LesliePooleLeslie B. Poole PhD36.08919100000000-80.26677800000000567Poole, LeslieBProfessorprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 34753423830624Nelson KJ, Parsonage D, Karplus PA, Poole LBMethods in enzymologyNelson KJ, Parsonage D, Karplus PA, Poole LB. Evaluating peroxiredoxin sensitivity toward inactivation by peroxide substrates. Methods Enzymol. 2013; 527:21-40.Methods Enzymol2013-01-01T00:00:002013Evaluating peroxiredoxin sensitivity toward inactivation by peroxide substrates.Authorship 386752Authorship 396567Authorship 397697Authorship 397794Authorship 40945224105931Furdui CM, Poole LBMass spectrometry reviewsFurdui CM, Poole LB. Chemical approaches to detect and analyze protein sulfenic acids. Mass Spectrom Rev. 2014 Mar-Apr; 33(2):126-46.Mass Spectrom Rev2013-09-17T00:00:002013Chemical approaches to detect and analyze protein sulfenic acids.24657741Klomsiri C, Rogers LC, Soito L, McCauley AK, King SB, Nelson KJ, Poole LB, Daniel LWFree radical biology & medicineKlomsiri C, Rogers LC, Soito L, McCauley AK, King SB, Nelson KJ, Poole LB, Daniel LW. Endosomal H2O2 production leads to localized cysteine sulfenic acid formation on proteins during lysophosphatidic acid-mediated cell signaling. Free Radic Biol Med. 2014 Jun; 71:49-60.Free Radic Biol Med2014-03-21T00:00:002014Endosomal H2O2 production leads to localized cysteine sulfenic acid formation on proteins during lysophosphatidic acid-mediated cell signaling.24719319Randall LM, Manta B, Hugo M, Gil M, Batthyàny C, Trujillo M, Poole LB, Denicola AThe Journal of biological chemistryRandall LM, Manta B, Hugo M, Gil M, Batthyàny C, Trujillo M, Poole LB, Denicola A. Nitration transforms a sensitive peroxiredoxin 2 into a more active and robust peroxidase. J Biol Chem. 2014 May 30; 289(22):15536-43.J Biol Chem2014-04-09T00:00:002014Nitration transforms a sensitive peroxiredoxin 2 into a more active and robust peroxidase.24724926Poole TH, Reisz JA, Zhao W, Poole LB, Furdui CM, King SBJournal of the American Chemical SocietyPoole TH, Reisz JA, Zhao W, Poole LB, Furdui CM, King SB. Strained cycloalkynes as new protein sulfenic acid traps. J Am Chem Soc. 2014 Apr 30; 136(17):6167-70.J Am Chem Soc2014-04-16T00:00:002014Strained cycloalkynes as new protein sulfenic acid traps.25403613Perkins A, Poole LB, Karplus PABiochemistryPerkins A, Poole LB, Karplus PA. Tuning of peroxiredoxin catalysis for various physiological roles. Biochemistry. 2014 Dec 16; 53(49):7693-705.Biochemistry2014-12-01T00:00:002014Tuning of peroxiredoxin catalysis for various physiological roles.BiochemistryMicrobiology and ImmunologyWake Forest School of MedicineCristinaFurduiCristina M. Furdui PhD36.09032400000000-80.26649100000000135Furdui, CristinaProfessorDouglasLylesDouglas S. Lyles PhD36.08919100000000-80.26677800000000233Lyles, DouglasProfessorAnthonyAtalaAnthony Atala MD36.08943500000000-80.268632000000003Atala, AnthonyProfessorJasonGraysonJason M. Grayson PhD36.08977400000000-80.26684000000000419Grayson, JasonAssociate ProfessorKimberlyNelsonKimberly J. Nelson PhD36.13393700000000-80.25477800000000526Nelson, KimberlyInstructor9.047850.0125879399research areas4.897780.028011517coauthor of136.7126.7105348similar to11127selected publicationsDerekParsonageDerek Parsonage PhD36.08919100000000-80.26677800000000740Parsonage, DerekAssistant ProfessorSusanSergeantSusan Sergeant PhD36.08919100000000-80.26677800000000936Sergeant, SusanAssistant ProfessorThomasHollisThomas Hollis PhD36.08919100000000-80.26677800000000973Hollis, ThomasProfessorWilliamLowtherWilliam T. Lowther PhD36.08919100000000-80.26677800000000982Lowther, WilliamProfessorAuthorship 41461725633283Parsonage D, Nelson KJ, Ferrer-Sueta G, Alley S, Karplus PA, Furdui CM, Poole LBBiochemistryParsonage D, Nelson KJ, Ferrer-Sueta G, Alley S, Karplus PA, Furdui CM, Poole LB. Dissecting peroxiredoxin catalysis: separating binding, peroxidation, and resolution for a bacterial AhpC. Biochemistry. 2015 Feb 24; 54(7):1567-75.Biochemistry2015-02-10T00:00:002015Dissecting peroxiredoxin catalysis: separating binding, peroxidation, and resolution for a bacterial AhpC.Authorship 41616125746478Poole LB, Schöneich CFree radical biology & medicinePoole LB, Schöneich C. Introduction: What we do and do not know regarding redox processes of thiols in signaling pathways. Free Radic Biol Med. 2015 Mar; 80:145-7.Free Radic Biol Med2015-03-01T00:00:002015Introduction: What we do and do not know regarding redox processes of thiols in signaling pathways.Authorship 42015125433365Poole LBFree radical biology & medicinePoole LB. The basics of thiols and cysteines in redox biology and chemistry. Free Radic Biol Med. 2015 Mar; 80:148-57.Free Radic Biol Med2014-11-27T00:00:002014The basics of thiols and cysteines in redox biology and chemistry.Authorship 42660426067716Perkins A, Nelson KJ, Parsonage D, Poole LB, Karplus PATrends in biochemical sciencesPerkins A, Nelson KJ, Parsonage D, Poole LB, Karplus PA. Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling. Trends Biochem Sci. 2015 Aug; 40(8):435-45.Trends Biochem Sci2015-06-09T00:00:002015Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling.Authorship 46391526209624Langston PK, Yang M, Bierbach U, Parsonage D, Poole LB, Price MJ, Grayson JMJournal of immunology (Baltimore, Md. : 1950)Langston PK, Yang M, Bierbach U, Parsonage D, Poole LB, Price MJ, Grayson JM. Au-ACRAMTU-PEt3 Alters Redox Balance To Inhibit T Cell Proliferation and Function. J Immunol. 2015 Sep 01; 195(5):1984-94.J Immunol2015-07-24T00:00:002015Au-ACRAMTU-PEt3 Alters Redox Balance To Inhibit T Cell Proliferation and Function.Authorship 47124926433273Vera T, D'Agostino RB, Jordan JH, Whitlock MC, Meléndez GC, Lamar ZS, Porosnicu M, Bonkovsky HL, Poole LB, Hundley WGThe American journal of cardiologyVera T, D'Agostino RB, Jordan JH, Whitlock MC, Meléndez GC, Lamar ZS, Porosnicu M, Bonkovsky HL, Poole LB, Hundley WG. Relation of Pre-anthracycline Serum Bilirubin Levels to Left Ventricular Ejection Fraction After Chemotherapy. Am J Cardiol. 2015 Dec 01; 116(11):1752-5.Am J Cardiol2015-09-10T00:00:002015Relation of Pre-anthracycline Serum Bilirubin Levels to Left Ventricular Ejection Fraction After Chemotherapy.Authorship 47440726314228Wood ST, Long DL, Reisz JA, Yammani RR, Burke EA, Klomsiri C, Poole LB, Furdui CM, Loeser RFArthritis & rheumatology (Hoboken, N.J.)Wood ST, Long DL, Reisz JA, Yammani RR, Burke EA, Klomsiri C, Poole LB, Furdui CM, Loeser RF. Cysteine-Mediated Redox Regulation of Cell Signaling in Chondrocytes Stimulated With Fibronectin Fragments. Arthritis Rheumatol. 2016 Jan; 68(1):117-26.Arthritis Rheumatol2016-01-01T00:00:002016Cysteine-Mediated Redox Regulation of Cell Signaling in Chondrocytes Stimulated With Fibronectin Fragments.Authorship 482901Authorship 483668Authorship 485694Authorship 48575526810075Poole LB, Nelson KJMolecules and cellsPoole LB, Nelson KJ. Distribution and Features of the Six Classes of Peroxiredoxins. Mol Cells. 2016 Jan; 39(1):53-9.Mol Cells2016-01-25T00:00:002016Distribution and Features of the Six Classes of Peroxiredoxins.26876147Parsonage D, Sheng F, Hirata K, Debnath A, McKerrow JH, Reed SL, Abagyan R, Poole LB, Podust LMJournal of structural biologyParsonage D, Sheng F, Hirata K, Debnath A, McKerrow JH, Reed SL, Abagyan R, Poole LB, Podust LM. X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action. J Struct Biol. 2016 May; 194(2):180-90.J Struct Biol2016-02-12T00:00:002016X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action.26438558Buchko GW, Perkins A, Parsonage D, Poole LB, Karplus PABiomolecular NMR assignmentsBuchko GW, Perkins A, Parsonage D, Poole LB, Karplus PA. Backbone chemical shift assignments for Xanthomonas campestris peroxiredoxin Q in the reduced and oxidized states: a dramatic change in backbone dynamics. Biomol NMR Assign. 2016 Apr; 10(1):57-61.Biomol NMR Assign2015-09-15T00:00:002015Backbone chemical shift assignments for Xanthomonas campestris peroxiredoxin Q in the reduced and oxidized states: a dramatic change in backbone dynamics.26612102Randall L, Manta B, Nelson KJ, Santos J, Poole LB, Denicola AArchives of biochemistry and biophysicsRandall L, Manta B, Nelson KJ, Santos J, Poole LB, Denicola A. Structural changes upon peroxynitrite-mediated nitration of peroxiredoxin 2; nitrated Prx2 resembles its disulfide-oxidized form. Arch Biochem Biophys. 2016 Jan 15; 590:101-108.Arch Biochem Biophys2015-11-22T00:00:002015Structural changes upon peroxynitrite-mediated nitration of peroxiredoxin 2; nitrated Prx2 resembles its disulfide-oxidized form.Authorship 48705726797130Collins JA, Wood ST, Nelson KJ, Rowe MA, Carlson CS, Chubinskaya S, Poole LB, Furdui CM, Loeser RFThe Journal of biological chemistryCollins JA, Wood ST, Nelson KJ, Rowe MA, Carlson CS, Chubinskaya S, Poole LB, Furdui CM, Loeser RF. Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes. J Biol Chem. 2016 Mar 25; 291(13):6641-54.J Biol Chem2016-01-21T00:00:002016Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes.Authorship 50608627594682Perkins A, Parsonage D, Nelson KJ, Ogba OM, Cheong PH, Poole LB, Karplus PAStructure (London, England : 1993)Perkins A, Parsonage D, Nelson KJ, Ogba OM, Cheong PH, Poole LB, Karplus PA. Peroxiredoxin Catalysis at Atomic Resolution. Structure. 2016 Oct 04; 24(10):1668-1678.Structure2016-09-01T00:00:002016Peroxiredoxin Catalysis at Atomic Resolution.Authorship 52732628187133Harper AF, Leuthaeuser JB, Babbitt PC, Morris JH, Ferrin TE, Poole LB, Fetrow JSPLoS computational biologyHarper AF, Leuthaeuser JB, Babbitt PC, Morris JH, Ferrin TE, Poole LB, Fetrow JS. An Atlas of Peroxiredoxins Created Using an Active Site Profile-Based Approach to Functionally Relevant Clustering of Proteins. PLoS Comput Biol. 2017 02; 13(2):e1005284.PLoS Comput Biol2017-02-10T00:00:002017An Atlas of Peroxiredoxins Created Using an Active Site Profile-Based Approach to Functionally Relevant Clustering of Proteins.2016-04-30NIHPOOLE, LESLIE B.1993-12-01Mechanistic Studies of Alkyl Hydroperoxide Reductase and Related Redox ProteinsR01GM0503891900-01-01NIHPOOLE, LESLIE B1989-11-30REVERSION MUTAGENESIS OF ACTIVE-SITE MUTANTS OF NUCLEASEF32GM0132112017-08-31NIHFURDUI, CRISTINA MARIA2013-09-01New Reagents for Tracking Protein Oxidation in Cells by MS and Imaging MethodsR33CA1774612012-08-31NIHPOOLE, LESLIE B2011-09-222012 Thiol-based Redox Regulation &Signaling GRC and GRSR13ES0211192012-04-30NIHPOOLE, LESLIE B2008-05-01Proteomic Profiling of Cancer-Related Redox Signaling PathwaysR33CA1266592011-04-30NIHPOOLE, LESLIE B2010-05-012010 Thiol-based Redox Regulation &Signaling Gordon Research ConferenceR13CA1443562008-10-31NIHPOOLE, LESLIE B2005-05-01Profiling of Redox-Sensitive Signaling ProteinsR21CA1121452021-06-30NIHHOLLIS, THOMAS J2011-07-01Structural and Computational Biophysics Training ProgramT32GM0954402021-03-31NIHPOOLE, LESLIE B2016-04-05Mechanisms and Regulation of PeroxiredoxinsR01GM119227Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorAuthorship 535249Authorship 53564828398823Mauney CH, Rogers LC, Harris RS, Daniel LW, Devarie-Baez NO, Wu H, Furdui CM, Poole LB, Perrino FW, Hollis TAntioxidants & redox signalingMauney CH, Rogers LC, Harris RS, Daniel LW, Devarie-Baez NO, Wu H, Furdui CM, Poole LB, Perrino FW, Hollis T. The SAMHD1 dNTP Triphosphohydrolase Is Controlled by a Redox Switch. Antioxid Redox Signal. 2017 Dec 01; 27(16):1317-1331.Antioxid Redox Signal2017-04-18T00:00:002017The SAMHD1 dNTP Triphosphohydrolase Is Controlled by a Redox Switch.28375740Nelson KJ, Perkins A, Van Swearingen AED, Hartman S, Brereton AE, Parsonage D, Salsbury FR, Karplus PA, Poole LBAntioxidants & redox signalingNelson KJ, Perkins A, Van Swearingen AED, Hartman S, Brereton AE, Parsonage D, Salsbury FR, Karplus PA, Poole LB. Experimentally Dissecting the Origins of Peroxiredoxin Catalysis. Antioxid Redox Signal. 2018 Mar 01; 28(7):521-536.Antioxid Redox Signal2017-04-04T00:00:002017Experimentally Dissecting the Origins of Peroxiredoxin Catalysis.Authorship 55134928687042Chen X, Wu H, Park CM, Poole TH, Keceli G, Devarie-Baez NO, Tsang AW, Lowther WT, Poole LB, King SB, Xian M, Furdui CMACS chemical biologyChen X, Wu H, Park CM, Poole TH, Keceli G, Devarie-Baez NO, Tsang AW, Lowther WT, Poole LB, King SB, Xian M, Furdui CM. Discovery of Heteroaromatic Sulfones As a New Class of Biologically Compatible Thiol-Selective Reagents. ACS Chem Biol. 2017 08 18; 12(8):2201-2208.ACS Chem Biol2017-07-19T00:00:002017Discovery of Heteroaromatic Sulfones As a New Class of Biologically Compatible Thiol-Selective Reagents.Authorship 554458Authorship 55547428887543Long D, Wu H, Tsang AW, Poole LB, Yoza BK, Wang X, Vachharajani V, Furdui CM, McCall CEScientific reportsLong D, Wu H, Tsang AW, Poole LB, Yoza BK, Wang X, Vachharajani V, Furdui CM, McCall CE. The Oxidative State of Cysteine Thiol 144 Regulates the SIRT6 Glucose Homeostat. Sci Rep. 2017 09 08; 7(1):11005.Sci Rep2017-09-08T00:00:002017The Oxidative State of Cysteine Thiol 144 Regulates the SIRT6 Glucose Homeostat.28843779Keyes JD, Parsonage D, Yammani RD, Rogers LC, Kesty C, Furdui CM, Nelson KJ, Poole LBFree radical biology & medicineKeyes JD, Parsonage D, Yammani RD, Rogers LC, Kesty C, Furdui CM, Nelson KJ, Poole LB. Endogenous, regulatory cysteine sulfenylation of ERK kinases in response to proliferative signals. Free Radic Biol Med. 2017 11; 112:534-543.Free Radic Biol Med2017-08-24T00:00:002017Endogenous, regulatory cysteine sulfenylation of ERK kinases in response to proliferative signals.RetoAsmisReto H. Asmis PhD36.09040200000000-80.267005999999992162Asmis, RetoProfessor2022-06-30NIHPOOLE, LESLIE B2018-07-01Redox Biology and Medicine Training ProgramT32GM127261Principal InvestigatorAuthorship 5785212Authorship 581696Authorship 586379Authorship 60054430050050Al-Barakati HJ, McConnell EW, Hicks LM, Poole LB, Newman RH, Kc DBScientific reportsAl-Barakati HJ, McConnell EW, Hicks LM, Poole LB, Newman RH, Kc DB. SVM-SulfoSite: A support vector machine based predictor for sulfenylation sites. Sci Rep. 2018 07 26; 8(1):11288.Sci Rep2018-07-26T00:00:002018SVM-SulfoSite: A support vector machine based predictor for sulfenylation sites.29884768Bolduc JA, Nelson KJ, Haynes AC, Lee J, Reisz JA, Graff AH, Clodfelter JE, Parsonage D, Poole LB, Furdui CM, Lowther WTThe Journal of biological chemistryBolduc JA, Nelson KJ, Haynes AC, Lee J, Reisz JA, Graff AH, Clodfelter JE, Parsonage D, Poole LB, Furdui CM, Lowther WT. Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins. J Biol Chem. 2018 07 27; 293(30):11901-11912.J Biol Chem2018-06-08T00:00:002018Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins.29553725Portillo-Ledesma S, Randall LM, Parsonage D, Dalla Rizza J, Karplus PA, Poole LB, Denicola A, Ferrer-Sueta GBiochemistryPortillo-Ledesma S, Randall LM, Parsonage D, Dalla Rizza J, Karplus PA, Poole LB, Denicola A, Ferrer-Sueta G. Differential Kinetics of Two-Cysteine Peroxiredoxin Disulfide Formation Reveal a Novel Model for Peroxide Sensing. Biochemistry. 2018 06 19; 57(24):3416-3424.Biochemistry2018-03-30T00:00:002018Differential Kinetics of Two-Cysteine Peroxiredoxin Disulfide Formation Reveal a Novel Model for Peroxide Sensing.29703899Holmila RJ, Vance SA, Chen X, Wu H, Shukla K, Bharadwaj MS, Mims J, Wary Z, Marrs G, Singh R, Molina AJ, Poole LB, King SB, Furdui CMScientific reportsHolmila RJ, Vance SA, Chen X, Wu H, Shukla K, Bharadwaj MS, Mims J, Wary Z, Marrs G, Singh R, Molina AJ, Poole LB, King SB, Furdui CM. Mitochondria-targeted Probes for Imaging Protein Sulfenylation. Sci Rep. 2018 04 27; 8(1):6635.Sci Rep2018-04-27T00:00:002018Mitochondria-targeted Probes for Imaging Protein Sulfenylation.20ProfessorAuthorship 6407210Authorship 641107Authorship 641988Authorship 645336Authorship 649471Authorship 663197Authorship 663777Authorship 66577630737390Teixeira F, Tse E, Castro H, Makepeace KAT, Meinen BA, Borchers CH, Poole LB, Bardwell JC, Tomás AM, Southworth DR, Jakob UNature communicationsTeixeira F, Tse E, Castro H, Makepeace KAT, Meinen BA, Borchers CH, Poole LB, Bardwell JC, Tomás AM, Southworth DR, Jakob U. Chaperone activation and client binding of a 2-cysteine peroxiredoxin. Nat Commun. 2019 02 08; 10(1):659.Nat Commun2019-02-08T00:00:002019Chaperone activation and client binding of a 2-cysteine peroxiredoxin.30354218Vukelic S, Xu Q, Seidel-Rogol B, Faidley EA, Dikalova AE, Hilenski LL, Jorde U, Poole LB, Lassègue B, Zhang G, Griendling KKArteriosclerosis, thrombosis, and vascular biologyVukelic S, Xu Q, Seidel-Rogol B, Faidley EA, Dikalova AE, Hilenski LL, Jorde U, Poole LB, Lassègue B, Zhang G, Griendling KK. NOX4 (NADPH Oxidase 4) and Poldip2 (Polymerase d-Interacting Protein 2) Induce Filamentous Actin Oxidation and Promote Its Interaction With Vinculin During Integrin-Mediated Cell Adhesion. Arterioscler Thromb Vasc Biol. 2018 10; 38(10):2423-2434.Arterioscler Thromb Vasc Biol2018-10-01T00:00:002018NOX4 (NADPH Oxidase 4) and Poldip2 (Polymerase d-Interacting Protein 2) Induce Filamentous Actin Oxidation and Promote Its Interaction With Vinculin During Integrin-Mediated Cell Adhesion.30461094Poole LB, Thorpe CProtein science : a publication of the Protein SocietyPoole LB, Thorpe C. Redox proteins. Protein Sci. 2019 01; 28(1):5-7.Protein Sci2019-01-01T00:00:002019Redox proteins.30190325Nelson KJ, Bolduc JA, Wu H, Collins JA, Burke EA, Reisz JA, Klomsiri C, Wood ST, Yammani RR, Poole LB, Furdui CM, Loeser RFThe Journal of biological chemistryNelson KJ, Bolduc JA, Wu H, Collins JA, Burke EA, Reisz JA, Klomsiri C, Wood ST, Yammani RR, Poole LB, Furdui CM, Loeser RF. H2O2 oxidation of cysteine residues in c-Jun N-terminal kinase 2 (JNK2) contributes to redox regulation in human articular chondrocytes. J Biol Chem. 2018 10 19; 293(42):16376-16389.J Biol Chem2018-09-06T00:00:002018H2O2 oxidation of cysteine residues in c-Jun N-terminal kinase 2 (JNK2) contributes to redox regulation in human articular chondrocytes.30609657Forshaw TE, Holmila R, Nelson KJ, Lewis JE, Kemp ML, Tsang AW, Poole LB, Lowther WT, Furdui CMAntioxidants (Basel, Switzerland)Forshaw TE, Holmila R, Nelson KJ, Lewis JE, Kemp ML, Tsang AW, Poole LB, Lowther WT, Furdui CM. Peroxiredoxins in Cancer and Response to Radiation Therapies. Antioxidants (Basel). 2019 Jan 01; 8(1).Antioxidants (Basel)2019-01-01T00:00:002019Peroxiredoxins in Cancer and Response to Radiation Therapies.30784263Li Z, Forshaw TE, Holmila RJ, Vance SA, Wu H, Poole LB, Furdui CM, King SBChemical research in toxicologyLi Z, Forshaw TE, Holmila RJ, Vance SA, Wu H, Poole LB, Furdui CM, King SB. Triphenylphosphonium-Derived Protein Sulfenic Acid Trapping Agents: Synthesis, Reactivity, and Effect on Mitochondrial Function. Chem Res Toxicol. 2019 03 18; 32(3):526-534.Chem Res Toxicol2019-03-04T00:00:002019Triphenylphosphonium-Derived Protein Sulfenic Acid Trapping Agents: Synthesis, Reactivity, and Effect on Mitochondrial Function.31323313Randall LM, Dalla Rizza J, Parsonage D, Santos J, Mehl RA, Lowther WT, Poole LB, Denicola AFree radical biology & medicineRandall LM, Dalla Rizza J, Parsonage D, Santos J, Mehl RA, Lowther WT, Poole LB, Denicola A. Unraveling the effects of peroxiredoxin 2 nitration; role of C-terminal tyrosine 193. Free Radic Biol Med. 2019 09; 141:492-501.Free Radic Biol Med2019-07-16T00:00:002019Unraveling the effects of peroxiredoxin 2 nitration; role of C-terminal tyrosine 193.30639614Collins JA, Wood ST, Bolduc JA, Nurmalasari NPD, Chubinskaya S, Poole LB, Furdui CM, Nelson KJ, Loeser RFFree radical biology & medicineCollins JA, Wood ST, Bolduc JA, Nurmalasari NPD, Chubinskaya S, Poole LB, Furdui CM, Nelson KJ, Loeser RF. Differential peroxiredoxin hyperoxidation regulates MAP kinase signaling in human articular chondrocytes. Free Radic Biol Med. 2019 04; 134:139-152.Free Radic Biol Med2019-01-09T00:00:002019Differential peroxiredoxin hyperoxidation regulates MAP kinase signaling in human articular chondrocytes.2025-01-31NIHPOOLE, LESLIE B2020-02-01Redox Regulation of Cysteine-Dependent Peroxidases and Signal Transduction PathwaysR35GM135179Principal InvestigatorAuthorship 6987510Authorship 698764Authorship 698779Authorship 698781Authorship 69879133287170Dushime R, Zhu Y, Wu H, Saez D, Shukla K, Brown-Harding H, Biavatti MW, Nelson KJ, Poole LB, Lowther WT, Jones PB, Furdui CM, Tsang AWAntioxidants (Basel, Switzerland)Dushime R, Zhu Y, Wu H, Saez D, Shukla K, Brown-Harding H, Biavatti MW, Nelson KJ, Poole LB, Lowther WT, Jones PB, Furdui CM, Tsang AW. Discovery of Spilanthol Endoperoxide as a Redox Natural Compound Active against Mammalian Prx3 and Chlamydiatrachomatis Infection. Antioxidants (Basel). 2020 Dec 03; 9(12).Antioxidants (Basel)2020-12-03T00:00:002020Discovery of Spilanthol Endoperoxide as a Redox Natural Compound Active against Mammalian Prx3 and Chlamydiatrachomatis Infection.33513391Schipper S, Wu H, Furdui CM, Poole LB, Delahunty CM, Park R, Yates JR, Becker K, Przyborski JMMolecular and biochemical parasitologySchipper S, Wu H, Furdui CM, Poole LB, Delahunty CM, Park R, Yates JR, Becker K, Przyborski JM. Identification of sulfenylation patterns in trophozoite stage Plasmodium falciparum using a non-dimedone based probe. Mol Biochem Parasitol. 2021 03; 242:111362.Mol Biochem Parasitol2021-01-26T00:00:002021Identification of sulfenylation patterns in trophozoite stage Plasmodium falciparum using a non-dimedone based probe.32031597Poole LB, Furdui CM, King SBEssays in biochemistryPoole LB, Furdui CM, King SB. Introduction to approaches and tools for the evaluation of protein cysteine oxidation. Essays Biochem. 2020 02 17; 64(1):1-17.Essays Biochem2020-02-17T00:00:002020Introduction to approaches and tools for the evaluation of protein cysteine oxidation.33600943Collins JA, Kapustina M, Bolduc JA, Pike JFW, Diekman BO, Mix K, Chubinskaya S, Eroglu E, Michel T, Poole LB, Furdui CM, Loeser RFFree radical biology & medicineCollins JA, Kapustina M, Bolduc JA, Pike JFW, Diekman BO, Mix K, Chubinskaya S, Eroglu E, Michel T, Poole LB, Furdui CM, Loeser RF. Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes. Free Radic Biol Med. 2021 Apr; 166:90-103.Free Radic Biol Med2021-02-16T00:00:002021Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes.32399061Poole LB, Parsonage D, Sergeant S, Miller LR, Lee J, Furdui CM, Chilton FHBiotechnology for biofuelsPoole LB, Parsonage D, Sergeant S, Miller LR, Lee J, Furdui CM, Chilton FH. Acyl-lipid desaturases and Vipp1 cooperate in cyanobacteria to produce novel omega-3 PUFA-containing glycolipids. Biotechnol Biofuels. 2020; 13:83.Biotechnol Biofuels2020-05-06T00:00:002020Acyl-lipid desaturases and Vipp1 cooperate in cyanobacteria to produce novel omega-3 PUFA-containing glycolipids.Authorship 106664Authorship 107484Authorship 108178Center for Redox Biology & Medicine (CRBM)Internal Medicine, Molecular MedicineUrologyAuthorship 110462Authorship 11093134952463Solingapuram Sai KK, Chen X, Li Z, Zhu C, Shukla K, Forshaw TE, Wu H, Vance SA, Pathirannahel BL, Madonna M, Dewhirst MW, Tsang AW, Poole LB, Ramanujam N, King SB, Furdui CMRedox biologySolingapuram Sai KK, Chen X, Li Z, Zhu C, Shukla K, Forshaw TE, Wu H, Vance SA, Pathirannahel BL, Madonna M, Dewhirst MW, Tsang AW, Poole LB, Ramanujam N, King SB, Furdui CM. [18F]Fluoro-DCP, a first generation PET radiotracer for monitoring protein sulfenylation in vivo. Redox Biol. 2021 Dec 18; 49:102218.Redox Biol2021-12-18T00:00:002021[18F]Fluoro-DCP, a first generation PET radiotracer for monitoring protein sulfenylation in vivo.http://www.wfirm.orgWFIRMAuthorship 36077624013634Taneja NK, Ganguly T, Bakaletz LO, Nelson KJ, Dubey P, Poole LB, Deora RJournal of bacteriologyTaneja NK, Ganguly T, Bakaletz LO, Nelson KJ, Dubey P, Poole LB, Deora R. D-alanine modification of a protease-susceptible outer membrane component by the Bordetella pertussis dra locus promotes resistance to antimicrobial peptides and polymorphonuclear leukocyte-mediated killing. J Bacteriol. 2013 Nov; 195(22):5102-11.J Bacteriol2013-09-06T00:00:002013D-alanine modification of a protease-susceptible outer membrane component by the Bordetella pertussis dra locus promotes resistance to antimicrobial peptides and polymorphonuclear leukocyte-mediated killing.Authorship 130834Authorship 7351710Authorship 735189Authorship 735194Authorship 735205Authorship 7352115Authorship 7352213Authorship 73523435753348Huynh MV, Parsonage D, Forshaw TE, Chirasani VR, Hobbs GA, Wu H, Lee J, Furdui CM, Poole LB, Campbell SLThe Journal of biological chemistryHuynh MV, Parsonage D, Forshaw TE, Chirasani VR, Hobbs GA, Wu H, Lee J, Furdui CM, Poole LB, Campbell SL. Oncogenic KRAS G12C: Kinetic and redox characterization of covalent inhibition. J Biol Chem. 2022 Aug; 298(8):102186.J Biol Chem2022-06-24T00:00:002022Oncogenic KRAS G12C: Kinetic and redox characterization of covalent inhibition.35696080Al-Barakati H, Newman RH, Kc DB, Poole LBMethods in molecular biology (Clifton, N.J.)Al-Barakati H, Newman RH, Kc DB, Poole LB. Bioinformatic Analyses of Peroxiredoxins and RF-Prx: A Random Forest-Based Predictor and Classifier for Prxs. Methods Mol Biol. 2022; 2499:155-176.Methods Mol Biol2022-01-01T00:00:002022Bioinformatic Analyses of Peroxiredoxins and RF-Prx: A Random Forest-Based Predictor and Classifier for Prxs.35609400Hu Q, Yammani RD, Brown-Harding H, Soto-Pantoja DR, Poole LB, Lukesh JCRedox biologyHu Q, Yammani RD, Brown-Harding H, Soto-Pantoja DR, Poole LB, Lukesh JC. Mitigation of doxorubicin-induced cardiotoxicity with an H2O2-Activated, H2S-Donating hybrid prodrug. Redox Biol. 2022 07; 53:102338.Redox Biol2022-05-16T00:00:002022Mitigation of doxorubicin-induced cardiotoxicity with an H2O2-Activated, H2S-Donating hybrid prodrug.35027734Das A, Ash D, Fouda AY, Sudhahar V, Kim YM, Hou Y, Hudson FZ, Stansfield BK, Caldwell RB, McMenamin M, Littlejohn R, Su H, Regan MR, Merrill BJ, Poole LB, Kaplan JH, Fukai T, Ushio-Fukai MNature cell biologyDas A, Ash D, Fouda AY, Sudhahar V, Kim YM, Hou Y, Hudson FZ, Stansfield BK, Caldwell RB, McMenamin M, Littlejohn R, Su H, Regan MR, Merrill BJ, Poole LB, Kaplan JH, Fukai T, Ushio-Fukai M. Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis. Nat Cell Biol. 2022 01; 24(1):35-50.Nat Cell Biol2022-01-13T00:00:002022Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis.34678159Estelle AB, Reardon PN, Pinckney SH, Poole LB, Barbar E, Karplus PAStructure (London, England : 1993)Estelle AB, Reardon PN, Pinckney SH, Poole LB, Barbar E, Karplus PA. Native state fluctuations in a peroxiredoxin active site match motions needed for catalysis. Structure. 2022 02 03; 30(2):278-288.e3.Structure2021-10-21T00:00:002021Native state fluctuations in a peroxiredoxin active site match motions needed for catalysis.35858297Coelho DR, Palma FR, Paviani V, He C, Danes JM, Huang Y, Calado JCP, Hart PC, Furdui CM, Poole LB, Schipma MJ, Bonini MGProceedings of the National Academy of Sciences of the United States of AmericaCoelho DR, Palma FR, Paviani V, He C, Danes JM, Huang Y, Calado JCP, Hart PC, Furdui CM, Poole LB, Schipma MJ, Bonini MG. Nuclear-localized, iron-bound superoxide dismutase-2 antagonizes epithelial lineage programs to promote stemness of breast cancer cells via a histone demethylase activity. Proc Natl Acad Sci U S A. 2022 07 19; 119(29):e2110348119.Proc Natl Acad Sci U S A2022-07-14T00:00:002022Nuclear-localized, iron-bound superoxide dismutase-2 antagonizes epithelial lineage programs to promote stemness of breast cancer cells via a histone demethylase activity.Authorship 1366314Authorship 137093Authorship 139471JingyunLeeJingyun Lee PhD3545Lee, JingyunAssistant Professorhttps://wfbmc.ilabsolutions.com/service_center/3917Proteomics and Metabolomics Shared Resource (PMSR)Authorship 144126Authorship 1554Authorship 155514Authorship 157822Authorship 36274424103186Reisz JA, Bechtold E, King SB, Poole LB, Furdui CMThe FEBS journalReisz JA, Bechtold E, King SB, Poole LB, Furdui CM. Thiol-blocking electrophiles interfere with labeling and detection of protein sulfenic acids. FEBS J. 2013 Dec; 280(23):6150-61.FEBS J2013-10-16T00:00:002013Thiol-blocking electrophiles interfere with labeling and detection of protein sulfenic acids.Authorship 16074Authorship 167717Authorship 36341524175952Perkins A, Nelson KJ, Williams JR, Parsonage D, Poole LB, Karplus PABiochemistryPerkins A, Nelson KJ, Williams JR, Parsonage D, Poole LB, Karplus PA. The sensitive balance between the fully folded and locally unfolded conformations of a model peroxiredoxin. Biochemistry. 2013 Dec 03; 52(48):8708-21.Biochemistry2013-11-20T00:00:002013The sensitive balance between the fully folded and locally unfolded conformations of a model peroxiredoxin.true1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1InstructorInstructortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessor2Co-DirectorCo-Directortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessorAuthorship 185541Authorship 188224Authorship 19105Authorship 194546Authorship 203247Authorship 205183Authorship 205303Authorship 216306Authorship 2181210Authorship 225813Authorship 226412Authorship 227862Authorship 237405Authorship 237934Authorship 238953Authorship 244144Authorship 248946Authorship 252191Authorship 254432Authorship 259699Authorship 260805Authorship 263616Authorship 264213Authorship 269262Authorship 272118Authorship 273742Authorship 277903Authorship 279224Authorship 283415Authorship 284271Authorship 286278Authorship 302843Authorship 305768Authorship 307458Authorship 310373Authorship 31051Authorship 339751Authorship 340331Authorship 36314Authorship 3972Authorship 55323Authorship 59973Authorship 63723Authorship 7664Authorship 7851Authorship 83188Authorship 83595Authorship 85004Authorship 89803Authorship 94165Authorship 96472Authorship 9732111885266Poole LB, Ellis HRMethods in enzymologyPoole LB, Ellis HR. Identification of cysteine sulfenic acid in AhpC of alkyl hydroperoxide reductase. Methods Enzymol. 2002; 348:122-36.Methods Enzymol2002-01-01T00:00:002002Identification of cysteine sulfenic acid in AhpC of alkyl hydroperoxide reductase.12119021Conway ME, Yennawar N, Wallin R, Poole LB, Hutson SMBiochemistryConway ME, Yennawar N, Wallin R, Poole LB, Hutson SM. Identification of a peroxide-sensitive redox switch at the CXXC motif in the human mitochondrial branched chain aminotransferase. Biochemistry. 2002 Jul 23; 41(29):9070-8.Biochemistry2002-07-23T00:00:002002Identification of a peroxide-sensitive redox switch at the CXXC motif in the human mitochondrial branched chain aminotransferase.12686109Conway ME, Yennawar N, Wallin R, Poole LB, Hutson SMBiochimica et biophysica actaConway ME, Yennawar N, Wallin R, Poole LB, Hutson SM. Human mitochondrial branched chain aminotransferase: structural basis for substrate specificity and role of redox active cysteines. Biochim Biophys Acta. 2003 Apr 11; 1647(1-2):61-5.Biochim Biophys Acta2003-04-11T00:00:002003Human mitochondrial branched chain aminotransferase: structural basis for substrate specificity and role of redox active cysteines.12714747Wood ZA, Poole LB, Karplus PAScience (New York, N.Y.)Wood ZA, Poole LB, Karplus PA. Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling. Science. 2003 Apr 25; 300(5619):650-3.Science2003-04-25T00:00:002003Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling.14744249Poole LB, Karplus PA, Claiborne AAnnual review of pharmacology and toxicologyPoole LB, Karplus PA, Claiborne A. Protein sulfenic acids in redox signaling. Annu Rev Pharmacol Toxicol. 2004; 44:325-47.Annu Rev Pharmacol Toxicol2004-01-01T00:00:002004Protein sulfenic acids in redox signaling.16060667Parsonage D, Youngblood DS, Sarma GN, Wood ZA, Karplus PA, Poole LBBiochemistryParsonage D, Youngblood DS, Sarma GN, Wood ZA, Karplus PA, Poole LB. Analysis of the link between enzymatic activity and oligomeric state in AhpC, a bacterial peroxiredoxin. Biochemistry. 2005 Aug 09; 44(31):10583-92.Biochemistry2005-08-09T00:00:002005Analysis of the link between enzymatic activity and oligomeric state in AhpC, a bacterial peroxiredoxin.16287263Poole LB, Zeng BB, Knaggs SA, Yakubu M, King SBBioconjugate chemistryPoole LB, Zeng BB, Knaggs SA, Yakubu M, King SB. Synthesis of chemical probes to map sulfenic acid modifications on proteins. Bioconjug Chem. 2005 Nov-Dec; 16(6):1624-8.Bioconjug Chem2005-11-01T00:00:002005Synthesis of chemical probes to map sulfenic acid modifications on proteins.18162165Nelson KJ, Day AE, Zeng BB, King SB, Poole LBAnalytical biochemistryNelson KJ, Day AE, Zeng BB, King SB, Poole LB. Isotope-coded, iodoacetamide-based reagent to determine individual cysteine pK(a) values by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal Biochem. 2008 Apr 15; 375(2):187-95.Anal Biochem2007-12-08T00:00:002007Isotope-coded, iodoacetamide-based reagent to determine individual cysteine pK(a) values by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.18282483Poole LB, Nelson KJCurrent opinion in chemical biologyPoole LB, Nelson KJ. Discovering mechanisms of signaling-mediated cysteine oxidation. Curr Opin Chem Biol. 2008 Feb; 12(1):18-24.Curr Opin Chem Biol2008-03-07T00:00:002008Discovering mechanisms of signaling-mediated cysteine oxidation.18718523Smith-Pearson PS, Kooshki M, Spitz DR, Poole LB, Zhao W, Robbins MEFree radical biology & medicineSmith-Pearson PS, Kooshki M, Spitz DR, Poole LB, Zhao W, Robbins ME. Decreasing peroxiredoxin II expression decreases glutathione, alters cell cycle distribution, and sensitizes glioma cells to ionizing radiation and H(2)O(2). Free Radic Biol Med. 2008 Oct 15; 45(8):1178-89.Free Radic Biol Med2008-07-27T00:00:002008Decreasing peroxiredoxin II expression decreases glutathione, alters cell cycle distribution, and sensitizes glioma cells to ionizing radiation and H(2)O(2).20476795Yuan Y, Knaggs M, Poole L, Fetrow J, Salsbury FJournal of biomolecular structure & dynamicsYuan Y, Knaggs M, Poole L, Fetrow J, Salsbury F. Conformational and oligomeric effects on the cysteine pK(a) of tryparedoxin peroxidase. J Biomol Struct Dyn. 2010 Aug; 28(1):51-70.J Biomol Struct Dyn2010-08-01T00:00:002010Conformational and oligomeric effects on the cysteine pK(a) of tryparedoxin peroxidase.20513472Klomsiri C, Nelson KJ, Bechtold E, Soito L, Johnson LC, Lowther WT, Ryu SE, King SB, Furdui CM, Poole LBMethods in enzymologyKlomsiri C, Nelson KJ, Bechtold E, Soito L, Johnson LC, Lowther WT, Ryu SE, King SB, Furdui CM, Poole LB. Use of dimedone-based chemical probes for sulfenic acid detection evaluation of conditions affecting probe incorporation into redox-sensitive proteins. Methods Enzymol. 2010; 473:77-94.Methods Enzymol2010-01-01T00:00:002010Use of dimedone-based chemical probes for sulfenic acid detection evaluation of conditions affecting probe incorporation into redox-sensitive proteins.20513473Nelson KJ, Klomsiri C, Codreanu SG, Soito L, Liebler DC, Rogers LC, Daniel LW, Poole LBMethods in enzymologyNelson KJ, Klomsiri C, Codreanu SG, Soito L, Liebler DC, Rogers LC, Daniel LW, Poole LB. Use of dimedone-based chemical probes for sulfenic acid detection methods to visualize and identify labeled proteins. Methods Enzymol. 2010; 473:95-115.Methods Enzymol2010-01-01T00:00:002010Use of dimedone-based chemical probes for sulfenic acid detection methods to visualize and identify labeled proteins.20643143Hall A, Parsonage D, Poole LB, Karplus PAJournal of molecular biologyHall A, Parsonage D, Poole LB, Karplus PA. Structural evidence that peroxiredoxin catalytic power is based on transition-state stabilization. J Mol Biol. 2010 Sep 10; 402(1):194-209.J Mol Biol2010-07-17T00:00:002010Structural evidence that peroxiredoxin catalytic power is based on transition-state stabilization.20799881Klomsiri C, Karplus PA, Poole LBAntioxidants & redox signalingKlomsiri C, Karplus PA, Poole LB. Cysteine-based redox switches in enzymes. Antioxid Redox Signal. 2011 Mar 15; 14(6):1065-77.Antioxid Redox Signal2010-09-17T00:00:002010Cysteine-based redox switches in enzymes.20934509Saunders JA, Rogers LC, Klomsiri C, Poole LB, Daniel LWFree radical biology & medicineSaunders JA, Rogers LC, Klomsiri C, Poole LB, Daniel LW. Reactive oxygen species mediate lysophosphatidic acid induced signaling in ovarian cancer cells. Free Radic Biol Med. 2010 Dec 15; 49(12):2058-67.Free Radic Biol Med2010-10-08T00:00:002010Reactive oxygen species mediate lysophosphatidic acid induced signaling in ovarian cancer cells.20963761Poole LBCurrent protocols in toxicologyPoole LB. Formation and functions of protein sulfenic acids. Curr Protoc Toxicol. 2004 Feb; Chapter 17:Unit17.1.Curr Protoc Toxicol2004-02-01T00:00:002004Formation and functions of protein sulfenic acids.20969484Hall A, Nelson K, Poole LB, Karplus PAAntioxidants & redox signalingHall A, Nelson K, Poole LB, Karplus PA. Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins. Antioxid Redox Signal. 2011 Aug 01; 15(3):795-815.Antioxid Redox Signal2011-04-20T00:00:002011Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins.21287625Nelson KJ, Knutson ST, Soito L, Klomsiri C, Poole LB, Fetrow JSProteinsNelson KJ, Knutson ST, Soito L, Klomsiri C, Poole LB, Fetrow JS. Analysis of the peroxiredoxin family: using active-site structure and sequence information for global classification and residue analysis. Proteins. 2011 Mar; 79(3):947-64.Proteins2010-12-22T00:00:002010Analysis of the peroxiredoxin family: using active-site structure and sequence information for global classification and residue analysis.21516234Nirudodhi S, Parsonage D, Karplus PA, Poole LB, Maier CSInternational journal of mass spectrometryNirudodhi S, Parsonage D, Karplus PA, Poole LB, Maier CS. Conformational studies of the robust 2-Cys peroxiredoxin Salmonella typhimurium AhpC by solution phase hydrogen/deuterium (H/D) exchange monitored by electrospray ionization mass spectrometry. Int J Mass Spectrom. 2011 Apr 30; 302(1-3):93-100.Int J Mass Spectrom2011-04-30T00:00:002011Conformational studies of the robust 2-Cys peroxiredoxin Salmonella typhimurium AhpC by solution phase hydrogen/deuterium (H/D) exchange monitored by electrospray ionization mass spectrometry.21615954Clarke TE, Romanov V, Chirgadze YN, Klomsiri C, Kisselman G, Wu-Brown J, Poole LB, Pai EF, Chirgadze NYBMC structural biologyClarke TE, Romanov V, Chirgadze YN, Klomsiri C, Kisselman G, Wu-Brown J, Poole LB, Pai EF, Chirgadze NY. Crystal structure of alkyl hydroperoxidase D like protein PA0269 from Pseudomonas aeruginosa: homology of the AhpD-like structural family. 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Structural and electrostatic asymmetry at the active site in typical and atypical peroxiredoxin dimers. J Phys Chem B. 2012 Jun 14; 116(23):6832-43.J Phys Chem B2012-04-04T00:00:002012Structural and electrostatic asymmetry at the active site in typical and atypical peroxiredoxin dimers.23055551Michalek RD, Crump KE, Weant AE, Hiltbold EM, Juneau DG, Moon EY, Yu DY, Poole LB, Grayson JMJournal of virologyMichalek RD, Crump KE, Weant AE, Hiltbold EM, Juneau DG, Moon EY, Yu DY, Poole LB, Grayson JM. Peroxiredoxin II regulates effector and secondary memory CD8+ T cell responses. J Virol. 2012 Dec; 86(24):13629-41.J Virol2012-10-10T00:00:002012Peroxiredoxin II regulates effector and secondary memory CD8+ T cell responses.11827546Reynolds CM, Meyer J, Poole LBBiochemistryReynolds CM, Meyer J, Poole LB. An NADH-dependent bacterial thioredoxin reductase-like protein in conjunction with a glutaredoxin homologue form a unique peroxiredoxin (AhpC) reducing system in Clostridium pasteurianum. Biochemistry. 2002 Feb 12; 41(6):1990-2001.Biochemistry2002-02-12T00:00:002002An NADH-dependent bacterial thioredoxin reductase-like protein in conjunction with a glutaredoxin homologue form a unique peroxiredoxin (AhpC) reducing system in Clostridium pasteurianum.11969410Wood ZA, Poole LB, Hantgan RR, Karplus PABiochemistryWood ZA, Poole LB, Hantgan RR, Karplus PA. Dimers to doughnuts: redox-sensitive oligomerization of 2-cysteine peroxiredoxins. Biochemistry. 2002 Apr 30; 41(17):5493-504.Biochemistry2002-04-30T00:00:002002Dimers to doughnuts: redox-sensitive oligomerization of 2-cysteine peroxiredoxins.12003933Yamamoto Y, Poole LB, Hantgan RR, Kamio YJournal of bacteriologyYamamoto Y, Poole LB, Hantgan RR, Kamio Y. An iron-binding protein, Dpr, from Streptococcus mutans prevents iron-dependent hydroxyl radical formation in vitro. J Bacteriol. 2002 Jun; 184(11):2931-9.J Bacteriol2002-06-01T00:00:002002An iron-binding protein, Dpr, from Streptococcus mutans prevents iron-dependent hydroxyl radical formation in vitro.12514184Baker LM, Poole LBThe Journal of biological chemistryBaker LM, Poole LB. Catalytic mechanism of thiol peroxidase from Escherichia coli. Sulfenic acid formation and overoxidation of essential CYS61. J Biol Chem. 2003 Mar 14; 278(11):9203-11.J Biol Chem2003-01-03T00:00:002003Catalytic mechanism of thiol peroxidase from Escherichia coli. Sulfenic acid formation and overoxidation of essential CYS61.12517450Wood ZA, Schröder E, Robin Harris J, Poole LBTrends in biochemical sciencesWood ZA, Schröder E, Robin Harris J, Poole LB. Structure, mechanism and regulation of peroxiredoxins. Trends Biochem Sci. 2003 Jan; 28(1):32-40.Trends Biochem Sci2003-01-01T00:00:002003Structure, mechanism and regulation of peroxiredoxins.12576076Schröder E, Jönsson T, Poole LAnalytical biochemistrySchröder E, Jönsson T, Poole L. Hydroxyapatite chromatography: altering the phosphate-dependent elution profile of protein as a function of pH. Anal Biochem. 2003 Feb 01; 313(1):176-8.Anal Biochem2003-02-01T00:00:002003Hydroxyapatite chromatography: altering the phosphate-dependent elution profile of protein as a function of pH.15182179Conway ME, Poole LB, Hutson SMBiochemistryConway ME, Poole LB, Hutson SM. Roles for cysteine residues in the regulatory CXXC motif of human mitochondrial branched chain aminotransferase enzyme. Biochemistry. 2004 Jun 15; 43(23):7356-64.Biochemistry2004-06-15T00:00:002004Roles for cysteine residues in the regulatory CXXC motif of human mitochondrial branched chain aminotransferase enzyme.15581580Poole LBArchives of biochemistry and biophysicsPoole LB. Bacterial defenses against oxidants: mechanistic features of cysteine-based peroxidases and their flavoprotein reductases. Arch Biochem Biophys. 2005 Jan 01; 433(1):240-54.Arch Biochem Biophys2005-01-01T00:00:002005Bacterial defenses against oxidants: mechanistic features of cysteine-based peroxidases and their flavoprotein reductases.15952770Jönsson TJ, Murray MS, Johnson LC, Poole LB, Lowther WTBiochemistryJönsson TJ, Murray MS, Johnson LC, Poole LB, Lowther WT. Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin. Biochemistry. 2005 Jun 21; 44(24):8634-42.Biochemistry2005-06-21T00:00:002005Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin.16131664Roberts BR, Wood ZA, Jönsson TJ, Poole LB, Karplus PAProtein science : a publication of the Protein SocietyRoberts BR, Wood ZA, Jönsson TJ, Poole LB, Karplus PA. Oxidized and synchrotron cleaved structures of the disulfide redox center in the N-terminal domain of Salmonella typhimurium AhpF. Protein Sci. 2005 Sep; 14(9):2414-20.Protein Sci2005-09-01T00:00:002005Oxidized and synchrotron cleaved structures of the disulfide redox center in the N-terminal domain of Salmonella typhimurium AhpF.16452421Panmanee W, Vattanaviboon P, Poole LB, Mongkolsuk SJournal of bacteriologyPanmanee W, Vattanaviboon P, Poole LB, Mongkolsuk S. Novel organic hydroperoxide-sensing and responding mechanisms for OhrR, a major bacterial sensor and regulator of organic hydroperoxide stress. J Bacteriol. 2006 Feb; 188(4):1389-95.J Bacteriol2006-02-01T00:00:002006Novel organic hydroperoxide-sensing and responding mechanisms for OhrR, a major bacterial sensor and regulator of organic hydroperoxide stress.17145963Phalen TJ, Weirather K, Deming PB, Anathy V, Howe AK, van der Vliet A, Jönsson TJ, Poole LB, Heintz NHThe Journal of cell biologyPhalen TJ, Weirather K, Deming PB, Anathy V, Howe AK, van der Vliet A, Jönsson TJ, Poole LB, Heintz NH. Oxidation state governs structural transitions in peroxiredoxin II that correlate with cell cycle arrest and recovery. J Cell Biol. 2006 Dec 04; 175(5):779-89.J Cell Biol2006-12-04T00:00:002006Oxidation state governs structural transitions in peroxiredoxin II that correlate with cell cycle arrest and recovery.17441733Jönsson TJ, Ellis HR, Poole LBBiochemistryJönsson TJ, Ellis HR, Poole LB. Cysteine reactivity and thiol-disulfide interchange pathways in AhpF and AhpC of the bacterial alkyl hydroperoxide reductase system. 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