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Yong Lu

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentMicrobiology_Immunology
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    Collapse Research 
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    K99CA190910     (LU, YONG)Feb 10, 2015 - Jan 31, 2017
    NIH/NCI
    Th9 cells as a promising effector T-cell subset for cancer therapy
    Role: Principal Investigator

    R00CA190910     (LU, YONG)Sep 15, 2017 - Aug 31, 2020
    NIH/NCI
    Th9 cells as a promising effector T-cell subset for cancer therapy
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Song Q, Hawkins GA, Wudel L, Chou PC, Forbes E, Pullikuth AK, Liu L, Jin G, Craddock L, Topaloglu U, Kucera G, O'Neill S, Levine EA, Sun P, Watabe K, Lu Y, Alexander-Miller MA, Pasche B, Miller LD, Zhang W. Dissecting intratumoral myeloid cell plasticity by single cell RNA-seq. Cancer Med. 2019 Jun; 8(6):3072-3085. PMID: 31033233.
      View in: PubMed
    2. Xue G, Jin G, Fang J, Lu Y. IL-4 together with IL-1ß induces antitumor Th9 cell differentiation in the absence of TGF-ß signaling. Nat Commun. 2019 03 26; 10(1):1376. PMID: 30914642.
      View in: PubMed
    3. Huang Q, Xi J, Wang L, Wang X, Ma X, Deng Q, Lu Y, Kumar M, Zhou Z, Li L, Zeng Z, Young KH, Yi Q, Zhang M, Li Y. Correction to: miR-153 suppresses IDO1 expression and enhances CAR T cell immunotherapy. J Hematol Oncol. 2018 Jul 03; 11(1):90. PMID: 29970126.
      View in: PubMed
    4. Lu Y, Wang Q, Xue G, Bi E, Ma X, Wang A, Qian J, Dong C, Yi Q. Th9 Cells Represent a Unique Subset of CD4+ T Cells Endowed with the Ability to Eradicate Advanced Tumors. Cancer Cell. 2018 06 11; 33(6):1048-1060.e7. PMID: 29894691.
      View in: PubMed
    5. Ma X, Bi E, Huang C, Lu Y, Xue G, Guo X, Wang A, Yang M, Qian J, Dong C, Yi Q. Cholesterol negatively regulates IL-9-producing CD8+ T cell differentiation and antitumor activity. J Exp Med. 2018 06 04; 215(6):1555-1569. PMID: 29743292.
      View in: PubMed
    6. Huang Q, Xia J, Wang L, Wang X, Ma X, Deng Q, Lu Y, Kumar M, Zhou Z, Li L, Zeng Z, Young KH, Yi Q, Zhang M, Li Y. miR-153 suppresses IDO1 expression and enhances CAR T cell immunotherapy. J Hematol Oncol. 2018 04 23; 11(1):58. PMID: 29685162.
      View in: PubMed
    7. Bi E, Ma X, Lu Y, Yang M, Wang Q, Xue G, Qian J, Wang S, Yi Q. Foxo1 and Foxp1 play opposing roles in regulating the differentiation and antitumor activity of TH9 cells programmed by IL-7. Sci Signal. 2017 Oct 10; 10(500). PMID: 29018172.
      View in: PubMed
    8. Wang Q, Lu Y, Li R, Jiang Y, Zheng Y, Qian J, Bi E, Zheng C, Hou J, Wang S, Yi Q. Therapeutic effects of CSF1R-blocking antibodies in multiple myeloma. Leukemia. 2018 01; 32(1):176-183. PMID: 28626216.
      View in: PubMed
    9. Chen J, Zhao Y, Chu X, Lu Y, Wang S, Yi Q. Dectin-1-activated dendritic cells: A potent Th9 cell inducer for tumor immunotherapy. Oncoimmunology. 2016; 5(11):e1238558. PMID: 27999759.
      View in: PubMed
    10. Zhao Y, Chu X, Chen J, Wang Y, Gao S, Jiang Y, Zhu X, Tan G, Zhao W, Yi H, Xu H, Ma X, Lu Y, Yi Q, Wang S. Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells. Nat Commun. 2016 08 05; 7:12368. PMID: 27492902.
      View in: PubMed
    11. Zheng Y, Wang Q, Li T, Qian J, Lu Y, Li Y, Bi E, Reu F, Qin Y, Drazba J, Hsi E, Yang J, Cai Z, Yi Q. Role of Myeloma-Derived MIF in Myeloma Cell Adhesion to Bone Marrow and Chemotherapy Response. J Natl Cancer Inst. 2016 11; 108(11). PMID: 27381622.
      View in: PubMed
    12. Wang L, Heng X, Lu Y, Cai Z, Yi Q, Che F. Could B7-H4 serve as a target to activate anti-cancer immunity? Int Immunopharmacol. 2016 Sep; 38:97-103. PMID: 27258187.
      View in: PubMed
    13. Xiong Q, Feng J, Zhang Y, Sun Y, Lu Y, Li T, Zhang X, Cao R, Jin L, Wu J. Promotion of atherosclerosis in high cholesterol diet-fed rabbits by immunization with the P277 peptide. Immunol Lett. 2016 Feb; 170:80-7. PMID: 26730848.
      View in: PubMed
    14. Li Y, Zheng Y, Li T, Wang Q, Qian J, Lu Y, Zhang M, Bi E, Yang M, Reu F, Yi Q, Cai Z. Chemokines CCL2, 3, 14 stimulate macrophage bone marrow homing, proliferation, and polarization in multiple myeloma. Oncotarget. 2015 Sep 15; 6(27):24218-29. PMID: 26155942.
      View in: PubMed
    15. Zhang M, He J, Liu Z, Lu Y, Zheng Y, Li H, Xu J, Liu H, Qian J, Orlowski RZ, Kwak LW, Yi Q, Yang J. Anti-ß2-microglobulin monoclonal antibodies overcome bortezomib resistance in multiple myeloma by inhibiting autophagy. Oncotarget. 2015 Apr 20; 6(11):8567-78. PMID: 25895124.
      View in: PubMed
    16. Li H, Lu Y, Qian J, Zheng Y, Zhang M, Bi E, He J, Liu Z, Xu J, Gao JY, Yi Q. Human osteoclasts are inducible immunosuppressive cells in response to T cell-derived IFN-? and CD40 ligand in vitro. J Bone Miner Res. 2014 Dec; 29(12):2666-75. PMID: 24916315.
      View in: PubMed
    17. Ma Y, Liu J, Hou J, Dong Y, Lu Y, Jin L, Cao R, Li T, Wu J. Oral administration of recombinant Lactococcus lactis expressing HSP65 and tandemly repeated P277 reduces the incidence of type I diabetes in non-obese diabetic mice. PLoS One. 2014; 9(8):e105701. PMID: 25157497.
      View in: PubMed
    18. Liu Z, Xu J, He J, Zheng Y, Li H, Lu Y, Qian J, Lin P, Weber DM, Yang J, Yi Q. A critical role of autocrine sonic hedgehog signaling in human CD138+ myeloma cell survival and drug resistance. Blood. 2014 Sep 25; 124(13):2061-71. PMID: 25049282.
      View in: PubMed
    19. Lu Y, Zhang M, Wang S, Hong B, Wang Z, Li H, Zheng Y, Yang J, Davis RE, Qian J, Hou J, Yi Q. p38 MAPK-inhibited dendritic cells induce superior antitumour immune responses and overcome regulatory T-cell-mediated immunosuppression. Nat Commun. 2014 Jun 24; 5:4229. PMID: 24957461.
      View in: PubMed
    20. Hong B, Li H, Lu Y, Zhang M, Zheng Y, Qian J, Yi Q. USP18 is crucial for IFN-?-mediated inhibition of B16 melanoma tumorigenesis and antitumor immunity. Mol Cancer. 2014 May 31; 13:132. PMID: 24884733.
      View in: PubMed
    21. Park J, Li H, Zhang M, Lu Y, Hong B, Zheng Y, He J, Yang J, Qian J, Yi Q. Murine Th9 cells promote the survival of myeloid dendritic cells in cancer immunotherapy. Cancer Immunol Immunother. 2014 Aug; 63(8):835-45. PMID: 24841535.
      View in: PubMed
    22. Hong B, Li H, Zhang M, Xu J, Lu Y, Zheng Y, Qian J, Chang JT, Yang J, Yi Q. p38 MAPK inhibits breast cancer metastasis through regulation of stromal expansion. Int J Cancer. 2015 Jan 01; 136(1):34-43. PMID: 24806617.
      View in: PubMed
    23. Lu Y, Wang Q, Yi Q. Anticancer Tc9 cells: Long-lived tumor-killing T cells for adoptive therapy. Oncoimmunology. 2014; 3:e28542. PMID: 25054087.
      View in: PubMed
    24. Zhang M, Qian J, Lan Y, Lu Y, Li H, Hong B, Zheng Y, He J, Yang J, Yi Q. Anti-ß2M monoclonal antibodies kill myeloma cells via cell- and complement-mediated cytotoxicity. Int J Cancer. 2014 Sep 01; 135(5):1132-41. PMID: 24474467.
      View in: PubMed
    25. Lu Y, Hong B, Li H, Zheng Y, Zhang M, Wang S, Qian J, Yi Q. Tumor-specific IL-9-producing CD8+ Tc9 cells are superior effector than type-I cytotoxic Tc1 cells for adoptive immunotherapy of cancers. Proc Natl Acad Sci U S A. 2014 Feb 11; 111(6):2265-70. PMID: 24469818.
      View in: PubMed
    26. Meko'o JL, Xing Y, Zhang H, Lu Y, Wu J, Cao R. Immunopreventive effects against murine H22 hepatocellular carcinoma in vivo by a DNA vaccine targeting a gastrin- releasing peptide. Asian Pac J Cancer Prev. 2014; 15(20):9039-43. PMID: 25374249.
      View in: PubMed
    27. Liu Z, Xu J, Li H, Zheng Y, He J, Liu H, Zhong Y, Lu Y, Hong B, Zhang M, Lin P, Du J, Hou J, Qian J, Kwak LW, Yi Q, Yang J. Bone marrow stromal cells derived MCP-1 reverses the inhibitory effects of multiple myeloma cells on osteoclastogenesis by upregulating the RANK expression. PLoS One. 2013; 8(12):e82453. PMID: 24340030.
      View in: PubMed
    28. Huiyong Z, Yong L, Yunxiao S, Wuling Z, Jingjing L, Taiming L. Generation of a chimeric plasmin-resistant VEGF165/VEGF183 (132-158) protein and its comparative activity. Protein Pept Lett. 2013 Aug; 20(8):947-54. PMID: 23469806.
      View in: PubMed
    29. Xu M, Zhou L, Zhang P, Lu Y, Ge C, Yao W, Xing Y, Xiao W, Dong Y, Wu J, Cao R, Li T. Enhanced antitumor efficacy by combination treatment with a human umbilical vein endothelial cell vaccine and a tumor cell lysate-based vaccine. Tumour Biol. 2013 Oct; 34(5):3173-82. PMID: 23771850.
      View in: PubMed
    30. Wang L, Qian J, Lu Y, Li H, Bao H, He D, Liu Z, Zheng Y, He J, Li Y, Neelapu S, Yang J, Kwak LW, Yi Q, Cai Z. Immune evasion of mantle cell lymphoma: expression of B7-H1 leads to inhibited T-cell response to and killing of tumor cells. Haematologica. 2013 Sep; 98(9):1458-66. PMID: 23508008.
      View in: PubMed
    31. Lu Y, Yi Q. Utilizing TH9 cells as a novel therapeutic strategy for malignancies. Oncoimmunology. 2013 Mar 01; 2(3):e23084. PMID: 23802062.
      View in: PubMed
    32. Hong S, Li H, Qian J, Yang J, Lu Y, Yi Q. Optimizing dendritic cell vaccine for immunotherapy in multiple myeloma: tumour lysates are more potent tumour antigens than idiotype protein to promote anti-tumour immunity. Clin Exp Immunol. 2012 Nov; 170(2):167-77. PMID: 23039887.
      View in: PubMed
    33. Lu Y, Hong S, Li H, Park J, Hong B, Wang L, Zheng Y, Liu Z, Xu J, He J, Yang J, Qian J, Yi Q. Th9 cells promote antitumor immune responses in vivo. J Clin Invest. 2012 Nov; 122(11):4160-71. PMID: 23064366.
      View in: PubMed
    34. He J, Liu Z, Zheng Y, Qian J, Li H, Lu Y, Xu J, Hong B, Zhang M, Lin P, Cai Z, Orlowski RZ, Kwak LW, Yi Q, Yang J. p38 MAPK in myeloma cells regulates osteoclast and osteoblast activity and induces bone destruction. Cancer Res. 2012 Dec 15; 72(24):6393-402. PMID: 23066034.
      View in: PubMed
    35. Zheng Y, Yang J, Qian J, Qiu P, Hanabuchi S, Lu Y, Wang Z, Liu Z, Li H, He J, Lin P, Weber D, Davis RE, Kwak L, Cai Z, Yi Q. PSGL-1/selectin and ICAM-1/CD18 interactions are involved in macrophage-induced drug resistance in myeloma. Leukemia. 2013 Mar; 27(3):702-10. PMID: 22996336.
      View in: PubMed
    36. Wang L, Zhao Y, Qian J, Sun L, Lu Y, Li H, Li Y, Yang J, Cai Z, Yi Q. Toll-like receptor-4 signaling in mantle cell lymphoma: effects on tumor growth and immune evasion. Cancer. 2013 Feb 15; 119(4):782-91. PMID: 22915070.
      View in: PubMed
    37. Yang J, He J, Wang J, Cao Y, Ling J, Qian J, Lu Y, Li H, Zheng Y, Lan Y, Hong S, Matthews J, Starbuck MW, Navone NM, Orlowski RZ, Lin P, Kwak LW, Yi Q. Constitutive activation of p38 MAPK in tumor cells contributes to osteolytic bone lesions in multiple myeloma. Leukemia. 2012 Sep; 26(9):2114-23. PMID: 22425892.
      View in: PubMed
    38. Zheng Y, Yang J, Qian J, Zhang L, Lu Y, Li H, Lin H, Lan Y, Liu Z, He J, Hong S, Thomas S, Shah J, Baladandayuthapani V, Kwak LW, Yi Q. Novel phosphatidylinositol 3-kinase inhibitor NVP-BKM120 induces apoptosis in myeloma cells and shows synergistic anti-myeloma activity with dexamethasone. J Mol Med (Berl). 2012 Jun; 90(6):695-706. PMID: 22207485.
      View in: PubMed
    39. Qian J, Zheng Y, Zheng C, Wang L, Qin H, Hong S, Li H, Lu Y, He J, Yang J, Neelapu S, Kwak LW, Hou J, Yi Q. Active vaccination with Dickkopf-1 induces protective and therapeutic antitumor immunity in murine multiple myeloma. Blood. 2012 Jan 05; 119(1):161-9. PMID: 22049519.
      View in: PubMed
    40. Zhang Y, Xiong Q, Hu X, Sun Y, Tan X, Zhang H, Lu Y, Liu J. A novel atherogenic epitope from Mycobacterium tuberculosis heat shock protein 65 enhances atherosclerosis in rabbit and LDL receptor-deficient mice. Heart Vessels. 2012 Jul; 27(4):411-8. PMID: 22038107.
      View in: PubMed
    41. Ge C, Xing Y, Wang Q, Xiao W, Lu Y, Hu X, Gao Z, Xu M, Ma Y, Cao R, Liu J. Improved efficacy of therapeutic vaccination with dendritic cells pulsed with tumor cell lysate against hepatocellular carcinoma by introduction of 2 tandem repeats of microbial HSP70 peptide epitope 407-426 and OK-432. Int Immunopharmacol. 2011 Dec; 11(12):2200-7. PMID: 22015603.
      View in: PubMed
    42. Hong S, Qian J, Li H, Yang J, Lu Y, Zheng Y, Yi Q. CpG or IFN-a are more potent adjuvants than GM-CSF to promote anti-tumor immunity following idiotype vaccine in multiple myeloma. Cancer Immunol Immunother. 2012 Apr; 61(4):561-71. PMID: 22002243.
      View in: PubMed
    43. Jing H, Yong L, Haiyan L, Yanjun M, Yun X, Yu Z, Taiming L, Rongyue C, Liang J, Jie W, Li Z, Jingjing L. Oral administration of Lactococcus lactis delivered heat shock protein 65 attenuates atherosclerosis in low-density lipoprotein receptor-deficient mice. Vaccine. 2011 May 31; 29(24):4102-9. PMID: 21497632.
      View in: PubMed
    44. Huiyong Z, Yong L, Didier M, Yu Z, Jing F, Rongyue C, Jingjing L. Enhanced inhibition of murine prostatic carcinoma growth by immunization with or administration of viable human umbilical vein endothelial cells and CRM197. Braz J Med Biol Res. 2011 Feb; 44(2):140-8. PMID: 21180889.
      View in: PubMed
    45. Yong L, Yunxiao S, Qiyan X, Yu Z, Jing H, Mekoo DJ, Fan Z, Xiangbing H, Yanjun M, Jingjing L, Taiming L. Immunization with P277 induces vascular leak syndrome in C57BL/6 mice via endothelial damage. Autoimmunity. 2010 Dec; 43(8):654-63. PMID: 20429836.
      View in: PubMed
    46. Liang J, Aihua Z, Yu W, Yong L, Jingjing L. HSP65 serves as an immunogenic carrier for a diabetogenic peptide P277 inducing anti-inflammatory immune response in NOD mice by nasal administration. Vaccine. 2010 Apr 26; 28(19):3312-7. PMID: 20226247.
      View in: PubMed
    47. Yong L, Huiyong Z, Jing H, Huaqian W, Xiangbing H, Yanjun M, Xiaoyu G, Li H, Yanan Y, Rongyue C, Hao F, Jingjing L, Jie W. Vaccination with a potent DNA vaccine targeting B-cell epitopes of hGRP induces prophylactic and therapeutic antitumor activity in vivo. Gene Ther. 2010 Apr; 17(4):459-68. PMID: 20130655.
      View in: PubMed
    48. Xiangbing H, Yankai Z, Ming L, Yong L, Yu Z, Huiyong Z, Yingying C, Jing H, Yun X, Liang J, Rongyue C, Jingjing L. The fusion protein of HSP65 with tandem repeats of beta-hCG acting as a potent tumor vaccine in suppressing hepatocarcinoma. Int Immunopharmacol. 2010 Feb; 10(2):230-8. PMID: 19913113.
      View in: PubMed
    49. Lu Y, Mekoo DJ, Ouyang K, Hu X, Liu Y, Lin M, Jin L, Cao R, Li T, Zhang Y, Fan H, Liu J. Strong humoral response elicited by a DNA vaccine targeting gastrin-releasing peptide with optimized adjuvants inhibits murine prostate carcinoma growth in vivo. Endocr Relat Cancer. 2009 Dec; 16(4):1171-84. PMID: 19648182.
      View in: PubMed
    50. Lu Y, Ouyang K, Fang J, Zhang H, Wu G, Ma Y, Zhang Y, Hu X, Jin L, Cao R, Fan H, Li T, Liu J. Improved efficacy of DNA vaccination against prostate carcinoma by boosting with recombinant protein vaccine and by introduction of a novel adjuvant epitope. Vaccine. 2009 Aug 27; 27(39):5411-8. PMID: 19616501.
      View in: PubMed
    51. Yong L, Huiyong Z, Jing F, Huaqian W, Kejun Y, Yanan Y, Suli L, Xuejun W, Yuhan M, Rongyue C, Hao F, Taiming L, Jingjing L. Study on preparation and unique properties of a novel insulin analogue with N-terminal Arg-4, Pro-3, Lys-2, Pro-1extension at insulin B-chain. Regul Pept. 2009 Oct 09; 157(1-3):92-8. PMID: 19523989.
      View in: PubMed
    52. Fang J, Lu Y, Ouyang K, Wu G, Zhang H, Liu Y, Chen Y, Lin M, Wang H, Jin L, Cao R, Roque RS, Zong L, Liu J, Li T. Specific antibodies elicited by a novel DNA vaccine targeting gastrin-releasing peptide inhibit murine melanoma growth in vivo. Clin Vaccine Immunol. 2009 Jul; 16(7):1033-9. PMID: 19458203.
      View in: PubMed
    53. Wang H, Yang J, Jin L, Feng J, Lu Y, Sun Y, Li T, Cao R, Wu J, Fan H, Liu J. Immunotherapy of autoimmune diabetes by nasal administration of tandem glutamic acid decarboxylase 65 peptides. Immunol Invest. 2009; 38(8):690-703. PMID: 19860582.
      View in: PubMed
    54. Zhu A, Lu Y, Jin L, Wu J, Li T, Liu J. [Improved efficacy of P277 fused to heat shock protein 65 of Mycobacterium tuberculosis against diabetes in nonobese diabetic mice]. Sheng Wu Gong Cheng Xue Bao. 2008 Apr; 24(4):640-5. PMID: 18616176.
      View in: PubMed
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