"Properdin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It stabilizes the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) and protects it from rapid inactivation, thus facilitating the cascade of COMPLEMENT ACTIVATION and the formation of MEMBRANE ATTACK COMPLEX. Individuals with mutation in the PFC gene exhibit properdin deficiency and have a high susceptibility to infections.
| Descriptor ID |
D011414
|
| MeSH Number(s) |
D12.776.124.486.274.965 D12.776.124.486.789 D12.776.124.790.223.624 D12.776.377.715.182.624
|
| Concept/Terms |
Properdin- Properdin
- Complement Factor P
- Factor P, Complement
|
Below are MeSH descriptors whose meaning is more general than "Properdin".
Below are MeSH descriptors whose meaning is more specific than "Properdin".
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Below are the most recent publications written about "Properdin" by people in Profiles.