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Clinical and Translational Science Institute

Last Name

Jason M. Grayson, Ph.D.

TitleAssociate Professor
InstitutionWake Forest School of Medicine
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    Collapse Research 
    Collapse research activities and funding
    F32AI010249     (GRAYSON, JASON M)Aug 1, 1999
    Role: Principal Investigator

    R01AI068952     (GRAYSON, JASON MITCHELL)Apr 1, 2008 - Mar 30, 2014
    Redox control of CD8 T cell proliferation, differentiation and death
    Role: Principal Investigator

    R56AI073571     (GRAYSON, JASON MITCHELL)Mar 1, 2010 - Feb 28, 2012
    Mechanisms of CD8+ T Cell Apoptosis During Acute and Chronic Viral Infections
    Role: Principal Investigator

    R03AI109224     (GRAYSON, JASON MITCHELL)Jul 10, 2014 - Jun 30, 2016
    Repurposed Drugs to Inhibit Human T Cells and Autoimmunity
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Liu M, Barton ES, Jennings RN, Oldenburg DG, Whirry JM, White DW, Grayson JM. Unsupervised learning techniques reveal heterogeneity in memory CD8+ T cell differentiation following acute, chronic and latent viral infections. Virology. 2017 09; 509:266-279. PMID: 28689040.
      View in: PubMed
    2. Dean TC, Yang M, Liu M, Grayson JM, DeMartino AW, Day CS, Lee J, Furdui CM, Bierbach U. Human Serum Albumin-Delivered [Au(PEt3)]+ Is a Potent Inhibitor of T Cell Proliferation. ACS Med Chem Lett. 2017 May 11; 8(5):572-576. PMID: 28523113.
      View in: PubMed
    3. McIver ZA, Grayson JM, Coe BN, Hill JE, Schamerhorn GA, Ohulchanskyy TY, Linder MK, Davies KS, Weiner RS, Detty MR. Targeting T Cell Bioenergetics by Modulating P-Glycoprotein Selectively Depletes Alloreactive T Cells To Prevent Graft-versus-Host Disease. J Immunol. 2016 09 01; 197(5):1631-41. PMID: 27456485; PMCID: PMC4992642 [Available on 09/01/17].
    4. McIver ZA, Kryman MW, Choi Y, Coe BN, Schamerhorn GA, Linder MK, Davies KS, Hill JE, Sawada GA, Grayson JM, Detty MR. Selective photodepletion of malignant T cells in extracorporeal photopheresis with selenorhodamine photosensitizers. Bioorg Med Chem. 2016 09 01; 24(17):3918-3931. PMID: 27301678.
      View in: PubMed
    5. Langston PK, Yang M, Bierbach U, Parsonage D, Poole LB, Price MJ, Grayson JM. Au-ACRAMTU-PEt3 Alters Redox Balance To Inhibit T Cell Proliferation and Function. J Immunol. 2015 Sep 01; 195(5):1984-94. PMID: 26209624; PMCID: PMC4854305.
    6. Grieves JL, Fye JM, Harvey S, Grayson JM, Hollis T, Perrino FW. Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease. Proc Natl Acad Sci U S A. 2015 Apr 21; 112(16):5117-22. PMID: 25848017; PMCID: PMC4413332.
    7. Jennings RN, Grayson JM, Barton ES. Type I interferon signaling enhances CD8+ T cell effector function and differentiation during murine gammaherpesvirus 68 infection. J Virol. 2014 Dec; 88(24):14040-9. PMID: 25253356; PMCID: PMC4249115.
    8. Barton ES, Rajkarnikar S, Langston PK, Price MJ, Grayson JM. Gammaherpesvirus latency differentially impacts the generation of primary versus secondary memory CD8+ T cells during subsequent infection. J Virol. 2014 Nov; 88(21):12740-51. PMID: 25142586; PMCID: PMC4248948.
    9. Lykken JM, DiLillo DJ, Weimer ET, Roser-Page S, Heise MT, Grayson JM, Weitzmann MN, Tedder TF. Acute and chronic B cell depletion disrupts CD4+ and CD8+ T cell homeostasis and expansion during acute viral infection in mice. J Immunol. 2014 Jul 15; 193(2):746-56. PMID: 24928986; PMCID: PMC4290158.
    10. Pellom ST, Michalek RD, Crump KE, Langston PK, Juneau DG, Grayson JM. Increased cell surface free thiols identify effector CD8+ T cells undergoing T cell receptor stimulation. PLoS One. 2013; 8(11):e81134. PMID: 24236211; PMCID: PMC3827480.
    11. Gorentla BK, Krishna S, Shin J, Inoue M, Shinohara ML, Grayson JM, Fukunaga R, Zhong XP. Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis. J Immunol. 2013 Feb 01; 190(3):1026-37. PMID: 23269249; PMCID: PMC3552100.
    12. Crump KE, Langston PK, Rajkarnikar S, Grayson JM. Antioxidant treatment regulates the humoral immune response during acute viral infection. J Virol. 2013 Mar; 87(5):2577-86. PMID: 23255789; PMCID: PMC3571411.
    13. Michalek RD, Crump KE, Weant AE, Hiltbold EM, Juneau DG, Moon EY, Yu DY, Poole LB, Grayson JM. Peroxiredoxin II regulates effector and secondary memory CD8+ T cell responses. J Virol. 2012 Dec; 86(24):13629-41. PMID: 23055551; PMCID: PMC3503052.
    14. Crump KE, Juneau DG, Poole LB, Haas KM, Grayson JM. The reversible formation of cysteine sulfenic acid promotes B-cell activation and proliferation. Eur J Immunol. 2012 Aug; 42(8):2152-64. PMID: 22674013.
      View in: PubMed
    15. Amoah S, Yammani RD, Grayson JM, Alexander-Miller MA. Changes in functional but not structural avidity during differentiation of CD8+ effector cells in vivo after virus infection. J Immunol. 2012 Jul 15; 189(2):638-45. PMID: 22706075; PMCID: PMC3397685.
    16. Tang S, Moore ML, Grayson JM, Dubey P. Increased CD8+ T-cell function following castration and immunization is countered by parallel expansion of regulatory T cells. Cancer Res. 2012 Apr 15; 72(8):1975-85. PMID: 22374980; PMCID: PMC3690568.
    17. Shin J, O'Brien TF, Grayson JM, Zhong XP. Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases. J Immunol. 2012 Mar 01; 188(5):2111-7. PMID: 22271650; PMCID: PMC3288785.
    18. Weant AE, Michalek RD, Crump KE, Liu C, Konopitski AP, Grayson JM. Defects in apoptosis increase memory CD8+ T cells following infection of Bim-/-Faslpr/lpr mice. Cell Immunol. 2011; 271(2):256-66. PMID: 21839428; PMCID: PMC3196032.
    19. Bates JT, Graff AH, Phipps JP, Grayson JM, Mizel SB. Enhanced antigen processing of flagellin fusion proteins promotes the antigen-specific CD8+ T cell response independently of TLR5 and MyD88. J Immunol. 2011 Jun 01; 186(11):6255-62. PMID: 21515787; PMCID: PMC3743533.
    20. Wilhelm AJ, Zabalawi M, Owen JS, Shah D, Grayson JM, Major AS, Bhat S, Gibbs DP, Thomas MJ, Sorci-Thomas MG. Apolipoprotein A-I modulates regulatory T cells in autoimmune LDLr-/-, ApoA-I-/- mice. J Biol Chem. 2010 Nov 12; 285(46):36158-69. PMID: 20833724; PMCID: PMC2975238.
    21. Henry CJ, Grayson JM, Brzoza-Lewis KL, Mitchell LM, Westcott MM, Cook AS, Hiltbold EM. The roles of IL-12 and IL-23 in CD8+ T cell-mediated immunity against Listeria monocytogenes: Insights from a DC vaccination model. Cell Immunol. 2010; 264(1):23-31. PMID: 20483409.
      View in: PubMed
    22. Pendergrass KD, Gwathmey TM, Michalek RD, Grayson JM, Chappell MC. The angiotensin II-AT1 receptor stimulates reactive oxygen species within the cell nucleus. Biochem Biophys Res Commun. 2009 Jun 26; 384(2):149-54. PMID: 19409874; PMCID: PMC2688692.
    23. Wilhelm AJ, Zabalawi M, Grayson JM, Weant AE, Major AS, Owen J, Bharadwaj M, Walzem R, Chan L, Oka K, Thomas MJ, Sorci-Thomas MG. Apolipoprotein A-I and its role in lymphocyte cholesterol homeostasis and autoimmunity. Arterioscler Thromb Vasc Biol. 2009 Jun; 29(6):843-9. PMID: 19286630; PMCID: PMC2761013.
    24. Michalek RD, Pellom ST, Holbrook BC, Grayson JM. The requirement of reactive oxygen intermediates for lymphocytic choriomeningitis virus binding and growth. Virology. 2008 Sep 30; 379(2):205-12. PMID: 18691729; PMCID: PMC2615401.
    25. Weant AE, Michalek RD, Khan IU, Holbrook BC, Willingham MC, Grayson JM. Apoptosis regulators Bim and Fas function concurrently to control autoimmunity and CD8+ T cell contraction. Immunity. 2008 Feb; 28(2):218-30. PMID: 18275832.
      View in: PubMed
    26. Michalek RD, Nelson KJ, Holbrook BC, Yi JS, Stridiron D, Daniel LW, Fetrow JS, King SB, Poole LB, Grayson JM. The requirement of reversible cysteine sulfenic acid formation for T cell activation and function. J Immunol. 2007 Nov 15; 179(10):6456-67. PMID: 17982034.
      View in: PubMed
    27. Constantin CM, Masopust D, Gourley T, Grayson J, Strickland OL, Ahmed R, Bonney EA. Normal establishment of virus-specific memory CD8 T cell pool following primary infection during pregnancy. J Immunol. 2007 Oct 01; 179(7):4383-9. PMID: 17878333.
      View in: PubMed
    28. Grayson JM, Weant AE, Holbrook BC, Hildeman D. Role of Bim in regulating CD8+ T-cell responses during chronic viral infection. J Virol. 2006 Sep; 80(17):8627-38. PMID: 16912311; PMCID: PMC1563887.
    29. Yi JS, Holbrook BC, Michalek RD, Laniewski NG, Grayson JM. Electron transport complex I is required for CD8+ T cell function. J Immunol. 2006 Jul 15; 177(2):852-62. PMID: 16818739.
      View in: PubMed
    30. Gamero AM, Potla R, Wegrzyn J, Szelag M, Edling AE, Shimoda K, Link DC, Dulak J, Baker DP, Tanabe Y, Grayson JM, Larner AC. Activation of Tyk2 and Stat3 is required for the apoptotic actions of interferon-beta in primary pro-B cells. J Biol Chem. 2006 Jun 16; 281(24):16238-44. PMID: 16601124.
      View in: PubMed
    31. Grayson JM, Laniewski NG, Holbrook BC. Partial reconstitution of virus-specific memory CD8+ T cells following whole body gamma-irradiation. Virology. 2006 Apr 25; 348(1):47-56. PMID: 16448681.
      View in: PubMed
    32. Laniewski NG, Grayson JM. Antioxidant treatment reduces expansion and contraction of antigen-specific CD8+ T cells during primary but not secondary viral infection. J Virol. 2004 Oct; 78(20):11246-57. PMID: 15452243; PMCID: PMC521823.
    33. Singh A, Svaren J, Grayson J, Suresh M. CD8 T cell responses to lymphocytic choriomeningitis virus in early growth response gene 1-deficient mice. J Immunol. 2004 Sep 15; 173(6):3855-62. PMID: 15356133.
      View in: PubMed
    34. Wansley EK, Grayson JM, Parks GD. Apoptosis induction and interferon signaling but not IFN-beta promoter induction by an SV5 P/V mutant are rescued by coinfection with wild-type SV5. Virology. 2003 Nov 10; 316(1):41-54. PMID: 14599789.
      View in: PubMed
    35. Grayson JM, Laniewski NG, Lanier JG, Ahmed R. Mitochondrial potential and reactive oxygen intermediates in antigen-specific CD8+ T cells during viral infection. J Immunol. 2003 May 01; 170(9):4745-51. PMID: 12707355.
      View in: PubMed
    36. Blattman JN, Grayson JM, Wherry EJ, Kaech SM, Smith KA, Ahmed R. Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo. Nat Med. 2003 May; 9(5):540-7. PMID: 12692546.
      View in: PubMed
    37. Grayson JM, Harrington LE, Lanier JG, Wherry EJ, Ahmed R. Differential sensitivity of naive and memory CD8+ T cells to apoptosis in vivo. J Immunol. 2002 Oct 01; 169(7):3760-70. PMID: 12244170.
      View in: PubMed
    38. Grayson JM, Lanier JG, Harrington LE, Altman JD, Ahmed R. Analysis of Mitochondrial Function in Antigen Specific na ve, Effector and MEmory CD8 + T Cells. ScientificWorldJournal. 2001; 1:53. PMID: 30147516.
      View in: PubMed
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