Associate Professor Emeritus of Biochemistry, Winston-Salem
Platelet Glycoprotein GPIIb-IIIa Complex
Professor Emeritus of Biochemistry, Winston-Salem
Professor of Cancer Biology, Winston-Salem
Associate Professor of Plastic & Reconstructive Surgery, Winston-Salem
Assistant Professor of Biochemistry, Winston-Salem
Professor Emeritus of Microbiology and Immunology, Winston-Salem
Professor of Biochemistry, Winston-Salem
Melchior JT, Sawyer JK, Kelley KL, Shah R, Wilson MD, Hantgan RR, Rudel LL
Melchior JT, Sawyer JK, Kelley KL, Shah R, Wilson MD, Hantgan RR, Rudel LL. LDL particle core enrichment in cholesteryl oleate increases proteoglycan binding and promotes atherosclerosis. J Lipid Res. 2013 Sep; 54(9):2495-503.
LDL particle core enrichment in cholesteryl oleate increases proteoglycan binding and promotes atherosclerosis.
Huang TC, Jordan RE, Hantgan RR, Alevriadou BR
Huang TC, Jordan RE, Hantgan RR, Alevriadou BR. Differential effects of c7E3 Fab on thrombus formation and rt-PA-Mediated thrombolysis under flow conditions. Thromb Res. 2001 Jun 01; 102(5):411-25.
Differential effects of c7E3 Fab on thrombus formation and rt-PA-Mediated thrombolysis under flow conditions.
Lounes KC, Lefkowitz JB, Coates AI, Hantgan RR, Henschen-Edman A, Lord ST
Annals of the New York Academy of Sciences
Lounes KC, Lefkowitz JB, Coates AI, Hantgan RR, Henschen-Edman A, Lord ST. Fibrinogen Longmont. A heterozygous abnormal fibrinogen with B beta Arg-166 to Cys substitution associated with defective fibrin polymerization. Ann N Y Acad Sci. 2001; 936:129-32.
Fibrinogen Longmont. A heterozygous abnormal fibrinogen with B beta Arg-166 to Cys substitution associated with defective fibrin polymerization.
Hantgan RR, Rocco M, Nagaswami C, Weisel JW
Protein science : a publication of the Protein Society
Hantgan RR, Rocco M, Nagaswami C, Weisel JW. Binding of a fibrinogen mimetic stabilizes integrin alphaIIbbeta3's open conformation. Protein Sci. 2001 Aug; 10(8):1614-26.
Binding of a fibrinogen mimetic stabilizes integrin alphaIIbbeta3's open conformation.
Hantgan RR, Stahle M, Del Gaizo V, Adams M, Lasher T, Jerome WG, McKenzie M, Lyles DS
Hantgan RR, Stahle M, Del Gaizo V, Adams M, Lasher T, Jerome WG, McKenzie M, Lyles DS. AlphaIIb's cytoplasmic domain is not required for ligand-induced clustering of integrin alphaIIbbeta3. Biochim Biophys Acta. 2001 Jul 25; 1540(1):82-95.
AlphaIIb's cytoplasmic domain is not required for ligand-induced clustering of integrin alphaIIbbeta3.
Mizel SB, West AP, Hantgan RR. Identification of a sequence in human toll-like receptor 5 required for the binding of Gram-negative flagellin. J Biol Chem. 2003 Jun 27; 278(26):23624-9.
Identification of a sequence in human toll-like receptor 5 required for the binding of Gram-negative flagellin.
Hantgan RR, Gibbs W, Stahle MC, Aster RH, Peterson JA
Hantgan RR, Gibbs W, Stahle MC, Aster RH, Peterson JA. Integrin clustering mechanisms explored with a soluble alphaIIbbeta3 ectodomain construct. Biochim Biophys Acta. 2004 Jul 01; 1700(1):19-25.
Integrin clustering mechanisms explored with a soluble alphaIIbbeta3 ectodomain construct.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada
Jerome WG, Handt S, Hantgan RR. Endothelial cells organize fibrin clots into structures that are more resistant to lysis. Microsc Microanal. 2005 Jun; 11(3):268-77.
Endothelial cells organize fibrin clots into structures that are more resistant to lysis.
O'Flaherty JT, Rogers LC, Paumi CM, Hantgan RR, Thomas LR, Clay CE, High K, Chen YQ, Willingham MC, Smitherman PK, Kute TE, Rao A, Cramer SD, Morrow CS
O'Flaherty JT, Rogers LC, Paumi CM, Hantgan RR, Thomas LR, Clay CE, High K, Chen YQ, Willingham MC, Smitherman PK, Kute TE, Rao A, Cramer SD, Morrow CS. 5-Oxo-ETE analogs and the proliferation of cancer cells. Biochim Biophys Acta. 2005 Oct 01; 1736(3):228-36.
5-Oxo-ETE analogs and the proliferation of cancer cells.
Hantgan RR, Stahle MC, Connor JH, Horita DA, Rocco M, McLane MA, Yakovlev S, Medved L
Hantgan RR, Stahle MC, Connor JH, Horita DA, Rocco M, McLane MA, Yakovlev S, Medved L. Integrin alphaIIbbeta3:ligand interactions are linked to binding-site remodeling. Protein Sci. 2006 Aug; 15(8):1893-906.
Integrin alphaIIbbeta3:ligand interactions are linked to binding-site remodeling.
Hantgan RR, Stahle MC, Connor JH, Connor RF, Mousa SA
Journal of thrombosis and haemostasis : JTH
Hantgan RR, Stahle MC, Connor JH, Connor RF, Mousa SA. AlphaIIbbeta3 priming and clustering by orally active and intravenous integrin antagonists. J Thromb Haemost. 2007 Mar; 5(3):542-50.
AlphaIIbbeta3 priming and clustering by orally active and intravenous integrin antagonists.
Hantgan RR, Hindriks G, Taylor RG, Sixma JJ, de Groot PG
Hantgan RR, Hindriks G, Taylor RG, Sixma JJ, de Groot PG. Glycoprotein Ib, von Willebrand factor, and glycoprotein IIb:IIIa are all involved in platelet adhesion to fibrin in flowing whole blood. Blood. 1990 Jul 15; 76(2):345-53.
Glycoprotein Ib, von Willebrand factor, and glycoprotein IIb:IIIa are all involved in platelet adhesion to fibrin in flowing whole blood.
Hantgan RR, Stahle MC, Horita DA. Entropy drives integrin alphaIIbbeta3:echistatin binding--evidence from surface plasmon resonance spectroscopy. Biochemistry. 2008 Mar 04; 47(9):2884-92.
Entropy drives integrin alphaIIbbeta3:echistatin binding--evidence from surface plasmon resonance spectroscopy.
Azarov I, He X, Jeffers A, Basu S, Ucer B, Hantgan RR, Levy A, Kim-Shapiro DB
Azarov I, He X, Jeffers A, Basu S, Ucer B, Hantgan RR, Levy A, Kim-Shapiro DB. Rate of nitric oxide scavenging by hemoglobin bound to haptoglobin. Nitric Oxide. 2008 Jun; 18(4):296-302.
Rate of nitric oxide scavenging by hemoglobin bound to haptoglobin.
Rocco M, Rosano C, Weisel JW, Horita DA, Hantgan RR
Rocco M, Rosano C, Weisel JW, Horita DA, Hantgan RR. Integrin conformational regulation: uncoupling extension/tail separation from changes in the head region by a multiresolution approach. Structure. 2008 Jun; 16(6):954-64.
Integrin conformational regulation: uncoupling extension/tail separation from changes in the head region by a multiresolution approach.
Carlisle CR, Coulais C, Namboothiry M, Carroll DL, Hantgan RR, Guthold M
Carlisle CR, Coulais C, Namboothiry M, Carroll DL, Hantgan RR, Guthold M. The mechanical properties of individual, electrospun fibrinogen fibers. Biomaterials. 2009 Feb; 30(6):1205-13.
The mechanical properties of individual, electrospun fibrinogen fibers.
Hantgan RR, Stahle MC. Integrin priming dynamics: mechanisms of integrin antagonist-promoted alphaIIbbeta3:PAC-1 molecular recognition. Biochemistry. 2009 Sep 08; 48(35):8355-65.
Integrin priming dynamics: mechanisms of integrin antagonist-promoted alphaIIbbeta3:PAC-1 molecular recognition.
Microbiology and Immunology, Winston-Salem
Plastic & Reconstructive Surgery, Winston-Salem
Tsurupa G, Hantgan RR, Burton RA, Pechik I, Tjandra N, Medved L
Tsurupa G, Hantgan RR, Burton RA, Pechik I, Tjandra N, Medved L. Structure, stability, and interaction of the fibrin(ogen) alphaC-domains. Biochemistry. 2009 Dec 29; 48(51):12191-201.
Structure, stability, and interaction of the fibrin(ogen) alphaC-domains.
Hantgan RR, Stahle MC, Lord ST. Dynamic regulation of fibrinogen: integrin aIIbß3 binding. Biochemistry. 2010 Nov 02; 49(43):9217-25.
Dynamic regulation of fibrinogen: integrin aIIbß3 binding.
Rahmany MB, Hantgan RR, Van Dyke M. A mechanistic investigation of the effect of keratin-based hemostatic agents on coagulation. Biomaterials. 2013 Mar; 34(10):2492-500.
A mechanistic investigation of the effect of keratin-based hemostatic agents on coagulation.
Burnett LR, Rahmany MB, Richter JR, Aboushwareb TA, Eberli D, Ward CL, Orlando G, Hantgan RR, Van Dyke ME
Burnett LR, Rahmany MB, Richter JR, Aboushwareb TA, Eberli D, Ward CL, Orlando G, Hantgan RR, Van Dyke ME. Hemostatic properties and the role of cell receptor recognition in human hair keratin protein hydrogels. Biomaterials. 2013 Apr; 34(11):2632-40.
Hemostatic properties and the role of cell receptor recognition in human hair keratin protein hydrogels.
Lewis JC, Johnson C, Ramsamooj P, Hantgan RR
Lewis JC, Johnson C, Ramsamooj P, Hantgan RR. Orientation and specificity of fibrin protofibril binding to ADP-stimulated platelets. Blood. 1988 Dec; 72(6):1992-2000.
Orientation and specificity of fibrin protofibril binding to ADP-stimulated platelets.
Hantgan RR, Taylor RG, Lewis JC. Platelets interact with fibrin only after activation. Blood. 1985 Jun; 65(6):1299-311.
Platelets interact with fibrin only after activation.
Hantgan RR. A study of the kinetics and mechanism of ADP-triggered platelet aggregation. Biochim Biophys Acta. 1985 Jul 30; 846(1):64-75.
A study of the kinetics and mechanism of ADP-triggered platelet aggregation.
Hantgan RR, Hammes GG, Scheraga HA. Pathways of folding of reduced bovine pancreatic ribonuclease. Biochemistry. 1974 Aug 13; 13(17):3421-31.
Pathways of folding of reduced bovine pancreatic ribonuclease.
Hantgan R, Fowler W, Erickson H, Hermans J
Hantgan R, Fowler W, Erickson H, Hermans J. Fibrin assembly: a comparison of electron microscopic and light scattering results. Thromb Haemost. 1980 Dec 19; 44(3):119-24.
Fibrin assembly: a comparison of electron microscopic and light scattering results.
Hantgan RR, Endenburg SC, Cavero I, Marguerie G, Uzan A, Sixma JJ, de Groot PG
Hantgan RR, Endenburg SC, Cavero I, Marguerie G, Uzan A, Sixma JJ, de Groot PG. Inhibition of platelet adhesion to fibrin(ogen) in flowing whole blood by Arg-Gly-Asp and fibrinogen gamma-chain carboxy terminal peptides. Thromb Haemost. 1992 Dec 07; 68(6):694-700.
Inhibition of platelet adhesion to fibrin(ogen) in flowing whole blood by Arg-Gly-Asp and fibrinogen gamma-chain carboxy terminal peptides.
Sunwook K, Nussbaum MA, Quandt SA, Laurienti PJ, Arcury TA
Journal of occupational and environmental medicine
Sunwook K, Nussbaum MA, Quandt SA, Laurienti PJ, Arcury TA. Effects of Lifetime Occupational Pesticide Exposure on Postural Control Among Farmworkers and Non-Farmworkers. J Occup Environ Med. 2016 Feb; 58(2):133-9.
Effects of Lifetime Occupational Pesticide Exposure on Postural Control Among Farmworkers and Non-Farmworkers.
Hantgan RR. Steady-state fluorescence polarization of dansylcadaverine-fibrinogen: evidence for flexibility. Biochemistry. 1982 Apr 13; 21(8):1821-9.
Steady-state fluorescence polarization of dansylcadaverine-fibrinogen: evidence for flexibility.
Rocco M, Spotorno B, Hantgan RR. Modeling the alpha IIb beta 3 integrin solution conformation. Protein Sci. 1993 Dec; 2(12):2154-66.
Modeling the alpha IIb beta 3 integrin solution conformation.
O'Toole ET, Hantgan RR, Lewis JC. Localization of fibrinogen during aggregation of avian thrombocytes. Exp Mol Pathol. 1994 Dec; 61(3):175-90.
Localization of fibrinogen during aggregation of avian thrombocytes.
Hantgan RR, Endenburg SC, Sixma JJ, de Groot PG
Hantgan RR, Endenburg SC, Sixma JJ, de Groot PG. Evidence that fibrin alpha-chain RGDX sequences are not required for platelet adhesion in flowing whole blood. Blood. 1995 Aug 01; 86(3):1001-9.
Evidence that fibrin alpha-chain RGDX sequences are not required for platelet adhesion in flowing whole blood.
Lewis JC, Gupta M, Landers SC, Hantgan RR, Jones NL
Lewis JC, Gupta M, Landers SC, Hantgan RR, Jones NL. Glycoprotein IIb/IIIa cross-reacting antigen in monocyte-derived macrophages from the pigeon. Exp Mol Pathol. 1993 Oct; 59(2):95-110.
Glycoprotein IIb/IIIa cross-reacting antigen in monocyte-derived macrophages from the pigeon.
Endenburg SC, Hantgan RR, Sixma JJ, de Groot PG, Zwaginga JJ
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
Endenburg SC, Hantgan RR, Sixma JJ, de Groot PG, Zwaginga JJ. Platelet adhesion to fibrin(ogen). Blood Coagul Fibrinolysis. 1993 Feb; 4(1):139-42.
Hantgan RR, Braaten JV, Rocco M. Dynamic light scattering studies of alpha IIb beta 3 solution conformation. Biochemistry. 1993 Apr 20; 32(15):3935-41.
Dynamic light scattering studies of alpha IIb beta 3 solution conformation.
Lyles DS, McKenzie MO, Hantgan RR. Stopped-flow, classical, and dynamic light scattering analysis of matrix protein binding to nucleocapsids of vesicular stomatitis virus. Biochemistry. 1996 May 21; 35(20):6508-18.
Stopped-flow, classical, and dynamic light scattering analysis of matrix protein binding to nucleocapsids of vesicular stomatitis virus.
Handt S, Jerome WG, Tietze L, Hantgan RR
Handt S, Jerome WG, Tietze L, Hantgan RR. Plasminogen activator inhibitor-1 secretion of endothelial cells increases fibrinolytic resistance of an in vitro fibrin clot: evidence for a key role of endothelial cells in thrombolytic resistance. Blood. 1996 May 15; 87(10):4204-13.
Plasminogen activator inhibitor-1 secretion of endothelial cells increases fibrinolytic resistance of an in vitro fibrin clot: evidence for a key role of endothelial cells in thrombolytic resistance.
Hensler ME, Frojmovic M, Taylor RG, Hantgan RR, Lewis JC
Hensler ME, Frojmovic M, Taylor RG, Hantgan RR, Lewis JC. Platelet morphologic changes and fibrinogen receptor localization. Initial responses in ADP-activated human platelets. Am J Pathol. 1992 Sep; 141(3):707-19.
Platelet morphologic changes and fibrinogen receptor localization. Initial responses in ADP-activated human platelets.
Tansey JT, Thuren TY, Jerome WG, Hantgan RR, Grant K, Waite M
Tansey JT, Thuren TY, Jerome WG, Hantgan RR, Grant K, Waite M. Hydrolysis of phosphatidylcholine by hepatic lipase in discoidal and spheroidal recombinant high-density lipoprotein. Biochemistry. 1997 Oct 07; 36(40):12227-34.
Hydrolysis of phosphatidylcholine by hepatic lipase in discoidal and spheroidal recombinant high-density lipoprotein.
Thomas MJ, Pang K, Chen Q, Lyles D, Hantgan R, Waite M
Thomas MJ, Pang K, Chen Q, Lyles D, Hantgan R, Waite M. Lipid exchange between mixed micelles of phospholipid and triton X-100. Biochim Biophys Acta. 1999 Feb 04; 1417(1):144-56.
Lipid exchange between mixed micelles of phospholipid and triton X-100.
Hantgan RR, Paumi C, Rocco M, Weisel JW. Effects of ligand-mimetic peptides Arg-Gly-Asp-X (X = Phe, Trp, Ser) on alphaIIbbeta3 integrin conformation and oligomerization. Biochemistry. 1999 Nov 02; 38(44):14461-74.
Effects of ligand-mimetic peptides Arg-Gly-Asp-X (X = Phe, Trp, Ser) on alphaIIbbeta3 integrin conformation and oligomerization.
Hogan KA, Gorkun OV, Lounes KC, Coates AI, Weisel JW, Hantgan RR, Lord ST
Hogan KA, Gorkun OV, Lounes KC, Coates AI, Weisel JW, Hantgan RR, Lord ST. Recombinant fibrinogen Vlissingen/Frankfurt IV. The deletion of residues 319 and 320 from the gamma chain of firbinogen alters calcium binding, fibrin polymerization, cross-linking, and platelet aggregation. J Biol Chem. 2000 Jun 09; 275(23):17778-85.
Recombinant fibrinogen Vlissingen/Frankfurt IV. The deletion of residues 319 and 320 from the gamma chain of firbinogen alters calcium binding, fibrin polymerization, cross-linking, and platelet aggregation.
Lounes KC, Lefkowitz JB, Henschen-Edman AH, Coates AI, Hantgan RR, Lord ST
Lounes KC, Lefkowitz JB, Henschen-Edman AH, Coates AI, Hantgan RR, Lord ST. The impaired polymerization of fibrinogen Longmont (Bbeta166Arg-->Cys) is not improved by removal of disulfide-linked dimers from a mixture of dimers and cysteine-linked monomers. Blood. 2001 Aug 01; 98(3):661-6.
The impaired polymerization of fibrinogen Longmont (Bbeta166Arg-->Cys) is not improved by removal of disulfide-linked dimers from a mixture of dimers and cysteine-linked monomers.
Wood ZA, Poole LB, Hantgan RR, Karplus PA
Wood ZA, Poole LB, Hantgan RR, Karplus PA. Dimers to doughnuts: redox-sensitive oligomerization of 2-cysteine peroxiredoxins. Biochemistry. 2002 Apr 30; 41(17):5493-504.
Dimers to doughnuts: redox-sensitive oligomerization of 2-cysteine peroxiredoxins.
Yamamoto Y, Poole LB, Hantgan RR, Kamio Y
Yamamoto Y, Poole LB, Hantgan RR, Kamio Y. An iron-binding protein, Dpr, from Streptococcus mutans prevents iron-dependent hydroxyl radical formation in vitro. J Bacteriol. 2002 Jun; 184(11):2931-9.
An iron-binding protein, Dpr, from Streptococcus mutans prevents iron-dependent hydroxyl radical formation in vitro.
Hantgan RR, Stahle MC, Jerome WG, Nagaswami C, Weisel JW
Hantgan RR, Stahle MC, Jerome WG, Nagaswami C, Weisel JW. Tirofiban blocks platelet adhesion to fibrin with minimal perturbation of GpIIb/IIIa structure. Thromb Haemost. 2002 May; 87(5):910-7.
Tirofiban blocks platelet adhesion to fibrin with minimal perturbation of GpIIb/IIIa structure.
Hantgan RR, Lyles DS, Mallett TC, Rocco M, Nagaswami C, Weisel JW
Hantgan RR, Lyles DS, Mallett TC, Rocco M, Nagaswami C, Weisel JW. Ligand binding promotes the entropy-driven oligomerization of integrin alpha IIb beta 3. J Biol Chem. 2003 Jan 31; 278(5):3417-26.
Ligand binding promotes the entropy-driven oligomerization of integrin alpha IIb beta 3.
Ramsamooj P, Lively MO, Hantgan RR. Evidence that the central region of glycoprotein IIIa participates in integrin receptor function. Biochem J. 1991 Jun 15; 276 ( Pt 3):725-32.
Evidence that the central region of glycoprotein IIIa participates in integrin receptor function.
Hantgan RR, Stahle MC, Connor JH, Lyles DS, Horita DA, Rocco M, Nagaswami C, Weisel JW, McLane MA
Hantgan RR, Stahle MC, Connor JH, Lyles DS, Horita DA, Rocco M, Nagaswami C, Weisel JW, McLane MA. The disintegrin echistatin stabilizes integrin alphaIIbbeta3's open conformation and promotes its oligomerization. J Mol Biol. 2004 Oct 01; 342(5):1625-36.
The disintegrin echistatin stabilizes integrin alphaIIbbeta3's open conformation and promotes its oligomerization.
Chen K, Ballas SK, Hantgan RR, Kim-Shapiro DB
Chen K, Ballas SK, Hantgan RR, Kim-Shapiro DB. Aggregation of normal and sickle hemoglobin in high concentration phosphate buffer. Biophys J. 2004 Dec; 87(6):4113-21.
Aggregation of normal and sickle hemoglobin in high concentration phosphate buffer.
Guthold M, Liu W, Stephens B, Lord ST, Hantgan RR, Erie DA, Taylor RM, Superfine R
Guthold M, Liu W, Stephens B, Lord ST, Hantgan RR, Erie DA, Taylor RM, Superfine R. Visualization and mechanical manipulations of individual fibrin fibers suggest that fiber cross section has fractal dimension 1.3. Biophys J. 2004 Dec; 87(6):4226-36.
Visualization and mechanical manipulations of individual fibrin fibers suggest that fiber cross section has fractal dimension 1.3.
Tsurupa G, Veklich Y, Hantgan R, Belkin AM, Weisel JW, Medved L
Tsurupa G, Veklich Y, Hantgan R, Belkin AM, Weisel JW, Medved L. Do the isolated fibrinogen alphaC-domains form ordered oligomers? Biophys Chem. 2004 Dec 20; 112(2-3):257-66.
Do the isolated fibrinogen alphaC-domains form ordered oligomers?
Eble KS, Coleman WB, Hantgan RR, Cunningham CC
Eble KS, Coleman WB, Hantgan RR, Cunningham CC. Tightly associated cardiolipin in the bovine heart mitochondrial ATP synthase as analyzed by 31P nuclear magnetic resonance spectroscopy. J Biol Chem. 1990 Nov 15; 265(32):19434-40.
Tightly associated cardiolipin in the bovine heart mitochondrial ATP synthase as analyzed by 31P nuclear magnetic resonance spectroscopy.
Ledford AS, Weinberg RB, Cook VR, Hantgan RR, Shelness GS
Ledford AS, Weinberg RB, Cook VR, Hantgan RR, Shelness GS. Self-association and lipid binding properties of the lipoprotein initiating domain of apolipoprotein B. J Biol Chem. 2006 Mar 31; 281(13):8871-6.
Self-association and lipid binding properties of the lipoprotein initiating domain of apolipoprotein B.
Liu W, Jawerth LM, Sparks EA, Falvo MR, Hantgan RR, Superfine R, Lord ST, Guthold M
Liu W, Jawerth LM, Sparks EA, Falvo MR, Hantgan RR, Superfine R, Lord ST, Guthold M. Fibrin fibers have extraordinary extensibility and elasticity. Science. 2006 Aug 04; 313(5787):634.
Fibrin fibers have extraordinary extensibility and elasticity.
Lewis JC, Hantgan RR, Stevenson SC, Thornburg T, Kieffer N, Guichard J, Breton-Gorius J
Lewis JC, Hantgan RR, Stevenson SC, Thornburg T, Kieffer N, Guichard J, Breton-Gorius J. Fibrinogen and glycoprotein IIb/IIIa localization during platelet adhesion. Localization to the granulomere and at sites of platelet interaction. Am J Pathol. 1990 Jan; 136(1):239-52.
Fibrinogen and glycoprotein IIb/IIIa localization during platelet adhesion. Localization to the granulomere and at sites of platelet interaction.
Hantgan RR, Nichols WL, Ruggeri ZM. von Willebrand factor competes with fibrin for occupancy of GPIIb:IIIa on thrombin-stimulated platelets. Blood. 1990 Feb 15; 75(4):889-94.
von Willebrand factor competes with fibrin for occupancy of GPIIb:IIIa on thrombin-stimulated platelets.
Levi N, Hantgan RR, Lively MO, Carroll DL, Prasad GL
Levi N, Hantgan RR, Lively MO, Carroll DL, Prasad GL. C60-fullerenes: detection of intracellular photoluminescence and lack of cytotoxic effects. J Nanobiotechnology. 2006 Dec 14; 4:14.
C60-fullerenes: detection of intracellular photoluminescence and lack of cytotoxic effects.
Burton RA, Tsurupa G, Hantgan RR, Tjandra N, Medved L
Burton RA, Tsurupa G, Hantgan RR, Tjandra N, Medved L. NMR solution structure, stability, and interaction of the recombinant bovine fibrinogen alphaC-domain fragment. Biochemistry. 2007 Jul 24; 46(29):8550-60.
NMR solution structure, stability, and interaction of the recombinant bovine fibrinogen alphaC-domain fragment.
Ramsamooj P, Doellgast GJ, Hantgan RR. Inhibition of fibrin(ogen) binding to stimulated platelets by a monoclonal antibody specific for a conformational determinant of GPIIIa. Thromb Res. 1990 Jun 15; 58(6):577-92.
Inhibition of fibrin(ogen) binding to stimulated platelets by a monoclonal antibody specific for a conformational determinant of GPIIIa.
Guthold M, Liu W, Sparks EA, Jawerth LM, Peng L, Falvo M, Superfine R, Hantgan RR, Lord ST
Guthold M, Liu W, Sparks EA, Jawerth LM, Peng L, Falvo M, Superfine R, Hantgan RR, Lord ST. A comparison of the mechanical and structural properties of fibrin fibers with other protein fibers. Cell Biochem Biophys. 2007; 49(3):165-81.
A comparison of the mechanical and structural properties of fibrin fibers with other protein fibers.
Shen K, Sergeant S, Hantgan RR, McPhail LC, Horita DA
Shen K, Sergeant S, Hantgan RR, McPhail LC, Horita DA. Mutations in the PX-SH3A linker of p47phox decouple PI(3,4)P2 binding from NADPH oxidase activation. Biochemistry. 2008 Aug 26; 47(34):8855-65.
Mutations in the PX-SH3A linker of p47phox decouple PI(3,4)P2 binding from NADPH oxidase activation.
Mizel SB, Graff AH, Sriranganathan N, Ervin S, Lees CJ, Lively MO, Hantgan RR, Thomas MJ, Wood J, Bell B
Mizel SB, Graff AH, Sriranganathan N, Ervin S, Lees CJ, Lively MO, Hantgan RR, Thomas MJ, Wood J, Bell B. Flagellin-F1-V fusion protein is an effective plague vaccine in mice and two species of nonhuman primates. Clin Vaccine Immunol. 2009 Jan; 16(1):21-8.
Flagellin-F1-V fusion protein is an effective plague vaccine in mice and two species of nonhuman primates.
Hantgan RR. Fibrin protofibril and fibrinogen binding to ADP-stimulated platelets: evidence for a common mechanism. Biochim Biophys Acta. 1988 Jan 18; 968(1):24-35.
Fibrin protofibril and fibrinogen binding to ADP-stimulated platelets: evidence for a common mechanism.
Hantgan RR. Localization of the domains of fibrin involved in binding to platelets. Biochim Biophys Acta. 1988 Jan 18; 968(1):36-44.
Localization of the domains of fibrin involved in binding to platelets.
Giri B, Smaldino PJ, Thys RG, Creacy SD, Routh ED, Hantgan RR, Lattmann S, Nagamine Y, Akman SA, Vaughn JP
Giri B, Smaldino PJ, Thys RG, Creacy SD, Routh ED, Hantgan RR, Lattmann S, Nagamine Y, Akman SA, Vaughn JP. G4 resolvase 1 tightly binds and unwinds unimolecular G4-DNA. Nucleic Acids Res. 2011 Sep 01; 39(16):7161-78.
G4 resolvase 1 tightly binds and unwinds unimolecular G4-DNA.
Riedel TJ, Johnson LC, Knight J, Hantgan RR, Holmes RP, Lowther WT
Riedel TJ, Johnson LC, Knight J, Hantgan RR, Holmes RP, Lowther WT. Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria. PLoS One. 2011; 6(10):e26021.
Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria.
Lema Tomé CM, Palma E, Ferluga S, Lowther WT, Hantgan R, Wykosky J, Debinski W
Lema Tomé CM, Palma E, Ferluga S, Lowther WT, Hantgan R, Wykosky J, Debinski W. Structural and functional characterization of monomeric EphrinA1 binding site to EphA2 receptor. J Biol Chem. 2012 Apr 20; 287(17):14012-22.
Structural and functional characterization of monomeric EphrinA1 binding site to EphA2 receptor.
Tsurupa G, Pechik I, Litvinov RI, Hantgan RR, Tjandra N, Weisel JW, Medved L
Tsurupa G, Pechik I, Litvinov RI, Hantgan RR, Tjandra N, Weisel JW, Medved L. On the mechanism of aC polymer formation in fibrin. Biochemistry. 2012 Mar 27; 51(12):2526-38.
On the mechanism of aC polymer formation in fibrin.
Nguyen V, Conyers JM, Zhu D, Gibo DM, Hantgan RR, Larson SM, Debinski W, Mintz A
Nguyen V, Conyers JM, Zhu D, Gibo DM, Hantgan RR, Larson SM, Debinski W, Mintz A. A novel ligand delivery system to non-invasively visualize and therapeutically exploit the IL13Ra2 tumor-restricted biomarker. Neuro Oncol. 2012 Oct; 14(10):1239-53.
A novel ligand delivery system to non-invasively visualize and therapeutically exploit the IL13Ra2 tumor-restricted biomarker.
Knoll D, Hantgan R, Williams J, McDonagh J, Hermans J
Knoll D, Hantgan R, Williams J, McDonagh J, Hermans J. Characterization of soluble polymerized fibrin formed in the presence of excess fibrinogen fragment D. Biochemistry. 1984 Jul 31; 23(16):3708-15.
Characterization of soluble polymerized fibrin formed in the presence of excess fibrinogen fragment D.
Endenburg SC, Hantgan RR, Lindeboom-Blokzijl L, Lankhof H, Jerome WG, Lewis JC, Sixma JJ, de Groot PG
Endenburg SC, Hantgan RR, Lindeboom-Blokzijl L, Lankhof H, Jerome WG, Lewis JC, Sixma JJ, de Groot PG. On the role of von Willebrand factor in promoting platelet adhesion to fibrin in flowing blood. Blood. 1995 Dec 01; 86(11):4158-65.
On the role of von Willebrand factor in promoting platelet adhesion to fibrin in flowing blood.
Carr ME, Carr SL, Hantgan RR, Braaten J. Glycoprotein IIb/IIIa blockade inhibits platelet-mediated force development and reduces gel elastic modulus. Thromb Haemost. 1995 Mar; 73(3):499-505.
Glycoprotein IIb/IIIa blockade inhibits platelet-mediated force development and reduces gel elastic modulus.
Webb CD, Hantgan RR, Byeff PD, Owen J. Fibrinogen New Britain: characterization of an A alpha Arg 16-->His variant human fibrinogen. Blood Coagul Fibrinolysis. 1994 Apr; 5(2):233-8.
Fibrinogen New Britain: characterization of an A alpha Arg 16-->His variant human fibrinogen.
Braaten JV, Jerome WG, Hantgan RR. Uncoupling fibrin from integrin receptors hastens fibrinolysis at the platelet-fibrin interface. Blood. 1994 Feb 15; 83(4):982-93.
Uncoupling fibrin from integrin receptors hastens fibrinolysis at the platelet-fibrin interface.
Braaten JV, Handt S, Jerome WG, Kirkpatrick J, Lewis JC, Hantgan RR
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Regulation of fibrinolysis by platelet-released plasminogen activator inhibitor 1: light scattering and ultrastructural examination of lysis of a model platelet-fibrin thrombus.
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Platelets and endothelial cells act in concert to delay thrombolysis--evidence from an in vitro model of the human occlusive thrombus.
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Inhibition of platelet-mediated clot retraction by integrin antagonists.
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No effect of clot age or thrombolysis on argatroban's inhibition of thrombin.
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Physiochemical properties of rat liver mitochondrial ribosomes.
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Effect of the apolipoprotein A-IV Q360H polymorphism on postprandial plasma triglyceride clearance.
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Biological and structural characterization of glycosylation on ephrin-A1, a preferred ligand for EphA2 receptor tyrosine kinase.