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Eisenach, James
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Academic Article Phase I safety assessment of intrathecal injection of an American formulation of adenosine in humans.
Academic Article Preliminary efficacy assessment of intrathecal injection of an American formulation of adenosine in humans.
Academic Article Intrathecal adenosine following spinal nerve ligation in rat: short residence time in cerebrospinal fluid and no change in A(1) receptor binding.
Academic Article Peripheral nerve injury alters the alpha2 adrenoceptor subtype activated by clonidine for analgesia.
Academic Article Perineural alpha(2A)-adrenoceptor activation inhibits spinal cord neuroplasticity and tactile allodynia after nerve injury.
Academic Article Phase I safety assessment of intrathecal ketorolac.
Academic Article Intrathecal ketorolac enhances antinociception from clonidine.
Academic Article Analgesia from a peripherally active kappa-opioid receptor agonist in patients with chronic pancreatitis.
Academic Article Intrathecal clonidine reduces hypersensitivity after nerve injury by a mechanism involving spinal m4 muscarinic receptors.
Academic Article Individual differences in pain sensitivity: implications for treatment decisions.
Academic Article Cyclooxygenase-1 in the spinal cord plays an important role in postoperative pain.
Academic Article Age-dependent responses to thermal hyperalgesia and mechanical allodynia in a rat model of acute postoperative pain.
Academic Article Intrathecal, but not intravenous adenosine reduces allodynia in patients with neuropathic pain.
Academic Article Four PGE2 EP receptors are up-regulated in injured nerve following partial sciatic nerve ligation.
Academic Article Cyclooxygenase-1 in the spinal cord is altered after peripheral nerve injury.
Academic Article Cystatin C in cerebrospinal fluid is not a diagnostic test for pain in humans.
Academic Article Did experimenter bias conceal the efficacy of spinal opioids in previous studies with the spinal nerve ligation model of neuropathic pain?
Academic Article Repeated dosing with oral allosteric modulator of adenosine A1 receptor produces tolerance in rats with neuropathic pain.
Academic Article The monoamine reuptake inhibitor milnacipran does not affect nociception to acute visceral distension in rats.
Academic Article Peripheral nerve injury sensitizes the response to visceral distension but not its inhibition by the antidepressant milnacipran.
Academic Article Spinal adenosine receptor activation reduces hypersensitivity after surgery by a different mechanism than after nerve injury.
Academic Article Polyanalgesic Consensus Conference 2003: an update on the management of pain by intraspinal drug delivery-- report of an expert panel.
Academic Article Effects of laparotomy on spontaneous exploratory activity and conditioned operant responding in the rat: a model for postoperative pain.
Academic Article Intrathecal clonidine for postoperative analgesia in elderly patients: the influence of baricity on hemodynamic and analgesic effects.
Academic Article Preoperative sciatic nerve block decreases mechanical allodynia more in young rats: is preemptive analgesia developmentally modulated?
Academic Article Effect of cyclooxygenase-1 inhibition in postoperative pain is developmentally regulated.
Academic Article The antinociceptive effects of spinal cyclooxygenase inhibitors on uterine cervical distension.
Academic Article Intrathecal morphine and ketorolac analgesia after surgery: comparison of spontaneous and elicited responses in rats.
Academic Article Medium and large injured dorsal root ganglion cells increase TRPV-1, accompanied by increased alpha2C-adrenoceptor co-expression and functional inhibition by clonidine.
Academic Article Intrathecal morphine reduces allodynia after peripheral nerve injury in rats via activation of a spinal A1 adenosine receptor.
Academic Article Spinal nerve ligation increases alpha2-adrenergic receptor G-protein coupling in the spinal cord.
Academic Article Intravenous butorphanol, meperidine, and their combination relieve pain and distress in women in labor.
Academic Article Peripheral block of the hyperpolarization-activated cation current (Ih) reduces mechanical allodynia in animal models of postoperative and neuropathic pain.
Academic Article Abdominal surgery decreases food-reinforced operant responding in rats: relevance of incisional pain.
Academic Article Alpha2-adrenoceptor stimulation transforms immune responses in neuritis and blocks neuritis-induced pain.
Academic Article Age-dependent responses to nerve injury-induced mechanical allodynia.
Academic Article Spinal cord dynorphin expression increases, but does not drive microglial prostaglandin production or mechanical hypersensitivity after incisional surgery in rats.
Academic Article Clonidine maintains intrathecal self-administration in rats following spinal nerve ligation.
Academic Article Perineural clonidine reduces p38 mitogen-activated protein kinase activation in sensory neurons.
Academic Article Clonidine reduces hypersensitivity and alters the balance of pro- and anti-inflammatory leukocytes after local injection at the site of inflammatory neuritis.
Academic Article Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics.
Academic Article Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery.
Academic Article Estrogen amplifies pain responses to uterine cervical distension in rats by altering transient receptor potential-1 function.
Academic Article Brain derived nerve growth factor induces spinal noradrenergic fiber sprouting and enhances clonidine analgesia following nerve injury in rats.
Academic Article Neostigmine decreases bupivacaine use by patient-controlled epidural analgesia during labor: a randomized controlled study.
Academic Article Epidural neostigmine: will it replace lipid soluble opioids for postoperative and labor analgesia?
Academic Article Science marches forward: a new tool to study the progress of labor.
Academic Article Role of spinal cyclooxygenase in human postoperative and chronic pain.
Academic Article Effects of intrathecal ketorolac on human experimental pain.
Academic Article Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming.
Academic Article Spinal alpha 2-adrenoceptor-mediated analgesia in neuropathic pain reflects brain-derived nerve growth factor and changes in spinal cholinergic neuronal function.
Academic Article Differing neurophysiologic mechanosensory input from glabrous and hairy skin in juvenile rats.
Academic Article Up-regulation of spinal glutamate transporters contributes to anti-hypersensitive effects of valproate in rats after peripheral nerve injury.
Academic Article Polyanalgesic consensus conference 2007: recommendations for the management of pain by intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel.
Academic Article Ondansetron reverses antihypersensitivity from clonidine in rats after peripheral nerve injury: role of ?-aminobutyric acid in a2-adrenoceptor and 5-HT3 serotonin receptor analgesia.
Academic Article Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain.
Academic Article Effect of kappa opioid agonists on visceral nociception induced by uterine cervical distension in rats.
Academic Article Spinal noradrenergic activation mediates allodynia reduction from an allosteric adenosine modulator in a rat model of neuropathic pain.
Academic Article Dose response of intrathecal adenosine in experimental pain and allodynia.
Academic Article Pharmacology of opioid inhibition to noxious uterine cervical distension.
Academic Article Intrathecal lidocaine reverses tactile allodynia caused by nerve injuries and potentiates the antiallodynic effect of the COX inhibitor ketorolac.
Academic Article Chronic constriction injury of sciatic nerve induces the up-regulation of descending inhibitory noradrenergic innervation to the lumbar dorsal horn of mice.
Academic Article Spinal adrenergic and cholinergic receptor interactions activated by clonidine in postincisional pain.
Academic Article Intrathecal morphine reduces the visceromotor response to acute uterine cervical distension in an estrogen-independent manner.
Academic Article Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury.
Academic Article Intravenous remifentanil produces withdrawal hyperalgesia in volunteers with capsaicin-induced hyperalgesia.
Academic Article Systemic, but not intrathecal ketorolac is antinociceptive to uterine cervical distension in rats.
Academic Article Epidural neostigmine produces analgesia but also sedation in women after cesarean delivery.
Academic Article Intrathecal but not intravenous opioids release adenosine from the spinal cord.
Academic Article Fishing for genes: practical ways to study genetic polymorphisms for pain.
Academic Article Knock down of the alpha 5 nicotinic acetylcholine receptor in spinal nerve-ligated rats alleviates mechanical allodynia.
Academic Article Spinal noradrenaline transporter inhibition by reboxetine and Xen2174 reduces tactile hypersensitivity after surgery in rats.
Academic Article alpha2-Adrenoceptor activation by clonidine enhances stimulation-evoked acetylcholine release from spinal cord tissue after nerve ligation in rats.
Academic Article Preoperative inhibition of cyclooxygenase-1 in the spinal cord reduces postoperative pain.
Academic Article Preventing chronic pain after surgery: who, how, and when?
Academic Article Perineural clonidine reduces mechanical hypersensitivity and cytokine production in established nerve injury.
Academic Article Multifactorial preoperative predictors for postcesarean section pain and analgesic requirement.
Academic Article Treating and preventing chronic pain: a view from the spinal cord--Bonica Lecture, ASRA Annual Meeting, 2005.
Academic Article Intrathecal administration of a cylcooxygenase-1, but not a cyclooxygenase-2 inhibitor, reverses the effects of laparotomy on exploratory activity in rats.
Academic Article A pain model after gynecologic surgery: the effect of intrathecal and systemic morphine.
Academic Article Spinal glial activation contributes to postoperative mechanical hypersensitivity in the rat.
Academic Article Analgesia induced by perineural clonidine is enhanced in persistent neuritis.
Academic Article Spinal cannabinoid receptor type 2 activation reduces hypersensitivity and spinal cord glial activation after paw incision.
Academic Article Oral donepezil reduces hypersensitivity after nerve injury by a spinal muscarinic receptor mechanism.
Academic Article Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil.
Academic Article ST91 [2-(2,6-diethylphenylamino)-2-imidazoline hydrochloride]-mediated spinal antinociception and synergy with opioids persists in the absence of functional alpha-2A- or alpha-2C-adrenergic receptors.
Academic Article Assessment of behavior during labor in rats and effect of intrathecal morphine.
Academic Article Electrophysiologic characteristics of large neurons in dorsal root ganglia during development and after hind paw incision in the rat.
Academic Article Regional anesthesia: advancing the practice of medicine; the 2008 Gaston Labat Award lecture.
Academic Article Animal models and the prediction of efficacy in clinical trials of analgesic drugs: a critical appraisal and call for uniform reporting standards.
Academic Article Severity of acute pain after childbirth, but not type of delivery, predicts persistent pain and postpartum depression.
Academic Article Multiplicative interactions to enhance gabapentin to treat neuropathic pain.
Academic Article Gabapentin acts within the locus coeruleus to alleviate neuropathic pain.
Academic Article The effect of peripherally administered CDP-choline in an acute inflammatory pain model: the role of alpha7 nicotinic acetylcholine receptor.
Academic Article Activation of glutamate transporters in the locus coeruleus paradoxically activates descending inhibition in rats.
Academic Article The need for a journal policy on intrathecal, epidural, and perineural administration of non-approved drugs.
Academic Article Contribution of the chemokine (C-C motif) ligand 2 (CCL2) to mechanical hypersensitivity after surgical incision in rats.
Academic Article Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat.
Academic Article A tropomyosine receptor kinase inhibitor blocks spinal neuroplasticity essential for the anti-hypersensitivity effects of gabapentin and clonidine in rats with peripheral nerve injury.
Academic Article Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors.
Academic Article Depletion of endogenous noradrenaline does not prevent spinal cord plasticity following peripheral nerve injury.
Academic Article Opioid-independent mechanisms supporting offset analgesia and temporal sharpening of nociceptive information.
Academic Article Skin incision-induced receptive field responses of mechanosensitive peripheral neurons are developmentally regulated in the rat.
Academic Article Resolution of pain after childbirth.
Academic Article Predicting acute pain after cesarean delivery using three simple questions.
Concept Pain Measurement
Concept Pain Threshold
Concept Abdominal Pain
Concept Complex Regional Pain Syndromes
Concept Labor Pain
Concept Back Pain
Concept Pain
Concept Pain, Postoperative
Academic Article Future directions for intrathecal pain management: a review and update from the interdisciplinary polyanalgesic consensus conference 2007.
Academic Article Valproate prevents dysregulation of spinal glutamate and reduces the development of hypersensitivity in rats after peripheral nerve injury.
Academic Article Nociceptor-selective peripheral nerve block induces delayed mechanical hypersensitivity and neurotoxicity in rats.
Academic Article Intrathecal ketorolac does not improve acute or chronic pain after hip arthroplasty: a randomized controlled trial.
Academic Article Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain.
Academic Article Modeling individual recovery after peripheral nerve injury in rats and the effects of parturition.
Academic Article Fast-conducting mechanoreceptors contribute to withdrawal behavior in normal and nerve injured rats.
Academic Article Nerve injury induces a new profile of tactile and mechanical nociceptor input from undamaged peripheral afferents.
Academic Article Phase 1 safety assessment of intrathecal oxytocin.
Academic Article Failure of intrathecal ketorolac to reduce remifentanil-induced postinfusion hyperalgesia in humans.
Academic Article Intrathecal clonidine and adenosine: effects on pain and sensory processing in patients with chronic regional pain syndrome.
Academic Article Individual differences in acute pain-induced endogenous analgesia predict time to resolution of postoperative pain in the rat.
Academic Article Impaired Pain-evoked Analgesia after Nerve Injury in Rats Reflects Altered Glutamate Regulation in the Locus Coeruleus.
Academic Article Down-regulation of astroglial glutamate transporter-1 in the locus coeruleus impairs pain-evoked endogenous analgesia in rats.
Academic Article Wherefore Gabapentinoids?: Was There Rush Too Soon to Judgment?
Academic Article Can a Blood Test of Immune Responsiveness Predict Speed of Recovery from Pain and Dysfunction after Surgery?
Academic Article A Randomized Controlled Trial Comparing Two Multimodal Analgesic Techniques in Patients Predicted to Have Severe Pain After Cesarean Delivery.
Academic Article Mindfulness-Meditation-Based Pain Relief Is Not Mediated by Endogenous Opioids.
Academic Article Disruption of Spinal Noradrenergic Activation Delays Recovery of Acute Incision-Induced Hypersensitivity and Increases Spinal Glial Activation in the Rat.
Academic Article Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations.
Academic Article Gabapentin loses efficacy over time after nerve injury in rats: role of glutamate transporter-1 in the locus coeruleus.
Academic Article Ethical Concerns Regarding Human Study.
Academic Article Pupil responses and pain ratings to heat stimuli: Reliability and effects of expectations and a conditioning pain stimulus.
Grant EPIDURAL CLONIDINE ANALGESIA IN OBSTETRICS
Grant Receptor Selective Spinal Analgesia
Grant Spinal Noradrenergic Sprouting after Nerve Injury
Grant Recovery from Pain and Disability after Surgery
Grant EPIDURAL CLONIDINE ANALGESIA IN OBSTETRICS
Grant SEX DIFFERENCES IN CHOLINERGIC MEDIATED ANALGESIA
Grant Receptor Selective Spinal Analgesia
Grant Pharmacologic Plasticity in the Presence of Pain
Grant Alpha2-Adrenergic Analgesia
Academic Article Assessment of Behavioral Disruption in Rats with Abdominal Inflammation Using Visual Cue Titration and the Five-choice Serial-reaction Time Task.
Academic Article Day-to-day experience in resolution of pain after surgery.
Academic Article Post-discharge hyperpolarization is an endogenous modulatory factor limiting input from fast-conducting nociceptors (AHTMRs).
Academic Article Blockade of a2-adrenergic or metabotropic glutamate receptors induces glutamate release in the locus coeruleus to activate descending inhibition in rats with chronic neuropathic hypersensitivity.
Academic Article Plasticity and Function of Spinal Oxytocin and Vasopressin Signaling during Recovery from Surgery with Nerve Injury.
Academic Article Incisional Nociceptive Input Impairs Attention-related Behavior and Is Associated with Reduced Neuronal Activity in the Prefrontal Cortex in Rats.
Academic Article Psychosocial Stress Delays Recovery of Postoperative Pain Following Incisional Surgery in the Rat.
Academic Article Pain after surgery.
Academic Article Patterns of recovery from pain after cesarean delivery.
Academic Article Peripheral oxytocin restores light touch and nociceptor sensory afferents towards normal after nerve injury.
Academic Article Spinal Exparel®-an extended duration of preclinical study needed.
Academic Article Recovery of physical activity after cesarean delivery and its relationship with pain.
Academic Article Tachykinins modulate nociceptive responsiveness and sensitization: In vivo electrical characterization of primary sensory neurons in tachykinin knockout (Tac1 KO) mice.
Academic Article Descending Noradrenergic Inhibition: An Important Mechanism of Gabapentin Analgesia in Neuropathic Pain.
Academic Article Checklist for the preparation and review of pain clinical trial publications: a pain-specific supplement to CONSORT.
Academic Article Peripheral nerve injury in rats induces alternations in choice behavior associated with food reinforcement.
Academic Article Nociceptive input after peripheral nerve injury results in cognitive impairment and alterations in primary afferent physiology in rats.
Academic Article Recovery from nerve injury induced behavioral hypersensitivity in rats parallels resolution of abnormal primary sensory afferent signaling.
Academic Article Capsaicin-induced pain and sensitisation in the postpartum period.
Academic Article Ambulatory continuous peripheral nerve blocks to treat postamputation phantom limb pain: a multicenter, randomized, quadruple-masked, placebo-controlled clinical trial.
Academic Article Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation: A Pragmatic Effectiveness Trial of a Nonpharmacologic Alternative for the Treatment of Postoperative Pain.
Academic Article Research approaches for evaluating opioid sparing in clinical trials of acute and chronic pain treatments: IMMPACT recommendations.
Academic Article Systemic administration of a ß2-adrenergic receptor agonist reduces mechanical allodynia and suppresses the immune response to surgery in a rat model of persistent post-incisional hypersensitivity.
Academic Article Percutaneous Neuromodulation of the Brachial Plexus and Sciatic Nerve for the Treatment of Acute Pain Following Surgery: Secondary Outcomes From a Multicenter, Randomized, Controlled Pilot Study.
Academic Article Immediate Effects of a Continuous Peripheral Nerve Block on Postamputation Phantom and Residual Limb Pain: Secondary Outcomes From a Multicenter Randomized Controlled Clinical Trial.
Academic Article Seeding of breast cancer cell line (MDA-MB-231LUC+) to the mandible induces overexpression of substance P and CGRP throughout the trigeminal ganglion and widespread peripheral sensory neuropathy throughout all three of its divisions.
Academic Article Heterogeneity in patterns of pain development after nerve injury in rats and the influence of sex.
Academic Article Gadgeteering for Pain Relief: The 2021 John W. Severinghaus Lecture on Translational Science.
Academic Article Ultrasound-Guided Percutaneous Cryoneurolysis to Treat Chronic Post-Amputation Phantom Limb Pain: A Multicenter, Randomized, Controlled Trial.
Academic Article Randomized controlled trial of intrathecal oxytocin on speed of recovery after hip arthroplasty.
Academic Article Improving Preclinical Development of Novel Interventions to Treat Pain: Insanity Is Doing the Same Thing Over and Over and Expecting Different Results.
Academic Article Preliminary results from a randomized, controlled, cross-over trial of intrathecal oxytocin for neuropathic pain.
Academic Article Patient-centered results from a multicenter study of continuous peripheral nerve blocks and postamputation phantom and residual limb pain: secondary outcomes from a randomized, clinical trial.
Academic Article Patient engagement in designing, conducting, and disseminating clinical pain research: IMMPACT recommended considerations.
Academic Article Smallest Clinically Meaningful Improvement in Amputation-Related Pain and Brief Pain Inventory Scores as Defined by Patient Reports of Global Improvement After Cryoneurolysis: a Retrospective Analysis of a Randomized, Controlled Clinical Trial.
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