An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)

Descriptor ID	D007968
MeSH Number(s)	C02.182.500.300.500 C02.256.721.500 C02.290.575 C02.839.550 C10.228.140.695.750 C10.228.228.210.150.300.500 C10.228.228.245.340.575 C10.228.518.750 C10.314.450
Concept/Terms	Leukoencephalopathy, Progressive Multifocal Leukoencephalopathy, Progressive Multifocal Leukoencephalopathies, Progressive Multifocal Multifocal Leukoencephalopathies, Progressive Multifocal Leukoencephalopathy, Progressive Progressive Multifocal Leukoencephalopathies JC Polyomavirus Encephalopathy Encephalopathies, JC Polyomavirus Encephalopathy, JC Polyomavirus Progressive Multifocal Leukoencephalopathy Encephalitis, JC Polyomavirus JC Polyomavirus Encephalitis

Below are MeSH descriptors whose meaning is more general than "Leukoencephalopathy, Progressive Multifocal".

Below are MeSH descriptors whose meaning is related to "Leukoencephalopathy, Progressive Multifocal".

Below are MeSH descriptors whose meaning is more specific than "Leukoencephalopathy, Progressive Multifocal".