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Clinical and Translational Science Institute

Keywords
Last Name

Edgar Alfonso Romero-Sandoval

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentAnesthesiology
Address
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    Collapse Research 
    Collapse research activities and funding
    R01DA025211     (ROMERO-SANDOVAL, EDGAR ALFONSO)Jun 1, 2009 - May 31, 2012
    NIH/NIDA
    Cannabinoids and Neuroimmune Interactions
    Role: Principal Investigator

    G11HD076487     (MESSERSMITH, AMY)May 15, 2013 - Apr 30, 2018
    NIH/NICHD
    Developing an Office of Sponsored Projects for Presbyterian College
    Role: Co-Principal Investigator

    R15GM109333     (ROMERO-SANDOVAL, EDGAR ALFONSO)Sep 1, 2014 - Aug 31, 2017
    NIH/NIGMS
    Cell-directed therapy using nanotechnology for the prevention of chronic postoper
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Romero-Sandoval EA, Fincham JE, Kolano AL, Sharpe BN, Alvarado-Vázquez PA. Cannabis for Chronic Pain: Challenges and Considerations. Pharmacotherapy. 2018 06; 38(6):651-662. PMID: 29637590.
      View in: PubMed
    2. Romero-Sandoval EA, Kolano AL, Alvarado-Vázquez PA. Cannabis and Cannabinoids for Chronic Pain. Curr Rheumatol Rep. 2017 Oct 05; 19(11):67. PMID: 28983880.
      View in: PubMed
    3. Alvarado-Vazquez PA, Bernal L, Paige CA, Grosick RL, Moracho Vilrriales C, Ferreira DW, Ulecia-Morón C, Romero-Sandoval EA. Macrophage-specific nanotechnology-driven CD163 overexpression in human macrophages results in an M2 phenotype under inflammatory conditions. Immunobiology. 2017 08; 222(8-9):900-912. PMID: 28545809.
      View in: PubMed
    4. Pruitt J, Moracho-Vilrriales C, Threatt T, Wagner S, Wu J, Romero-Sandoval EA. Identification, prevalence, and treatment of painful diabetic neuropathy in patients from a rural area in South Carolina. J Pain Res. 2017; 10:833-843. PMID: 28435320.
      View in: PubMed
    5. Skopelja-Gardner S, Saha M, Alvarado-Vazquez PA, Liponis BS, Martinez E, Romero-Sandoval EA. Mitogen-activated protein kinase phosphatase-3 (MKP-3) in the surgical wound is necessary for the resolution of postoperative pain in mice. J Pain Res. 2017; 10:763-774. PMID: 28405172.
      View in: PubMed
    6. Bort A, Alvarado-Vazquez PA, Moracho-Vilrriales C, Virga KG, Gumina G, Romero-Sandoval A, Asbill S. Effects of JWH015 in cytokine secretion in primary human keratinocytes and fibroblasts and its suitability for topical/transdermal delivery. Mol Pain. 2017 01; 13:1744806916688220. PMID: 28326930.
      View in: PubMed
    7. Bernal L, Alvarado-Vázquez A, Ferreira DW, Paige CA, Ulecia-Morón C, Hill B, Caesar M, Romero-Sandoval EA. Evaluation of a nanotechnology-based approach to induce gene-expression in human THP-1 macrophages under inflammatory conditions. Immunobiology. 2017 02; 222(2):399-408. PMID: 27615510.
      View in: PubMed
    8. Savage SR, Romero-Sandoval A, Schatman M, Wallace M, Fanciullo G, McCarberg B, Ware M. Cannabis in Pain Treatment: Clinical and Research Considerations. J Pain. 2016 06; 17(6):654-68. PMID: 26961090.
      View in: PubMed
    9. Romero-Sandoval EA, Asbill S, Paige CA, Byrd-Glover K. Peripherally Restricted Cannabinoids for the Treatment of Pain. Pharmacotherapy. 2015 Oct; 35(10):917-25. PMID: 26497478.
      View in: PubMed
    10. Heustess A, Spigener S, Sweitzer S, Romero-Sandoval A, Asbill S. Analgesic Efficacy and Transdermal Penetration of Topical Gabapentin Creams: Finding an Optimal Dose and Pre-treatment Time. Int J Pharm Compd. 2015 Mar-Apr; 19(2):167-73. PMID: 26685497.
      View in: PubMed
    11. Romero-Salndoval EA, Sweitzer SM. . Molecular and Cell Biology of Pain. Theodore Price, Greg Dussor, eds. Nonneuronal central mechanisms of pain. 2015; 131:325-358.
    12. Paige C, Hill B, Canterbury J, Sweitzer S, Romero-Sandoval EA. Construction of an affordable and easy-to-build zebrafish facility. J Vis Exp. 2014 Nov 22; (93):e51989. PMID: 25490519.
      View in: PubMed
    13. Asbill S, Sweitzer SM, Spigener S, Romero-Sandoval A. Compounded pain formulations: what is the evidence? Int J Pharm Compd. 2014 Jul-Aug; 18(4):278-86. PMID: 25508635.
      View in: PubMed
    14. Ndong C, Landry RP, Saha M, Romero-Sandoval EA. Mitogen-activated protein kinase (MAPK) phosphatase-3 (MKP-3) displays a p-JNK-MAPK substrate preference in astrocytes in vitro. Neurosci Lett. 2014 Jul 11; 575:13-8. PMID: 24861519.
      View in: PubMed
    15. Saha M, Skopelja S, Martinez E, Alvarez DL, Liponis BS, Romero-Sandoval EA. Spinal mitogen-activated protein kinase phosphatase-3 (MKP-3) is necessary for the normal resolution of mechanical allodynia in a mouse model of acute postoperative pain. J Neurosci. 2013 Oct 23; 33(43):17182-7. PMID: 24155322.
      View in: PubMed
    16. Romero-Sandoval EA. Peripheral benzodiazepine receptors: are they potential biomarkers for glial activation in pain states? Eur J Pain. 2013 May; 17(5):635-7. PMID: 23526770.
      View in: PubMed
    17. Landry RP, Martinez E, DeLeo JA, Romero-Sandoval EA. Spinal cannabinoid receptor type 2 agonist reduces mechanical allodynia and induces mitogen-activated protein kinase phosphatases in a rat model of neuropathic pain. J Pain. 2012 Sep; 13(9):836-48. PMID: 22901764.
      View in: PubMed
    18. Ndong C, Landry RP, DeLeo JA, Romero-Sandoval EA. Mitogen activated protein kinase phosphatase-1 prevents the development of tactile sensitivity in a rodent model of neuropathic pain. Mol Pain. 2012 Apr 27; 8:34. PMID: 22540262.
      View in: PubMed
    19. Jacobs VL, Landry RP, Liu Y, Romero-Sandoval EA, De Leo JA. Propentofylline decreases tumor growth in a rodent model of glioblastoma multiforme by a direct mechanism on microglia. Neuro Oncol. 2012 Feb; 14(2):119-31. PMID: 22086978.
      View in: PubMed
    20. Landry RP, Jacobs VL, Romero-Sandoval EA, DeLeo JA. Propentofylline, a CNS glial modulator does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages. Exp Neurol. 2012 Apr; 234(2):340-50. PMID: 22119425.
      View in: PubMed
    21. Romero-Sandoval EA. Depression and pain: does ketamine improve the quality of life of patients in chronic pain by targeting their mood? Anesthesiology. 2011 Oct; 115(4):687-8. PMID: 21841467.
      View in: PubMed
    22. Horvath RJ, Romero-Sandoval EA, De Leo JA. Inhibition of microglial P2X4 receptors attenuates morphine tolerance, Iba1, GFAP and mu opioid receptor protein expression while enhancing perivascular microglial ED2. Pain. 2010 Sep; 150(3):401-13. PMID: 20573450.
      View in: PubMed
    23. Alkaitis MS, Solorzano C, Landry RP, Piomelli D, DeLeo JA, Romero-Sandoval EA. Evidence for a role of endocannabinoids, astrocytes and p38 phosphorylation in the resolution of postoperative pain. PLoS One. 2010 May 28; 5(5):e10891. PMID: 20531936.
      View in: PubMed
    24. Horvath RJ, Landry RP, Romero-Sandoval EA, DeLeo JA. Morphine tolerance attenuates the resolution of postoperative pain and enhances spinal microglial p38 and extracellular receptor kinase phosphorylation. Neuroscience. 2010 Aug 25; 169(2):843-54. PMID: 20493931.
      View in: PubMed
    25. Romero-Sandoval EA, Horvath R, Landry RP, DeLeo JA. Cannabinoid receptor type 2 activation induces a microglial anti-inflammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation. Mol Pain. 2009 May 28; 5:25. PMID: 19476641.
      View in: PubMed
    26. Romero-Sandoval EA, Horvath RJ, DeLeo JA. Neuroimmune interactions and pain: focus on glial-modulating targets. Curr Opin Investig Drugs. 2008 Jul; 9(7):726-34. PMID: 18600578.
      View in: PubMed
    27. Romero-Sandoval A, Chai N, Nutile-McMenemy N, Deleo JA. A comparison of spinal Iba1 and GFAP expression in rodent models of acute and chronic pain. Brain Res. 2008 Jul 11; 1219:116-26. PMID: 18538310.
      View in: PubMed
    28. Romero-Sandoval A, Nutile-McMenemy N, DeLeo JA. Spinal microglial and perivascular cell cannabinoid receptor type 2 activation reduces behavioral hypersensitivity without tolerance after peripheral nerve injury. Anesthesiology. 2008 Apr; 108(4):722-34. PMID: 18362605.
      View in: PubMed
    29. Summer GJ, Romero-Sandoval EA, Bogen O, Dina OA, Khasar SG, Levine JD. Proinflammatory cytokines mediating burn-injury pain. Pain. 2008 Mar; 135(1-2):98-107. PMID: 17590515.
      View in: PubMed
    30. Romero-Sandoval A, Eisenach JC. Spinal cannabinoid receptor type 2 activation reduces hypersensitivity and spinal cord glial activation after paw incision. Anesthesiology. 2007 Apr; 106(4):787-94. PMID: 17413917.
      View in: PubMed
    31. Romero-Sandoval A, Bynum T, Eisenach JC. Analgesia induced by perineural clonidine is enhanced in persistent neuritis. Neuroreport. 2007 Jan 08; 18(1):67-71. PMID: 17259863.
      View in: PubMed
    32. Romero-Sandoval EA, Curros-Criado MM, Gaitan G, Molina C, Herrero JF. Nitroparacetamol (NCX-701) and pain: first in a series of novel analgesics. CNS Drug Rev. 2007; 13(3):279-95. PMID: 17894645.
      View in: PubMed
    33. Romero-Sandoval A, Eisenach JC. Clonidine reduces hypersensitivity and alters the balance of pro- and anti-inflammatory leukocytes after local injection at the site of inflammatory neuritis. Brain Behav Immun. 2007 Jul; 21(5):569-80. PMID: 17079113.
      View in: PubMed
    34. Alfonso Romero-Sandoval E, Molina C, Herrero JF. Enhancement of the analgesic activity of paracetamol and nitroparacetamol by the oral administration of all-trans retinoic acid. Neuropharmacology. 2006 Sep; 51(4):858-65. PMID: 16870215.
      View in: PubMed
    35. Romero-Sandoval EA, Molina C, Alique M, Moreno-Manzano V, Lucio FJ, Herrero JF. Vitamin A active metabolite, all-trans retinoic acid, induces spinal cord sensitization. I. Effects after oral administration. Br J Pharmacol. 2006 Sep; 149(1):56-64. PMID: 16847436.
      View in: PubMed
    36. Romero-Sandoval A, Eisenach JC. Perineural clonidine reduces mechanical hypersensitivity and cytokine production in established nerve injury. Anesthesiology. 2006 Feb; 104(2):351-5. PMID: 16436856.
      View in: PubMed
    37. Romero-Sandoval EA, McCall C, Eisenach JC. Alpha2-adrenoceptor stimulation transforms immune responses in neuritis and blocks neuritis-induced pain. J Neurosci. 2005 Sep 28; 25(39):8988-94. PMID: 16192389.
      View in: PubMed
    38. Romero-Sandoval EA, Alique M, Moreno-Manzano V, Molina C, Lucio FJ, Herrero JF. The oral administration of retinoic acid enhances nociceptive withdrawal reflexes in rats with soft-tissue inflammation. Inflamm Res. 2004 Jul; 53(7):297-303. PMID: 15241564.
      View in: PubMed
    39. Alfonso Romero-Sandoval E, Del Soldato P, Herrero JF. The effects of sham and full spinalization on the antinociceptive effects of NCX-701 (nitroparacetamol) in monoarthritic rats. Neuropharmacology. 2003 Sep; 45(3):412-9. PMID: 12871658.
      View in: PubMed
    40. Herrero JF, Romero-Sandoval EA, Gaitan G, Mazario J. Antinociception and the new COX inhibitors: research approaches and clinical perspectives. CNS Drug Rev. 2003; 9(3):227-52. PMID: 14530796.
      View in: PubMed
    41. Romero-Sandoval EA, Mazario J, Howat D, Herrero JF. NCX-701 (nitroparacetamol) is an effective antinociceptive agent in rat withdrawal reflexes and wind-up. Br J Pharmacol. 2002 Mar; 135(6):1556-62. PMID: 11906970.
      View in: PubMed
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