy AK, Gmeiner WH, Ghosh S. Hairpin Oligonucleotide Can Functionalize Gold Nanorods for in Vivo Application Delivering Cytotoxic Nucleotides and Curcumin: A Comprehensive Study in Combination with Near-Infrared Laser. ACS Omega. 2020 Nov 10; 5(44):28463-28474. PMID: 33195896.
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    5. Gmeiner WH. Chemistry of Fluorinated Pyrimidines in the Era of Personalized Medicine. Molecules. 2020 Jul 29; 25(15). PMID: 32751071.
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    6. Gmeiner WH. Fluoropyrimidine Modulation of the Anti-Tumor Immune Response-Prospects for Improved Colorectal Cancer Treatment. Cancers (Basel). 2020 Jun 21; 12(6). PMID: 32575843.
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    7. Gmeiner, William H. Cancers. Fluoropyrimidine Modulation of the Anti-Tumor Immune Response?Prospects for Improved Colorectal Cancer Treatment. 2020; 12(6). View Publication.
    8. Gmeiner WH, Miller LD, Chou JW, Dominijanni A, Mutkus L, Marini F, Ruiz J, Dotson T, Thomas KW, Parks G, Bellinger CR. Dysregulated Pyrimidine Biosynthesis Contributes to 5-FU Resistance in SCLC Patient-Derived Organoids but Response to a Novel Polymeric Fluoropyrimidine, CF10. Cancers (Basel). 2020 Mar 26; 12(4). PMID: 32224870.
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    9. Gmeiner WH. Entrapment of DNA topoisomerase-DNA complexes by nucleotide/nucleoside analogs. Cancer Drug Resist. 2019; 2:994-1001. PMID: 31930190.
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    10. Mani C, Jonnalagadda S, Lingareddy J, Awasthi S, Gmeiner WH, Palle K. Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells. Breast Cancer Res. 2019 09 06; 21(1):104. PMID: 31492187.
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    11. Forsythe S, Mehta N, Devarasetty M, Sivakumar H, Gmeiner W, Soker S, Votanopoulos K, Skardal A. Development of a Colorectal Cancer 3D Micro-tumor Construct Platform From Cell Lines and Patient Tumor Biospecimens for Standard-of-Care and Experimental Drug Screening. Ann Biomed Eng. 2020 Mar; 48(3):940-952. PMID: 31020445.
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    12. Mani C, Pai S, Papke CM, Palle K, Gmeiner WH. Thymineless Death by the Fluoropyrimidine Polymer F10 Involves Replication Fork Collapse and Is Enhanced by Chk1 Inhibition. Neoplasia. 2018 12; 20(12):1236-1245. PMID: 30439567.
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    13. Das U, Sahoo A, Haldar S, Bhattacharya S, Mandal SS, Gmeiner WH, Ghosh S. Secondary Structure-Dependent Physicochemical Interaction of Oligonucleotides with Gold Nanorod and Photothermal Effect for Future Applications: A New Insight. ACS Omega. 2018 Oct 31; 3(10):14349-14360. PMID: 30411066.
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    14. Dominijanni A, Gmeiner WH. Improved potency of F10 relative to 5-fluorouracil in colorectal cancer cells with p53 mutations. Cancer Drug Resist. 2018; 1:48-58. PMID: 30613833.
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    15. Bhatt NB, Pandya DN, Dezarn WA, Marini FC, Zhao D, Gmeiner WH, Triozzi PL, Wadas TJ. Practical Guidelines for Cerenkov Luminescence Imaging with Clinically Relevant Isotopes. Methods Mol Biol. 2018; 1790:197-208. PMID: 29858793.
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    16. Ghosh S, Mallick S, Das U, Verma A, Pal U, Chatterjee S, Nandy A, Saha KD, Maiti NC, Baishya B, Suresh Kumar G, Gmeiner WH. Curcumin stably interacts with DNA hairpin through minor groove binding and demonstrates enhanced cytotoxicity in combination with FdU nucleotides. Biochim Biophys Acta Gen Subj. 2018 Mar; 1862(3):485-494. PMID: 29107813.
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    17. Godwin RC, Gmeiner WH, Salsbury FR. All-atom molecular dynamics comparison of disease-associated zinc fingers. J Biomol Struct Dyn. 2018 Aug; 36(10):2581-2594. PMID: 28814200.
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    18. Melvin RL, Gmeiner WH, Salsbury FR. All-atom MD indicates ion-dependent behavior of therapeutic DNA polymer. Phys Chem Chem Phys. 2017 Aug 23; 19(33):22363-22374. PMID: 28805211.
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    19. Melvin RL, Gmeiner WH, Salsbury FR. All-Atom MD Predicts Magnesium-Induced Hairpin in Chemically Perturbed RNA Analog of F10 Therapeutic. J Phys Chem B. 2017 08 24; 121(33):7803-7812. PMID: 28745046.
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    20. Melvin RL, Thompson WG, Godwin RC, Gmeiner WH, Salsbury FR. MutSa's Multi-Domain Allosteric Response to Three DNA Damage Types Revealed by Machine Learning. Front Phys. 2017 Mar; 5. PMID: 31938712.
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    21. Godwin RC, Melvin RL, Gmeiner WH, Salsbury FR. Binding Site Configurations Probe the Structure and Dynamics of the Zinc Finger of NEMO (NF-?B Essential Modulator). Biochemistry. 2017 01 31; 56(4):623-633. PMID: 28035815.
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    22. Stuart CH, Riley KR, Boyacioglu O, Herpai DM, Debinski W, Qasem S, Marini FC, Colyer CL, Gmeiner WH. Selection of a Novel Aptamer Against Vitronectin Using Capillary Electrophoresis and Next Generation Sequencing. Mol Ther Nucleic Acids. 2016 Nov 15; 5(11):e386. PMID: 27845768.
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    23. Melvin RL, Gmeiner WH, Salsbury FR. All-Atom Molecular Dynamics Reveals Mechanism of Zinc Complexation with Therapeutic F10. J Phys Chem B. 2016 10 06; 120(39):10269-10279. PMID: 27606431.
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    24. Gmeiner WH, Gearhart PJ, Pommier Y, Nakamura J. F10 cytotoxicity via topoisomerase I cleavage complex repair consistent with a unique mechanism for thymineless death. Future Oncol. 2016 Oct; 12(19):2183-8. PMID: 27333295.
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    25. Gmeiner WH, Debinski W, Milligan C, Caudell D, Pardee TS. The applications of the novel polymeric fluoropyrimidine F10 in cancer treatment: current evidence. Future Oncol. 2016 Sep; 12(17):2009-20. PMID: 27279153.
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    26. Stuart CH, Singh R, Smith TL, D'Agostino R, Caudell D, Balaji KC, Gmeiner WH. Prostate-specific membrane antigen-targeted liposomes specifically deliver the Zn(2+) chelator TPEN inducing oxidative stress in prostate cancer cells. Nanomedicine (Lond). 2016 05; 11(10):1207-22. PMID: 27077564.
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    27. Godwin R, Gmeiner W, Salsbury FR. Importance of long-time simulations for rare event sampling in zinc finger proteins. J Biomol Struct Dyn. 2016; 34(1):125-34. PMID: 25734227.
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    28. Gmeiner WH, Ghosh S. Nanotechnology for cancer treatment. Nanotechnol Rev. 2015 Apr; 3(2):111-122. PMID: 26082884.
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    29. Gmeiner WH, Jennings-Gee J, Stuart CH, Pardee TS. Thymineless death in F10-treated AML cells occurs via lipid raft depletion and Fas/FasL co-localization in the plasma membrane with activation of the extrinsic apoptotic pathway. Leuk Res. 2015 Feb; 39(2):229-35. PMID: 25510486.
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    30. Gmeiner WH, Boyacioglu O, Stuart CH, Jennings-Gee J, Balaji KC. The cytotoxic and pro-apoptotic activities of the novel fluoropyrimidine F10 towards prostate cancer cells are enhanced by Zn(2+) -chelation and inhibiting the serine protease Omi/HtrA2. Prostate. 2015 Mar 01; 75(4):360-9. PMID: 25408502.
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    31. Gmeiner WH, Willingham MC, Bourland JD, Hatcher HC, Smith TL, D'Agostino RB, Blackstock W. F10 Inhibits Growth of PC3 Xenografts and Enhances the Effects of Radiation Therapy. J Clin Oncol Res. 2014 Jul-Aug; 2(4). PMID: 26020060.
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    32. Pardee TS, Stadelman K, Jennings-Gee J, Caudell DL, Gmeiner WH. The poison oligonucleotide F10 is highly effective against acute lymphoblastic leukemia while sparing normal hematopoietic cells. Oncotarget. 2014 Jun 30; 5(12):4170-9. PMID: 24961587.
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    33. Stuart CH, Horita DA, Thomas MJ, Salsbury FR, Lively MO, Gmeiner WH. Site-specific DNA-doxorubicin conjugates display enhanced cytotoxicity to breast cancer cells. Bioconjug Chem. 2014 Feb 19; 25(2):406-13. PMID: 24450459.
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    34. Gmeiner WH, Lema-Tome C, Gibo D, Jennings-Gee J, Milligan C, Debinski W. Selective anti-tumor activity of the novel fluoropyrimidine polymer F10 towards G48a orthotopic GBM tumors. J Neurooncol. 2014 Feb; 116(3):447-54. PMID: 24346635.
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    35. Ghosh S, Ucer KB, D'Agostino R, Grant K, Sirintrapun J, Thomas MJ, Hantgan R, Bharadwaj M, Gmeiner WH. Non-covalent assembly of meso-tetra-4-pyridyl porphine with single-stranded DNA to form nano-sized complexes with hydrophobicity-dependent DNA release and anti-tumor activity. Nanomedicine. 2014 Feb; 10(2):451-61. PMID: 23988714.
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    36. Boyacioglu O, Stuart CH, Kulik G, Gmeiner WH. Dimeric DNA Aptamer Complexes for High-capacity-targeted Drug Delivery Using pH-sensitive Covalent Linkages. Mol Ther Nucleic Acids. 2013 Jul 16; 2:e107. PMID: 23860551.
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    37. Huang SY, Murai J, Dalla Rosa I, Dexheimer TS, Naumova A, Gmeiner WH, Pommier Y. TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs. Nucleic Acids Res. 2013 Sep; 41(16):7793-803. PMID: 23775789.
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    38. Wu SY, Chen TM, Gmeiner WH, Chu E, Schmitz JC. Development of modified siRNA molecules incorporating 5-fluoro-2'-deoxyuridine residues to enhance cytotoxicity. Nucleic Acids Res. 2013 Apr; 41(8):4650-9. PMID: 23449220.
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    39. Ghosh S, Salsbury FR, Horita DA, Gmeiner WH. Cooperative stabilization of Zn(2+):DNA complexes through netropsin binding in the minor groove of FdU-substituted DNA. J Biomol Struct Dyn. 2013; 31(11):1301-10. PMID: 23153072.
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    40. Jennings-Gee J, Pardee TS, Gmeiner WH. Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity. Exp Hematol. 2013 Feb; 41(2):180-188.e4. PMID: 23085462.
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    41. Pardee TS, Gomes E, Jennings-Gee J, Caudell D, Gmeiner WH. Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity. Blood. 2012 Apr 12; 119(15):3561-70. PMID: 22362039.
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    42. Gmeiner WH, Salsbury F, Olsen CM, Marky LA. The stability of a model substrate for topoisomerase 1-mediated DNA religation depends on the presence of mismatched base pairs. J Nucleic Acids. 2011; 2011:631372. PMID: 21904666.
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    43. Ghosh S, Salsbury FR, Horita DA, Gmeiner WH. Zn2+ selectively stabilizes FdU-substituted DNA through a unique major groove binding motif. Nucleic Acids Res. 2011 May; 39(10):4490-8. PMID: 21296761.
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    44. Gmeiner WH, Reinhold WC, Pommier Y. Genome-wide mRNA and microRNA profiling of the NCI 60 cell-line screen and comparison of FdUMP[10] with fluorouracil, floxuridine, and topoisomerase 1 poisons. Mol Cancer Ther. 2010 Dec; 9(12):3105-14. PMID: 21159603.
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    45. Ghosh S, Dutta S, Gomes E, Carroll D, D'Agostino R, Olson J, Guthold M, Gmeiner WH. Increased heating efficiency and selective thermal ablation of malignant tissue with DNA-encased multiwalled carbon nanotubes. ACS Nano. 2009 Sep 22; 3(9):2667-73. PMID: 19655728.
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    46. Gmeiner WH, Hellmann GM, Shen P. Tissue-dependent and -independent gene expression changes in metastatic colon cancer. Oncol Rep. 2008 Jan; 19(1):245-51. PMID: 18097602.
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    47. Bijnsdorp IV, Comijn EM, Padron JM, Gmeiner WH, Peters GJ. Mechanisms of action of FdUMP[10]: metabolite activation and thymidylate synthase inhibition. Oncol Rep. 2007 Jul; 18(1):287-91. PMID: 17549381.
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    48. Olsen CM, Gmeiner WH, Marky LA. Unfolding of G-quadruplexes: energetic, and ion and water contributions of G-quartet stacking. J Phys Chem B. 2006 Apr 06; 110(13):6962-9. PMID: 16571009.
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    49. Liao ZY, Sordet O, Zhang HL, Kohlhagen G, Antony S, Gmeiner WH, Pommier Y. A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes. Cancer Res. 2005 Jun 01; 65(11):4844-51. PMID: 15930305.
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    50. Mao XA, Gmeiner WH. NMR study of the folding-unfolding mechanism for the thrombin-binding DNA aptamer d(GGTTGGTGTGGTTGG). Biophys Chem. 2005 Feb 01; 113(2):155-60. PMID: 15617822.
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    51. Gmeiner WH. Novel chemical strategies for thymidylate synthase inhibition. Curr Med Chem. 2005; 12(2):191-202. PMID: 15638735.
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    52. Mao X, Marky LA, Gmeiner WH. NMR structure of the thrombin-binding DNA aptamer stabilized by Sr2+. J Biomol Struct Dyn. 2004 Aug; 22(1):25-33. PMID: 15214802.
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    53. Mao XA, Cui W, Gmeiner WH. Line shape analyses for water 17O NMR quintet observed in a bacteriophage Pf1 solution at different temperatures. Biophys Chem. 2004 Feb 15; 107(3):255-62. PMID: 14967240.
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    54. Gmeiner WH, Trump E, Wei C. Enhanced DNA-directed effects of FdUMP[10] compared to 5FU. Nucleosides Nucleotides Nucleic Acids. 2004; 23(1-2):401-10. PMID: 15043163.
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    55. Gmeiner WH, Yu S, Pon RT, Pourquier P, Pommier Y. Structural basis for topoisomerase I inhibition by nucleoside analogs. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug; 22(5-8):653-8. PMID: 14565246.
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    56. Gmeiner WH. Antimetabolite incorporation into DNA: structural and thermodynamic basis for anticancer activity. Biopolymers. 2002 Nov 05; 65(3):180-9. PMID: 12228923.
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    57. Comolli LR, Ulyanov NB, Soto AM, Marky LA, James TL, Gmeiner WH. NMR structure of the 3' stem-loop from human U4 snRNA. Nucleic Acids Res. 2002 Oct 15; 30(20):4371-9. PMID: 12384583.
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    58. Liu C, Willingham M, Liu J, Gmeiner WH. Efficacy and safety of FdUMP[10] in treatment of HT-29 human colon cancer xenografts. Int J Oncol. 2002 Aug; 21(2):303-8. PMID: 12118325.
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    59. Pourquier P, Gioffre C, Kohlhagen G, Urasaki Y, Goldwasser F, Hertel LW, Yu S, Pon RT, Gmeiner WH, Pommier Y. Gemcitabine (2',2'-difluoro-2'-deoxycytidine), an antimetabolite that poisons topoisomerase I. Clin Cancer Res. 2002 Aug; 8(8):2499-504. PMID: 12171875.
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    60. Soto AM, Gmeiner WH, Marky LA. Energetic and conformational contributions to the stability of Okazaki fragments. Biochemistry. 2002 May 28; 41(21):6842-9. PMID: 12022889.
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    61. Gmeiner WH. The structure and dynamics of the U4/U6 snRNP: implications for pre-mRNA splicing and use as a model system to investigate the RNA-mediated effects of (5F)Ura. J Biomol Struct Dyn. 2002 Apr; 19(5):853-62. PMID: 11922840.
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    62. Gmeiner WH. The Lown Symposium: The Field of DNA Minor Groove Binders Celebrates the Career of Professor J. William Lown. J Biomol Struct Dyn. 2002 Apr; 19(5):731-733. PMID: 22594568.
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    63. Konerding D, James TL, Trump E, Soto AM, Marky LA, Gmeiner WH. NMR structure of a gemcitabine-substituted model Okazaki fragment. Biochemistry. 2002 Jan 22; 41(3):839-46. PMID: 11790105.
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    64. Cui W, Gmeiner WH. Effect of 5-FU substitution and mutation on Sm protein binding to human U4 snRNA. Nucleosides Nucleotides Nucleic Acids. 2002; 21(2):139-54. PMID: 11991141.
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    65. Liu J, Kolar C, Lawson TA, Gmeiner WH. Targeted drug delivery to chemoresistant cells: folic acid derivatization of FdUMP[10] enhances cytotoxicity toward 5-FU-resistant human colorectal tumor cells. J Org Chem. 2001 Aug 24; 66(17):5655-63. PMID: 11511236.
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    66. Guo JX, Gmeiner WH. Molecular dynamics simulation of the human U2B" protein complex with U2 snRNA hairpin IV in aqueous solution. Biophys J. 2001 Aug; 81(2):630-42. PMID: 11463612.
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    67. Gmeiner WH, Xu I, Horita DA, Smithgall TE, Engen JR, Smith DL, Byrd RA. Intramolecular binding of a proximal PPII helix to an SH3 domain in the fusion protein SH3Hck : PPIIhGAP. Cell Biochem Biophys. 2001; 35(2):115-26. PMID: 11892787.
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    68. Gmeiner WH, Horita DA. Implications of SH3 domain structure and dynamics for protein regulation and drug design. Cell Biochem Biophys. 2001; 35(2):127-40. PMID: 11892788.
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    69. Guo J, Daizadeh I, Gmeiner WH. Structure of the Sm binding site from human U4 snRNA derived from a 3 ns PME molecular dynamics simulation. J Biomol Struct Dyn. 2000 Dec; 18(3):335-44. PMID: 11149510.
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    70. Kotchetkov R, Gröschel B, Gmeiner WH, Krivtchik AA, Trump E, Bitoova M, Cinatl J, Kornhuber B, Cinatl J. Antineoplastic activity of a novel multimeric gemcitabine-monophosphate prodrug against thyroid cancer cells in vitro. Anticancer Res. 2000 Sep-Oct; 20(5A):2915-22. PMID: 11062701.
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    71. Gmeiner WH, Cui W, Sharma S, Soto AM, Marky LA, Lown JW. Shape-selective binding of geometrically-constrained bis-distamycins to a DNA duplex and a model Okazaki fragment of identical sequence. Nucleosides Nucleotides Nucleic Acids. 2000 Aug; 19(8):1365-79. PMID: 11097065.
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    72. Gmeiner WH, Hudalla CJ, Soto AM, Marky L. Binding of ethidium to DNA measured using a 2D diffusion-modulated gradient COSY NMR experiment. FEBS Lett. 2000 Jan 14; 465(2-3):148-52. PMID: 10631323.
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    73. Horita DA, Zhang W, Smithgall TE, Gmeiner WH, Byrd RA. Dynamics of the Hck-SH3 domain: comparison of experiment with multiple molecular dynamics simulations. Protein Sci. 2000 Jan; 9(1):95-103. PMID: 10739251.
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    74. Gmeiner WH, Cui W, Konerding DE, Keifer PA, Sharma SK, Soto AM, Marky LA, Lown JW. Shape-selective recognition of a model Okazaki fragment by geometrically-constrained bis-distamycins. J Biomol Struct Dyn. 1999 Dec; 17(3):507-18. PMID: 10636085.
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    75. Liu J, Kolath J, Anderson J, Kolar C, Lawson TA, Talmadge J, Gmeiner WH. Positive interaction between 5-FU and FdUMP[10] in the inhibition of human colorectal tumor cell proliferation. Antisense Nucleic Acid Drug Dev. 1999 Oct; 9(5):481-6. PMID: 10555156.
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    76. Liu J, Skradis A, Kolar C, Kolath J, Anderson J, Lawson T, Talmadge J, Gmeiner WH. Increased cytotoxicity and decreased in vivo toxicity of FdUMP[10] relative to 5-FU. Nucleosides Nucleotides. 1999 Aug; 18(8):1789-802. PMID: 10478484.
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    77. Engen JR, Gmeiner WH, Smithgall TE, Smith DL. Hydrogen exchange shows peptide binding stabilizes motions in Hck SH2. Biochemistry. 1999 Jul 13; 38(28):8926-35. PMID: 10413466.
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    78. Gmeiner WH, Skradis A, Pon RT, Liu J. Cytotoxicity and in-vivo tolerance of FdUMP[10]: a novel pro-drug of the TS inhibitory nucleotide FdUMP. Nucleosides Nucleotides. 1999 Jun-Jul; 18(6-7):1729-30. PMID: 10474257.
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    79. Gmeiner WH, Skradis A, Pon RT, Liu J. Cytarabine-induced destabilization and bending of a model Okazaki fragment. Nucleosides Nucleotides. 1999 Jun-Jul; 18(6-7):1577-8. PMID: 10474234.
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    80. Engen JR, Smithgall TE, Gmeiner WH, Smith DL. Comparison of SH3 and SH2 domain dynamics when expressed alone or in an SH(3+2) construct: the role of protein dynamics in functional regulation. J Mol Biol. 1999 Apr 02; 287(3):645-56. PMID: 10092465.
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    81. Gmeiner WH, Konerding D, James TL. Effect of cytarabine on the NMR structure of a model okazaki fragment from the SV40 genome. Biochemistry. 1999 Jan 26; 38(4):1166-75. PMID: 9930976.
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    82. Zhang W, Smithgall TE, Gmeiner WH. Self-association and backbone dynamics of the hck SH2 domain in the free and phosphopeptide-complexed forms. Biochemistry. 1998 May 19; 37(20):7119-26. PMID: 9585523.
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    83. Gmeiner WH, Skradis A, Pon RT, Liu J. Cytarabine-induced destabilization of a model Okazaki fragment. Nucleic Acids Res. 1998 May 15; 26(10):2359-65. PMID: 9580686.
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    84. Horita DA, Baldisseri DM, Zhang W, Altieri AS, Smithgall TE, Gmeiner WH, Byrd RA. Solution structure of the human Hck SH3 domain and identification of its ligand binding site. J Mol Biol. 1998 Apr 24; 278(1):253-65. PMID: 9571048.
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    85. Gmeiner WH. NMR spectroscopy as a tool to investigate the structural basis of anticancer drugs. Curr Med Chem. 1998 Apr; 5(2):115-35. PMID: 9481037.
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    86. Engen JR, Smithgall TE, Gmeiner WH, Smith DL. Identification and localization of slow, natural, cooperative unfolding in the hematopoietic cell kinase SH3 domain by amide hydrogen exchange and mass spectrometry. Biochemistry. 1997 Nov 25; 36(47):14384-91. PMID: 9398156.
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    87. Zhang W, Smithgall TE, Gmeiner WH. Three-dimensional structure of the Hck SH2 domain in solution. J Biomol NMR. 1997 Oct; 10(3):263-72. PMID: 9390404.
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    88. Sahasrabudhe PV, Gmeiner WH. Solution structures of 5-fluorouracil-substituted RNA duplexes containing G-U wobble base pairs. Biochemistry. 1997 May 20; 36(20):5981-91. PMID: 9166768.
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    89. Zhang W, Smithgall TE, Gmeiner WH. Sequential assignment and secondary structure determination for the Src homology 2 domain of hematopoietic cellular kinase. FEBS Lett. 1997 Apr 07; 406(1-2):131-5. PMID: 9109402.
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    90. Sahasrabudhe PV, Sun J, Gmeiner WH. The 5' stem-loop from human U4 snRNA adopts a novel conformation stabilized by G-C and G-U base pairs. J Biomol Struct Dyn. 1997 Apr; 14(5):567-77. PMID: 9130079.
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    91. Sahasrabudhe PV, Pon RT, Gmeiner WH. Solution structures of 5-fluorouracil-substituted DNA and RNA decamer duplexes. Biochemistry. 1996 Oct 22; 35(42):13597-608. PMID: 8885839.
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    92. Zhang W, Gmeiner WH. A 3D NOESY-(HCACO)NH experiment for the measurement of NOEs involving 1H alpha in 13C/15N-labeled proteins dissolved in H2O. J Biomol NMR. 1996 Oct; 8(3):357-9. PMID: 8953222.
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    93. Zhang W, Smithgall TE, Gmeiner WH. Separation of NOEs from degenerate amide protons in 13C/15N-labeled proteins using a 3D 13C'-edited NOESY-H(N)CO experiment. J Magn Reson B. 1996 Jun; 111(3):305-9. PMID: 8661298.
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    94. Zhang W, Gmeiner WH. Improved 3D gd-HCACO and gd-(H)CACO-TOCSY experiments for isotopically enriched proteins dissolved in H2O. J Biomol NMR. 1996 May; 7(3):247-50. PMID: 8785500.
      Citations:    
    95. Gmeiner WH, Facelli JC. Quantum mechanical calculations and experimental measurement of N-terminal charge effects on 1HN and 1HC alpha chemical shifts in peptides. Biopolymers. 1996 May; 38(5):573-81. PMID: 8722227.
      Citations:    
    96. Sahasrabudhe PV, Gmeiner WH. The affinity of an oligodeoxynucleotide-peptide conjugate for an RNA hairpin loop depends on stereochemistry at the DNA-peptide junction. J Biomol Struct Dyn. 1996 Feb; 13(4):585-91. PMID: 8906879.
      Citations:    
    97. Sherman SA, Gmeiner WH, Kirnarskiy L, Perini F, Ruddon RW. A linear 23-residue peptide reveals a propensity to form an unusual native-like conformation. J Biomol Struct Dyn. 1995 Dec; 13(3):441-6. PMID: 8825723.
      Citations:    
    98. Sahasrabudhe PV, Pon RT, Gmeiner WH. Effects of site-specific substitution of 5-fluorouridine on the stabilities of duplex DNA and RNA. Nucleic Acids Res. 1995 Oct 11; 23(19):3916-21. PMID: 7479036.
      Citations:    
    99. McConnell JR, Swindells S, Ong CS, Gmeiner WH, Chu WK, Brown DK, Gendelman HE. Prospective utility of cerebral proton magnetic resonance spectroscopy in monitoring HIV infection and its associated neurological impairment. AIDS Res Hum Retroviruses. 1994 Aug; 10(8):977-82. PMID: 7811549.
      Citations:    
    100. Gmeiner WH, Rayner B, Morvan F, Imbach JL, Lown JW. Structure and conformation in solution of the parallel-stranded hybrid alpha-d(CGCAATTCGC).beta-d(GCGTTAAGCG) by high-resolution 2D NMR. J Biomol NMR. 1992 May; 2(3):275-88. PMID: 1392570.
      Citations:    
    101. Gmeiner WH, Rao KE, Rayner B, Vasseur JJ, Morvan F, Imbach JL, Lown JW. Polarity of annealing and structural analysis of the RNase H resistant alpha-5'-d[TACACA].beta-5'-r[AUGUGU] hybrid determined by high-field 1H, 13C, and 31P NMR analysis. Biochemistry. 1990 Nov 13; 29(45):10329-41. PMID: 1702022.
      Citations:    
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