"Complement C1r" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 80-kDa subcomponent of complement C1, existing as a SERINE PROTEASE proenzyme in the intact complement C1 complex. When COMPLEMENT C1Q is bound to antibodies, the changed tertiary structure causes autolytic activation of complement C1r which is cleaved into two chains, A (heavy) and B (light, the serine protease), connected by disulfide bonds. The activated C1r serine protease, in turn, activates COMPLEMENT C1S proenzyme by cleaving the Arg426-Ile427 bond. No fragment is released when either C1r or C1s is cleaved.
| Descriptor ID |
D015923
|
| MeSH Number(s) |
D08.811.277.300.280 D12.776.124.486.274.045.280 D12.776.124.486.274.050.280
|
| Concept/Terms |
Complement C1r- Complement C1r
- C1r, Complement
- Complement 1r
- Complement Component 1r
- Component 1r, Complement
- C1r Complement
- Complement, C1r
|
Below are MeSH descriptors whose meaning is more general than "Complement C1r".
Below are MeSH descriptors whose meaning is more specific than "Complement C1r".
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