Professor Emeritus of Microbiology and Immunology, Winston-Salem
Professor of Internal Medicine, Winston-Salem - Infectious Disease
Associate Professor of Microbiology and Immunology, Winston-Salem
Professor of Microbiology and Immunology, Winston-Salem
Professor Emeritus of Biochemistry, Winston-Salem
Professor of Pathology, Winston-Salem - Comparative Medicine
Associate Professor Emeritus of Biochemistry, Winston-Salem
Kim JR, Holbrook BC, Hayward SL, Blevins LK, Jorgensen MJ, Kock ND, De Paris K, D'Agostino RB, Aycock ST, Mizel SB, Parks GD, Alexander-Miller MA
Kim JR, Holbrook BC, Hayward SL, Blevins LK, Jorgensen MJ, Kock ND, De Paris K, D'Agostino RB, Aycock ST, Mizel SB, Parks GD, Alexander-Miller MA. Inclusion of Flagellin during Vaccination against Influenza Enhances Recall Responses in Nonhuman Primate Neonates. J Virol. 2015 Jul; 89(14):7291-303.
Inclusion of Flagellin during Vaccination against Influenza Enhances Recall Responses in Nonhuman Primate Neonates.
Assistant Professor of Orthopedic Surgery & Rehabilitation, Winston-Salem
Department Orthopaedic Surgery and Rehabilitation
Moors MA, Li L, Mizel SB. Activation of interleukin-1 receptor-associated kinase by gram-negative flagellin. Infect Immun. 2001 Jul; 69(7):4424-9.
Activation of interleukin-1 receptor-associated kinase by gram-negative flagellin.
Mizel SB, Snipes JA. Gram-negative flagellin-induced self-tolerance is associated with a block in interleukin-1 receptor-associated kinase release from toll-like receptor 5. J Biol Chem. 2002 Jun 21; 277(25):22414-20.
Gram-negative flagellin-induced self-tolerance is associated with a block in interleukin-1 receptor-associated kinase release from toll-like receptor 5.
Mizel SB, West AP, Hantgan RR. Identification of a sequence in human toll-like receptor 5 required for the binding of Gram-negative flagellin. J Biol Chem. 2003 Jun 27; 278(26):23624-9.
Identification of a sequence in human toll-like receptor 5 required for the binding of Gram-negative flagellin.
Carruth LM, Demczuk S, Mizel SB. Involvement of a calpain-like protease in the processing of the murine interleukin 1 alpha precursor. J Biol Chem. 1991 Jul 05; 266(19):12162-7.
Involvement of a calpain-like protease in the processing of the murine interleukin 1 alpha precursor.
Honko AN, Mizel SB. Mucosal administration of flagellin induces innate immunity in the mouse lung. Infect Immun. 2004 Nov; 72(11):6676-9.
Mucosal administration of flagellin induces innate immunity in the mouse lung.
Honko AN, Mizel SB. Effects of flagellin on innate and adaptive immunity. Immunol Res. 2005; 33(1):83-101.
Effects of flagellin on innate and adaptive immunity.
Chedid M, Mizel SB. Involvement of cyclic AMP-dependent protein kinases in the signal transduction pathway for interleukin-1. Mol Cell Biol. 1990 Jul; 10(7):3824-7.
Involvement of cyclic AMP-dependent protein kinases in the signal transduction pathway for interleukin-1.
Honko AN, Sriranganathan N, Lees CJ, Mizel SB
Honko AN, Sriranganathan N, Lees CJ, Mizel SB. Flagellin is an effective adjuvant for immunization against lethal respiratory challenge with Yersinia pestis. Infect Immun. 2006 Feb; 74(2):1113-20.
Flagellin is an effective adjuvant for immunization against lethal respiratory challenge with Yersinia pestis.
Bates JT, Honko AN, Graff AH, Kock ND, Mizel SB
Bates JT, Honko AN, Graff AH, Kock ND, Mizel SB. Mucosal adjuvant activity of flagellin in aged mice. Mech Ageing Dev. 2008 May; 129(5):271-81.
Mucosal adjuvant activity of flagellin in aged mice.
Shirakawa F, Mizel SB. In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-dependent protein kinase and protein kinase C. Mol Cell Biol. 1989 Jun; 9(6):2424-30.
In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-dependent protein kinase and protein kinase C.
Weimer ET, Lu H, Kock ND, Wozniak DJ, Mizel SB
Weimer ET, Lu H, Kock ND, Wozniak DJ, Mizel SB. A fusion protein vaccine containing OprF epitope 8, OprI, and type A and B flagellins promotes enhanced clearance of nonmucoid Pseudomonas aeruginosa. Infect Immun. 2009 Jun; 77(6):2356-66.
A fusion protein vaccine containing OprF epitope 8, OprI, and type A and B flagellins promotes enhanced clearance of nonmucoid Pseudomonas aeruginosa.
Weimer ET, Ervin SE, Wozniak DJ, Mizel SB
Weimer ET, Ervin SE, Wozniak DJ, Mizel SB. Immunization of young African green monkeys with OprF epitope 8-OprI-type A- and B-flagellin fusion proteins promotes the production of protective antibodies against nonmucoid Pseudomonas aeruginosa. Vaccine. 2009 Nov 12; 27(48):6762-9.
Immunization of young African green monkeys with OprF epitope 8-OprI-type A- and B-flagellin fusion proteins promotes the production of protective antibodies against nonmucoid Pseudomonas aeruginosa.
Internal Medicine, Winston-Salem - Infectious Disease
Microbiology and Immunology, Winston-Salem
Pathology, Winston-Salem - Comparative Medicine
Delaney KN, Phipps JP, Johnson JB, Mizel SB
Delaney KN, Phipps JP, Johnson JB, Mizel SB. A recombinant flagellin-poxvirus fusion protein vaccine elicits complement-dependent protection against respiratory challenge with vaccinia virus in mice. Viral Immunol. 2010 Apr; 23(2):201-10.
A recombinant flagellin-poxvirus fusion protein vaccine elicits complement-dependent protection against respiratory challenge with vaccinia virus in mice.
Journal of immunology (Baltimore, Md. : 1950)
Minnich-Carruth LL, Suttles J, Mizel SB. Evidence against the existence of a membrane form of murine IL-1 alpha. J Immunol. 1989 Jan 15; 142(2):526-30.
Evidence against the existence of a membrane form of murine IL-1 alpha.
Mizel SB, Bates JT. Flagellin as an adjuvant: cellular mechanisms and potential. J Immunol. 2010 Nov 15; 185(10):5677-82.
Flagellin as an adjuvant: cellular mechanisms and potential.
DeLuca D, Mizel SB. I-A-positive nonlymphoid cells and T cell development in murine fetal thymus organ cultures: interleukin 1 circumvents the block in T cell differentiation induced by monoclonal anti-I-A antibodies. J Immunol. 1986 Sep 01; 137(5):1435-41.
I-A-positive nonlymphoid cells and T cell development in murine fetal thymus organ cultures: interleukin 1 circumvents the block in T cell differentiation induced by monoclonal anti-I-A antibodies.
Moldawer LL, Lonnroth C, Mizel SB, Lundholm KG
Moldawer LL, Lonnroth C, Mizel SB, Lundholm KG. Down-regulation of interleukin 1 production by macrophages of sarcoma-bearing mice. J Immunol. 1987 Jun 15; 138(12):4270-4.
Down-regulation of interleukin 1 production by macrophages of sarcoma-bearing mice.
Farrar WL, Mizel SB, Farrar JJ. Participation of lymphocyte activating factor (Interleukin 1) in the induction of cytotoxic T cell responses. J Immunol. 1980 Mar; 124(3):1371-7.
Participation of lymphocyte activating factor (Interleukin 1) in the induction of cytotoxic T cell responses.
Howard M, Mizel SB, Lachman L, Ansel J, Johnson B, Paul WE
Howard M, Mizel SB, Lachman L, Ansel J, Johnson B, Paul WE. Role of interleukin 1 in anti-immunoglobulin-induced B cell proliferation. J Exp Med. 1983 May 01; 157(5):1529-43.
Role of interleukin 1 in anti-immunoglobulin-induced B cell proliferation.
Farrar JJ, Mizel SB, Fuller-Farrar J, Farrar WL, Hilfiker ML
Farrar JJ, Mizel SB, Fuller-Farrar J, Farrar WL, Hilfiker ML. Macrophage-independent activation of helper T cells. I. Production of Interleukin 2. J Immunol. 1980 Aug; 125(2):793-8.
Macrophage-independent activation of helper T cells. I. Production of Interleukin 2.
Mizel SB, Oppenheim JJ, Rosenstreich DL. Characterization of lymphocyte-activating factor (LAF) produced by the macrophage cell line, P388D1. I. Enhancement of LAF production by activated T lymphocytes. J Immunol. 1978 May; 120(5):1497-503.
Characterization of lymphocyte-activating factor (LAF) produced by the macrophage cell line, P388D1. I. Enhancement of LAF production by activated T lymphocytes.
Ciacci-Woolwine F, Kucera LS, Richardson SH, Iyer NP, Mizel SB
Ciacci-Woolwine F, Kucera LS, Richardson SH, Iyer NP, Mizel SB. Salmonellae activate tumor necrosis factor alpha production in a human promonocytic cell line via a released polypeptide. Infect Immun. 1997 Nov; 65(11):4624-33.
Salmonellae activate tumor necrosis factor alpha production in a human promonocytic cell line via a released polypeptide.
Ciacci-Woolwine F, Blomfield IC, Richardson SH, Mizel SB
Ciacci-Woolwine F, Blomfield IC, Richardson SH, Mizel SB. Salmonella flagellin induces tumor necrosis factor alpha in a human promonocytic cell line. Infect Immun. 1998 Mar; 66(3):1127-34.
Salmonella flagellin induces tumor necrosis factor alpha in a human promonocytic cell line.
Ciacci-Woolwine F, McDermott PF, Mizel SB
Ciacci-Woolwine F, McDermott PF, Mizel SB. Induction of cytokine synthesis by flagella from gram-negative bacteria may be dependent on the activation or differentiation state of human monocytes. Infect Immun. 1999 Oct; 67(10):5176-85.
Induction of cytokine synthesis by flagella from gram-negative bacteria may be dependent on the activation or differentiation state of human monocytes.
McDermott PF, Ciacci-Woolwine F, Snipes JA, Mizel SB
McDermott PF, Ciacci-Woolwine F, Snipes JA, Mizel SB. High-affinity interaction between gram-negative flagellin and a cell surface polypeptide results in human monocyte activation. Infect Immun. 2000 Oct; 68(10):5525-9.
High-affinity interaction between gram-negative flagellin and a cell surface polypeptide results in human monocyte activation.
Mizel SB, Honko AN, Moors MA, Smith PS, West AP
Mizel SB, Honko AN, Moors MA, Smith PS, West AP. Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes. J Immunol. 2003 Jun 15; 170(12):6217-23.
Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes.
West AP, Dancho BA, Mizel SB. Gangliosides inhibit flagellin signaling in the absence of an effect on flagellin binding to toll-like receptor 5. J Biol Chem. 2005 Mar 11; 280(10):9482-8.
Gangliosides inhibit flagellin signaling in the absence of an effect on flagellin binding to toll-like receptor 5.
Mizel SB, Rosenstreich DL. Regulation of lymphocyte-activating factor (LAF) production and secretion in P388D1 cells: identification of high molecular weight precursors of LAF. J Immunol. 1979 Jun; 122(6):2173-9.
Regulation of lymphocyte-activating factor (LAF) production and secretion in P388D1 cells: identification of high molecular weight precursors of LAF.
Arimilli S, Johnson JB, Clark KM, Graff AH, Alexander-Miller MA, Mizel SB, Parks GD
Arimilli S, Johnson JB, Clark KM, Graff AH, Alexander-Miller MA, Mizel SB, Parks GD. Engineered expression of the TLR5 ligand flagellin enhances paramyxovirus activation of human dendritic cell function. J Virol. 2008 Nov; 82(22):10975-85.
Engineered expression of the TLR5 ligand flagellin enhances paramyxovirus activation of human dendritic cell function.
Mizel SB, Graff AH, Sriranganathan N, Ervin S, Lees CJ, Lively MO, Hantgan RR, Thomas MJ, Wood J, Bell B
Mizel SB, Graff AH, Sriranganathan N, Ervin S, Lees CJ, Lively MO, Hantgan RR, Thomas MJ, Wood J, Bell B. Flagellin-F1-V fusion protein is an effective plague vaccine in mice and two species of nonhuman primates. Clin Vaccine Immunol. 2009 Jan; 16(1):21-8.
Flagellin-F1-V fusion protein is an effective plague vaccine in mice and two species of nonhuman primates.
Giri JG, Lomedico PT, Mizel SB. Studies on the synthesis and secretion of interleukin 1. I. A 33,000 molecular weight precursor for interleukin 1. J Immunol. 1985 Jan; 134(1):343-9.
Studies on the synthesis and secretion of interleukin 1. I. A 33,000 molecular weight precursor for interleukin 1.
Bates JT, Uematsu S, Akira S, Mizel SB. Direct stimulation of tlr5+/+ CD11c+ cells is necessary for the adjuvant activity of flagellin. J Immunol. 2009 Jun 15; 182(12):7539-47.
Direct stimulation of tlr5+/+ CD11c+ cells is necessary for the adjuvant activity of flagellin.
Braxton CL, Puckett SH, Mizel SB, Lyles DS
Braxton CL, Puckett SH, Mizel SB, Lyles DS. Protection against lethal vaccinia virus challenge by using an attenuated matrix protein mutant vesicular stomatitis virus vaccine vector expressing poxvirus antigens. J Virol. 2010 Apr; 84(7):3552-61.
Protection against lethal vaccinia virus challenge by using an attenuated matrix protein mutant vesicular stomatitis virus vaccine vector expressing poxvirus antigens.
Ahmed M, Puckett S, Arimilli S, Braxton CL, Mizel SB, Lyles DS
Ahmed M, Puckett S, Arimilli S, Braxton CL, Mizel SB, Lyles DS. Stimulation of human dendritic cells by wild-type and M protein mutant vesicular stomatitis viruses engineered to express bacterial flagellin. J Virol. 2010 Nov; 84(22):12093-8.
Stimulation of human dendritic cells by wild-type and M protein mutant vesicular stomatitis viruses engineered to express bacterial flagellin.
Sunwook K, Nussbaum MA, Quandt SA, Laurienti PJ, Arcury TA
Journal of occupational and environmental medicine
Sunwook K, Nussbaum MA, Quandt SA, Laurienti PJ, Arcury TA. Effects of Lifetime Occupational Pesticide Exposure on Postural Control Among Farmworkers and Non-Farmworkers. J Occup Environ Med. 2016 Feb; 58(2):133-9.
Effects of Lifetime Occupational Pesticide Exposure on Postural Control Among Farmworkers and Non-Farmworkers.
Clark KM, Johnson JB, Kock ND, Mizel SB, Parks GD
Clark KM, Johnson JB, Kock ND, Mizel SB, Parks GD. Parainfluenza virus 5-based vaccine vectors expressing vaccinia virus (VACV) antigens provide long-term protection in mice from lethal intranasal VACV challenge. Virology. 2011 Oct 25; 419(2):97-106.
Parainfluenza virus 5-based vaccine vectors expressing vaccinia virus (VACV) antigens provide long-term protection in mice from lethal intranasal VACV challenge.
Mizel SB, Kilian PL, Lewis JC, Paganelli KA, Chizzonite RA
Mizel SB, Kilian PL, Lewis JC, Paganelli KA, Chizzonite RA. The interleukin 1 receptor. Dynamics of interleukin 1 binding and internalization in T cells and fibroblasts. J Immunol. 1987 May 01; 138(9):2906-12.
The interleukin 1 receptor. Dynamics of interleukin 1 binding and internalization in T cells and fibroblasts.
Markham RB, Pier GB, Goellner JJ, Mizel SB
Markham RB, Pier GB, Goellner JJ, Mizel SB. In vitro T cell-mediated killing of Pseudomonas aeruginosa. II. The role of macrophages and T cell subsets in T cell killing. J Immunol. 1985 Jun; 134(6):4112-7.
In vitro T cell-mediated killing of Pseudomonas aeruginosa. II. The role of macrophages and T cell subsets in T cell killing.
Rao A, Mizel SB, Cantor H. Disparate functional properties of two interleukin 1-responsive Ly-1+2- T cell clones: distinction of T cell growth factor and T cell-replacing factor activities. J Immunol. 1983 Apr; 130(4):1743-8.
Disparate functional properties of two interleukin 1-responsive Ly-1+2- T cell clones: distinction of T cell growth factor and T cell-replacing factor activities.
Kaye J, Gillis S, Mizel SB, Shevach EM, Malek TR, Dinarello CA, Lachman LB, Janeway CA
Kaye J, Gillis S, Mizel SB, Shevach EM, Malek TR, Dinarello CA, Lachman LB, Janeway CA. Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2. J Immunol. 1984 Sep; 133(3):1339-45.
Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2.
Sztein MB, Vogel SN, Sipe JD, Murphy PA, Mizel SB, Oppenheim JJ, Rosenstreich DL
Sztein MB, Vogel SN, Sipe JD, Murphy PA, Mizel SB, Oppenheim JJ, Rosenstreich DL. The role of macrophages in the acute-phase response: SAA inducer is closely related to lymphocyte activating factor and endogenous pyrogen. Cell Immunol. 1981 Sep 01; 63(1):164-76.
The role of macrophages in the acute-phase response: SAA inducer is closely related to lymphocyte activating factor and endogenous pyrogen.
Chedid M, Yoza BK, Brooks JW, Mizel SB. Activation of AP-1 by IL-1 and phorbol esters in T cells. Role of protein kinase A and protein phosphatases. J Immunol. 1991 Aug 01; 147(3):867-73.
Activation of AP-1 by IL-1 and phorbol esters in T cells. Role of protein kinase A and protein phosphatases.
Moors MA, Mizel SB. Proteasome-mediated regulation of interleukin-1beta turnover and export in human monocytes. J Leukoc Biol. 2000 Jul; 68(1):131-6.
Proteasome-mediated regulation of interleukin-1beta turnover and export in human monocytes.