Professor Emeritus of Pediatrics, Winston-Salem - Neonatology
Schweikhard V, Meng C, Murakami K, Kaplan CD, Kornberg RD, Block SM
Proceedings of the National Academy of Sciences of the United States of America
Schweikhard V, Meng C, Murakami K, Kaplan CD, Kornberg RD, Block SM. Transcription factors TFIIF and TFIIS promote transcript elongation by RNA polymerase II by synergistic and independent mechanisms. Proc Natl Acad Sci U S A. 2014 May 06; 111(18):6642-7.
Transcription factors TFIIF and TFIIS promote transcript elongation by RNA polymerase II by synergistic and independent mechanisms.
Larson MH, Mooney RA, Peters JM, Windgassen T, Nayak D, Gross CA, Block SM, Greenleaf WJ, Landick R, Weissman JS
Larson MH, Mooney RA, Peters JM, Windgassen T, Nayak D, Gross CA, Block SM, Greenleaf WJ, Landick R, Weissman JS. A pause sequence enriched at translation start sites drives transcription dynamics in vivo. Science. 2014 May 30; 344(6187):1042-7.
A pause sequence enriched at translation start sites drives transcription dynamics in vivo.
Woodside MT, Block SM. Reconstructing folding energy landscapes by single-molecule force spectroscopy. Annu Rev Biophys. 2014; 43:19-39.
Reconstructing folding energy landscapes by single-molecule force spectroscopy.
Milic B, Andreasson JO, Hancock WO, Block SM
Milic B, Andreasson JO, Hancock WO, Block SM. Kinesin processivity is gated by phosphate release. Proc Natl Acad Sci U S A. 2014 Sep 30; 111(39):14136-40.
Kinesin processivity is gated by phosphate release.
Blakely BL, Dumelin CE, Trappmann B, McGregor LM, Choi CK, Anthony PC, Duesterberg VK, Baker BM, Block SM, Liu DR, Chen CS
Blakely BL, Dumelin CE, Trappmann B, McGregor LM, Choi CK, Anthony PC, Duesterberg VK, Baker BM, Block SM, Liu DR, Chen CS. A DNA-based molecular probe for optically reporting cellular traction forces. Nat Methods. 2014 Dec; 11(12):1229-32.
A DNA-based molecular probe for optically reporting cellular traction forces.
Professor Emeritus of Radiology, Winston-Salem
Associate Professor of Pediatrics, Winston-Salem - Neonatology
Professor of Pediatrics, Winston-Salem - Neonatology
Academic medicine : journal of the Association of American Medical Colleges
Block SM, Sonnino RE, Bellini L. Defining "faculty" in academic medicine: responding to the challenges of a changing environment. Acad Med. 2015 Mar; 90(3):279-82.
Defining "faculty" in academic medicine: responding to the challenges of a changing environment.
Andreasson JO, Shastry S, Hancock WO, Block SM
Andreasson JO, Shastry S, Hancock WO, Block SM. The Mechanochemical Cycle of Mammalian Kinesin-2 KIF3A/B under Load. Curr Biol. 2015 May 04; 25(9):1166-75.
The Mechanochemical Cycle of Mammalian Kinesin-2 KIF3A/B under Load.
Andreasson JO, Milic B, Chen GY, Guydosh NR, Hancock WO, Block SM
Andreasson JO, Milic B, Chen GY, Guydosh NR, Hancock WO, Block SM. Examining kinesin processivity within a general gating framework. Elife. 2015 Apr 22; 4.
Examining kinesin processivity within a general gating framework.
García-García C, Frieda KL, Feoktistova K, Fraser CS, Block SM
García-García C, Frieda KL, Feoktistova K, Fraser CS, Block SM. RNA BIOCHEMISTRY. Factor-dependent processivity in human eIF4A DEAD-box helicase. Science. 2015 Jun 26; 348(6242):1486-8.
RNA BIOCHEMISTRY. Factor-dependent processivity in human eIF4A DEAD-box helicase.
Fazal FM, Meng CA, Murakami K, Kornberg RD, Block SM
Fazal FM, Meng CA, Murakami K, Kornberg RD, Block SM. Real-time observation of the initiation of RNA polymerase II transcription. Nature. 2015 Sep 10; 525(7568):274-7.
Real-time observation of the initiation of RNA polymerase II transcription.
Fazal FM, Koslover DJ, Luisi BF, Block SM
Fazal FM, Koslover DJ, Luisi BF, Block SM. Direct observation of processive exoribonuclease motion using optical tweezers. Proc Natl Acad Sci U S A. 2015 Dec 08; 112(49):15101-6.
Direct observation of processive exoribonuclease motion using optical tweezers.
Duesterberg VK, Fischer-Hwang IT, Perez CF, Hogan DW, Block SM
Duesterberg VK, Fischer-Hwang IT, Perez CF, Hogan DW, Block SM. Observation of long-range tertiary interactions during ligand binding by the TPP riboswitch aptamer. Elife. 2015 Dec 28; 4.
Observation of long-range tertiary interactions during ligand binding by the TPP riboswitch aptamer.
Lang MJ, Block SM. Resource Letter: LBOT-1: Laser-based optical tweezers. Am J Phys. 2003 Mar; 71(3):201-215.
Resource Letter: LBOT-1: Laser-based optical tweezers.
Fazal FM, Block SM. Optical tweezers study life under tension. Nat Photonics. 2011 May 31; 5:318-321.
Optical tweezers study life under tension.
Savinov A, Perez CF, Block SM. Single-molecule studies of riboswitch folding. Biochim Biophys Acta. 2014 Oct; 1839(10):1030-1045.
Single-molecule studies of riboswitch folding.
Methods in molecular biology (Clifton, N.J.)
Chakraborty A, Meng CA, Block SM. Observing Single RNA Polymerase Molecules Down to Base-Pair Resolution. Methods Mol Biol. 2017; 1486:391-409.
Observing Single RNA Polymerase Molecules Down to Base-Pair Resolution.
Nucleic Acid Enzymes Studied at the Molecular Level
Nucleic Acid Enzymes and Nucleic Acids Studied at the Molecular Level
Microtubule Motors Studied on a Molecular Scale
Webb P, Block S. Support for agriculture during economic transformation: impacts on poverty and undernutrition. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12309-14.
Support for agriculture during economic transformation: impacts on poverty and undernutrition.
Anstrom JA, Brown WR, Moody DM, Thore CR, Challa VR, Block SM
Journal of neuropathology and experimental neurology
Anstrom JA, Brown WR, Moody DM, Thore CR, Challa VR, Block SM. Temporal expression pattern of cerebrovascular endothelial cell alkaline phosphatase during human gestation. J Neuropathol Exp Neurol. 2002 Jan; 61(1):76-84.
Temporal expression pattern of cerebrovascular endothelial cell alkaline phosphatase during human gestation.
Kemper K, Martin K, Block SM, Shoaf R, Woods C
Alternative therapies in health and medicine
Kemper K, Martin K, Block SM, Shoaf R, Woods C. Attitudes and expectations about music therapy for premature infants among staff in a neonatal intensive care unit. Altern Ther Health Med. 2004 Mar-Apr; 10(2):50-4.
Attitudes and expectations about music therapy for premature infants among staff in a neonatal intensive care unit.
Anstrom JA, Thore CR, Moody DM, Challa VR, Block SM, Brown WR
Anstrom JA, Thore CR, Moody DM, Challa VR, Block SM, Brown WR. Morphometric assessment of collagen accumulation in germinal matrix vessels of premature human neonates. Neuropathol Appl Neurobiol. 2005 Apr; 31(2):181-90.
Morphometric assessment of collagen accumulation in germinal matrix vessels of premature human neonates.
Coe K, Butler M, Reavis N, Klinepeter ME, Purkey C, Oliver T, Starbuck A, Griffin J, Wilmoth C, Block S
Coe K, Butler M, Reavis N, Klinepeter ME, Purkey C, Oliver T, Starbuck A, Griffin J, Wilmoth C, Block S. Special Premie Oxygen Targeting (SPOT): a program to decrease the incidence of blindness in infants with retinopathy of prematurity. J Nurs Care Qual. 2006 Jul-Sep; 21(3):230-5.
Special Premie Oxygen Targeting (SPOT): a program to decrease the incidence of blindness in infants with retinopathy of prematurity.
Zhou J, Ha KS, La Porta A, Landick R, Block SM
Zhou J, Ha KS, La Porta A, Landick R, Block SM. Applied force provides insight into transcriptional pausing and its modulation by transcription factor NusA. Mol Cell. 2011 Nov 18; 44(4):635-46.
Applied force provides insight into transcriptional pausing and its modulation by transcription factor NusA.
Larson MH, Zhou J, Kaplan CD, Palangat M, Kornberg RD, Landick R, Block SM
Larson MH, Zhou J, Kaplan CD, Palangat M, Kornberg RD, Landick R, Block SM. Trigger loop dynamics mediate the balance between the transcriptional fidelity and speed of RNA polymerase II. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):6555-60.
Trigger loop dynamics mediate the balance between the transcriptional fidelity and speed of RNA polymerase II.
Palangat M, Larson MH, Hu X, Gnatt A, Block SM, Landick R
Palangat M, Larson MH, Hu X, Gnatt A, Block SM, Landick R. Efficient reconstitution of transcription elongation complexes for single-molecule studies of eukaryotic RNA polymerase II. Transcription. 2012 May-Jun; 3(3):146-53.
Efficient reconstitution of transcription elongation complexes for single-molecule studies of eukaryotic RNA polymerase II.
Anstrom JA, Brown WR, Moody DM, Thore CR, Challa VR, Block SM. Anatomical analysis of the developing cerebral vasculature in premature neonates: absence of precapillary arteriole-to-venous shunts. Pediatr Res. 2002 Oct; 52(4):554-60.
Anatomical analysis of the developing cerebral vasculature in premature neonates: absence of precapillary arteriole-to-venous shunts.
Anstrom JA, Brown WR, Moody DM, Thore CR, Challa VR, Block SM. Subependymal veins in premature neonates: implications for hemorrhage. Pediatr Neurol. 2004 Jan; 30(1):46-53.
Subependymal veins in premature neonates: implications for hemorrhage.
Brain research. Developmental brain research
Anstrom JA, Thore CR, Moody DM, Challa VR, Block SM, Brown WR. Germinal matrix cells associate with veins and a glial scaffold in the human fetal brain. Brain Res Dev Brain Res. 2005 Nov 07; 160(1):96-100.
Germinal matrix cells associate with veins and a glial scaffold in the human fetal brain.
Anthony PC, Perez CF, García-García C, Block SM
Anthony PC, Perez CF, García-García C, Block SM. Folding energy landscape of the thiamine pyrophosphate riboswitch aptamer. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):1485-9.
Folding energy landscape of the thiamine pyrophosphate riboswitch aptamer.
Anthony PC, Sim AY, Chu VB, Doniach S, Block SM, Herschlag D
Journal of the American Chemical Society
Anthony PC, Sim AY, Chu VB, Doniach S, Block SM, Herschlag D. Electrostatics of nucleic acid folding under conformational constraint. J Am Chem Soc. 2012 Mar 14; 134(10):4607-14.
Electrostatics of nucleic acid folding under conformational constraint.
Koslover DJ, Fazal FM, Mooney RA, Landick R, Block SM
Koslover DJ, Fazal FM, Mooney RA, Landick R, Block SM. Binding and translocation of termination factor rho studied at the single-molecule level. J Mol Biol. 2012 Nov 09; 423(5):664-76.
Binding and translocation of termination factor rho studied at the single-molecule level.
Zhou J, Schweikhard V, Block SM. Single-molecule studies of RNAPII elongation. Biochim Biophys Acta. 2013 Jan; 1829(1):29-38.
Single-molecule studies of RNAPII elongation.
Frieda KL, Block SM. Direct observation of cotranscriptional folding in an adenine riboswitch. Science. 2012 Oct 19; 338(6105):397-400.
Direct observation of cotranscriptional folding in an adenine riboswitch.