D004264Chemicals & DrugsD08.811.399.403.483490.988772DNA Topoisomerases, Type IFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:meshTreeNumberMeSH tree numberprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierDepartmentvivo:hrJobTitleHR job titleInformation ResourcePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlevivo:researchAreaOfresearch area ofvivo:subjectAreaForsubject area forrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAnesthesiologyCancer BiologyWake Forest School of MedicineTimothyPardeeTimothy S. Pardee MD, PhD36.08959100000000-80.268599000000001000Pardee, TimothyAssistant ProfessorDavidCaudellDavid L. Caudell DVM, PhD36.08943500000000-80.268632000000001400Caudell, DavidAssociate ProfessorWilliamGmeinerWilliam H. Gmeiner PhD36.09032400000000-80.2664910000000080Gmeiner, WilliamProfessor27333295Gmeiner WH, Gearhart PJ, Pommier Y, Nakamura JFuture oncology (London, England)Gmeiner WH, Gearhart PJ, Pommier Y, Nakamura J. F10 cytotoxicity via topoisomerase I cleavage complex repair consistent with a unique mechanism for thymineless death. Future Oncol. 2016 Oct; 12(19):2183-8.Future Oncol2016-06-22T00:00:002016F10 cytotoxicity via topoisomerase I cleavage complex repair consistent with a unique mechanism for thymineless death.Caio MaxRocha LimaCaio Max S. Rocha Lima MD, MS2211Rocha Lima, Caio MaxProfessor20Professor24040417Dillon LW, Pierce LC, Lehman CE, Nikiforov YE, Wang YHPloS oneDillon LW, Pierce LC, Lehman CE, Nikiforov YE, Wang YH. DNA topoisomerases participate in fragility of the oncogene RET. PLoS One. 2013; 8(9):e75741.PLoS One2013-09-11T00:00:002013DNA topoisomerases participate in fragility of the oncogene RET.Internal Medicine, Hematology & OncologyPathology, Comparative Medicinetrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professor15930305Liao ZY, Sordet O, Zhang HL, Kohlhagen G, Antony S, Gmeiner WH, Pommier YCancer researchLiao ZY, Sordet O, Zhang HL, Kohlhagen G, Antony S, Gmeiner WH, Pommier Y. A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes. Cancer Res. 2005 Jun 01; 65(11):4844-51.Cancer Res2005-06-01T00:00:002005A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes.22362039Pardee TS, Gomes E, Jennings-Gee J, Caudell D, Gmeiner WHBloodPardee TS, Gomes E, Jennings-Gee J, Caudell D, Gmeiner WH. Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity. Blood. 2012 Apr 12; 119(15):3561-70.Blood2012-02-23T00:00:002012Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity.23085462Jennings-Gee J, Pardee TS, Gmeiner WHExperimental hematologyJennings-Gee J, Pardee TS, Gmeiner WH. Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity. Exp Hematol. 2013 Feb; 41(2):180-188.e4.Exp Hematol2012-10-17T00:00:002012Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity.1.52730.08133744research area of0.586910.06378217subject area for