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One or more keywords matched the following properties of Drenan, Ryan
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keywords nicotine
overview We study the physiological processes regulated by native nicotinic acetylcholine receptors (nAChRs), a large family of ligand gated ion channel proteins. These receptors mediate key aspects of cholinergic signaling in the brain and are involved in several important cognitive processes, including motivated behavior, affective behavior, attention and learning/memory. Aberrant nAChR activity is linked to several neurological diseases/disorders, such as nicotine addiction, schizophrenia, major depressive disorder, Alzheimer's disease and Parkinson's disease. We use a broad range of techniques, including patch clamp electrophysiology, confocal and two-photon imaging, immunohistochemistry and behavioral approaches such as drug self-administration.
One or more keywords matched the following items that are connected to Drenan, Ryan
Item TypeName
Concept Nicotine
Grant Alpha6* nAChRs in Dopamine Transmission and Nicotine Dependence
Grant Nicotinic ACh Receptors and Noradrenergic Neurotransmission in Nicotine Addiction
Grant Alpha6* nAChRs in Dopamine Transmission and Nicotine Dependence
Grant Identifying nicotine withdrawal mechanisms hidden within habenular complexity
Grant Nicotinic acetylcholine receptor function in the mesolimbic dopamine system
Grant Photoactivatable ligands for nicotinic optopharmacology
Academic Article Nicotine and ethanol cooperate to enhance ventral tegmental area AMPA receptor function via a6-containing nicotinic receptors.
Academic Article Probing Nicotinic Acetylcholine Receptor Function in Mouse Brain Slices via Laser Flash Photolysis of Photoactivatable Nicotine.
Academic Article Photoactivatable drugs for nicotinic optopharmacology.
Academic Article a6-Containing nicotinic acetylcholine receptors in midbrain dopamine neurons are poised to govern dopamine-mediated behaviors and synaptic plasticity.
Academic Article Structural differences determine the relative selectivity of nicotinic compounds for native alpha 4 beta 2*-, alpha 6 beta 2*-, alpha 3 beta 4*- and alpha 7-nicotine acetylcholine receptors.
Academic Article Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors.
Academic Article Differential expression and function of nicotinic acetylcholine receptors in subdivisions of medial habenula.
Academic Article Cholinergic modulation of locomotion and striatal dopamine release is mediated by alpha6alpha4* nicotinic acetylcholine receptors.
Academic Article Chronic Nicotine Exposure Alters the Neurophysiology of Habenulo-Interpeduncular Circuitry.
Academic Article Evidence for a role for a6(*) nAChRs in l-dopa-induced dyskinesias using Parkinsonian a6(*) nAChR gain-of-function mice.
Academic Article Nicotine Dependence Reveals Distinct Responses from Neurons and Their Resident Nicotinic Receptors in Medial Habenula.
Academic Article Insights into the neurobiology of the nicotinic cholinergic system and nicotine addiction from mice expressing nicotinic receptors harboring gain-of-function mutations.
Academic Article Altered nicotine reward-associated behavior following a4 nAChR subunit deletion in ventral midbrain.
Academic Article TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus.
Academic Article Differential Nicotinic Modulation of Glutamatergic and GABAergic VTA Microcircuits.
Grant Photoactivatable ligands for nicotinic optopharmacology
Academic Article Nicotine Self-Administration Induces Plastic Changes to Nicotinic Receptors in Medial Habenula.
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