D005468Chemicals & DrugsD03.383.742.686.850.210.200D13.695.201.200.270D13.695.740.850.210.2004220.969868Fluorodeoxyuridylateprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:meshTreeNumberMeSH tree numberprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierDepartmentvivo:hrJobTitleHR job titleInformation ResourcePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlevivo:researchAreaOfresearch area ofvivo:subjectAreaForsubject area forrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson4.630840.1419564research area of0.6926630.17989916subject area forAnesthesiologyCancer BiologyWake Forest School of MedicineTimothyPardeeTimothy S. Pardee MD, PhD36.08959100000000-80.268599000000001000Pardee, TimothyAssistant ProfessorDavidCaudellDavid L. Caudell DVM, PhD36.08943500000000-80.268632000000001400Caudell, DavidAssociate ProfessorWaldemarDebinskiWaldemar Debinski MD, PhD36.08959100000000-80.26859900000000201Debinski, WaldemarProfessorWilliamGmeinerWilliam H. Gmeiner PhD36.09032400000000-80.2664910000000080Gmeiner, WilliamProfessor25408502Gmeiner WH, Boyacioglu O, Stuart CH, Jennings-Gee J, Balaji KCThe ProstateGmeiner WH, Boyacioglu O, Stuart CH, Jennings-Gee J, Balaji KC. The cytotoxic and pro-apoptotic activities of the novel fluoropyrimidine F10 towards prostate cancer cells are enhanced by Zn(2+) -chelation and inhibiting the serine protease Omi/HtrA2. Prostate. 2015 Mar 01; 75(4):360-9.Prostate2014-11-18T00:00:002014The cytotoxic and pro-apoptotic activities of the novel fluoropyrimidine F10 towards prostate cancer cells are enhanced by Zn(2+) -chelation and inhibiting the serine protease Omi/HtrA2.27279153Gmeiner WH, Debinski W, Milligan C, Caudell D, Pardee TSFuture oncology (London, England)Gmeiner WH, Debinski W, Milligan C, Caudell D, Pardee TS. The applications of the novel polymeric fluoropyrimidine F10 in cancer treatment: current evidence. Future Oncol. 2016 Sep; 12(17):2009-20.Future Oncol2016-06-09T00:00:002016The applications of the novel polymeric fluoropyrimidine F10 in cancer treatment: current evidence.27606431Melvin RL, Gmeiner WH, Salsbury FRThe journal of physical chemistry. BMelvin RL, Gmeiner WH, Salsbury FR. All-Atom Molecular Dynamics Reveals Mechanism of Zinc Complexation with Therapeutic F10. J Phys Chem B. 2016 10 06; 120(39):10269-10279.J Phys Chem B2016-09-21T00:00:002016All-Atom Molecular Dynamics Reveals Mechanism of Zinc Complexation with Therapeutic F10.28745046Melvin RL, Gmeiner WH, Salsbury FRThe journal of physical chemistry. BMelvin RL, Gmeiner WH, Salsbury FR. All-Atom MD Predicts Magnesium-Induced Hairpin in Chemically Perturbed RNA Analog of F10 Therapeutic. J Phys Chem B. 2017 08 24; 121(33):7803-7812.J Phys Chem B2017-08-10T00:00:002017All-Atom MD Predicts Magnesium-Induced Hairpin in Chemically Perturbed RNA Analog of F10 Therapeutic.30439567Mani C, Pai S, Papke CM, Palle K, Gmeiner WHNeoplasia (New York, N.Y.)Mani C, Pai S, Papke CM, Palle K, Gmeiner WH. Thymineless Death by the Fluoropyrimidine Polymer F10 Involves Replication Fork Collapse and Is Enhanced by Chk1 Inhibition. Neoplasia. 2018 12; 20(12):1236-1245.Neoplasia2018-11-12T00:00:002018Thymineless Death by the Fluoropyrimidine Polymer F10 Involves Replication Fork Collapse and Is Enhanced by Chk1 Inhibition.Pathology, Comparative Medicinetrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professor