Professor Emeritus of Biochemistry, Winston-Salem
Professor of Biochemistry, Winston-Salem
Professor of Pathology, Winston-Salem - Comparative Medicine
Assistant Professor of Biochemistry, Winston-Salem
Associate Professor Emeritus of Biochemistry, Winston-Salem
Associate Professor of Biochemistry, Winston-Salem
Yohan Suryo, Hawkins, Clare L, Kalinowski, Danuta S., Morrow, Charles S., Townsend, Alan J., Ponka, Prem and Richardson, Des R.
Nitric Oxide Storage and Transport in Cells Are Mediated by Glutathione S-Transferase P1-1 and Multidrug Resistance Protein 1 via Dinitrosyl Iron Complexes
Yohan Suryo, Hawkins, Clare L, Kalinowski, Danuta S., Morrow, Charles S., Townsend, Alan J., Ponka, Prem and Richardson, Des R. Journal of Biological Chemistry. Nitric Oxide Storage and Transport in Cells Are Mediated by Glutathione S-Transferase P1-1 and Multidrug Resistance Protein 1 via Dinitrosyl Iron Complexes. 2011; 287:607-618.
Smitherman PK, Townsend AJ, Kute TE, Morrow CS
The Journal of pharmacology and experimental therapeutics
Smitherman PK, Townsend AJ, Kute TE, Morrow CS. Role of multidrug resistance protein 2 (MRP2, ABCC2) in alkylating agent detoxification: MRP2 potentiates glutathione S-transferase A1-1-mediated resistance to chlorambucil cytotoxicity. J Pharmacol Exp Ther. 2004 Jan; 308(1):260-7.
Role of multidrug resistance protein 2 (MRP2, ABCC2) in alkylating agent detoxification: MRP2 potentiates glutathione S-transferase A1-1-mediated resistance to chlorambucil cytotoxicity.
Paumi CM, Smitherman PK, Townsend AJ, Morrow CS
Paumi CM, Smitherman PK, Townsend AJ, Morrow CS. Glutathione S-transferases (GSTs) inhibit transcriptional activation by the peroxisomal proliferator-activated receptor gamma (PPAR gamma) ligand, 15-deoxy-delta 12,14prostaglandin J2 (15-d-PGJ2). Biochemistry. 2004 Mar 02; 43(8):2345-52.
Glutathione S-transferases (GSTs) inhibit transcriptional activation by the peroxisomal proliferator-activated receptor gamma (PPAR gamma) ligand, 15-deoxy-delta 12,14prostaglandin J2 (15-d-PGJ2).
Riddick DS, Lee C, Ramji S, Chinje EC, Cowen RL, Williams KJ, Patterson AV, Stratford IJ, Morrow CS, Townsend AJ, Jounaidi Y, Chen CS, Su T, Lu H, Schwartz PS, Waxman DJ
Drug metabolism and disposition: the biological fate of chemicals
Riddick DS, Lee C, Ramji S, Chinje EC, Cowen RL, Williams KJ, Patterson AV, Stratford IJ, Morrow CS, Townsend AJ, Jounaidi Y, Chen CS, Su T, Lu H, Schwartz PS, Waxman DJ. Cancer chemotherapy and drug metabolism. Drug Metab Dispos. 2005 Aug; 33(8):1083-96.
Cancer chemotherapy and drug metabolism.
Kushman ME, Kabler SL, Fleming MH, Ravoori S, Gupta RC, Doehmer J, Morrow CS, Townsend AJ
Kushman ME, Kabler SL, Fleming MH, Ravoori S, Gupta RC, Doehmer J, Morrow CS, Townsend AJ. Expression of human glutathione S-transferase P1 confers resistance to benzo[a]pyrene or benzo[a]pyrene-7,8-dihydrodiol mutagenesis, macromolecular alkylation and formation of stable N2-Gua-BPDE adducts in stably transfected V79MZ cells co-expressing hCYP1A1. Carcinogenesis. 2007 Jan; 28(1):207-14.
Expression of human glutathione S-transferase P1 confers resistance to benzo[a]pyrene or benzo[a]pyrene-7,8-dihydrodiol mutagenesis, macromolecular alkylation and formation of stable N2-Gua-BPDE adducts in stably transfected V79MZ cells co-expressing hCYP1A1.
Kushman ME, Kabler SL, Ahmad S, Doehmer J, Morrow CS, Townsend AJ
Kushman ME, Kabler SL, Ahmad S, Doehmer J, Morrow CS, Townsend AJ. Cytotoxicity and mutagenicity of dibenzo[a,l]pyrene and (+/-)-dibenzo[a,l]pyrene-11,12-dihydrodiol in V79MZ cells co-expressing either hCYP1A1 or hCYP1B1 together with human glutathione-S-transferase A1. Mutat Res. 2007 Nov 01; 624(1-2):80-7.
Cytotoxicity and mutagenicity of dibenzo[a,l]pyrene and (+/-)-dibenzo[a,l]pyrene-11,12-dihydrodiol in V79MZ cells co-expressing either hCYP1A1 or hCYP1B1 together with human glutathione-S-transferase A1.
Sibhatu MB, Smitherman PK, Townsend AJ, Morrow CS
Sibhatu MB, Smitherman PK, Townsend AJ, Morrow CS. Expression of MRP1 and GSTP1-1 modulate the acute cellular response to treatment with the chemopreventive isothiocyanate, sulforaphane. Carcinogenesis. 2008 Apr; 29(4):807-15.
Expression of MRP1 and GSTP1-1 modulate the acute cellular response to treatment with the chemopreventive isothiocyanate, sulforaphane.
Bates DJ, Lively MO, Gorczynski MJ, King SB, Townsend AJ, Morrow CS
Bates DJ, Lively MO, Gorczynski MJ, King SB, Townsend AJ, Morrow CS. Noncatalytic interactions between glutathione S-transferases and nitroalkene fatty acids modulate nitroalkene-mediated activation of peroxisomal proliferator-activated receptor gamma. Biochemistry. 2009 May 19; 48(19):4159-69.
Noncatalytic interactions between glutathione S-transferases and nitroalkene fatty acids modulate nitroalkene-mediated activation of peroxisomal proliferator-activated receptor gamma.
Pathology, Winston-Salem - Comparative Medicine
Bates DJ, Smitherman PK, Townsend AJ, King SB, Morrow CS
Bates DJ, Smitherman PK, Townsend AJ, King SB, Morrow CS. Nitroalkene fatty acids mediate activation of Nrf2/ARE-dependent and PPAR?-dependent transcription by distinct signaling pathways and with significantly different potencies. Biochemistry. 2011 Sep 13; 50(36):7765-73.
Nitroalkene fatty acids mediate activation of Nrf2/ARE-dependent and PPAR?-dependent transcription by distinct signaling pathways and with significantly different potencies.
Rudd LP, Kabler SL, Morrow CS, Townsend AJ
Rudd LP, Kabler SL, Morrow CS, Townsend AJ. Enhanced glutathione depletion, protein adduct formation, and cytotoxicity following exposure to 4-hydroxy-2-nonenal (HNE) in cells expressing human multidrug resistance protein-1 (MRP1) together with human glutathione S-transferase-M1 (GSTM1). Chem Biol Interact. 2011 Nov 15; 194(2-3):113-9.
Enhanced glutathione depletion, protein adduct formation, and cytotoxicity following exposure to 4-hydroxy-2-nonenal (HNE) in cells expressing human multidrug resistance protein-1 (MRP1) together with human glutathione S-transferase-M1 (GSTM1).
Townsend AJ, Kabler SL, Doehmer J, Morrow CS
Townsend AJ, Kabler SL, Doehmer J, Morrow CS. Modeling the metabolic competency of glutathione S-transferases using genetically modified cell lines. Toxicology. 2002 Dec 27; 181-182:265-9.
Modeling the metabolic competency of glutathione S-transferases using genetically modified cell lines.
Pietsch EC, Hurley AL, Scott EE, Duckworth BP, Welker ME, Leone-Kabler S, Townsend AJ, Torti FM, Torti SV
Pietsch EC, Hurley AL, Scott EE, Duckworth BP, Welker ME, Leone-Kabler S, Townsend AJ, Torti FM, Torti SV. Oxathiolene oxides: a novel family of compounds that induce ferritin, glutathione S-transferase, and other proteins of the phase II response. Biochem Pharmacol. 2003 Apr 15; 65(8):1261-9.
Oxathiolene oxides: a novel family of compounds that induce ferritin, glutathione S-transferase, and other proteins of the phase II response.
Pappa A, Chen C, Koutalos Y, Townsend AJ, Vasiliou V
Pappa A, Chen C, Koutalos Y, Townsend AJ, Vasiliou V. Aldh3a1 protects human corneal epithelial cells from ultraviolet- and 4-hydroxy-2-nonenal-induced oxidative damage. Free Radic Biol Med. 2003 May 01; 34(9):1178-89.
Aldh3a1 protects human corneal epithelial cells from ultraviolet- and 4-hydroxy-2-nonenal-induced oxidative damage.
Paumi CM, Wright M, Townsend AJ, Morrow CS
Paumi CM, Wright M, Townsend AJ, Morrow CS. Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells. Biochemistry. 2003 May 13; 42(18):5429-37.
Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells.
Peklak-Scott C, Townsend AJ, Morrow CS. Dynamics of glutathione conjugation and conjugate efflux in detoxification of the carcinogen, 4-nitroquinoline 1-oxide: contributions of glutathione, glutathione S-transferase, and MRP1. Biochemistry. 2005 Mar 22; 44(11):4426-33.
Dynamics of glutathione conjugation and conjugate efflux in detoxification of the carcinogen, 4-nitroquinoline 1-oxide: contributions of glutathione, glutathione S-transferase, and MRP1.
Morrow CS, Peklak-Scott C, Bishwokarma B, Kute TE, Smitherman PK, Townsend AJ
Morrow CS, Peklak-Scott C, Bishwokarma B, Kute TE, Smitherman PK, Townsend AJ. Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux. Mol Pharmacol. 2006 Apr; 69(4):1499-505.
Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux.
Xu M, Moore JE, Leone-Kabler S, McCoy TP, Swank A, Nelson GB, Ross JA, Townsend AJ, Miller MS
Xu M, Moore JE, Leone-Kabler S, McCoy TP, Swank A, Nelson GB, Ross JA, Townsend AJ, Miller MS. Expression of glutathione S-transferases in fetal lung and liver tissue from parental strains and F1 crosses between C57BL/6 and BALB/c F1 mice following in utero exposure to 3-methylcholanthrene. Biochem Pharmacol. 2006 Jun 28; 72(1):115-23.
Expression of glutathione S-transferases in fetal lung and liver tissue from parental strains and F1 crosses between C57BL/6 and BALB/c F1 mice following in utero exposure to 3-methylcholanthrene.
Hu Y, Kabler SL, Tennant AH, Townsend AJ, Kligerman AD
Hu Y, Kabler SL, Tennant AH, Townsend AJ, Kligerman AD. Induction of DNA-protein crosslinks by dichloromethane in a V79 cell line transfected with the murine glutathione-S-transferase theta 1 gene. Mutat Res. 2006 Sep 05; 607(2):231-9.
Induction of DNA-protein crosslinks by dichloromethane in a V79 cell line transfected with the murine glutathione-S-transferase theta 1 gene.
Toxicological sciences : an official journal of the Society of Toxicology
Kushman ME, Kabler SL, Ahmad S, Doehmer J, Morrow CS, Townsend AJ. Protective efficacy of hGSTM1-1 against B[a]P and (+)- or (-)-B[a]P-7,8-dihydrodiol cytotoxicity, mutagenicity, and macromolecular adducts in V79 cells coexpressing hCYP1A1. Toxicol Sci. 2007 Sep; 99(1):51-7.
Protective efficacy of hGSTM1-1 against B[a]P and (+)- or (-)-B[a]P-7,8-dihydrodiol cytotoxicity, mutagenicity, and macromolecular adducts in V79 cells coexpressing hCYP1A1.
Peklak-Scott C, Smitherman PK, Townsend AJ, Morrow CS
Peklak-Scott C, Smitherman PK, Townsend AJ, Morrow CS. Role of glutathione S-transferase P1-1 in the cellular detoxification of cisplatin. . 2008 Oct; 7(10):3247-55.
Role of glutathione S-transferase P1-1 in the cellular detoxification of cisplatin.
Ahmad S, Kabler SL, Rudd L, Amin S, Doehmer J, Morrow CS, Townsend AJ
Ahmad S, Kabler SL, Rudd L, Amin S, Doehmer J, Morrow CS, Townsend AJ. Cytotoxicity and mutagenicity of 5-methylchrysene and its 1,2-dihydrodiol in V79MZ cells modified to express human CYP1A1 or CYP1B1, in the presence or absence of human GSTP1 coexpression. Toxicol Lett. 2008 Dec 15; 183(1-3):99-104.
Cytotoxicity and mutagenicity of 5-methylchrysene and its 1,2-dihydrodiol in V79MZ cells modified to express human CYP1A1 or CYP1B1, in the presence or absence of human GSTP1 coexpression.
Kabler SL, Seidel A, Jacob J, Doehmer J, Morrow CS, Townsend AJ
Kabler SL, Seidel A, Jacob J, Doehmer J, Morrow CS, Townsend AJ. Differential protection by human glutathione S-transferase P1 against cytotoxicity of benzo[a]pyrene, dibenzo[a,l]pyrene, or their dihydrodiol metabolites, in bi-transgenic cell lines that co-express rat versus human cytochrome P4501A1. Chem Biol Interact. 2009 May 15; 179(2-3):240-6.
Differential protection by human glutathione S-transferase P1 against cytotoxicity of benzo[a]pyrene, dibenzo[a,l]pyrene, or their dihydrodiol metabolites, in bi-transgenic cell lines that co-express rat versus human cytochrome P4501A1.
Dance-Barnes ST, Kock ND, Moore JE, Lin EY, Mosley LJ, D'Agostino RB, McCoy TP, Townsend AJ, Miller MS
Dance-Barnes ST, Kock ND, Moore JE, Lin EY, Mosley LJ, D'Agostino RB, McCoy TP, Townsend AJ, Miller MS. Lung tumor promotion by curcumin. Carcinogenesis. 2009 Jun; 30(6):1016-23.
Rudd, Lisa P., Kabler, Sandra L., Morrow, Charles S. and Townsend, Alan J.
Cytotoxicity, Glutathione Depletion and HNE-protein Adduct Formation by 4-hydroxy-2-nonenal (HNE) in cell lines expressing GSTM1 and or MRP1/MRP2.
Rudd, Lisa P., Kabler, Sandra L., Morrow, Charles S. and Townsend, Alan J. Chemico-Biological Interactions. Cytotoxicity, Glutathione Depletion and HNE-protein Adduct Formation by 4-hydroxy-2-nonenal (HNE) in cell lines expressing GSTM1 and or MRP1/MRP2. 2011; 194:113-119.
Lok HC, Rahmanto YS, Hawkins CL, Kalinowski DS, Morrow CS, Townsend AJ, Ponka P, Richardson DR
Lok HC, Rahmanto YS, Hawkins CL, Kalinowski DS, Morrow CS, Townsend AJ, Ponka P, Richardson DR. Nitric oxide storage and transport in cells are mediated by glutathione S-transferase P1-1 and multidrug resistance protein 1 via dinitrosyl iron complexes. J Biol Chem. 2012 Jan 02; 287(1):607-618.
Nitric oxide storage and transport in cells are mediated by glutathione S-transferase P1-1 and multidrug resistance protein 1 via dinitrosyl iron complexes.