"Cytochrome P-450 CYP1A2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cytochrome P-450 monooxygenase that can be induced by polycyclic aromatic xenobiotics in the liver of human and several animal species. This enzyme is of significant clinical interest due to the large number of drug interactions associated with its induction and its metabolism of THEOPHYLLINE. Caffeine is considered to be a model substrate for this enzyme. CYP1A2 activity can also be increased by environmental factors such as cigarette smoking, charbroiled meat, cruciferous vegetables, and a number of drugs including phenytoin, phenobarbital, and omeprazole.
| Descriptor ID |
D019388
|
| MeSH Number(s) |
D08.244.453.040.777 D08.811.682.690.708.170.040.443 D12.776.422.220.453.040.555
|
| Concept/Terms |
Cytochrome P-450 CYP1A2- Cytochrome P-450 CYP1A2
- CYP1A2, Cytochrome P-450
- Cytochrome P 450 CYP1A2
- Cytochrome P-450d
- Cytochrome P 450d
- Phenacetin O-Dealkylase
- O-Dealkylase, Phenacetin
- Phenacetin O Dealkylase
- Caffeine Demethylase
- Demethylase, Caffeine
- Cytochrome P-450 LM4
- Cytochrome P450 1A2
- CYP1A2
- CYP 1A2
- Cytochrome P-450 LM(4)
|
Below are MeSH descriptors whose meaning is more general than "Cytochrome P-450 CYP1A2".
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cytochrome P-450 CYP1A2" by people in Profiles.