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Search Results to James C. Eisenach, M.D.

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Item TypeName
Academic Article Intrathecal adenosine following spinal nerve ligation in rat: short residence time in cerebrospinal fluid and no change in A(1) receptor binding.
Academic Article Spinal norepinephrine release from nitric oxide species is not increased following peripheral nerve injury in rats.
Academic Article Peripheral nerve injury alters the alpha2 adrenoceptor subtype activated by clonidine for analgesia.
Academic Article Perineural alpha(2A)-adrenoceptor activation inhibits spinal cord neuroplasticity and tactile allodynia after nerve injury.
Academic Article Intrathecal ketorolac enhances antinociception from clonidine.
Academic Article Clonidine-induced neuronal activation in the spinal cord is altered after peripheral nerve injury.
Academic Article Intrathecal clonidine reduces hypersensitivity after nerve injury by a mechanism involving spinal m4 muscarinic receptors.
Academic Article Intraspinal adenosine induces spinal cord norepinephrine release in spinal nerve-ligated rats but not in normal or sham controls.
Academic Article Uterine cervical distension induces cFos expression in deep dorsal horn neurons of the rat spinal cord.
Academic Article Cyclooxygenase-1 in the spinal cord plays an important role in postoperative pain.
Academic Article Age-dependent responses to thermal hyperalgesia and mechanical allodynia in a rat model of acute postoperative pain.
Academic Article Intrathecal injection of cAMP response element binding protein (CREB) antisense oligonucleotide attenuates tactile allodynia caused by partial sciatic nerve ligation.
Academic Article Four PGE2 EP receptors are up-regulated in injured nerve following partial sciatic nerve ligation.
Academic Article Cyclooxygenase-1 in the spinal cord is altered after peripheral nerve injury.
Academic Article Plasticity of spinal nicotinic acetylcholine receptors following spinal nerve ligation.
Academic Article Did experimenter bias conceal the efficacy of spinal opioids in previous studies with the spinal nerve ligation model of neuropathic pain?
Academic Article Repeated dosing with oral allosteric modulator of adenosine A1 receptor produces tolerance in rats with neuropathic pain.
Academic Article The monoamine reuptake inhibitor milnacipran does not affect nociception to acute visceral distension in rats.
Academic Article Peripheral nerve injury sensitizes the response to visceral distension but not its inhibition by the antidepressant milnacipran.
Academic Article Spinal adenosine receptor activation reduces hypersensitivity after surgery by a different mechanism than after nerve injury.
Academic Article Intrathecal ketorolac in dogs and rats.
Academic Article Effects of laparotomy on spontaneous exploratory activity and conditioned operant responding in the rat: a model for postoperative pain.
Academic Article Preoperative sciatic nerve block decreases mechanical allodynia more in young rats: is preemptive analgesia developmentally modulated?
Academic Article Effect of cyclooxygenase-1 inhibition in postoperative pain is developmentally regulated.
Academic Article The antinociceptive effects of spinal cyclooxygenase inhibitors on uterine cervical distension.
Academic Article Intrathecal morphine and ketorolac analgesia after surgery: comparison of spontaneous and elicited responses in rats.
Academic Article Medium and large injured dorsal root ganglion cells increase TRPV-1, accompanied by increased alpha2C-adrenoceptor co-expression and functional inhibition by clonidine.
Academic Article Intrathecal morphine reduces allodynia after peripheral nerve injury in rats via activation of a spinal A1 adenosine receptor.
Academic Article Spinal nerve ligation increases alpha2-adrenergic receptor G-protein coupling in the spinal cord.
Academic Article Chronic estrogen sensitizes a subset of mechanosensitive afferents innervating the uterine cervix.
Academic Article Allosteric modulation of adenosine A1 receptor coupling to G-proteins in brain.
Academic Article Peripheral block of the hyperpolarization-activated cation current (Ih) reduces mechanical allodynia in animal models of postoperative and neuropathic pain.
Academic Article Abdominal surgery decreases food-reinforced operant responding in rats: relevance of incisional pain.
Academic Article Alpha2-adrenoceptor stimulation transforms immune responses in neuritis and blocks neuritis-induced pain.
Academic Article Hyperexcitability of axotomized and neighboring unaxotomized sensory neurons is reduced days after perineural clonidine at the site of injury.
Academic Article Adenosine reduces glutamate release in rat spinal synaptosomes.
Academic Article Age-dependent responses to nerve injury-induced mechanical allodynia.
Academic Article Developmental differences in spinal cyclooxygenase 1 expression after surgical incision.
Academic Article Uterine cervical afferents in thoracolumbar dorsal root ganglia express transient receptor potential vanilloid type 1 channel and calcitonin gene-related peptide, but not P2X3 receptor and somatostatin.
Academic Article Spinal cord dynorphin expression increases, but does not drive microglial prostaglandin production or mechanical hypersensitivity after incisional surgery in rats.
Academic Article Clonidine maintains intrathecal self-administration in rats following spinal nerve ligation.
Academic Article Perineural clonidine reduces p38 mitogen-activated protein kinase activation in sensory neurons.
Academic Article Clonidine reduces hypersensitivity and alters the balance of pro- and anti-inflammatory leukocytes after local injection at the site of inflammatory neuritis.
Academic Article Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics.
Academic Article Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery.
Academic Article Estrogen amplifies pain responses to uterine cervical distension in rats by altering transient receptor potential-1 function.
Academic Article Brain derived nerve growth factor induces spinal noradrenergic fiber sprouting and enhances clonidine analgesia following nerve injury in rats.
Academic Article Toxicology profile of N-methyl-D-aspartate antagonists delivered by intrathecal infusion in the canine model.
Academic Article Pregnancy increases excitability of mechanosensitive afferents innervating the uterine cervix.
Academic Article Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming.
Academic Article Spinal alpha 2-adrenoceptor-mediated analgesia in neuropathic pain reflects brain-derived nerve growth factor and changes in spinal cholinergic neuronal function.
Academic Article Differing neurophysiologic mechanosensory input from glabrous and hairy skin in juvenile rats.
Academic Article Up-regulation of spinal glutamate transporters contributes to anti-hypersensitive effects of valproate in rats after peripheral nerve injury.
Academic Article Developmental differences in peripheral glabrous skin mechanosensory nerve receptive field and intracellular electrophysiologic properties: phenotypic characterization in infant and juvenile rats.
Academic Article Gabapentin inhibits ?-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats.
Academic Article Ondansetron reverses antihypersensitivity from clonidine in rats after peripheral nerve injury: role of ?-aminobutyric acid in a2-adrenoceptor and 5-HT3 serotonin receptor analgesia.
Academic Article The puerperium alters spinal cord plasticity following peripheral nerve injury.
Academic Article Estrogen reduces efficacy of mu- but Not kappa-opioid agonist inhibition in response to uterine cervical distension.
Academic Article Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain.
Academic Article Effect of kappa opioid agonists on visceral nociception induced by uterine cervical distension in rats.
Academic Article Spinal noradrenergic activation mediates allodynia reduction from an allosteric adenosine modulator in a rat model of neuropathic pain.
Academic Article Role of adenosine receptors in spinal G-protein activation after peripheral nerve injury.
Academic Article Nicotinic acetylcholine receptor regulation of spinal norepinephrine release.
Academic Article Pharmacology of opioid inhibition to noxious uterine cervical distension.
Academic Article Intrathecal ketorolac reverses hypersensitivity following acute fentanyl exposure.
Academic Article Intrathecal lidocaine reverses tactile allodynia caused by nerve injuries and potentiates the antiallodynic effect of the COX inhibitor ketorolac.
Academic Article Allosteric adenosine receptor modulation reduces hypersensitivity following peripheral inflammation by a central mechanism.
Academic Article Chronic constriction injury of sciatic nerve induces the up-regulation of descending inhibitory noradrenergic innervation to the lumbar dorsal horn of mice.
Academic Article Spinal adrenergic and cholinergic receptor interactions activated by clonidine in postincisional pain.
Academic Article Immunocytochemical localization of the alpha3, alpha4, alpha5, alpha7, beta2, beta3 and beta4 nicotinic acetylcholine receptor subunits in the locus coeruleus of the rat.
Academic Article Intrathecal morphine reduces the visceromotor response to acute uterine cervical distension in an estrogen-independent manner.
Academic Article Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury.
Academic Article Systemic, but not intrathecal ketorolac is antinociceptive to uterine cervical distension in rats.
Academic Article Electrical field stimulation to study inhibitory mechanisms in individual sensory neurons in culture.
Academic Article Knock down of the alpha 5 nicotinic acetylcholine receptor in spinal nerve-ligated rats alleviates mechanical allodynia.
Academic Article Spinal noradrenaline transporter inhibition by reboxetine and Xen2174 reduces tactile hypersensitivity after surgery in rats.
Academic Article alpha2-Adrenoceptor activation by clonidine enhances stimulation-evoked acetylcholine release from spinal cord tissue after nerve ligation in rats.
Academic Article Preoperative inhibition of cyclooxygenase-1 in the spinal cord reduces postoperative pain.
Academic Article Perineural clonidine reduces mechanical hypersensitivity and cytokine production in established nerve injury.
Academic Article Treating and preventing chronic pain: a view from the spinal cord--Bonica Lecture, ASRA Annual Meeting, 2005.
Academic Article Intrathecal administration of a cylcooxygenase-1, but not a cyclooxygenase-2 inhibitor, reverses the effects of laparotomy on exploratory activity in rats.
Academic Article Chronic activation of spinal adenosine A1 receptors results in hypersensitivity.
Academic Article A pain model after gynecologic surgery: the effect of intrathecal and systemic morphine.
Academic Article Spinal glial activation contributes to postoperative mechanical hypersensitivity in the rat.
Academic Article Neuronal nitric oxide synthase is upregulated in a subset of primary sensory afferents after nerve injury which are necessary for analgesia from alpha2-adrenoceptor stimulation.
Academic Article Analgesia induced by perineural clonidine is enhanced in persistent neuritis.
Academic Article Spinal cannabinoid receptor type 2 activation reduces hypersensitivity and spinal cord glial activation after paw incision.
Academic Article Oral donepezil reduces hypersensitivity after nerve injury by a spinal muscarinic receptor mechanism.
Academic Article Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil.
Academic Article ST91 [2-(2,6-diethylphenylamino)-2-imidazoline hydrochloride]-mediated spinal antinociception and synergy with opioids persists in the absence of functional alpha-2A- or alpha-2C-adrenergic receptors.
Academic Article Assessment of behavior during labor in rats and effect of intrathecal morphine.
Academic Article Electrophysiologic characteristics of large neurons in dorsal root ganglia during development and after hind paw incision in the rat.
Academic Article Animal models and the prediction of efficacy in clinical trials of analgesic drugs: a critical appraisal and call for uniform reporting standards.
Academic Article Multiplicative interactions to enhance gabapentin to treat neuropathic pain.
Academic Article Gabapentin acts within the locus coeruleus to alleviate neuropathic pain.
Academic Article The effect of peripherally administered CDP-choline in an acute inflammatory pain model: the role of alpha7 nicotinic acetylcholine receptor.
Academic Article Activation of glutamate transporters in the locus coeruleus paradoxically activates descending inhibition in rats.
Academic Article Contribution of the chemokine (C-C motif) ligand 2 (CCL2) to mechanical hypersensitivity after surgical incision in rats.
Academic Article Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat.
Academic Article A tropomyosine receptor kinase inhibitor blocks spinal neuroplasticity essential for the anti-hypersensitivity effects of gabapentin and clonidine in rats with peripheral nerve injury.
Academic Article Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors.
Academic Article Oxytocin inhibits the membrane depolarization-induced increase in intracellular calcium in capsaicin sensitive sensory neurons: a peripheral mechanism of analgesic action.
Academic Article Depletion of endogenous noradrenaline does not prevent spinal cord plasticity following peripheral nerve injury.
Academic Article Riluzole and gabapentinoids activate glutamate transporters to facilitate glutamate-induced glutamate release from cultured astrocytes.
Academic Article Skin incision-induced receptive field responses of mechanosensitive peripheral neurons are developmentally regulated in the rat.
Academic Article Relief of hypersensitivity after nerve injury from systemic donepezil involves spinal cholinergic and ?-aminobutyric acid mechanisms.
Academic Article Reversal of peripheral nerve injury-induced hypersensitivity in the postpartum period: role of spinal oxytocin.
Concept Pregnancy, Animal
Concept Models, Animal
Concept Animals
Concept Behavior, Animal
Concept Disease Models, Animal
Concept Animals, Newborn
Academic Article Valproate prevents dysregulation of spinal glutamate and reduces the development of hypersensitivity in rats after peripheral nerve injury.
Academic Article Nociceptor-selective peripheral nerve block induces delayed mechanical hypersensitivity and neurotoxicity in rats.
Academic Article Preclinical toxicity screening of intrathecal oxytocin in rats and dogs.
Academic Article Gabapentin increases extracellular glutamatergic level in the locus coeruleus via astroglial glutamate transporter-dependent mechanisms.
Academic Article Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain.
Academic Article Modeling individual recovery after peripheral nerve injury in rats and the effects of parturition.
Academic Article Fast-conducting mechanoreceptors contribute to withdrawal behavior in normal and nerve injured rats.
Academic Article Nerve injury induces a new profile of tactile and mechanical nociceptor input from undamaged peripheral afferents.
Academic Article Assessment of attention threshold in rats by titration of visual cue duration during the five choice serial reaction time task.
Academic Article Individual differences in acute pain-induced endogenous analgesia predict time to resolution of postoperative pain in the rat.
Academic Article Impaired Pain-evoked Analgesia after Nerve Injury in Rats Reflects Altered Glutamate Regulation in the Locus Coeruleus.
Academic Article Down-regulation of astroglial glutamate transporter-1 in the locus coeruleus impairs pain-evoked endogenous analgesia in rats.
Academic Article Reporting of Preclinical Research in Anesthesiology: Transparency and Enforcement.
Academic Article Disruption of Spinal Noradrenergic Activation Delays Recovery of Acute Incision-Induced Hypersensitivity and Increases Spinal Glial Activation in the Rat.
Academic Article Mechanical sensibility of nociceptive and non-nociceptive fast-conducting afferents is modulated by skin temperature.
Academic Article Gabapentin loses efficacy over time after nerve injury in rats: role of glutamate transporter-1 in the locus coeruleus.
Grant EPIDURAL CLONIDINE ANALGESIA IN OBSTETRICS
Grant Receptor Selective Spinal Analgesia
Grant Spinal Noradrenergic Sprouting after Nerve Injury
Grant Recovery from Pain and Disability after Surgery
Grant EPIDURAL CLONIDINE ANALGESIA IN OBSTETRICS
Grant Receptor Selective Spinal Analgesia
Grant Pharmacologic Plasticity in the Presence of Pain
Grant Alpha2-Adrenergic Analgesia
Academic Article Assessment of Behavioral Disruption in Rats with Abdominal Inflammation Using Visual Cue Titration and the Five-choice Serial-reaction Time Task.
Academic Article Post-discharge hyperpolarization is an endogenous modulatory factor limiting input from fast-conducting nociceptors (AHTMRs).
Academic Article Blockade of a2-adrenergic or metabotropic glutamate receptors induces glutamate release in the locus coeruleus to activate descending inhibition in rats with chronic neuropathic hypersensitivity.
Academic Article Plasticity and Function of Spinal Oxytocin and Vasopressin Signaling during Recovery from Surgery with Nerve Injury.
Academic Article Incisional Nociceptive Input Impairs Attention-related Behavior and Is Associated with Reduced Neuronal Activity in the Prefrontal Cortex in Rats.
Academic Article Psychosocial Stress Delays Recovery of Postoperative Pain Following Incisional Surgery in the Rat.
Academic Article Peripheral oxytocin restores light touch and nociceptor sensory afferents towards normal after nerve injury.
Academic Article Spinal Exparel®-an extended duration of preclinical study needed.
Academic Article Tachykinins modulate nociceptive responsiveness and sensitization: In vivo electrical characterization of primary sensory neurons in tachykinin knockout (Tac1 KO) mice.
Academic Article Descending Noradrenergic Inhibition: An Important Mechanism of Gabapentin Analgesia in Neuropathic Pain.
Academic Article Peripheral nerve injury in rats induces alternations in choice behavior associated with food reinforcement.
Academic Article Nociceptive input after peripheral nerve injury results in cognitive impairment and alterations in primary afferent physiology in rats.
Academic Article Recovery from nerve injury induced behavioral hypersensitivity in rats parallels resolution of abnormal primary sensory afferent signaling.
Academic Article Capsaicin-induced pain and sensitisation in the postpartum period.

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