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Gmeiner, William
One or more keywords matched the following items that are connected to
Gmeiner, William
Item Type
Name
Academic Article
A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes.
Academic Article
Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity.
Academic Article
Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity.
Concept
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Concept
Leukemia P388
Concept
Leukemia, Monocytic, Acute
Concept
Leukemia, Promyelocytic, Acute
Concept
Leukemia, Myeloid, Acute
Academic Article
The poison oligonucleotide F10 is highly effective against acute lymphoblastic leukemia while sparing normal hematopoietic cells.
Academic Article
Thymineless death in F10-treated AML cells occurs via lipid raft depletion and Fas/FasL co-localization in the plasma membrane with activation of the extrinsic apoptotic pathway.
Search Criteria
Leukemia