D001905Chemicals & DrugsD12.776.097.156D23.946.123.17911370.962067Botulinum ToxinsFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:meshTreeNumberMeSH tree numberprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierDepartmentvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlevivo:researchAreaOfresearch area ofvivo:subjectAreaForsubject area forURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonNeurologyWake Forest School of MedicineJamesPirkleJames L. Pirkle MD36.08959100000000-80.268599000000001173Pirkle, JamesAssociate ProfessorL.KomanL. A. Koman MD36.08959100000000-80.26859900000000560Koman, L.ProfessorStevenClaytonSteven B. Clayton MD36.09040200000000-80.267005999999992287Clayton, StevenAssociate Professor24Assistant Professor22Associate ProfessorPatrickMcNuttPatrick M. McNutt PhD2623McNutt, PatrickAssociate Professor28220863Vazquez-Cintron EJ, Beske PH, Tenezaca L, Tran BQ, Oyler JM, Glotfelty EJ, Angeles CA, Syngkon A, Mukherjee J, Kalb SR, Band PA, McNutt PM, Shoemaker CB, Ichtchenko KScientific reportsVazquez-Cintron EJ, Beske PH, Tenezaca L, Tran BQ, Oyler JM, Glotfelty EJ, Angeles CA, Syngkon A, Mukherjee J, Kalb SR, Band PA, McNutt PM, Shoemaker CB, Ichtchenko K. Engineering Botulinum Neurotoxin C1 as a Molecular Vehicle for Intra-Neuronal Drug Delivery. Sci Rep. 2017 02 21; 7:42923.Sci Rep2017-02-21T00:00:002017Engineering Botulinum Neurotoxin C1 as a Molecular Vehicle for Intra-Neuronal Drug Delivery.33218099Winner BM, Bodt SML, McNutt PMInternational journal of molecular sciencesWinner BM, Bodt SML, McNutt PM. Special Delivery: Potential Mechanisms of Botulinum Neurotoxin Uptake and Trafficking within Motor Nerve Terminals. Int J Mol Sci. 2020 Nov 18; 21(22).Int J Mol Sci2020-11-18T00:00:002020Special Delivery: Potential Mechanisms of Botulinum Neurotoxin Uptake and Trafficking within Motor Nerve Terminals.32101733Lam KH, Tremblay JM, Vazquez-Cintron E, Perry K, Ondeck C, Webb RP, McNutt PM, Shoemaker CB, Jin RCell reportsLam KH, Tremblay JM, Vazquez-Cintron E, Perry K, Ondeck C, Webb RP, McNutt PM, Shoemaker CB, Jin R. Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins. Cell Rep. 2020 02 25; 30(8):2526-2539.e6.Cell Rep2020-02-25T00:00:002020Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins.29054436Beske PH, Bradford AB, Hoffman KM, Mason SJ, McNutt PMToxicon : official journal of the International Society on ToxinologyBeske PH, Bradford AB, Hoffman KM, Mason SJ, McNutt PM. In vitro and ex vivo screening of candidate therapeutics to restore neurotransmission in nerve terminals intoxicated by botulinum neurotoxin serotype A1. Toxicon. 2018 Jun 01; 147:47-53.Toxicon2017-10-17T00:00:002017In vitro and ex vivo screening of candidate therapeutics to restore neurotransmission in nerve terminals intoxicated by botulinum neurotoxin serotype A1.Mary AnnThenganattMary Ann Thenganatt MD2649Thenganatt, Mary AnnClinical Assistant ProfessorInternal Medicine, GastroenterologyInternal Medicine, NephrologyOrthopedic Surgery Wake Forest Institute for Regenerative Medicine35803998Mukherjee J, Ondeck CA, Tremblay JM, Archer J, Debatis M, Foss A, Awata J, Erasmus JH, McNutt PM, Shoemaker CBScientific reportsMukherjee J, Ondeck CA, Tremblay JM, Archer J, Debatis M, Foss A, Awata J, Erasmus JH, McNutt PM, Shoemaker CB. Intramuscular delivery of formulated RNA encoding six linked nanobodies is highly protective for exposures to three Botulinum neurotoxin serotypes. Sci Rep. 2022 Jul 08; 12(1):11664.Sci Rep2022-07-08T00:00:002022Intramuscular delivery of formulated RNA encoding six linked nanobodies is highly protective for exposures to three Botulinum neurotoxin serotypes.https://school.wakehealth.edu/departments/orthopaedic-surgery-and-rehabilitationDepartment Orthopaedic Surgery and Rehabilitation true1Associate ProfessorAssociate Professortrue1Associate ProfessorAssociate Professortrue1Clinical Assistant ProfessorClinical Assistant Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professor124Clinical Assistant Professor3.55380.11823311research area of0.892210.060389641subject area for