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Parks, John
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Academic Article Dietary n-3 polyunsaturated fat increases the fractional catabolic rate of medium-sized HDL particles in African green monkeys.
Academic Article Alteration of plasma HDL cholesteryl ester composition with transgenic expression of a point mutation (E149A) of human LCAT.
Academic Article Lecithin:cholesterol acyltransferase deficiency increases atherosclerosis in the low density lipoprotein receptor and apolipoprotein E knockout mice.
Academic Article Dietary fish oil effects on biliary lipid secretion and cholesterol gallstone formation in the African green monkey.
Academic Article Reduced proteoglycan binding of low density lipoproteins from monkeys (Macaca fascicularis) fed a fish oil versus lard diet.
Academic Article Isolation and characterization of high density lipoprotein apoproteins in the non-human primate (vervet).
Academic Article Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice.
Academic Article Negative charge at amino acid 149 is the molecular determinant for substrate specificity of lecithin: cholesterol acyltransferase for phosphatidylcholine containing 20-carbon sn-2 fatty acyl chains.
Academic Article Studies on the effect of dietary fish oil on the physical and chemical properties of low density lipoproteins in cynomolgus monkeys.
Academic Article Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potential.
Academic Article ACAT2 contributes cholesteryl esters to newly secreted VLDL, whereas LCAT adds cholesteryl ester to LDL in mice.
Academic Article Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I.
Academic Article HDLs in apoA-I transgenic Abca1 knockout mice are remodeled normally in plasma but are hypercatabolized by the kidney.
Academic Article Oral contraceptives, lipoproteins, and atherosclerosis.
Academic Article Intestinal ABCA1 directly contributes to HDL biogenesis in vivo.
Academic Article Inhibition of coronary artery atherosclerosis by 17-beta estradiol in ovariectomized monkeys. Lack of an effect of added progesterone.
Academic Article Effect of dietary fish oil on coronary artery and aortic atherosclerosis in African green monkeys.
Academic Article Reduction in ABCG1 in Type 2 diabetic mice increases macrophage foam cell formation.
Academic Article Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels.
Academic Article Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment.
Academic Article LXR signaling couples sterol metabolism to proliferation in the acquired immune response.
Academic Article Rosuvastatin induces delayed preconditioning against oxygen-glucose deprivation in cultured cortical neurons.
Academic Article Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function.
Academic Article Fish oil decreases hepatic cholesteryl ester secretion but not apoB secretion in African green monkeys.
Academic Article Combined therapy of dietary fish oil and stearoyl-CoA desaturase 1 inhibition prevents the metabolic syndrome and atherosclerosis.
Academic Article Alternative splicing attenuates transgenic expression directed by the apolipoprotein E promoter-enhancer based expression vector pLIV11.
Academic Article Targeted deletion of hepatocyte ABCA1 leads to very low density lipoprotein triglyceride overproduction and low density lipoprotein hypercatabolism.
Academic Article Myeloid differentiation primary response protein 88 couples reverse cholesterol transport to inflammation.
Academic Article Intracellular lipid flux and membrane microdomains as organizing principles in inflammatory cell signaling.
Academic Article Adipose tissue ATP binding cassette transporter A1 contributes to high-density lipoprotein biogenesis in vivo.
Academic Article Hepatic ABCA1 and VLDL triglyceride production.
Academic Article Contraceptive steroid effects on lipids and lipoproteins in cynomolgus monkeys.
Academic Article Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis.
Academic Article Omega-3 fatty acids ameliorate atherosclerosis by favorably altering monocyte subsets and limiting monocyte recruitment to aortic lesions.
Academic Article An ACACB variant implicated in diabetic nephropathy associates with body mass index and gene expression in obese subjects.
Academic Article Lecithin:cholesterol acyltransferase-induced modifications of liver perfusate discoidal high density lipoproteins from African green monkeys.
Academic Article Effect of fish oil versus lard diets on the chemical and physical properties of low density lipoproteins of nonhuman primates.
Academic Article Alteration of high density lipoprotein subfraction distribution with induction of serum amyloid A protein (SAA) in the nonhuman primate.
Academic Article Different kinetic fates of apolipoproteins A-I and A-II from lymph chylomicra of nonhuman primates. Effect of saturated versus polyunsaturated dietary fat.
Academic Article Physical characterization of lymph chylomicrons and very low density lipoproteins from nonhuman primates fed saturated dietary fat.
Academic Article Dietary polyunsaturated fat modifies low-density lipoproteins and reduces atherosclerosis of nonhuman primates with high and low diet responsiveness.
Academic Article ACAT inhibitors CL 283,546 and CL 283,796 reduce LDL cholesterol without affecting cholesterol absorption in African green monkeys.
Academic Article Dietary fatty acid modification of HDL phospholipid molecular species alters lecithin: cholesterol acyltransferase reactivity in cynomolgus monkeys.
Academic Article Effect of apolipoprotein A-I deficiency on lecithin:cholesterol acyltransferase activation in mouse plasma.
Academic Article Dietary polyunsaturated fat decreases interaction between low density lipoproteins and arterial proteoglycans.
Academic Article Dietary fish oil-induced decrease in low density lipoprotein binding to fibroblasts is mediated by apolipoprotein E.
Academic Article Effect of interleukin-1 alpha on lipoprotein lipids in cynomolgus monkeys: comparison to tumor necrosis factor.
Academic Article Lipoprotein lipase enhances the interaction of low density lipoproteins with artery-derived extracellular matrix proteoglycans.
Academic Article Dietary fish oil modification of cynomolgus monkey low density lipoproteins results in decreased binding and cholesteryl ester accumulation by cultured fibroblasts.
Academic Article Glycosylation structure and enzyme activity of lecithin:cholesterol acyltransferase from human plasma, HepG2 cells, and baculoviral and Chinese hamster ovary cell expression systems.
Academic Article Plasma cholesteryl ester transfer activity is modulated by the phase transition of the lipoprotein core.
Academic Article Amino acid residue 149 of lecithin:cholesterol acyltransferase determines phospholipase A2 and transacylase fatty acyl specificity.
Academic Article Influence of vesicle surface composition on the interfacial binding of lecithin:cholesterol acyltransferase and apolipoprotein A-I.
Academic Article Cloning and in vitro expression of rat lecithin:cholesterol acyltransferase.
Academic Article Role of glutamic acid residues 154, 155, and 165 of lecithin:cholesterol acyltransferase in cholesterol esterification and phospholipase A2 activities.
Academic Article Small HDL particles containing two apoA-I molecules are precursors in vivo to medium and large HDL particles containing three and four apoA-I molecules in nonhuman primates.
Academic Article Lysosomal acid lipase mutations that determine phenotype in Wolman and cholesterol ester storage disease.
Academic Article In vivo contribution of LCAT to apolipoprotein B lipoprotein cholesteryl esters in LDL receptor and apolipoprotein E knockout mice.
Academic Article Age and dietary polyunsaturated fat alter high density lipoprotein subfraction cholesterol concentrations in a pediatric population of African green monkeys.
Academic Article Transgenic overexpression of human lecithin: cholesterol acyltransferase (LCAT) in mice does not increase aortic cholesterol deposition.
Academic Article Enhancement of scavenger receptor class B type I-mediated selective cholesteryl ester uptake from apoA-I(-/-) high density lipoprotein (HDL) by apolipoprotein A-I requires HDL reorganization by lecithin cholesterol acyltransferase.
Academic Article Identification of the lipoprotein initiating domain of apolipoprotein B.
Academic Article Harmful effects of increased LDLR expression in mice with human APOE*4 but not APOE*3.
Academic Article Compared with Acyl-CoA:cholesterol O-acyltransferase (ACAT) 1 and lecithin:cholesterol acyltransferase, ACAT2 displays the greatest capacity to differentiate cholesterol from sitosterol.
Academic Article Prebeta high density lipoprotein has two metabolic fates in human apolipoprotein A-I transgenic mice.
Academic Article ATP-binding cassette transporter AI and its role in HDL formation.
Academic Article Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteins.
Academic Article Hepatic ATP-binding cassette transporter A1 is a key molecule in high-density lipoprotein cholesteryl ester metabolism in mice.
Academic Article Effect of fish oil on atherosclerosis and lipoprotein metabolism.
Academic Article Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo.
Academic Article Functional LCAT deficiency in human apolipoprotein A-I transgenic, SR-BI knockout mice.
Academic Article Effect of fish oil diet on hepatic lipid metabolism in nonhuman primates: lowering of secretion of hepatic triglyceride but not apoB.
Academic Article Whole-body cholesterol metabolism in cholesterol-fed African green monkeys with a variable hypercholesterolemic response.
Academic Article Lipopolysaccharide and tumor necrosis factor cause a fall in plasma concentration of lecithin: cholesterol acyltransferase in cynomolgus monkeys.
Academic Article Echium oil reduces plasma lipids and hepatic lipogenic gene expression in apoB100-only LDL receptor knockout mice.
Academic Article Mechanisms by which botanical lipids affect inflammatory disorders.
Academic Article Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages.
Academic Article Initial interaction of apoA-I with ABCA1 impacts in vivo metabolic fate of nascent HDL.
Academic Article Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis.
Academic Article LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins.
Academic Article Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis.
Academic Article Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.
Academic Article An innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2.
Academic Article Apolipoprotein M expression increases the size of nascent pre beta HDL formed by ATP binding cassette transporter A1.
Academic Article ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation.
Academic Article ABCG1 deficiency in mice promotes endothelial activation and monocyte-endothelial interactions.
Academic Article A novel role for ABCA1-generated large pre-beta migrating nascent HDL in the regulation of hepatic VLDL triglyceride secretion.
Academic Article Lipoprotein abnormalities associated with lipopolysaccharide-induced lecithin: cholesterol acyltransferase and lipase deficiency.
Academic Article An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells.
Academic Article Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol.
Academic Article The reactivity of plasma phospholipids with lecithin:cholesterol acyltransferase is decreased in fish oil-fed monkeys.
Academic Article Echium oil reduces atherosclerosis in apoB100-only LDLrKO mice.
Academic Article CGI-58/ABHD5-derived signaling lipids regulate systemic inflammation and insulin action.
Academic Article Hepatic ABC transporters and triglyceride metabolism.
Academic Article New roles of HDL in inflammation and hematopoiesis.
Academic Article The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence.
Academic Article Myeloid cell-specific ABCA1 deletion protects mice from bacterial infection.
Academic Article ATP-binding cassette transporter G1 intrinsically regulates invariant NKT cell development.
Academic Article Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration.
Academic Article Low density lipoproteins in atherosclerosis.
Academic Article Detection of immunological heterogeneity of an isolated, purified protein (vervet apolipoprotein A-I).
Academic Article Metabolism of the serum amyloid A proteins (SSA) in high-density lipoproteins and chylomicrons of nonhuman primates (vervet monkey).
Academic Article 1H NMR studies of lymph chylomicra and very low density lipoproteins from nonhuman primates.
Academic Article Compared with dietary monounsaturated and saturated fat, polyunsaturated fat protects African green monkeys from coronary artery atherosclerosis.
Academic Article Lipid metabolism.
Academic Article Portacaval shunt and whole-body cholesterol metabolism in the cholesterol-fed African green monkey.
Academic Article Hepatic ACAT activity in African green monkeys is highly correlated to plasma LDL cholesteryl ester enrichment and coronary artery atherosclerosis.
Academic Article Interrelationships of alpha-tocopherol with plasma lipoproteins in African green monkeys: effects of dietary fats.
Academic Article High level secretion of wild-type and mutant forms of human proapoA-I using baculovirus-mediated Sf-9 cell expression.
Academic Article Reduction of cholesterol absorption by dietary oleinate and fish oil in African green monkeys.
Academic Article Low density lipoprotein particle size and core cholesteryl ester physical state affect the proton NMR magnetic environment of fatty acid methylene and methyl nuclei.
Academic Article The effects of testosterone on lipids and eicosanoids in cynomolgus monkeys.
Academic Article Effects of hormone replacement modalities on low density lipoprotein composition and distribution in ovariectomized cynomolgus monkeys.
Academic Article Effects of contraceptive estrogen and progestin on the atherogenic potential of plasma LDLs in cynomolgus monkeys.
Academic Article Lipoprotein and cholesterol metabolism in diet-induced coronary artery atherosclerosis in primates. Role of cholesterol and fatty acids.
Academic Article Characterization of C-terminal histidine-tagged human recombinant lecithin:cholesterol acyltransferase.
Academic Article Determination of the tissue sites responsible for the catabolism of large high density lipoprotein in the African green monkey.
Academic Article Low-dose contraceptive estrogen-progestin and coronary artery atherosclerosis of monkeys.
Academic Article Vesicle-binding properties of wild-type and cysteine mutant forms of alpha(1) domain of apolipoprotein B.
Concept Physical Conditioning, Animal
Concept Animals
Concept Animal Feed
Concept Disease Models, Animal
Academic Article Deficiency of ATP-binding cassette transporters A1 and G1 in macrophages increases inflammation and accelerates atherosclerosis in mice.
Academic Article Increased cholesterol content in gammadelta (?d) T lymphocytes differentially regulates their activation.
Academic Article Echium oil reduces plasma triglycerides by increasing intravascular lipolysis in apoB100-only low density lipoprotein (LDL) receptor knockout mice.
Academic Article Liver ABCA1 deletion in LDLrKO mice does not impair macrophage reverse cholesterol transport or exacerbate atherogenesis.
Academic Article Myeloid cell-specific ABCA1 deletion does not worsen insulin resistance in HF diet-induced or genetically obese mouse models.
Academic Article Lipid absorption defects in intestine-specific microsomal triglyceride transfer protein and ATP-binding cassette transporter A1-deficient mice.
Academic Article Hepatic apolipoprotein M (apoM) overexpression stimulates formation of larger apoM/sphingosine 1-phosphate-enriched plasma high density lipoprotein.
Academic Article Myeloid cell-specific ATP-binding cassette transporter A1 deletion has minimal impact on atherogenesis in atherogenic diet-fed low-density lipoprotein receptor knockout mice.
Academic Article Dietary cholesterol promotes adipocyte hypertrophy and adipose tissue inflammation in visceral, but not in subcutaneous, fat in monkeys.
Academic Article Histone deacetylase 9 represses cholesterol efflux and alternatively activated macrophages in atherosclerosis development.
Academic Article Inhibiting DNA Methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation.
Academic Article Uncleaved ApoM signal peptide is required for formation of large ApoM/sphingosine 1-phosphate (S1P)-enriched HDL particles.
Academic Article Botanical oils enriched in n-6 and n-3 FADS2 products are equally effective in preventing atherosclerosis and fatty liver.
Academic Article Proteomic Analysis of ABCA1-Null Macrophages Reveals a Role for Stomatin-Like Protein-2 in Raft Composition and Toll-Like Receptor Signaling.
Academic Article Biogenesis and cytotoxicity of APOL1 renal risk variant proteins in hepatocytes and hepatoma cells.
Academic Article LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling.
Academic Article Dietary cholesterol effects on adipose tissue inflammation.
Academic Article A Systematic Investigation of Structure/Function Requirements for the Apolipoprotein A-I/Lecithin Cholesterol Acyltransferase Interaction Loop of High-density Lipoprotein.
Academic Article Myeloid Deletion of a1AMPK Exacerbates Atherosclerosis in LDL Receptor Knockout (LDLRKO) Mice.
Academic Article Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Endothelial Cells Accelerates Atherosclerosis in Mice.
Academic Article MicroRNA-33 Regulates the Innate Immune Response via ATP Binding Cassette Transporter-mediated Remodeling of Membrane Microdomains.
Academic Article Very Low Density Lipoprotein Assembly Is Required for cAMP-responsive Element-binding Protein H Processing and Hepatic Apolipoprotein A-IV Expression.
Academic Article In vivo activation of leukocyte GPR120/FFAR4 by PUFAs has minimal impact on atherosclerosis in LDL receptor knockout mice.
Academic Article Quercetin, a functional compound of onion peel, remodels white adipocytes to brown-like adipocytes.
Grant DIETARY PUFA AND HDL SUBFRACTION METABOLISM
Grant ATHEROGENIC PROPERTIES OF LOW DENSITY LIPOPROTEINS
Grant Integrative Lipid Metabolism, Inflammation, and Chronic Diseases
Academic Article Hepatocyte ABCA1 Deletion Impairs Liver Insulin Signaling and Lipogenesis.
Academic Article Hepatic ABCA1 deficiency is associated with delayed apolipoprotein B secretory trafficking and augmented VLDL triglyceride secretion.
Academic Article Slfn2 mutation-induced loss of T-cell quiescence leads to elevated de novo sterol synthesis.
Academic Article ?-5 Fatty Acid Desaturase FADS1 Impacts Metabolic Disease by Balancing Proinflammatory and Proresolving Lipid Mediators.
Academic Article LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis.
Academic Article Targeted Deletion of Adipocyte Abca1 (ATP-Binding Cassette Transporter A1) Impairs Diet-Induced Obesity.
Academic Article Tpcn2 knockout mice have improved insulin sensitivity and are protected against high-fat diet-induced weight gain.
Academic Article Feeding of tobacco blend or nicotine induced weight loss associated with decreased adipocyte size and increased physical activity in male mice.
Academic Article Targeted Deletion of Hepatocyte Abca1 Increases Plasma HDL (High-Density Lipoprotein) Reverse Cholesterol Transport via the LDL (Low-Density Lipoprotein) Receptor.
Academic Article Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis.
Academic Article Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 Promote the Transendothelial Transport of High-Density Lipoprotein.
Academic Article Early time-restricted feeding improves high-density lipoprotein amount and function in nonhuman primates, without effects on body composition.
Academic Article The effects of brewers' spent grain on high-fat diet-induced fatty liver.
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