Abnormalities in the development of the CEREBRAL CORTEX. These include malformations arising from abnormal neuronal CELL PROLIFERATION or APOPTOSIS; abnormal neuronal migration; and abnormal establishment of cortical organization via neurite extension, synaptogenesis, or neuronal maturation. As well as mutations effecting these developmental processes directly, there are a variety of inborn metabolic errors, such as PEROXISOMAL DISORDERS and mitochondrial and pyruvate metabolic disorders which effect them secondarily and also exhibit these malformations. They are common causes of EPILEPSY and developmental delay and are often a component of multiple congenital anomalies.

Descriptor ID	D054220
MeSH Number(s)	C10.500.507 C16.131.666.507
Concept/Terms	Malformations of Cortical Development Malformations of Cortical Development Cortical Development Malformation Cortical Development Malformations Development Malformation, Cortical Development Malformations, Cortical Malformations of Cerebral Cortex Development Hemimegalencephaly Hemimegalencephaly Hemimegalencephalies Schizencephaly Schizencephaly Schizencephalies Cortical Dysplasia Cortical Dysplasia Cortical Dysplasias Dysplasia, Cortical Dysplasias, Cortical Cortical Dysplasia, Cerebral Cerebral Cortical Dysplasias Cortical Dysplasias, Cerebral Dysplasia, Cerebral Cortical Dysplasias, Cerebral Cortical Cerebral Cortical Dysplasia Polymicrogyria Polymicrogyria Polymicrogyrias

Below are MeSH descriptors whose meaning is more general than "Malformations of Cortical Development".

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