PatrickMcNuttPatrick M. McNutt PhD2623McNutt, Patrickbotulinum neurotoxinsneurotoxicologyNeuropharmacologyCorneal Diseasebiological and chemical warfare agentsOrganophosphatesDrug developmentMichaelI am excited to return to Wake Forest University, where I earned undergraduate degrees in Biology and Chemistry before completing a PhD in Cellular and Molecular Biology at Princeton University. After graduate school, I served as an Army officer for eight years, including a tour in Iraq. I accepted a DoD Principal Investigator position in 2010, where I built a large research program developing countermeasures for highly dangerous biological and chemical poisons affecting the central and peripheral nervous systems as well as the cornea of the eye. In 2020, I accepted a faculty position at the Wake Forest Institute for Regenerative Medicine (WFIRM), where I am (1) conducting fundamental studies to understand toxic mechanisms of diverse poisons at scales ranging from individual receptors to multi-organ physiological responses; (2) developing comprehensive therapies that mitigate toxicity and promote regeneration; and (3) exploiting WFIRM's unique capabilities to develop organoid models of complex diseases and toxic injuries.
My research priorities are:
1. Investigate molecular, cellular and functional mechanisms underlying toxicity and regeneration, with the goal of applying new knowledge to treat and cure human disease
2. Expand scientific knowledge through creativity, excellence and rigor
3. Advance the next generation of scientists.
A current list of publications is available at
https://orcid.org/0000-0002-5703-4565
and
https://scholar.google.com/citations?user=ceRIHocAAAAJ&hlAssociate Professororng:hasLinksWebsitesprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:trainingAtOrganizationeducational organizationprns:trainingLocationtraining locationprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:degreeEarneddegree earnedDepartmentvivo:educationalTrainingeducation and trainingEducational Trainingvivo:freetextKeywordkeywordsvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:majorFieldmajor field of degreevivo:middleNamemiddle name or initialvivo:overviewoverviewvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD009151Chemicals & Drugs280.976535Mustard GasWake Forest School of MedicineRonaldDavisRonald L. Davis MD36.08546200000000-80.302559000000001147Davis, RonaldAssociate ProfessorAnthonyAtalaAnthony Atala MD36.08943500000000-80.268632000000003Atala, AnthonyProfessorOsvaldoDelbonoOsvaldo Delbono MD, PhD36.08977400000000-80.26684000000000730Delbono, OsvaldoProfessor22Associate Professor3.820670.00688568214research areas76.6416.5858738similar to1144selected publications12/2000Princeton UniversityPrinceton, NJPrinceton University, Cellular and Molecular BiologyPhDCellular and Molecular Biology12/1994Wake Forest UniversityWinston-Salem, NCWake Forest University, BiologyBSBiology12/1994Wake Forest UniversityWinston-Salem, NCWake Forest University, ChemistryBAChemistry05/1996Princeton UniversityPrinceton, NJPrinceton University, Cellular and Molecular BiologyMACellular and Molecular BiologyAuthorship 701391Authorship 701401Authorship 701413Authorship 701421Authorship 7014313Authorship 701449Authorship 701453Authorship 7014614Authorship 701477Authorship 701481Authorship 701496Authorship 701509Authorship 701516Authorship 701524Authorship 701535Authorship 701545Authorship 7015512Authorship 701561Authorship 701578Authorship 701582Authorship 701594Authorship 701604Authorship 701614Authorship 701621Authorship 701636Authorship 701646Authorship 701656Authorship 701661Authorship 701675Authorship 701681Authorship 701692Authorship 701701Authorship 701719Authorship 701721Authorship 701734Authorship 701741Authorship 701753Authorship 701765Authorship 701773Authorship 701782Authorship 70179829988463Thirunavukkarasu N, Johnson E, Pillai S, Hodge D, Stanker L, Wentz T, Singh B, Venkateswaran K, McNutt P, Adler M, Brown E, Hammack T, Burr D, Sharma SFrontiers in bioengineering and biotechnologyThirunavukkarasu N, Johnson E, Pillai S, Hodge D, Stanker L, Wentz T, Singh B, Venkateswaran K, McNutt P, Adler M, Brown E, Hammack T, Burr D, Sharma S. Botulinum Neurotoxin Detection Methods for Public Health Response and Surveillance. Front Bioeng Biotechnol. 2018; 6:80.Front Bioeng Biotechnol2018-06-22T00:00:002018Botulinum Neurotoxin Detection Methods for Public Health Response and Surveillance.29366638Bradford AB, Machamer JB, Russo TM, McNutt PMToxicology and applied pharmacologyBradford AB, Machamer JB, Russo TM, McNutt PM. 3,4-diaminopyridine reverses paralysis in botulinum neurotoxin-intoxicated diaphragms through two functionally distinct mechanisms. Toxicol Appl Pharmacol. 2018 02 15; 341:77-86.Toxicol Appl Pharmacol2018-01-30T00:00:0020183,4-diaminopyridine reverses paralysis in botulinum neurotoxin-intoxicated diaphragms through two functionally distinct mechanisms.10508659Steinberg MS, McNutt PMCurrent opinion in cell biologySteinberg MS, McNutt PM. Cadherins and their connections: adhesion junctions have broader functions. Curr Opin Cell Biol. 1999 Oct; 11(5):554-60.Curr Opin Cell Biol1999-10-01T00:00:001999Cadherins and their connections: adhesion junctions have broader functions.33497768McNutt PM, Kelly KEM, Altvater AC, Nelson MR, Lyman ME, O'Brien S, Conroy MT, Ondeck CA, Bodt SML, Wolfe SE, Schulz SM, Kniffin DM, Hall NB, Hamilton TAToxicology lettersMcNutt PM, Kelly KEM, Altvater AC, Nelson MR, Lyman ME, O'Brien S, Conroy MT, Ondeck CA, Bodt SML, Wolfe SE, Schulz SM, Kniffin DM, Hall NB, Hamilton TA. Dose-dependent emergence of acute and recurrent corneal lesions in sulfur mustard-exposed rabbit eyes. Toxicol Lett. 2021 May 01; 341:33-42.Toxicol Lett2021-01-23T00:00:002021Dose-dependent emergence of acute and recurrent corneal lesions in sulfur mustard-exposed rabbit eyes.28220863Vazquez-Cintron EJ, Beske PH, Tenezaca L, Tran BQ, Oyler JM, Glotfelty EJ, Angeles CA, Syngkon A, Mukherjee J, Kalb SR, Band PA, McNutt PM, Shoemaker CB, Ichtchenko KScientific reportsVazquez-Cintron EJ, Beske PH, Tenezaca L, Tran BQ, Oyler JM, Glotfelty EJ, Angeles CA, Syngkon A, Mukherjee J, Kalb SR, Band PA, McNutt PM, Shoemaker CB, Ichtchenko K. Engineering Botulinum Neurotoxin C1 as a Molecular Vehicle for Intra-Neuronal Drug Delivery. Sci Rep. 2017 02 21; 7:42923.Sci Rep2017-02-21T00:00:002017Engineering Botulinum Neurotoxin C1 as a Molecular Vehicle for Intra-Neuronal Drug Delivery.22069721Mesngon M, McNutt PToxinsMesngon M, McNutt P. Alpha-latrotoxin rescues SNAP-25 from BoNT/A-mediated proteolysis in embryonic stem cell-derived neurons. Toxins (Basel). 2011 05; 3(5):489-503.Toxins (Basel)2011-05-13T00:00:002011Alpha-latrotoxin rescues SNAP-25 from BoNT/A-mediated proteolysis in embryonic stem cell-derived neurons.16971202Cronk DR, Houseworth TP, Cuadrado DG, Herbert GS, McNutt PM, Azarow KSCurrent surgeryCronk DR, Houseworth TP, Cuadrado DG, Herbert GS, McNutt PM, Azarow KS. Intestinal fatty acid binding protein (I-FABP) for the detection of strangulated mechanical small bowel obstruction. Curr Surg. 2006 Sep-Oct; 63(5):322-5.Curr Surg2006-09-01T00:00:002006Intestinal fatty acid binding protein (I-FABP) for the detection of strangulated mechanical small bowel obstruction.25742030Hubbard K, Beske P, Lyman M, McNutt PJournal of visualized experiments : JoVEHubbard K, Beske P, Lyman M, McNutt P. Functional evaluation of biological neurotoxins in networked cultures of stem cell-derived central nervous system neurons. J Vis Exp. 2015 Feb 05; (96).J Vis Exp2015-02-05T00:00:002015Functional evaluation of biological neurotoxins in networked cultures of stem cell-derived central nervous system neurons.23691214Gut IM, Beske PH, Hubbard KS, Lyman ME, Hamilton TA, McNutt PMPloS oneGut IM, Beske PH, Hubbard KS, Lyman ME, Hamilton TA, McNutt PM. Novel application of stem cell-derived neurons to evaluate the time- and dose-dependent progression of excitotoxic injury. PLoS One. 2013; 8(5):e64423.PLoS One2013-05-14T00:00:002013Novel application of stem cell-derived neurons to evaluate the time- and dose-dependent progression of excitotoxic injury.33218099Winner BM, Bodt SML, McNutt PMInternational journal of molecular sciencesWinner BM, Bodt SML, McNutt PM. Special Delivery: Potential Mechanisms of Botulinum Neurotoxin Uptake and Trafficking within Motor Nerve Terminals. Int J Mol Sci. 2020 Nov 18; 21(22).Int J Mol Sci2020-11-18T00:00:002020Special Delivery: Potential Mechanisms of Botulinum Neurotoxin Uptake and Trafficking within Motor Nerve Terminals.26615023Beske PH, Bradford AB, Grynovicki JO, Glotfelty EJ, Hoffman KM, Hubbard KS, Tuznik KM, McNutt PMToxicological sciences : an official journal of the Society of ToxicologyBeske PH, Bradford AB, Grynovicki JO, Glotfelty EJ, Hoffman KM, Hubbard KS, Tuznik KM, McNutt PM. Botulinum and Tetanus Neurotoxin-Induced Blockade of Synaptic Transmission in Networked Cultures of Human and Rodent Neurons. Toxicol Sci. 2016 Feb; 149(2):503-15.Toxicol Sci2015-11-28T00:00:002015Botulinum and Tetanus Neurotoxin-Induced Blockade of Synaptic Transmission in Networked Cultures of Human and Rodent Neurons.32987745Tremblay JM, Vazquez-Cintron E, Lam KH, Mukherjee J, Bedenice D, Ondeck CA, Conroy MT, Bodt SML, Winner BM, Webb RP, Ichtchenko K, Jin R, McNutt PM, Shoemaker CBToxinsTremblay JM, Vazquez-Cintron E, Lam KH, Mukherjee J, Bedenice D, Ondeck CA, Conroy MT, Bodt SML, Winner BM, Webb RP, Ichtchenko K, Jin R, McNutt PM, Shoemaker CB. Camelid VHH Antibodies that Neutralize Botulinum Neurotoxin Serotype E Intoxication or Protease Function. Toxins (Basel). 2020 09 24; 12(10).Toxins (Basel)2020-09-24T00:00:002020Camelid VHH Antibodies that Neutralize Botulinum Neurotoxin Serotype E Intoxication or Protease Function.21215258McNutt P, Celver J, Hamilton T, Mesngon MBiochemical and biophysical research communicationsMcNutt P, Celver J, Hamilton T, Mesngon M. Embryonic stem cell-derived neurons are a novel, highly sensitive tissue culture platform for botulinum research. Biochem Biophys Res Commun. 2011 Feb 04; 405(1):85-90.Biochem Biophys Res Commun2011-01-05T00:00:002011Embryonic stem cell-derived neurons are a novel, highly sensitive tissue culture platform for botulinum research.32182542McCarren HS, Eisen MR, Nguyen DL, Dubée PB, Ardinger CE, Dunn EN, Haines KM, Santoro AN, Bodner PM, Ondeck CA, Honnold CL, McDonough JH, Beske PH, McNutt PMEpilepsy researchMcCarren HS, Eisen MR, Nguyen DL, Dubée PB, Ardinger CE, Dunn EN, Haines KM, Santoro AN, Bodner PM, Ondeck CA, Honnold CL, McDonough JH, Beske PH, McNutt PM. Characterization and treatment of spontaneous recurrent seizures following nerve agent-induced status epilepticus in mice. Epilepsy Res. 2020 05; 162:106320.Epilepsy Res2020-03-10T00:00:002020Characterization and treatment of spontaneous recurrent seizures following nerve agent-induced status epilepticus in mice.16385254Harsha WT, Kalandarova E, McNutt P, Irwin R, Noel JJournal of pediatric gastroenterology and nutritionHarsha WT, Kalandarova E, McNutt P, Irwin R, Noel J. Nutritional supplementation with transforming growth factor-beta, glutamine, and short chain fatty acids minimizes methotrexate-induced injury. J Pediatr Gastroenterol Nutr. 2006 Jan; 42(1):53-8.J Pediatr Gastroenterol Nutr2006-01-01T00:00:002006Nutritional supplementation with transforming growth factor-beta, glutamine, and short chain fatty acids minimizes methotrexate-induced injury.32044824McNutt PM, Nguyen DL, Nelson MR, Lyman ME, Eisen MM, Ondeck CA, Wolfe SE, Pagarigan KT, Mangkhalakhili MC, Kniffin DM, Hamilton TACorneaMcNutt PM, Nguyen DL, Nelson MR, Lyman ME, Eisen MM, Ondeck CA, Wolfe SE, Pagarigan KT, Mangkhalakhili MC, Kniffin DM, Hamilton TA. Corneal Endothelial Cell Toxicity Determines Long-Term Outcome After Ocular Exposure to Sulfur Mustard Vapor. Cornea. 2020 May; 39(5):640-648.Cornea2020-05-01T00:00:002020Corneal Endothelial Cell Toxicity Determines Long-Term Outcome After Ocular Exposure to Sulfur Mustard Vapor.16912867McNutt PM, Dehart MJ, Matej LAPlant cell reportsMcNutt PM, Dehart MJ, Matej LA. Characterization of the 16S-23S internal transcribed spacer among 34 higher plants: suitability for interspecific plastid transformation. . 2007 Jan; 26(1):47-60.2006-08-16T00:00:002006Characterization of the 16S-23S internal transcribed spacer among 34 higher plants: suitability for interspecific plastid transformation.25781714McNutt P, Gut I, Hubbard K, Beske PStatistical applications in genetics and molecular biologyMcNutt P, Gut I, Hubbard K, Beske P. A novel method to prioritize RNAseq data for post-hoc analysis based on absolute changes in transcript abundance. Stat Appl Genet Mol Biol. 2015 Jun; 14(3):227-41.Stat Appl Genet Mol Biol2015-06-01T00:00:002015A novel method to prioritize RNAseq data for post-hoc analysis based on absolute changes in transcript abundance.32101733Lam KH, Tremblay JM, Vazquez-Cintron E, Perry K, Ondeck C, Webb RP, McNutt PM, Shoemaker CB, Jin RCell reportsLam KH, Tremblay JM, Vazquez-Cintron E, Perry K, Ondeck C, Webb RP, McNutt PM, Shoemaker CB, Jin R. Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins. Cell Rep. 2020 02 25; 30(8):2526-2539.e6.Cell Rep2020-02-25T00:00:002020Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins.22316652McNutt P, Hamilton T, Nelson M, Adkins A, Swartz A, Lawrence R, Milhorn DCorneaMcNutt P, Hamilton T, Nelson M, Adkins A, Swartz A, Lawrence R, Milhorn D. Pathogenesis of acute and delayed corneal lesions after ocular exposure to sulfur mustard vapor. Cornea. 2012 Mar; 31(3):280-90.Cornea2012-03-01T00:00:002012Pathogenesis of acute and delayed corneal lesions after ocular exposure to sulfur mustard vapor.31132436Hoffman KM, Eisen MR, Chandler JK, Nelson MR, Johnson EA, McNutt PMNeuropharmacologyHoffman KM, Eisen MR, Chandler JK, Nelson MR, Johnson EA, McNutt PM. Retrograde activation of CB1R by muscarinic receptors protects against central organophosphorus toxicity. Neuropharmacology. 2019 09 01; 155:113-120.Neuropharmacology2019-05-24T00:00:002019Retrograde activation of CB1R by muscarinic receptors protects against central organophosphorus toxicity.29158500Beske PH, Hoffman KM, Machamer JB, Eisen MR, McNutt PMScientific reportsBeske PH, Hoffman KM, Machamer JB, Eisen MR, McNutt PM. Use-dependent potentiation of voltage-gated calcium channels rescues neurotransmission in nerve terminals intoxicated by botulinum neurotoxin serotype A. Sci Rep. 2017 Nov 20; 7(1):15862.Sci Rep2017-11-20T00:00:002017Use-dependent potentiation of voltage-gated calcium channels rescues neurotransmission in nerve terminals intoxicated by botulinum neurotoxin serotype A.32691075Machamer JB, Apland JP, Winner BM, Wolfe SE, Pagarigan KT, Bounader KM, Kasten SA, Adler M, McNutt PMArchives of toxicologyMachamer JB, Apland JP, Winner BM, Wolfe SE, Pagarigan KT, Bounader KM, Kasten SA, Adler M, McNutt PM. Functional basis for dose-dependent antagonism of rat and rabbit neuromuscular transmission by the bis-pyridinium oxime MMB4. Arch Toxicol. 2020 11; 94(11):3877-3891.Arch Toxicol2020-07-20T00:00:002020Functional basis for dose-dependent antagonism of rat and rabbit neuromuscular transmission by the bis-pyridinium oxime MMB4.32464237Yeung DT, Araj H, McNutt PMToxicology lettersYeung DT, Araj H, McNutt PM. Abstracts of Presentations from the 2020 Trans-Agency Scientific Meeting on Developing Medical Countermeasures to Treat the Acute and Chronic Effects of Ocular Chemical Toxicity, 25-26 February, Bethesda, Maryland. Toxicol Lett. 2020 May 25; 1-3.Toxicol Lett2020-05-25T00:00:002020Abstracts of Presentations from the 2020 Trans-Agency Scientific Meeting on Developing Medical Countermeasures to Treat the Acute and Chronic Effects of Ocular Chemical Toxicity, 25-26 February, Bethesda, Maryland.17000234Gotkin JL, Celver J, McNutt P, Shields AD, Howard BC, Paonessa DJ, Napolitano PGAmerican journal of obstetrics and gynecologyGotkin JL, Celver J, McNutt P, Shields AD, Howard BC, Paonessa DJ, Napolitano PG. Progesterone reduces lipopolysaccharide induced interleukin-6 secretion in fetoplacental chorionic arteries, fractionated cord blood, and maternal mononuclear cells. Am J Obstet Gynecol. 2006 Oct; 195(4):1015-9.Am J Obstet Gynecol2006-10-01T00:00:002006Progesterone reduces lipopolysaccharide induced interleukin-6 secretion in fetoplacental chorionic arteries, fractionated cord blood, and maternal mononuclear cells.33408188McNutt PM, Vazquez-Cintron EJ, Tenezaca L, Ondeck CA, Kelly KE, Mangkhalakhili M, Machamer JB, Angeles CA, Glotfelty EJ, Cika J, Benjumea CH, Whitfield JT, Band PA, Shoemaker CB, Ichtchenko KScience translational medicineMcNutt PM, Vazquez-Cintron EJ, Tenezaca L, Ondeck CA, Kelly KE, Mangkhalakhili M, Machamer JB, Angeles CA, Glotfelty EJ, Cika J, Benjumea CH, Whitfield JT, Band PA, Shoemaker CB, Ichtchenko K. Neuronal delivery of antibodies has therapeutic effects in animal models of botulism. Sci Transl Med. 2021 Jan 06; 13(575).Sci Transl Med2021-01-06T00:00:002021Neuronal delivery of antibodies has therapeutic effects in animal models of botulism.24045986McNutt P, Tuznik K, Nelson M, Adkins A, Lyman M, Glotfelty E, Hughes J, Hamilton TInvestigative ophthalmology & visual scienceMcNutt P, Tuznik K, Nelson M, Adkins A, Lyman M, Glotfelty E, Hughes J, Hamilton T. Structural, morphological, and functional correlates of corneal endothelial toxicity following corneal exposure to sulfur mustard vapor. Invest Ophthalmol Vis Sci. 2013 Oct 15; 54(10):6735-44.Invest Ophthalmol Vis Sci2013-10-15T00:00:002013Structural, morphological, and functional correlates of corneal endothelial toxicity following corneal exposure to sulfur mustard vapor.24358889Hubbard KS, Gut IM, Lyman ME, McNutt PMF1000ResearchHubbard KS, Gut IM, Lyman ME, McNutt PM. Longitudinal RNA sequencing of the deep transcriptome during neurogenesis of cortical glutamatergic neurons from murine ESCs. F1000Res. 2013; 2:35.F1000Res2013-02-07T00:00:002013Longitudinal RNA sequencing of the deep transcriptome during neurogenesis of cortical glutamatergic neurons from murine ESCs.20536452Milhorn D, Hamilton T, Nelson M, McNutt PAnnals of the New York Academy of SciencesMilhorn D, Hamilton T, Nelson M, McNutt P. Progression of ocular sulfur mustard injury: development of a model system. Ann N Y Acad Sci. 2010 Apr; 1194:72-80.Ann N Y Acad Sci2010-04-01T00:00:002010Progression of ocular sulfur mustard injury: development of a model system.22892216Hubbard KS, Gut IM, Scheeler SM, Lyman ME, McNutt PMBMC research notesHubbard KS, Gut IM, Scheeler SM, Lyman ME, McNutt PM. Compatibility of SYTO 13 and Hoechst 33342 for longitudinal imaging of neuron viability and cell death. BMC Res Notes. 2012 Aug 14; 5:437.BMC Res Notes2012-08-14T00:00:002012Compatibility of SYTO 13 and Hoechst 33342 for longitudinal imaging of neuron viability and cell death.29766717Wang H, Wagner GW, Lu AX, Nguyen DL, Buchanan JH, McNutt PM, Karwacki CJACS applied materials & interfacesWang H, Wagner GW, Lu AX, Nguyen DL, Buchanan JH, McNutt PM, Karwacki CJ. Photocatalytic Oxidation of Sulfur Mustard and Its Simulant on BODIPY-Incorporated Polymer Coatings and Fabrics. ACS Appl Mater Interfaces. 2018 Jun 06; 10(22):18771-18777.ACS Appl Mater Interfaces2018-05-25T00:00:002018Photocatalytic Oxidation of Sulfur Mustard and Its Simulant on BODIPY-Incorporated Polymer Coatings and Fabrics.24162749Gore A, Horwitz V, Gutman H, Tveria L, Cohen L, Cohen-Jacob O, Turetz J, McNutt PM, Dachir S, Kadar TCorneaGore A, Horwitz V, Gutman H, Tveria L, Cohen L, Cohen-Jacob O, Turetz J, McNutt PM, Dachir S, Kadar T. Cultivation and characterization of limbal epithelial stem cells on contact lenses with a feeder layer: toward the treatment of limbal stem cell deficiency. Cornea. 2014 Jan; 33(1):65-71.Cornea2014-01-01T00:00:002014Cultivation and characterization of limbal epithelial stem cells on contact lenses with a feeder layer: toward the treatment of limbal stem cell deficiency.29054436Beske PH, Bradford AB, Hoffman KM, Mason SJ, McNutt PMToxicon : official journal of the International Society on ToxinologyBeske PH, Bradford AB, Hoffman KM, Mason SJ, McNutt PM. In vitro and ex vivo screening of candidate therapeutics to restore neurotransmission in nerve terminals intoxicated by botulinum neurotoxin serotype A1. Toxicon. 2018 Jun 01; 147:47-53.Toxicon2017-10-17T00:00:002017In vitro and ex vivo screening of candidate therapeutics to restore neurotransmission in nerve terminals intoxicated by botulinum neurotoxin serotype A1.23597229Andres D, Keyser BM, Petrali J, Benton B, Hubbard KS, McNutt PM, Ray RBMC neuroscienceAndres D, Keyser BM, Petrali J, Benton B, Hubbard KS, McNutt PM, Ray R. Morphological and functional differentiation in BE(2)-M17 human neuroblastoma cells by treatment with Trans-retinoic acid. BMC Neurosci. 2013 Apr 18; 14:49.BMC Neurosci2013-04-18T00:00:002013Morphological and functional differentiation in BE(2)-M17 human neuroblastoma cells by treatment with Trans-retinoic acid.27310673McNutt PM, Tuznik KM, Glotfelty EJ, Nelson MR, Lyman ME, Hamilton TAAnnals of the New York Academy of SciencesMcNutt PM, Tuznik KM, Glotfelty EJ, Nelson MR, Lyman ME, Hamilton TA. Contributions of tissue-specific pathologies to corneal injuries following exposure to SM vapor. Ann N Y Acad Sci. 2016 06; 1374(1):132-43.Ann N Y Acad Sci2016-06-16T00:00:002016Contributions of tissue-specific pathologies to corneal injuries following exposure to SM vapor.25954159Beske PH, Scheeler SM, Adler M, McNutt PMFrontiers in cellular neuroscienceBeske PH, Scheeler SM, Adler M, McNutt PM. Accelerated intoxication of GABAergic synapses by botulinum neurotoxin A disinhibits stem cell-derived neuron networks prior to network silencing. Front Cell Neurosci. 2015; 9:159.Front Cell Neurosci2015-04-23T00:00:002015Accelerated intoxication of GABAergic synapses by botulinum neurotoxin A disinhibits stem cell-derived neuron networks prior to network silencing.33200044McNutt PM, Mohan RRTranslational vision science & technologyMcNutt PM, Mohan RR. The Need for Improved Therapeutic Approaches to Protect the Cornea Against Chemotoxic Injuries. Transl Vis Sci Technol. 2020 11; 9(12):2.Transl Vis Sci Technol2020-11-02T00:00:002020The Need for Improved Therapeutic Approaches to Protect the Cornea Against Chemotoxic Injuries.31996484Vazquez-Cintron E, Machamer J, Ondeck C, Pagarigan K, Winner B, Bodner P, Kelly K, Pennington MR, McNutt PJCI insightVazquez-Cintron E, Machamer J, Ondeck C, Pagarigan K, Winner B, Bodner P, Kelly K, Pennington MR, McNutt P. Symptomatic treatment of botulism with a clinically approved small molecule. JCI Insight. 2020 01 30; 5(2).JCI Insight2020-01-30T00:00:002020Symptomatic treatment of botulism with a clinically approved small molecule.22900056McNutt P, Lyman M, Swartz A, Tuznik K, Kniffin D, Whitten K, Milhorn D, Hamilton TPloS oneMcNutt P, Lyman M, Swartz A, Tuznik K, Kniffin D, Whitten K, Milhorn D, Hamilton T. Architectural and biochemical expressions of mustard gas keratopathy: preclinical indicators and pathogenic mechanisms. PLoS One. 2012; 7(8):e42837.PLoS One2012-08-10T00:00:002012Architectural and biochemical expressions of mustard gas keratopathy: preclinical indicators and pathogenic mechanisms.23095170Hubbard KS, Gut IM, Lyman ME, Tuznik KM, Mesngon MT, McNutt PMBMC neuroscienceHubbard KS, Gut IM, Lyman ME, Tuznik KM, Mesngon MT, McNutt PM. High yield derivation of enriched glutamatergic neurons from suspension-cultured mouse ESCs for neurotoxicology research. BMC Neurosci. 2012 Oct 24; 13:127.BMC Neurosci2012-10-24T00:00:002012High yield derivation of enriched glutamatergic neurons from suspension-cultured mouse ESCs for neurotoxicology research.26240679Bradford AB, McNutt PMWorld journal of stem cellsBradford AB, McNutt PM. Importance of being Nernst: Synaptic activity and functional relevance in stem cell-derived neurons. World J Stem Cells. 2015 Jul 26; 7(6):899-921.World J Stem Cells2015-07-26T00:00:002015Importance of being Nernst: Synaptic activity and functional relevance in stem cell-derived neurons.Family & Community MedicineUrologyWake Forest Institute for Regenerative Medicinehttp://www.wfirm.orgWFIRMAuthorship 734209Authorship 734219Authorship 73422335803998Mukherjee J, Ondeck CA, Tremblay JM, Archer J, Debatis M, Foss A, Awata J, Erasmus JH, McNutt PM, Shoemaker CBScientific reportsMukherjee J, Ondeck CA, Tremblay JM, Archer J, Debatis M, Foss A, Awata J, Erasmus JH, McNutt PM, Shoemaker CB. Intramuscular delivery of formulated RNA encoding six linked nanobodies is highly protective for exposures to three Botulinum neurotoxin serotypes. Sci Rep. 2022 Jul 08; 12(1):11664.Sci Rep2022-07-08T00:00:002022Intramuscular delivery of formulated RNA encoding six linked nanobodies is highly protective for exposures to three Botulinum neurotoxin serotypes.35659174Machamer JB, Vazquez-Cintron EJ, O'Brien SW, Kelly KE, Altvater AC, Pagarigan KT, Dubee PB, Ondeck CA, McNutt PMMolecular medicine (Cambridge, Mass.)Machamer JB, Vazquez-Cintron EJ, O'Brien SW, Kelly KE, Altvater AC, Pagarigan KT, Dubee PB, Ondeck CA, McNutt PM. Antidotal treatment of botulism in rats by continuous infusion with 3,4-diaminopyridine. Mol Med. 2022 06 03; 28(1):61.Mol Med2022-06-03T00:00:002022Antidotal treatment of botulism in rats by continuous infusion with 3,4-diaminopyridine.34122121Cao Z, Wang JL, McNutt PM, Utkin YN, Shahbazzadeh D, Wulff H, Kovacic H, Sabatier JMFrontiers in pharmacologyCao Z, Wang JL, McNutt PM, Utkin YN, Shahbazzadeh D, Wulff H, Kovacic H, Sabatier JM. Editorial: Venoms, Animal and Microbial Toxins. Front Pharmacol. 2021; 12:706573.Front Pharmacol2021-05-26T00:00:002021Editorial: Venoms, Animal and Microbial Toxins.true1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate ProfessorD009474Anatomy661910.850203NeuronsD000992Chemicals & Drugs260.987832AntitoxinsD001906Disorders490.986343BotulismD001905Chemicals & Drugs11370.962067Botulinum Toxins