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Clinical and Translational Science Institute

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Last Name

Reto Herbert Rudolf Asmis, Ph.D.

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine - Molecular Medicine
Address
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    Other Positions
    TitleAssociate Director
    InstitutionWake Forest School of Medicine
    DepartmentCenter for Precision Medicine


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Nguyen HN, Ahn YJ, Medina EA, Asmis R. Dietary 23-hydroxy ursolic acid protects against atherosclerosis and obesity by preventing dyslipidemia-induced monocyte priming and dysfunction. Atherosclerosis. 2018 Aug; 275:333-341. PMID: 30015296.
      View in: PubMed
    2. Guo J, Kim HS, Asmis R, Ludueña RF. Interactions of ß tubulin isotypes with glutathione in differentiated neuroblastoma cells subject to oxidative stress. Cytoskeleton (Hoboken). 2018 Jul; 75(7):283-289. PMID: 29663696.
      View in: PubMed
    3. Akhtar F, Rouse CA, Catano G, Montalvo M, Ullevig SL, Asmis R, Kharbanda K, Maffi SK. Acute maternal oxidant exposure causes susceptibility of the fetal brain to inflammation and oxidative stress. J Neuroinflammation. 2017 Sep 30; 14(1):195. PMID: 28962577.
      View in: PubMed
    4. Short JD, Tavakoli S, Nguyen HN, Carrera A, Farnen C, Cox LA, Asmis R. Dyslipidemic Diet-Induced Monocyte "Priming" and Dysfunction in Non-Human Primates Is Triggered by Elevated Plasma Cholesterol and Accompanied by Altered Histone Acetylation. Front Immunol. 2017; 8:958. PMID: 28878765.
      View in: PubMed
    5. Asmis R, Downs K, Tavakoli S, Short J, Nguyen HN. Monocytic glutaredoxin 1 protects mice against obesity, hyperglycemia and atherosclerosis. Atherosclerosis. 2017 Aug; 263:e13. PMID: 29365523.
      View in: PubMed
    6. Tavakoli S, Downs K, Short JD, Nguyen HN, Lai Y, Jerabek PA, Goins B, Toczek J, Sadeghi MM, Asmis R. Characterization of Macrophage Polarization States Using Combined Measurement of 2-Deoxyglucose and Glutamine Accumulation: Implications for Imaging of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2017 10; 37(10):1840-1848. PMID: 28798141.
      View in: PubMed
    7. Jahrling JB, Lin AL, DeRosa N, Hussong SA, Van Skike CE, Girotti M, Javors M, Zhao Q, Maslin LA, Asmis R, Galvan V. mTOR drives cerebral blood flow and memory deficits in LDLR-/- mice modeling atherosclerosis and vascular cognitive impairment. J Cereb Blood Flow Metab. 2018 01; 38(1):58-74. PMID: 28511572.
      View in: PubMed
    8. Kim HS, Asmis R. Mitogen-activated protein kinase phosphatase 1 (MKP-1) in macrophage biology and cardiovascular disease. A redox-regulated master controller of monocyte function and macrophage phenotype. Free Radic Biol Med. 2017 08; 109:75-83. PMID: 28330703.
      View in: PubMed
    9. Tavakoli S, Short JD, Downs K, Nguyen HN, Lai Y, Zhang W, Jerabek P, Goins B, Sadeghi MM, Asmis R. Differential Regulation of Macrophage Glucose Metabolism by Macrophage Colony-stimulating Factor and Granulocyte-Macrophage Colony-stimulating Factor: Implications for 18F FDG PET Imaging of Vessel Wall Inflammation. Radiology. 2017 04; 283(1):87-97. PMID: 27849433.
      View in: PubMed
    10. Kim HS, Tavakoli S, Piefer LA, Nguyen HN, Asmis R. Monocytic MKP-1 is a Sensor of the Metabolic Environment and Regulates Function and Phenotypic Fate of Monocyte-Derived Macrophages in Atherosclerosis. Sci Rep. 2016 09 27; 6:34223. PMID: 27670844.
      View in: PubMed
    11. Asmis R. Monocytes and Macrophages: A Fresh Look at Functional and Phenotypic Diversity. Antioxid Redox Signal. 2016 11 10; 25(14):756-757. PMID: 27488399.
      View in: PubMed
    12. Moritz RJ, LeBaron RG, Phelix CF, Rupaimoole R, Kim HS, Tsin A, Asmis R. Macrophage TGF-ß1 and the Proapoptotic Extracellular Matrix Protein BIGH3 Induce Renal Cell Apoptosis in Prediabetic and Diabetic Conditions. Int J Clin Med. 2016 Jul; 7(7):496-510. PMID: 28149671.
      View in: PubMed
    13. Short JD, Downs K, Tavakoli S, Asmis R. Protein Thiol Redox Signaling in Monocytes and Macrophages. Antioxid Redox Signal. 2016 11 20; 25(15):816-835. PMID: 27288099.
      View in: PubMed
    14. Ullevig SL, Kim HS, Short JD, Tavakoli S, Weintraub ST, Downs K, Asmis R. Protein S-Glutathionylation Mediates Macrophage Responses to Metabolic Cues from the Extracellular Environment. Antioxid Redox Signal. 2016 11 20; 25(15):836-851. PMID: 26984580.
      View in: PubMed
    15. Halaney DL, Zahedivash A, Phipps JE, Wang T, Dwelle J, Saux CJ, Asmis R, Milner TE, Feldman MD. Differences in forward angular light scattering distributions between M1 and M2 macrophages. J Biomed Opt. 2015 Nov; 20(11):115002. PMID: 26538329.
      View in: PubMed
    16. Mondragon AA, Betts-Obregon BS, Moritz RJ, Parvathaneni K, Navarro MM, Kim HS, Lee CF, LeBaron RG, Asmis R, Tsin AT. BIGH3 protein and macrophages in retinal endothelial cell apoptosis. Apoptosis. 2015 Jan; 20(1):29-37. PMID: 25378215.
      View in: PubMed
    17. Phipps JE, Vela D, Hoyt T, Halaney DL, Mancuso JJ, Buja LM, Asmis R, Milner TE, Feldman MD. Macrophages and intravascular OCT bright spots: a quantitative study. JACC Cardiovasc Imaging. 2015 Jan; 8(1):63-72. PMID: 25499133.
      View in: PubMed
    18. Barman SA, Chen F, Su Y, Dimitropoulou C, Wang Y, Catravas JD, Han W, Orfi L, Szantai-Kis C, Keri G, Szabadkai I, Barabutis N, Rafikova O, Rafikov R, Black SM, Jonigk D, Giannis A, Asmis R, Stepp DW, Ramesh G, Fulton DJ. NADPH oxidase 4 is expressed in pulmonary artery adventitia and contributes to hypertensive vascular remodeling. Arterioscler Thromb Vasc Biol. 2014 Aug; 34(8):1704-15. PMID: 24947524.
      View in: PubMed
    19. Kim HS, Ullevig SL, Nguyen HN, Vanegas D, Asmis R. Redox regulation of 14-3-3? controls monocyte migration. Arterioscler Thromb Vasc Biol. 2014 Jul; 34(7):1514-21. PMID: 24812321.
      View in: PubMed
    20. Ullevig SL, Kim HS, Nguyen HN, Hambright WS, Robles AJ, Tavakoli S, Asmis R. Ursolic acid protects monocytes against metabolic stress-induced priming and dysfunction by preventing the induction of Nox4. Redox Biol. 2014; 2:259-66. PMID: 24494201.
      View in: PubMed
    21. Tavakoli S, Zamora D, Ullevig S, Asmis R. Bioenergetic profiles diverge during macrophage polarization: implications for the interpretation of 18F-FDG PET imaging of atherosclerosis. J Nucl Med. 2013 Sep; 54(9):1661-7. PMID: 23886729.
      View in: PubMed
    22. Ullevig S, Kim HS, Asmis R. S-glutathionylation in monocyte and macrophage (dys)function. Int J Mol Sci. 2013 Jul 24; 14(8):15212-32. PMID: 23887649.
      View in: PubMed
    23. Lee CF, Ullevig S, Kim HS, Asmis R. Regulation of Monocyte Adhesion and Migration by Nox4. PLoS One. 2013; 8(6):e66964. PMID: 23825596.
      View in: PubMed
    24. Howard MA, Asmis R, Evans KK, Mustoe TA. Oxygen and wound care: a review of current therapeutic modalities and future direction. Wound Repair Regen. 2013 Jul-Aug; 21(4):503-11. PMID: 23756299.
      View in: PubMed
    25. Kim HS, Ullevig SL, Zamora D, Lee CF, Asmis R. Redox regulation of MAPK phosphatase 1 controls monocyte migration and macrophage recruitment. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):E2803-12. PMID: 22991462.
      View in: PubMed
    26. Jenkins JT, Halaney DL, Sokolov KV, Ma LL, Shipley HJ, Mahajan S, Louden CL, Asmis R, Milner TE, Johnston KP, Feldman MD. Excretion and toxicity of gold-iron nanoparticles. Nanomedicine. 2013 Apr; 9(3):356-65. PMID: 22960192.
      View in: PubMed
    27. Liu M, Xiang R, Wilk SA, Zhang N, Sloane LB, Azarnoush K, Zhou L, Chen H, Xiang G, Walter CA, Austad SN, Musi N, DeFronzo RA, Asmis R, Scherer PE, Dong LQ, Liu F. Fat-specific DsbA-L overexpression promotes adiponectin multimerization and protects mice from diet-induced obesity and insulin resistance. Diabetes. 2012 Nov; 61(11):2776-86. PMID: 22807031.
      View in: PubMed
    28. Khandelwal AR, Hebert VY, Kleinedler JJ, Rogers LK, Ullevig SL, Asmis R, Shi R, Dugas TR. Resveratrol and quercetin interact to inhibit neointimal hyperplasia in mice with a carotid injury. J Nutr. 2012 Aug; 142(8):1487-94. PMID: 22718033.
      View in: PubMed
    29. Tavakoli S, Asmis R. Reactive oxygen species and thiol redox signaling in the macrophage biology of atherosclerosis. Antioxid Redox Signal. 2012 Dec 15; 17(12):1785-95. PMID: 22540532.
      View in: PubMed
    30. Wang T, Mancuso JJ, Sapozhnikova V, Dwelle J, Ma LL, Willsey B, Kazmi SM, Qiu J, Li X, Asmis R, Johnston KP, Feldman MD, Milner TE. Dual-wavelength multifrequency photothermal wave imaging combined with optical coherence tomography for macrophage and lipid detection in atherosclerotic plaques using gold nanoparticles. J Biomed Opt. 2012 Mar; 17(3):036009. PMID: 22502567.
      View in: PubMed
    31. Sapozhnikova V, Willsey B, Asmis R, Wang T, Jenkins JT, Mancuso J, Ma LL, Kuranov R, Milner TE, Johnston K, Feldman MD. Use of near-infrared luminescent gold nanoclusters for detection of macrophages. J Biomed Opt. 2012 Feb; 17(2):026006. PMID: 22463038.
      View in: PubMed
    32. Ullevig S, Zhao Q, Lee CF, Seok Kim H, Zamora D, Asmis R. NADPH oxidase 4 mediates monocyte priming and accelerated chemotaxis induced by metabolic stress. Arterioscler Thromb Vasc Biol. 2012 Feb; 32(2):415-26. PMID: 22095986.
      View in: PubMed
    33. Ullevig SL, Zhao Q, Zamora D, Asmis R. Ursolic acid protects diabetic mice against monocyte dysfunction and accelerated atherosclerosis. Atherosclerosis. 2011 Dec; 219(2):409-16. PMID: 21752377.
      View in: PubMed
    34. Asmis R. "Topical" HDL for vein grafts: a new solution to an old problem? Atherosclerosis. 2011 Feb; 214(2):259-60. PMID: 21146819.
      View in: PubMed
    35. Asmis R, Qiao M, Zhao Q. Low flow oxygenation of full-excisional skin wounds on diabetic mice improves wound healing by accelerating wound closure and reepithelialization. Int Wound J. 2010 Oct; 7(5):349-57. PMID: 20659184.
      View in: PubMed
    36. Thompson JS, Asmis R, Tapp AA, Nelson B, Chu Y, Glass J, Moneyhon M, Brown SA. Pyrrolidine dithiocarbamate (PDTC) blocks apoptosis and promotes ionizing radiation-induced necrosis of freshly-isolated normal mouse spleen cells. Apoptosis. 2010 Jun; 15(6):705-14. PMID: 20333468.
      View in: PubMed
    37. Lee CF, Qiao M, Schröder K, Zhao Q, Asmis R. Nox4 is a novel inducible source of reactive oxygen species in monocytes and macrophages and mediates oxidized low density lipoprotein-induced macrophage death. Circ Res. 2010 May 14; 106(9):1489-97. PMID: 20360249.
      View in: PubMed
    38. Ma LL, Feldman MD, Tam JM, Paranjape AS, Cheruku KK, Larson TA, Tam JO, Ingram DR, Paramita V, Villard JW, Jenkins JT, Wang T, Clarke GD, Asmis R, Sokolov K, Chandrasekar B, Milner TE, Johnston KP. Small multifunctional nanoclusters (nanoroses) for targeted cellular imaging and therapy. ACS Nano. 2009 Sep 22; 3(9):2686-96. PMID: 19711944.
      View in: PubMed
    39. Qiao M, Zhao Q, Lee CF, Tannock LR, Smart EJ, LeBaron RG, Phelix CF, Rangel Y, Asmis R. Thiol oxidative stress induced by metabolic disorders amplifies macrophage chemotactic responses and accelerates atherogenesis and kidney injury in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol. 2009 Nov; 29(11):1779-86. PMID: 19592463.
      View in: PubMed
    40. Zamilpa R, Rupaimoole R, Phelix CF, Somaraki-Cormier M, Haskins W, Asmis R, LeBaron RG. C-terminal fragment of transforming growth factor beta-induced protein (TGFBIp) is required for apoptosis in human osteosarcoma cells. Matrix Biol. 2009 Jul; 28(6):347-53. PMID: 19505574.
      View in: PubMed
    41. Asmis LM, Asmis R, Sulzer I, Furlan M, Lämmle B. Contact system activation in human sepsis - 47kD HK, a marker of sepsis severity? Swiss Med Wkly. 2008 Mar 08; 138(9-10):142-9. PMID: 18330734.
      View in: PubMed
    42. Rutkute K, Asmis RH, Nikolova-Karakashian MN. Regulation of neutral sphingomyelinase-2 by GSH: a new insight to the role of oxidative stress in aging-associated inflammation. J Lipid Res. 2007 Nov; 48(11):2443-52. PMID: 17693623.
      View in: PubMed
    43. Qiao M, Kisgati M, Cholewa JM, Zhu W, Smart EJ, Sulistio MS, Asmis R. Increased expression of glutathione reductase in macrophages decreases atherosclerotic lesion formation in low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol. 2007 Jun; 27(6):1375-82. PMID: 17363688.
      View in: PubMed
    44. Kisgati M, Asmis R. Generation of retroviruses for the overexpression of cytosolic and mitochondrial glutathione reductase in macrophages in vivo. Cytotechnology. 2007 May; 54(1):5-14. PMID: 19003013.
      View in: PubMed
    45. Fanti P, Asmis R, Stephenson TJ, Sawaya BP, Franke AA. Positive effect of dietary soy in ESRD patients with systemic inflammation--correlation between blood levels of the soy isoflavones and the acute-phase reactants. Nephrol Dial Transplant. 2006 Aug; 21(8):2239-46. PMID: 16766544.
      View in: PubMed
    46. Wang Y, Qiao M, Mieyal JJ, Asmis LM, Asmis R. Molecular mechanism of glutathione-mediated protection from oxidized low-density lipoprotein-induced cell injury in human macrophages: role of glutathione reductase and glutaredoxin. Free Radic Biol Med. 2006 Sep 01; 41(5):775-85. PMID: 16895798.
      View in: PubMed
    47. Asmis R, Qiao M, Rossi RR, Cholewa J, Xu L, Asmis LM. Adriamycin promotes macrophage dysfunction in mice. Free Radic Biol Med. 2006 Jul 01; 41(1):165-74. PMID: 16781464.
      View in: PubMed
    48. Li XA, Guo L, Asmis R, Nikolova-Karakashian M, Smart EJ. Scavenger receptor BI prevents nitric oxide-induced cytotoxicity and endotoxin-induced death. Circ Res. 2006 Apr 14; 98(7):e60-5. PMID: 16574909.
      View in: PubMed
    49. Thompson JS, Asmis R, Glass J, Liu H, Wilson C, Nelson B, Brown SA, Stromberg AJ. P53 status influences regulation of HSPs and ribosomal proteins by PDTC and radiation. Biochem Biophys Res Commun. 2006 May 05; 343(2):435-42. PMID: 16546138.
      View in: PubMed
    50. Asmis R, Wang Y, Xu L, Kisgati M, Begley JG, Mieyal JJ. A novel thiol oxidation-based mechanism for adriamycin-induced cell injury in human macrophages. FASEB J. 2005 Nov; 19(13):1866-8. PMID: 16160061.
      View in: PubMed
    51. Asmis R, Begley JG, Jelk J, Everson WV. Lipoprotein aggregation protects human monocyte-derived macrophages from OxLDL-induced cytotoxicity. J Lipid Res. 2005 Jun; 46(6):1124-32. PMID: 15772426.
      View in: PubMed
    52. Li XA, Guo L, Dressman JL, Asmis R, Smart EJ. A novel ligand-independent apoptotic pathway induced by scavenger receptor class B, type I and suppressed by endothelial nitric-oxide synthase and high density lipoprotein. J Biol Chem. 2005 May 13; 280(19):19087-96. PMID: 15749707.
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    53. Zhao Z, de Beer MC, Cai L, Asmis R, de Beer FC, de Villiers WJ, van der Westhuyzen DR. Low-density lipoprotein from apolipoprotein E-deficient mice induces macrophage lipid accumulation in a CD36 and scavenger receptor class A-dependent manner. Arterioscler Thromb Vasc Biol. 2005 Jan; 25(1):168-73. PMID: 15514202.
      View in: PubMed
    54. Romerio SC, Linder L, Nyfeler J, Wenk M, Litynsky P, Asmis R, Haefeli WE. Acute hyperhomocysteinemia decreases NO bioavailability in healthy adults. Atherosclerosis. 2004 Oct; 176(2):337-44. PMID: 15380457.
      View in: PubMed
    55. Asmis R, Begley JG. Oxidized LDL promotes peroxide-mediated mitochondrial dysfunction and cell death in human macrophages: a caspase-3-independent pathway. Circ Res. 2003 Jan 10; 92(1):e20-9. PMID: 12522131.
      View in: PubMed
    56. Hojo Y, Saito Y, Tanimoto T, Hoefen RJ, Baines CP, Yamamoto K, Haendeler J, Asmis R, Berk BC. Fluid shear stress attenuates hydrogen peroxide-induced c-Jun NH2-terminal kinase activation via a glutathione reductase-mediated mechanism. Circ Res. 2002 Oct 18; 91(8):712-8. PMID: 12386148.
      View in: PubMed
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