D044943Chemicals & DrugsD08.811.682.690.708.39216450.961227Fatty Acid DesaturasesFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:meshTreeNumberMeSH tree numberprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierDepartmentvivo:hrJobTitleHR job titleInformation ResourcePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlevivo:researchAreaOfresearch area ofvivo:subjectAreaForsubject area forrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonBiochemistryWake Forest School of MedicineMichaelSeedsMichael C. Seeds PhD36.09003100000000-80.268028000000001138Seeds, MichaelAssistant ProfessorJohnParksJohn S. Parks PhD36.08943500000000-80.26863200000000464Parks, JohnProfessorSusanSergeantSusan Sergeant PhD36.08919100000000-80.26677800000000936Sergeant, SusanAssistant ProfessorTimothyHowardTimothy D. Howard PhD36.09040200000000-80.26700599999999966Howard, TimothyAssistant ProfessorLindsayReynoldsLindsay M. Reynolds PhD1856Reynolds, LindsayAssistant Professor29074585Gromovsky AD, Schugar RC, Brown AL, Helsley RN, Burrows AC, Ferguson D, Zhang R, Sansbury BE, Lee RG, Morton RE, Allende DS, Parks JS, Spite M, Brown JMArteriosclerosis, thrombosis, and vascular biologyGromovsky AD, Schugar RC, Brown AL, Helsley RN, Burrows AC, Ferguson D, Zhang R, Sansbury BE, Lee RG, Morton RE, Allende DS, Parks JS, Spite M, Brown JM. ?-5 Fatty Acid Desaturase FADS1 Impacts Metabolic Disease by Balancing Proinflammatory and Proresolving Lipid Mediators. Arterioscler Thromb Vasc Biol. 2018 01; 38(1):218-231.Arterioscler Thromb Vasc Biol2017-10-26T00:00:002017?-5 Fatty Acid Desaturase FADS1 Impacts Metabolic Disease by Balancing Proinflammatory and Proresolving Lipid Mediators.29082420Wang M, Chen H, Ailati A, Chen W, Chilton FH, Todd Lowther W, Chen YQApplied microbiology and biotechnologyWang M, Chen H, Ailati A, Chen W, Chilton FH, Todd Lowther W, Chen YQ. Substrate specificity and membrane topologies of the iron-containing ?3 and ?6 desaturases from Mortierella alpina. Appl Microbiol Biotechnol. 2018 Jan; 102(1):211-223.Appl Microbiol Biotechnol2017-10-30T00:00:002017Substrate specificity and membrane topologies of the iron-containing ?3 and ?6 desaturases from Mortierella alpina.29590160Reynolds LM, Howard TD, Ruczinski I, Kanchan K, Seeds MC, Mathias RA, Chilton FHPloS oneReynolds LM, Howard TD, Ruczinski I, Kanchan K, Seeds MC, Mathias RA, Chilton FH. Tissue-specific impact of FADS cluster variants on FADS1 and FADS2 gene expression. PLoS One. 2018; 13(3):e0194610.PLoS One2018-03-28T00:00:002018Tissue-specific impact of FADS cluster variants on FADS1 and FADS2 gene expression.29636834Rahbar E, Waits CMK, Kirby EH, Miller LR, Ainsworth HC, Cui T, Sergeant S, Howard TD, Langefeld CD, Chilton FHClinical epigeneticsRahbar E, Waits CMK, Kirby EH, Miller LR, Ainsworth HC, Cui T, Sergeant S, Howard TD, Langefeld CD, Chilton FH. Allele-specific methylation in the FADS genomic region in DNA from human saliva, CD4+ cells, and total leukocytes. Clin Epigenetics. 2018; 10:46.Clin Epigenetics2018-04-06T00:00:002018Allele-specific methylation in the FADS genomic region in DNA from human saliva, CD4+ cells, and total leukocytes.24Assistant Professor32985521Reynolds LM, Dutta R, Seeds MC, Lake KN, Hallmark B, Mathias RA, Howard TD, Chilton FHScientific reportsReynolds LM, Dutta R, Seeds MC, Lake KN, Hallmark B, Mathias RA, Howard TD, Chilton FH. FADS genetic and metabolomic analyses identify the ?5 desaturase (FADS1) step as a critical control point in the formation of biologically important lipids. Sci Rep. 2020 09 28; 10(1):15873.Sci Rep2020-09-28T00:00:002020FADS genetic and metabolomic analyses identify the ?5 desaturase (FADS1) step as a critical control point in the formation of biologically important lipids.Davie Hospital Emergency DepartmentEpidemiology & Prevention (Public Health Sciences)Internal Medicine, Molecular MedicineWake Forest Institute for Regenerative Medicinetrue1Assistant ProfessorAssistant Professortrue1Assistant ProfessorAssistant Professortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professor1.434570.028769116research area of0.788970.10711820subject area for