Overexpression of MN1 confers resistance to chemotherapy, accelerates leukemia onset, and suppresses p53 and Bim induction.

Pardee TS. Overexpression of MN1 confers resistance to chemotherapy, accelerates leukemia onset, and suppresses p53 and Bim induction. PLoS One. 2012; 7(8):e43185.

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subject areas

Animals
Antineoplastic Agents
Apoptosis Regulatory Proteins
Cell Line, Tumor
Cytarabine
Disease Models, Animal
Doxorubicin
Gene Expression Regulation, Leukemic
Histones
Leukemia, Myeloid, Acute
Membrane Proteins
Mice
Mice, Inbred C57BL
Neoplasm Transplantation
Oncogene Proteins
Prognosis
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-mdm2
Trans-Activators
Tumor Suppressor Protein p53
Tumor Suppressor Proteins

authors with profiles

Timothy S. Pardee MD, PhD