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Bumsoo Ahn PhD

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Gerontology & Geriatric Medicine
Address
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    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    Irene Diamond Fund Postdoctoral Transition Award     (Bumsoo Ahn)Jul 1, 2018 - Jun 30, 2020
    American Federation of Aging Research
    Unacylated ghrelin as a therapeutic strategy for age-associated skeletal muscle weakness
    Role: Principal Investigator

    K99AG064143     (AHN, BUMSOO)Feb 15, 2020 - Jan 31, 2022
    NIH
    The role of unacylated ghrelin on age-associated progressive muscle weakness and cachexia elicited by cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ahn B, Ranjit R, Kneis P, Xu H, Piekarz KM, Freeman WM, Kinter M, Richardson A, Ran Q, Brooks SV, Van Remmen H. Scavenging mitochondrial hydrogen peroxide by peroxiredoxin 3 overexpression attenuates contractile dysfunction and muscle atrophy in a murine model of accelerated sarcopenia. Aging Cell. 2022 Feb 24; e13569. PMID: 35199907.
      Citations:    
    2. Varshney R, Ranjit R, Chiao YA, Kinter M, Ahn B. Myocardial Hypertrophy and Compensatory Increase in Systolic Function in a Mouse Model of Oxidative Stress. Int J Mol Sci. 2021 Feb 18; 22(4). PMID: 33670798.
      Citations:    
    3. Su Y, Ahn B, Macpherson PCD, Ranjit R, Claflin DR, Van Remmen H, Brooks SV. Transgenic expression of SOD1 specifically in neurons of Sod1 deficient mice prevents defects in muscle mitochondrial function and calcium handling. Free Radic Biol Med. 2021 03; 165:299-311. PMID: 33561489.
      Citations:    
    4. Qaisar R, Pharaoh G, Bhaskaran S, Xu H, Ranjit R, Bian J, Ahn B, Georgescu C, Wren JD, Van Remmen H. Restoration of Sarcoplasmic Reticulum Ca2+ ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice. Int J Mol Sci. 2020 Dec 22; 22(1). PMID: 33375170.
      Citations:    
    5. Hall SE, Ahn B, Smuder AJ, Morton AB, Hinkley JM, Wiggs MP, Sollanek KJ, Hyatt H, Powers SK. Comparative Efficacy of Angiotensin II Type 1 Receptor Blockers Against Ventilator-Induced Diaphragm Dysfunction in Rats. Clin Transl Sci. 2021 03; 14(2):481-486. PMID: 33222389.
      Citations:    
    6. Brown JL, Lawrence MM, Ahn B, Kneis P, Piekarz KM, Qaisar R, Ranjit R, Bian J, Pharaoh G, Brown C, Peelor FF, Kinter MT, Miller BF, Richardson A, Van Remmen H. Cancer cachexia in a mouse model of oxidative stress. J Cachexia Sarcopenia Muscle. 2020 12; 11(6):1688-1704. PMID: 32918528.
      Citations:    
    7. Bhaskaran S, Pollock N, C Macpherson P, Ahn B, Piekarz KM, Staunton CA, Brown JL, Qaisar R, Vasilaki A, Richardson A, McArdle A, Jackson MJ, Brooks SV, Van Remmen H. Neuron-specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice. Aging Cell. 2020 10; 19(10):e13225. PMID: 32886862.
      Citations:    
    8. Ahn B, Smith N, Saunders D, Ranjit R, Kneis P, Towner RA, Van Remmen H. Using MRI to measure in vivo free radical production and perfusion dynamics in a mouse model of elevated oxidative stress and neurogenic atrophy. Redox Biol. 2019 09; 26:101308. PMID: 31470261.
      Citations:    
    9. Pharaoh G, Sataranatarajan K, Street K, Hill S, Gregston J, Ahn B, Kinter C, Kinter M, Van Remmen H. Metabolic and Stress Response Changes Precede Disease Onset in the Spinal Cord of Mutant SOD1 ALS Mice. Front Neurosci. 2019; 13:487. PMID: 31213966.
      Citations:    
    10. Smuder AJ, Morton AB, Hall SE, Wiggs MP, Ahn B, Wawrzyniak NR, Sollanek KJ, Min K, Kwon OS, Nelson WB, Powers SK. Effects of exercise preconditioning and HSP72 on diaphragm muscle function during mechanical ventilation. J Cachexia Sarcopenia Muscle. 2019 08; 10(4):767-781. PMID: 30972953.
      Citations:    
    11. Pearsall EA, Cheng R, Matsuzaki S, Zhou K, Ding L, Ahn B, Kinter M, Humphries KM, Quiambao AB, Farjo RA, Ma JX. Neuroprotective effects of PPARa in retinopathy of type 1 diabetes. PLoS One. 2019; 14(2):e0208399. PMID: 30716067.
      Citations:    
    12. Ahn B, Ranjit R, Premkumar P, Pharaoh G, Piekarz KM, Matsuzaki S, Claflin DR, Riddle K, Judge J, Bhaskaran S, Satara Natarajan K, Barboza E, Wronowski B, Kinter M, Humphries KM, Griffin TM, Freeman WM, Richardson A, Brooks SV, Van Remmen H. Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching. J Cachexia Sarcopenia Muscle. 2019 04; 10(2):411-428. PMID: 30706998.
      Citations:    
    13. Coblentz PD, Ahn B, Hayward LF, Yoo JK, Christou DD, Ferreira LF. Small-hairpin RNA and pharmacological targeting of neutral sphingomyelinase prevent diaphragm weakness in rats with heart failure and reduced ejection fraction. Am J Physiol Lung Cell Mol Physiol. 2019 04 01; 316(4):L679-L690. PMID: 30702345.
      Citations:    
    14. Morton AB, Smuder AJ, Wiggs MP, Hall SE, Ahn B, Hinkley JM, Ichinoseki-Sekine N, Huertas AM, Ozdemir M, Yoshihara T, Wawrzyniak NR, Powers SK. Increased SOD2 in the diaphragm contributes to exercise-induced protection against ventilator-induced diaphragm dysfunction. Redox Biol. 2019 01; 20:402-413. PMID: 30414534.
      Citations:    
    15. Qaisar R, Bhaskaran S, Premkumar P, Ranjit R, Natarajan KS, Ahn B, Riddle K, Claflin DR, Richardson A, Brooks SV, Van Remmen H. Oxidative stress-induced dysregulation of excitation-contraction coupling contributes to muscle weakness. J Cachexia Sarcopenia Muscle. 2018 10; 9(5):1003-1017. PMID: 30073804.
      Citations:    
    16. Ahn B, Pharaoh G, Premkumar P, Huseman K, Ranjit R, Kinter M, Szweda L, Kiss T, Fulop G, Tarantini S, Csiszar A, Ungvari Z, Van Remmen H. Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass. Redox Biol. 2018 07; 17:47-58. PMID: 29673700.
      Citations:    
    17. Sollanek KJ, Burniston JG, Kavazis AN, Morton AB, Wiggs MP, Ahn B, Smuder AJ, Powers SK. Global Proteome Changes in the Rat Diaphragm Induced by Endurance Exercise Training. PLoS One. 2017; 12(1):e0171007. PMID: 28135290.
      Citations:    
    18. Ahn B, Coblentz PD, Beharry AW, Patel N, Judge AR, Moylan JS, Hoopes CW, Bonnell MR, Ferreira LF. Diaphragm Abnormalities in Patients with End-Stage Heart Failure: NADPH Oxidase Upregulation and Protein Oxidation. Front Physiol. 2016; 7:686. PMID: 28119629.
      Citations:    
    19. Powers SK, Morton AB, Ahn B, Smuder AJ. Redox control of skeletal muscle atrophy. Free Radic Biol Med. 2016 09; 98:208-217. PMID: 26912035.
      Citations:    
    20. Laitano O, Ahn B, Patel N, Coblentz PD, Smuder AJ, Yoo JK, Christou DD, Adhihetty PJ, Ferreira LF. Pharmacological targeting of mitochondrial reactive oxygen species counteracts diaphragm weakness in chronic heart failure. J Appl Physiol (1985). 2016 Apr 01; 120(7):733-42. PMID: 26846552.
      Citations:    
    21. Ahn B, Beharry AW, Frye GS, Judge AR, Ferreira LF. NAD(P)H oxidase subunit p47phox is elevated, and p47phox knockout prevents diaphragm contractile dysfunction in heart failure. Am J Physiol Lung Cell Mol Physiol. 2015 Sep 01; 309(5):L497-505. PMID: 26209274.
      Citations:    
    22. Bost ER, Frye GS, Ahn B, Ferreira LF. Diaphragm dysfunction caused by sphingomyelinase requires the p47(phox) subunit of NADPH oxidase. Respir Physiol Neurobiol. 2015 Jan 01; 205:47-52. PMID: 25448394.
      Citations:    
    23. Ahn B, Beaver T, Martin T, Hess P, Brumback BA, Ahmed S, Smith BK, Leeuwenburgh C, Martin AD, Ferreira LF. Phrenic nerve stimulation increases human diaphragm fiber force after cardiothoracic surgery. Am J Respir Crit Care Med. 2014 Oct 01; 190(7):837-9. PMID: 25271750.
      Citations:    
    24. Roberts BM, Frye GS, Ahn B, Ferreira LF, Judge AR. Cancer cachexia decreases specific force and accelerates fatigue in limb muscle. Biochem Biophys Res Commun. 2013 Jun 07; 435(3):488-92. PMID: 23673294.
      Citations:    
    25. Senf SM, Howard TM, Ahn B, Ferreira LF, Judge AR. Loss of the inducible Hsp70 delays the inflammatory response to skeletal muscle injury and severely impairs muscle regeneration. PLoS One. 2013; 8(4):e62687. PMID: 23626847.
      Citations:    
    26. Ahn B, Empinado HM, Al-Rajhi M, Judge AR, Ferreira LF. Diaphragm atrophy and contractile dysfunction in a murine model of pulmonary hypertension. PLoS One. 2013; 8(4):e62702. PMID: 23614054.
      Citations:    
    27. Roberts BM, Ahn B, Smuder AJ, Al-Rajhi M, Gill LC, Beharry AW, Powers SK, Fuller DD, Ferreira LF, Judge AR. Diaphragm and ventilatory dysfunction during cancer cachexia. FASEB J. 2013 Jul; 27(7):2600-10. PMID: 23515443.
      Citations:    
    28. Ahn B, McMurray R, Harrell J. Scaling of VO2max and its relationship with insulin resistance in children. Pediatr Exerc Sci. 2013 Feb; 25(1):43-51. PMID: 23406706.
      Citations:    
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