HoomanSadriHooman Sadri MD, PhD36.08943500000000-80.268632000000002033Sadri, HoomanMale InfertilitySpermatogenesisTestisSpermatogonial Stem Cell transplantationStem CellRegenerative MedicineStem Cell TransplantationKlinefelter SyndromeReproductive Technique, AssistedReproductionReproductive HealthReproductive MedicineReproductive geneticsReproductive endocrinologyIn Vitro SpermatogenesisCryptorchidismElectroEjaculationAndrologyTesticular Sperm ExtractionSpinal Cord InjuryDr. Hooman Sadri-Ardekani is currently the director of male fertility research program at Wake Forest Institute for Regenerative Medicine (WFIRM) and Department of Urology. He has been a fellowship trained male reproductive medicine clinician since 2003. After couple of years of providing clinical services and serving as the director of a reproductive medicine center in Tehran (Avicenna Infertility Center), he sought to learn more about reproductive biology and joined the University of Amsterdam where he got his PhD in December 2011. He has since established the first in vitro propagation system for human Spermatogonial Stem Cells (SSCs) (JAMA 2009 and 2011) which has been recognized as a milestone in autotransplantation of human SSCs (Nature Reviews Urology February 2010). He has received several awards based on his innovations in the field of male reproductive biology; including the AMC Young scientist publication 2009, The 11th Royan International Research Award in Stem Cells and Developmental Biology in 2010, the Jan Swammerdam Fertility Prize 2010 and The 17th Razi research Festival award on medical science 2012). In January 2012 he moved to WFIRM to establish male fertility research program. Dr. Sadri-Ardekani is currently practicing as a clinician in Urology clinic and Wake Forest Center for Reproductive Medicine. He is running a national comprehensive referral program to preserve fertility in high risk infertility patients in different ages, from childhood to adolescence to adults; including but not limited to those with cancer, Klinefelter syndrome, spinal cord injury, diabetes and multiple sclerosis.
SYNOPSIS OF AREA OF INTEREST:
*Male reproductive medicine and biology
*Stem cell therapies for male infertility
*Tissue engineering 3D human testis organoid platform for in vitro spermatogenesis, androgen replacement, toxicology and drug screening
DETAILED AREA OF INTEREST:
Dr.Sadri-Ardekani current laboratory’s research focuses on the dynamics of male germ lineage development, which establishes the pool of Spermatogonial Stem Cells (SSCs) and the mechanisms that regulate SSC self-renewal and differentiation, ensuring continuous sperm production. His lab is actively investigating the feasibility and safety of translating In Vitro Spermatogenesis and SSC transplantation to the male fertility clinic.Assistant Professorprns:awardConferredByaward conferred byprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:trainingAtOrganizationeducational organizationprns:trainingLocationtraining locationprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:awardOrHonorawards and honorsAward or Honor Receiptvivo:degreeEarneddegree earnedDepartmentvivo:educationalTrainingeducation and trainingEducational Trainingvivo:freetextKeywordkeywordsvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:majorFieldmajor field of degreevivo:overviewoverviewvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD033581Procedures562020.855429Stem Cell TransplantationD013737Anatomy17600.948683Testis25157677Sadri-Ardekani H, Atala AStem cell research & therapySadri-Ardekani H, Atala A. Testicular tissue cryopreservation and spermatogonial stem cell transplantation to restore fertility: from bench to bedside. Stem Cell Res Ther. 2014 May 28; 5(3):68.Stem Cell Res Ther2014-05-28T00:00:002014Testicular tissue cryopreservation and spermatogonial stem cell transplantation to restore fertility: from bench to bedside.PathologyPediatricsWake Forest School of MedicineWeixinZhaoWeixin Zhao MD36.08943500000000-80.268632000000001028Zhao, WeixinAssistant ProfessorColinBishopColin E. Bishop PhD36.08943500000000-80.26863200000000122Bishop, ColinProfessorXueweiZhuXuewei Zhu PhD36.08943500000000-80.268632000000001224Zhu, XueweiAssociate ProfessorGiuseppeOrlandoGiuseppe Orlando MD, PhD36.08959100000000-80.268599000000001226Orlando, GiuseppeAssociate ProfessorAnthonyAtalaAnthony Atala MD36.08943500000000-80.268632000000003Atala, AnthonyProfessorJohnPettyJohn K. Petty MD36.08919100000000-80.26677800000000467Petty, JohnProfessorJamesYooJames J. Yoo MD, PhD36.08943500000000-80.26863200000000500Yoo, JamesProfessorSteveHodgesSteve J. Hodges MD36.08546200000000-80.30255900000000895Hodges, SteveAssociate ProfessorShaySokerShay Soker PhD36.08943500000000-80.26863200000000939Soker, ShayProfessorThomasMcLeanThomas W. McLean MD36.08915800000000-80.26686200000000984McLean, ThomasProfessor25453265Sadri-Ardekani H, Atala AAdvanced drug delivery reviewsSadri-Ardekani H, Atala A. Regenerative medicine for the treatment of reproductive system disorders: current and potential options. Adv Drug Deliv Rev. 2015 Mar; 82-83:145-52.Adv Drug Deliv Rev2014-10-23T00:00:002014Regenerative medicine for the treatment of reproductive system disorders: current and potential options.Young MinJuYoung Min Ju PhD36.08943500000000-80.268632000000001787Ju, Young MinAssistant Professor26917042Sadri-Ardekani H, McLean TW, Kogan S, Sirintrapun J, Crowell K, Yousif MQ, Hodges SJ, Petty J, Pranikoff T, Sieren L, Zeller K, Atala AMethods (San Diego, Calif.)Sadri-Ardekani H, McLean TW, Kogan S, Sirintrapun J, Crowell K, Yousif MQ, Hodges SJ, Petty J, Pranikoff T, Sieren L, Zeller K, Atala A. Experimental testicular tissue banking to generate spermatogenesis in the future: A multidisciplinary team approach. Methods. 2016 Apr 15; 99:120-7.Methods2016-02-23T00:00:002016Experimental testicular tissue banking to generate spermatogenesis in the future: A multidisciplinary team approach.27107595Galdon G, Atala A, Sadri-Ardekani HCurrent urology reportsGaldon G, Atala A, Sadri-Ardekani H. In Vitro Spermatogenesis: How Far from Clinical Application? Curr Urol Rep. 2016 Jul; 17(7):49.Curr Urol Rep2016-07-01T00:00:002016In Vitro Spermatogenesis: How Far from Clinical Application?2.193070.008537478research areas2.126680.1434248coauthor of124.2232.783254similar to1113selected publications1999SBMUTehran, IranSBMU, MedicineM.D.Medicine2011University of AmsterdamAmsterdam, The NetherlandsUniversity of Amsterdam, Reproductive biology & GeneticsPh.D.Reproductive biology & Genetics2016Wake Forest Institute for Regenerative Medicine (WFIRM)Winston-Salem,NCWake Forest Institute for Regenerative Medicine (WFIRM), Regenerative Medicine & Tissue EngineeringResearch FellowshipRegenerative Medicine & Tissue Engineering2016Department of Urology, School of Medicine, Wake Forest Baptist Health UniversityWinston-Salem,NCDepartment of Urology, School of Medicine, Wake Forest Baptist Health University, Male Reproductive MedicineClinical FellowshipMale Reproductive MedicineUniversity of Amsterdam20092009AMC Young scientist publication award (first place) Royan Institute2010201011th Royan International Research Award, Stem Cells and Developmental Biology fieldDutch fertility prize selection committe20102010Jan Swammerdam Fertility National Research Center for Medical Sciences of Iran (NRCMSI)20122012The 17th Razi research Festival award on medical science American Urological Association (AUA)20152015AUA early career investigators training award Wake Forest School of Medicine 20152015Gold Award,Fellow Basic Science, Surgical Sciences, 23th Annual Residents’ and Fellows Research Day28339648Pendergraft SS, Sadri-Ardekani H, Atala A, Bishop CEBiology of reproductionPendergraft SS, Sadri-Ardekani H, Atala A, Bishop CE. Three-dimensional testicular organoid: a novel tool for the study of human spermatogenesis and gonadotoxicity in vitro. Biol Reprod. 2017 03 01; 96(3):720-732.Biol Reprod2017-03-01T00:00:002017Three-dimensional testicular organoid: a novel tool for the study of human spermatogenesis and gonadotoxicity in vitro.Authorship 553472Authorship 553483Authorship 553501Authorship 553511Authorship 553531Authorship 553541Authorship 553551Authorship 553561Authorship 553571Authorship 553583Authorship 55359419815622Mizrak SC, Chikhovskaya JV, Sadri-Ardekani H, van Daalen S, Korver CM, Hovingh SE, Roepers-Gajadien HL, Raya A, Fluiter K, de Reijke TM, de la Rosette JJ, Knegt AC, Belmonte JC, van der Veen F, de Rooij DG, Repping S, van Pelt AMHuman reproduction (Oxford, England)Mizrak SC, Chikhovskaya JV, Sadri-Ardekani H, van Daalen S, Korver CM, Hovingh SE, Roepers-Gajadien HL, Raya A, Fluiter K, de Reijke TM, de la Rosette JJ, Knegt AC, Belmonte JC, van der Veen F, de Rooij DG, Repping S, van Pelt AM. Embryonic stem cell-like cells derived from adult human testis. Hum Reprod. 2010 Jan; 25(1):158-67.Hum Reprod2009-10-08T00:00:002009Embryonic stem cell-like cells derived from adult human testis.21673293Sadri-Ardekani H, Akhondi MA, van der Veen F, Repping S, van Pelt AMJAMASadri-Ardekani H, Akhondi MA, van der Veen F, Repping S, van Pelt AM. In vitro propagation of human prepubertal spermatogonial stem cells. JAMA. 2011 Jun 15; 305(23):2416-8.JAMA2011-06-15T00:00:002011In vitro propagation of human prepubertal spermatogonial stem cells.23332678Sadri-Ardekani H, Akhondi MM, Vossough P, Maleki H, Sedighnejad S, Kamali K, Ghorbani B, van Wely M, van der Veen F, Repping SFertility and sterilitySadri-Ardekani H, Akhondi MM, Vossough P, Maleki H, Sedighnejad S, Kamali K, Ghorbani B, van Wely M, van der Veen F, Repping S. Parental attitudes toward fertility preservation in boys with cancer: context of different risk levels of infertility and success rates of fertility restoration. Fertil Steril. 2013 Mar 01; 99(3):796-802.Fertil Steril2013-02-01T00:00:002013Parental attitudes toward fertility preservation in boys with cancer: context of different risk levels of infertility and success rates of fertility restoration.19920237Sadri-Ardekani H, Mizrak SC, van Daalen SK, Korver CM, Roepers-Gajadien HL, Koruji M, Hovingh S, de Reijke TM, de la Rosette JJ, van der Veen F, de Rooij DG, Repping S, van Pelt AMJAMASadri-Ardekani H, Mizrak SC, van Daalen SK, Korver CM, Roepers-Gajadien HL, Koruji M, Hovingh S, de Reijke TM, de la Rosette JJ, van der Veen F, de Rooij DG, Repping S, van Pelt AM. Propagation of human spermatogonial stem cells in vitro. JAMA. 2009 Nov 18; 302(19):2127-34.JAMA2009-11-18T00:00:002009Propagation of human spermatogonial stem cells in vitro.19164176Ahmed EA, Barten-van Rijbroek AD, Kal HB, Sadri-Ardekani H, Mizrak SC, van Pelt AM, de Rooij DGBiology of reproductionAhmed EA, Barten-van Rijbroek AD, Kal HB, Sadri-Ardekani H, Mizrak SC, van Pelt AM, de Rooij DG. Proliferative activity in vitro and DNA repair indicate that adult mouse and human Sertoli cells are not terminally differentiated, quiescent cells. Biol Reprod. 2009 Jun; 80(6):1084-91.Biol Reprod2009-01-21T00:00:002009Proliferative activity in vitro and DNA repair indicate that adult mouse and human Sertoli cells are not terminally differentiated, quiescent cells.24581582Sadri-Ardekani H, Homburg CH, van Capel TM, van den Berg H, van der Veen F, van der Schoot CE, van Pelt AM, Repping SFertility and sterilitySadri-Ardekani H, Homburg CH, van Capel TM, van den Berg H, van der Veen F, van der Schoot CE, van Pelt AM, Repping S. Eliminating acute lymphoblastic leukemia cells from human testicular cell cultures: a pilot study. Fertil Steril. 2014 Apr; 101(4):1072-1078.e1.Fertil Steril2014-02-26T00:00:002014Eliminating acute lymphoblastic leukemia cells from human testicular cell cultures: a pilot study.MarshallSchwartzMarshall Z. Schwartz MD36.08943500000000-80.268632000000002146Schwartz, MarshallAssistant Professor30013372Zarandi NP, Galdon G, Kogan S, Atala A, Sadri-Ardekani HStem cells and cloning : advances and applicationsZarandi NP, Galdon G, Kogan S, Atala A, Sadri-Ardekani H. Cryostorage of immature and mature human testis tissue to preserve spermatogonial stem cells (SSCs): a systematic review of current experiences toward clinical applications. Stem Cells Cloning. 2018; 11:23-38.Stem Cells Cloning2018-07-06T00:00:002018Cryostorage of immature and mature human testis tissue to preserve spermatogonial stem cells (SSCs): a systematic review of current experiences toward clinical applications.29739931Strange DP, Zarandi NP, Trivedi G, Atala A, Bishop CE, Sadri-Ardekani H, Verma SEmerging microbes & infectionsStrange DP, Zarandi NP, Trivedi G, Atala A, Bishop CE, Sadri-Ardekani H, Verma S. Human testicular organoid system as a novel tool to study Zika virus pathogenesis. Emerg Microbes Infect. 2018 05 09; 7(1):82.Emerg Microbes Infect2018-05-09T00:00:002018Human testicular organoid system as a novel tool to study Zika virus pathogenesis.Authorship 609971Authorship 60998520Professor24Assistant ProfessorInternal Medicine, Molecular MedicineObstetrics and Gynecology, Maternal FetalPediatrics, Hematology & OncologySurgery, Pediatric SurgerySurgery, TransplantUrologyWake Forest Institute for Regenerative Medicinehttp://www.wfirm.orgWFIRMtrue1Associate ProfessorAssociate Professortrue1Assistant ProfessorAssistant Professor2Assistant ProfessorAssistant Professortrue1Associate ProfessorAssociate Professor3Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1ProfessorProfessor4Assistant ProfessorAssistant Professortrue1ProfessorProfessorD015925Procedures29420.969893CryopreservationD007248Disorders13260.974165Infertility, MaleD013091Physiology13450.950136Spermatogenesis