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Hollis, Thomas

One or more keywords matched the following items that are connected to Hollis, Thomas

Item Type	Name
Academic Article	A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus.
Academic Article	Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.
Academic Article	The TREX1 exonuclease R114H mutation in Aicardi-Goutières syndrome and lupus reveals dimeric structure requirements for DNA degradation activity.
Academic Article	RNaseH2 mutants that cause Aicardi-Goutieres syndrome are active nucleases.
Academic Article	Dominant mutation of the TREX1 exonuclease gene in lupus and Aicardi-Goutieres syndrome.
Concept	Mutation, Missense
Academic Article	The Arg-62 residues of the TREX1 exonuclease act across the dimer interface contributing to catalysis in the opposing protomers.

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Mutation Missense