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Hollis, Thomas

One or more keywords matched the following items that are connected to Hollis, Thomas

Item Type	Name
Academic Article	The human TREX2 3' -> 5'-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysis.
Academic Article	A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus.
Academic Article	Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.
Academic Article	Functional consequences of the RNase H2A subunit mutations that cause Aicardi-Goutieres syndrome.
Academic Article	The TREX1 exonuclease R114H mutation in Aicardi-Goutières syndrome and lupus reveals dimeric structure requirements for DNA degradation activity.
Academic Article	The molecular mechanism of DNA damage recognition by MutS homologs and its consequences for cell death response.
Academic Article	The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering.
Academic Article	Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome.
Academic Article	DNA damage recognition and repair by 3-methyladenine DNA glycosylase I (TAG).
Academic Article	Cooperative DNA binding and communication across the dimer interface in the TREX2 3' --> 5'-exonuclease.
Academic Article	The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease.
Academic Article	RNaseH2 mutants that cause Aicardi-Goutieres syndrome are active nucleases.
Academic Article	The structure of the mammalian RNase H2 complex provides insight into RNA.NA hybrid processing to prevent immune dysfunction.
Academic Article	AmrZ beta-sheet residues are essential for DNA binding and transcriptional control of Pseudomonas aeruginosa virulence genes.
Academic Article	Dominant mutation of the TREX1 exonuclease gene in lupus and Aicardi-Goutieres syndrome.
Academic Article	Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease.
Concept	Mutation
Concept	Mutation, Missense
Concept	Frameshift Mutation
Academic Article	The Arg-62 residues of the TREX1 exonuclease act across the dimer interface contributing to catalysis in the opposing protomers.
Academic Article	Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease.
Grant	Structure and Regulation of the TREX1 Exonuclease

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Mutation