SarfarazAhmadSarfaraz Ahmad PhD36.09032400000000-80.266491000000001656Ahmad, SarfarazAssistant Professorprns:coAuthorOfcoauthor ofFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD007703Chemicals & Drugs241890.880176Peptidyl-Dipeptidase AAuthorship 365153Authorship 365163Authorship 365261Authorship 365342Authorship 365472Authorship 365482Authorship 365521Authorship 365791Authorship 365823Authorship 365968Authorship 365992Authorship 366153Authorship 366171Authorship 366252Authorship 366604Authorship 366767Authorship 369911Authorship 370272Authorship 372112Authorship 372562Authorship 389432Authorship 393612Authorship 39596112076509Ahmad S, Kitchin KT, Cullen WRToxicology lettersAhmad S, Kitchin KT, Cullen WR. Plasmid DNA damage caused by methylated arsenicals, ascorbic acid and human liver ferritin. Toxicol Lett. 2002 Jul 07; 133(1):47-57.Toxicol Lett2002-07-07T00:00:002002Plasmid DNA damage caused by methylated arsenicals, ascorbic acid and human liver ferritin.12505428Kitchin KT, Ahmad SToxicology lettersKitchin KT, Ahmad S. Oxidative stress as a possible mode of action for arsenic carcinogenesis. Toxicol Lett. 2003 Jan 31; 137(1-2):3-13.Toxicol Lett2003-01-31T00:00:002003Oxidative stress as a possible mode of action for arsenic carcinogenesis.15908511Zalups RK, Ahmad SThe Journal of pharmacology and experimental therapeuticsZalups RK, Ahmad S. Transport of N-acetylcysteine s-conjugates of methylmercury in Madin-Darby canine kidney cells stably transfected with human isoform of organic anion transporter 1. J Pharmacol Exp Ther. 2005 Sep; 314(3):1158-68.J Pharmacol Exp Ther2005-05-20T00:00:002005Transport of N-acetylcysteine s-conjugates of methylmercury in Madin-Darby canine kidney cells stably transfected with human isoform of organic anion transporter 1.16164645Zalups RK, Ahmad SKidney internationalZalups RK, Ahmad S. Handling of cysteine S-conjugates of methylmercury in MDCK cells expressing human OAT1. Kidney Int. 2005 Oct; 68(4):1684-99.Kidney Int2005-10-01T00:00:002005Handling of cysteine S-conjugates of methylmercury in MDCK cells expressing human OAT1.24329563Ferrario CM, Ahmad S, Nagata S, Simington SW, Varagic J, Kon N, Dell'italia LJClinical science (London, England : 1979)Ferrario CM, Ahmad S, Nagata S, Simington SW, Varagic J, Kon N, Dell'italia LJ. An evolving story of angiotensin-II-forming pathways in rodents and humans. Clin Sci (Lond). 2014 Apr; 126(7):461-9.Clin Sci (Lond)2014-04-01T00:00:002014An evolving story of angiotensin-II-forming pathways in rodents and humans.24510672Varagic J, Ahmad S, Nagata S, Ferrario CMCurrent hypertension reportsVaragic J, Ahmad S, Nagata S, Ferrario CM. ACE2: angiotensin II/angiotensin-(1-7) balance in cardiac and renal injury. Curr Hypertens Rep. 2014 Mar; 16(3):420.Curr Hypertens Rep2014-03-01T00:00:002014ACE2: angiotensin II/angiotensin-(1-7) balance in cardiac and renal injury.24633843Ahmad S, Varagic J, Groban L, Dell'Italia LJ, Nagata S, Kon ND, Ferrario CMCurrent hypertension reportsAhmad S, Varagic J, Groban L, Dell'Italia LJ, Nagata S, Kon ND, Ferrario CM. Angiotensin-(1-12): a chymase-mediated cellular angiotensin II substrate. Curr Hypertens Rep. 2014 May; 16(5):429.Curr Hypertens Rep2014-05-01T00:00:002014Angiotensin-(1-12): a chymase-mediated cellular angiotensin II substrate.AnesthesiologyWake Forest School of MedicineCarlosFerrarioCarlos M. Ferrario MD36.09032400000000-80.26649100000000132Ferrario, CarlosProfessor EmeritusDebraDizDebra I. Diz PhD36.09032400000000-80.26649100000000200Diz, DebraProfessorJamesJordanJames E. Jordan PhD36.09032400000000-80.26649100000000407Jordan, JamesAssociate ProfessorMarkChappellMark C. Chappell PhD36.09032400000000-80.26649100000000616Chappell, MarkProfessorNealKonNeal D. Kon MD36.08959100000000-80.26859900000000718Kon, NealProfessorStevenKridelSteven J. Kridel PhD36.09032400000000-80.26649100000000902Kridel, StevenAssociate ProfessorTonySimmonsTony W. Simmons MD36.09023500000000-80.26924600000000997Simmons, TonyProfessorDavidSoto PantojaDavid Soto Pantoja PhD36.09032400000000-80.266491000000001771Soto Pantoja, DavidAssociate ProfessorAuthorship 46489726082339Nagata S, Varagic J, Kon ND, Wang H, Groban L, Simington SW, Ahmad S, Dell'Italia LJ, VonCannon JL, Deal D, Ferrario CMTherapeutic advances in cardiovascular diseaseNagata S, Varagic J, Kon ND, Wang H, Groban L, Simington SW, Ahmad S, Dell'Italia LJ, VonCannon JL, Deal D, Ferrario CM. Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue. Ther Adv Cardiovasc Dis. 2015 Aug; 9(4):168-80.Ther Adv Cardiovasc Dis2015-06-16T00:00:002015Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue.Authorship 48289526807691Fu L, Wei CC, Powell PC, Bradley WE, Ahmad S, Ferrario CM, Collawn JF, Dell'Italia LJJournal of molecular and cellular cardiologyFu L, Wei CC, Powell PC, Bradley WE, Ahmad S, Ferrario CM, Collawn JF, Dell'Italia LJ. Increased fibroblast chymase production mediates procollagen autophagic digestion in volume overload. J Mol Cell Cardiol. 2016 Mar; 92:1-9.J Mol Cell Cardiol2016-01-22T00:00:002016Increased fibroblast chymase production mediates procollagen autophagic digestion in volume overload.Authorship 48867426873967Ferrario CM, VonCannon J, Jiao Y, Ahmad S, Bader M, Dell'Italia LJ, Groban L, Varagic JAmerican journal of physiology. Heart and circulatory physiologyFerrario CM, VonCannon J, Jiao Y, Ahmad S, Bader M, Dell'Italia LJ, Groban L, Varagic J. Cardiac angiotensin-(1-12) expression and systemic hypertension in rats expressing the human angiotensinogen gene. . 2016 Apr 15; 310(8):H995-1002.2016-02-12T00:00:002016Cardiac angiotensin-(1-12) expression and systemic hypertension in rats expressing the human angiotensinogen gene.Authorship 49421726981683Wang H, da Silva J, Alencar A, Zapata-Sudo G, Lin MR, Sun X, Ahmad S, Ferrario CM, Groban LJournal of cardiovascular pharmacologyWang H, da Silva J, Alencar A, Zapata-Sudo G, Lin MR, Sun X, Ahmad S, Ferrario CM, Groban L. Mast Cell Inhibition Attenuates Cardiac Remodeling and Diastolic Dysfunction in Middle-aged, Ovariectomized Fischer 344 × Brown Norway Rats. J Cardiovasc Pharmacol. 2016 Jul; 68(1):49-57.J Cardiovasc Pharmacol2016-07-01T00:00:002016Mast Cell Inhibition Attenuates Cardiac Remodeling and Diastolic Dysfunction in Middle-aged, Ovariectomized Fischer 344 × Brown Norway Rats.Authorship 49571227233763Ferrario CM, Ahmad S, Varagic J, Cheng CP, Groban L, Wang H, Collawn JF, Dell Italia LJAmerican journal of physiology. Heart and circulatory physiologyFerrario CM, Ahmad S, Varagic J, Cheng CP, Groban L, Wang H, Collawn JF, Dell Italia LJ. Intracrine angiotensin II functions originate from noncanonical pathways in the human heart. . 2016 08 01; 311(2):H404-14.2016-05-27T00:00:002016Intracrine angiotensin II functions originate from noncanonical pathways in the human heart.Authorship 49797127465904Ahmad S, Varagic J, VonCannon JL, Groban L, Collawn JF, Dell'Italia LJ, Ferrario CMBiochemical and biophysical research communicationsAhmad S, Varagic J, VonCannon JL, Groban L, Collawn JF, Dell'Italia LJ, Ferrario CM. Primacy of cardiac chymase over angiotensin converting enzyme as an angiotensin-(1-12) metabolizing enzyme. Biochem Biophys Res Commun. 2016 09 16; 478(2):559-64.Biochem Biophys Res Commun2016-07-25T00:00:002016Primacy of cardiac chymase over angiotensin converting enzyme as an angiotensin-(1-12) metabolizing enzyme.AmitSahaAmit K. Saha PhD, MS36.09003100000000-80.268028000000001893Saha, AmitAssociate ProfessorGaganDeepGagan Deep PhD36.09032400000000-80.266491000000001924Deep, GaganProfessorAuthorship 53203328233239Reyes S, Varagic J, Ahmad S, VonCannon J, Kon ND, Wang H, Groban L, Cheng CP, Dell'Italia LJ, Ferrario CMCurrent hypertension reportsReyes S, Varagic J, Ahmad S, VonCannon J, Kon ND, Wang H, Groban L, Cheng CP, Dell'Italia LJ, Ferrario CM. Novel Cardiac Intracrine Mechanisms Based on Ang-(1-12)/Chymase Axis Require a Revision of Therapeutic Approaches in Human Heart Disease. Curr Hypertens Rep. 2017 Feb; 19(2):16.Curr Hypertens Rep2017-02-01T00:00:002017Novel Cardiac Intracrine Mechanisms Based on Ang-(1-12)/Chymase Axis Require a Revision of Therapeutic Approaches in Human Heart Disease.Authorship 53596428403787Ola MS, Alhomida AS, Ferrario CM, Ahmad SCurrent medicinal chemistryOla MS, Alhomida AS, Ferrario CM, Ahmad S. Role of Tissue Renin-angiotensin System and the Chymase/angiotensin-( 1-12) Axis in the Pathogenesis of Diabetic Retinopathy. Curr Med Chem. 2017; 24(28):3104-3114.Curr Med Chem2017-01-01T00:00:002017Role of Tissue Renin-angiotensin System and the Chymase/angiotensin-( 1-12) Axis in the Pathogenesis of Diabetic Retinopathy.Authorship 55215428748720da Silva JS, Gabriel-Costa D, Wang H, Ahmad S, Sun X, Varagic J, Sudo RT, Ferrario CM, Dell Italia LJ, Sudo GZ, Groban LJournal of the renin-angiotensin-aldosterone system : JRAASda Silva JS, Gabriel-Costa D, Wang H, Ahmad S, Sun X, Varagic J, Sudo RT, Ferrario CM, Dell Italia LJ, Sudo GZ, Groban L. Blunting of cardioprotective actions of estrogen in female rodent heart linked to altered expression of cardiac tissue chymase and ACE2. J Renin Angiotensin Aldosterone Syst. 2017 Jul-Sep; 18(3):1470320317722270.J Renin Angiotensin Aldosterone Syst2017-07-01T00:00:002017Blunting of cardioprotective actions of estrogen in female rodent heart linked to altered expression of cardiac tissue chymase and ACE2.Authorship 55552128888034Ahmad S, Sun X, Lin M, Varagic J, Zapata-Sudo G, Ferrario CM, Groban L, Wang HJournal of cellular physiologyAhmad S, Sun X, Lin M, Varagic J, Zapata-Sudo G, Ferrario CM, Groban L, Wang H. Blunting of estrogen modulation of cardiac cellular chymase/RAS activity and function in SHR. J Cell Physiol. 2018 04; 233(4):3330-3342.J Cell Physiol2017-10-04T00:00:002017Blunting of estrogen modulation of cardiac cellular chymase/RAS activity and function in SHR.23812388Moniwa N, Varagic J, Simington SW, Ahmad S, Nagata S, Voncannon JL, Ferrario CMAmerican journal of physiology. Heart and circulatory physiologyMoniwa N, Varagic J, Simington SW, Ahmad S, Nagata S, Voncannon JL, Ferrario CM. Primacy of angiotensin converting enzyme in angiotensin-(1-12) metabolism. . 2013 Sep 01; 305(5):H644-50.2013-06-28T00:00:002013Primacy of angiotensin converting enzyme in angiotensin-(1-12) metabolism.Authorship 59466529685688Li T, Zhang X, Cheng HJ, Zhang Z, Ahmad S, Varagic J, Li W, Cheng CP, Ferrario CMInternational journal of cardiologyLi T, Zhang X, Cheng HJ, Zhang Z, Ahmad S, Varagic J, Li W, Cheng CP, Ferrario CM. Critical role of the chymase/angiotensin-(1-12) axis in modulating cardiomyocyte contractility. Int J Cardiol. 2018 08 01; 264:137-144.Int J Cardiol2018-04-21T00:00:002018Critical role of the chymase/angiotensin-(1-12) axis in modulating cardiomyocyte contractility.30712071Wang H, Sun X, Ahmad S, Su J, Ferrario CM, Groban LMolecular and cellular biochemistryWang H, Sun X, Ahmad S, Su J, Ferrario CM, Groban L. Estrogen modulates the differential expression of cardiac myocyte chymase isoforms and diastolic function. Mol Cell Biochem. 2019 Jun; 456(1-2):85-93.Mol Cell Biochem2019-02-02T00:00:002019Estrogen modulates the differential expression of cardiac myocyte chymase isoforms and diastolic function.Authorship 637993Authorship 651731Authorship 66679330278800Ahmad S, Ferrario CMExpert opinion on therapeutic patentsAhmad S, Ferrario CM. Chymase inhibitors for the treatment of cardiac diseases: a patent review (2010-2018). Expert Opin Ther Pat. 2018 11; 28(11):755-764.Expert Opin Ther Pat2018-10-10T00:00:002018Chymase inhibitors for the treatment of cardiac diseases: a patent review (2010-2018).31361702da Silva JS, Sun X, Ahmad S, Wang H, Sudo RT, Varagic J, Ferrario CM, Zapata-Sudo G, Groban LJournal of cardiovascular pharmacologyda Silva JS, Sun X, Ahmad S, Wang H, Sudo RT, Varagic J, Ferrario CM, Zapata-Sudo G, Groban L. G-Protein-Coupled Estrogen Receptor Agonist G1 Improves Diastolic Function and Attenuates Cardiac Renin-Angiotensin System Activation in Estrogen-Deficient Hypertensive Rats. J Cardiovasc Pharmacol. 2019 11; 74(5):443-452.J Cardiovasc Pharmacol2019-11-01T00:00:002019G-Protein-Coupled Estrogen Receptor Agonist G1 Improves Diastolic Function and Attenuates Cardiac Renin-Angiotensin System Activation in Estrogen-Deficient Hypertensive Rats.24Assistant Professor22Associate Professor31521437Li T, Zhang Z, Zhang X, Chen Z, Cheng HJ, Ahmad S, Ferrario CM, Cheng CPInternational journal of cardiologyLi T, Zhang Z, Zhang X, Chen Z, Cheng HJ, Ahmad S, Ferrario CM, Cheng CP. Reversal of angiotensin-(1-12)-caused positive modulation on left ventricular contractile performance in heart failure: Assessment by pressure-volume analysis. Int J Cardiol. 2020 02 15; 301:135-141.Int J Cardiol2019-09-06T00:00:002019Reversal of angiotensin-(1-12)-caused positive modulation on left ventricular contractile performance in heart failure: Assessment by pressure-volume analysis.31803758Ferrario CM, VonCannon J, Ahmad S, Wright KN, Roberts DJ, Wang H, Yamashita T, Groban L, Cheng CP, Collawn JF, Dell'Italia LJ, Varagic JFrontiers in cardiovascular medicineFerrario CM, VonCannon J, Ahmad S, Wright KN, Roberts DJ, Wang H, Yamashita T, Groban L, Cheng CP, Collawn JF, Dell'Italia LJ, Varagic J. Activation of the Human Angiotensin-(1-12)-Chymase Pathway in Rats With Human Angiotensinogen Gene Transcripts. Front Cardiovasc Med. 2019; 6:163.Front Cardiovasc Med2019-11-15T00:00:002019Activation of the Human Angiotensin-(1-12)-Chymase Pathway in Rats With Human Angiotensinogen Gene Transcripts.31629566Reyes S, Cheng CP, Roberts DJ, Yamashita T, Ahmad S, VonCannon JL, Wright KN, Dell'Italia LJ, Varagic J, Ferrario CMInternational journal of cardiologyReyes S, Cheng CP, Roberts DJ, Yamashita T, Ahmad S, VonCannon JL, Wright KN, Dell'Italia LJ, Varagic J, Ferrario CM. Angiotensin-(1-12)/chymase axis modulates cardiomyocyte L-type calcium currents in rats expressing human angiotensinogen. Int J Cardiol. 2019 12 15; 297:104-110.Int J Cardiol2019-10-08T00:00:002019Angiotensin-(1-12)/chymase axis modulates cardiomyocyte L-type calcium currents in rats expressing human angiotensinogen.31466718Ahmad S, Wright KN, Sun X, Groban L, Ferrario CMBiochemical and biophysical research communicationsAhmad S, Wright KN, Sun X, Groban L, Ferrario CM. Mast cell peptidases (carboxypeptidase A and chymase)-mediated hydrolysis of human angiotensin-(1-12) substrate. Biochem Biophys Res Commun. 2019 10 22; 518(4):651-656.Biochem Biophys Res Commun2019-08-26T00:00:002019Mast cell peptidases (carboxypeptidase A and chymase)-mediated hydrolysis of human angiotensin-(1-12) substrate.31813348Yamashita T, Ahmad S, Wright KN, Roberts DJ, VonCannon JL, Wang H, Groban L, Dell'Italia LJ, Ferrario CMHypertension (Dallas, Tex. : 1979)Yamashita T, Ahmad S, Wright KN, Roberts DJ, VonCannon JL, Wang H, Groban L, Dell'Italia LJ, Ferrario CM. Noncanonical Mechanisms for Direct Bone Marrow Generating Ang II (Angiotensin II) Predominate in CD68 Positive Myeloid Lineage Cells. Hypertension. 2020 02; 75(2):500-509.Hypertension2019-12-09T00:00:002019Noncanonical Mechanisms for Direct Bone Marrow Generating Ang II (Angiotensin II) Predominate in CD68 Positive Myeloid Lineage Cells.32332868Ferrario CM, Ahmad S, Groban LNature reviews. CardiologyFerrario CM, Ahmad S, Groban L. Mechanisms by which angiotensin-receptor blockers increase ACE2 levels. Nat Rev Cardiol. 2020 06; 17(6):378.Nat Rev Cardiol2020-06-01T00:00:002020Mechanisms by which angiotensin-receptor blockers increase ACE2 levels.32361612Wang H, Varagic J, Nagata S, Kon ND, Ahmad S, VonCannon JL, Wright KN, Sun X, Deal D, Groban L, Ferrario CMThe Journal of surgical researchWang H, Varagic J, Nagata S, Kon ND, Ahmad S, VonCannon JL, Wright KN, Sun X, Deal D, Groban L, Ferrario CM. Differential Expression of the Angiotensin-(1-12)/Chymase Axis in Human Atrial Tissue. J Surg Res. 2020 09; 253:173-184.J Surg Res2020-04-30T00:00:002020Differential Expression of the Angiotensin-(1-12)/Chymase Axis in Human Atrial Tissue.32490094Wang H, Varagic J, Nagata S, Kon ND, Ahmad S, VonCannon JL, Wright KN, Sun X, Deal D, Groban L, Ferrario CMData in briefWang H, Varagic J, Nagata S, Kon ND, Ahmad S, VonCannon JL, Wright KN, Sun X, Deal D, Groban L, Ferrario CM. Atrial angiotensin-(1-12)/chymase expression data in patient of heart diseases. Data Brief. 2020 Aug; 31:105744.Data Brief2020-05-22T00:00:002020Atrial angiotensin-(1-12)/chymase expression data in patient of heart diseases.32852624Groban L, Wang H, Sun X, Ahmad S, Ferrario CMCurrent hypertension reportsGroban L, Wang H, Sun X, Ahmad S, Ferrario CM. Is Sex a Determinant of COVID-19 Infection? Truth or Myth? Curr Hypertens Rep. 2020 08 27; 22(9):62.Curr Hypertens Rep2020-08-27T00:00:002020Is Sex a Determinant of COVID-19 Infection? Truth or Myth?33063823Ferrario CM, Ahmad S, Groban LClinical science (London, England : 1979)Ferrario CM, Ahmad S, Groban L. Twenty years of progress in angiotensin converting enzyme 2 and its link to SARS-CoV-2 disease. Clin Sci (Lond). 2020 10 16; 134(19):2645-2664.Clin Sci (Lond)2020-10-16T00:00:002020Twenty years of progress in angiotensin converting enzyme 2 and its link to SARS-CoV-2 disease.33309638Ferrario CM, Groban L, Wang H, Cheng CP, VonCannon JL, Wright KN, Sun X, Ahmad SMolecular and cellular endocrinologyFerrario CM, Groban L, Wang H, Cheng CP, VonCannon JL, Wright KN, Sun X, Ahmad S. The Angiotensin-(1-12)/Chymase axis as an alternate component of the tissue renin angiotensin system. Mol Cell Endocrinol. 2021 06 01; 529:111119.Mol Cell Endocrinol2020-12-10T00:00:002020The Angiotensin-(1-12)/Chymase axis as an alternate component of the tissue renin angiotensin system.33461312Ferrario CM, Iyer SR, Burnett JC, Ahmad S, Wright KN, VonCannon JL, Saha A, Groban LHypertension (Dallas, Tex. : 1979)Ferrario CM, Iyer SR, Burnett JC, Ahmad S, Wright KN, VonCannon JL, Saha A, Groban L. Angiotensin (1-12) in Humans With Normal Blood Pressure and Primary Hypertension. Hypertension. 2021 Mar 03; 77(3):882-890.Hypertension2021-01-19T00:00:002021Angiotensin (1-12) in Humans With Normal Blood Pressure and Primary Hypertension.33798634Ahmad S, Punzi HA, Wright KN, Groban L, Ferrario CMMolecular and cellular endocrinologyAhmad S, Punzi HA, Wright KN, Groban L, Ferrario CM. Newly developed radioimmunoassay for Human Angiotensin-(1-12) measurements in plasma and urine. Mol Cell Endocrinol. 2021 06 01; 529:111256.Mol Cell Endocrinol2021-03-30T00:00:002021Newly developed radioimmunoassay for Human Angiotensin-(1-12) measurements in plasma and urine.33835151Ferrario CM, Groban L, Wang H, Ahmad SClinical science (London, England : 1979)Ferrario CM, Groban L, Wang H, Ahmad S. Letter to the Editor: Brain renin-angiotensin system and liver-directed siRNA targeted to angiotensinogen. Clin Sci (Lond). 2021 Apr 16; 135(7):907-910.Clin Sci (Lond)2021-04-16T00:00:002021Letter to the Editor: Brain renin-angiotensin system and liver-directed siRNA targeted to angiotensinogen.33915312Sun X, Wang H, Hodge H, Wright KN, Ahmad S, Ferrario CM, Groban LTranslational research : the journal of laboratory and clinical medicineSun X, Wang H, Hodge H, Wright KN, Ahmad S, Ferrario CM, Groban L. Amplifying effect of chronic lisinopril therapy on diastolic function and the angiotensin-(1-7) Axis by the G1 agonist in ovariectomized spontaneously hypertensive rats. Transl Res. 2021 Apr 26.Transl Res2021-04-26T00:00:002021Amplifying effect of chronic lisinopril therapy on diastolic function and the angiotensin-(1-7) Axis by the G1 agonist in ovariectomized spontaneously hypertensive rats.Authorship 705575Authorship 705584Authorship 705591Authorship 705604Authorship 705618Authorship 705622Authorship 705634Authorship 705645Authorship 705655Authorship 705662Authorship 705672Authorship 705683Authorship 705695Authorship 705706Authorship 705711Authorship 705724Authorship 705732Authorship 705742Authorship 705753Authorship 70576223925285Assiri A, Saeed A, Alnimri A, Ahmad S, Saeed E, Jameel SPaediatrics and international child healthAssiri A, Saeed A, Alnimri A, Ahmad S, Saeed E, Jameel S. Five Arab children with glucose-galactose malabsorption. Paediatr Int Child Health. 2013 May; 33(2):108-10.Paediatr Int Child Health2013-05-01T00:00:002013Five Arab children with glucose-galactose malabsorption.16081680Zalups RK, Ahmad SThe Journal of pharmacology and experimental therapeuticsZalups RK, Ahmad S. Handling of the homocysteine S-conjugate of methylmercury by renal epithelial cells: role of organic anion transporter 1 and amino acid transporters. J Pharmacol Exp Ther. 2005 Nov; 315(2):896-904.J Pharmacol Exp Ther2005-08-04T00:00:002005Handling of the homocysteine S-conjugate of methylmercury by renal epithelial cells: role of organic anion transporter 1 and amino acid transporters.15284288Zalups RK, Ahmad SJournal of the American Society of Nephrology : JASNZalups RK, Ahmad S. Homocysteine and the renal epithelial transport and toxicity of inorganic mercury: role of basolateral transporter organic anion transporter 1. J Am Soc Nephrol. 2004 Aug; 15(8):2023-31.J Am Soc Nephrol2004-08-01T00:00:002004Homocysteine and the renal epithelial transport and toxicity of inorganic mercury: role of basolateral transporter organic anion transporter 1.15200431Zalups RK, Aslamkhan AG, Ahmad SKidney internationalZalups RK, Aslamkhan AG, Ahmad S. Human organic anion transporter 1 mediates cellular uptake of cysteine-S conjugates of inorganic mercury. Kidney Int. 2004 Jul; 66(1):251-61.Kidney Int2004-07-01T00:00:002004Human organic anion transporter 1 mediates cellular uptake of cysteine-S conjugates of inorganic mercury.12620369Zalups RK, Ahmad SToxicology and applied pharmacologyZalups RK, Ahmad S. Molecular handling of cadmium in transporting epithelia. Toxicol Appl Pharmacol. 2003 Feb 01; 186(3):163-88.Toxicol Appl Pharmacol2003-02-01T00:00:002003Molecular handling of cadmium in transporting epithelia.Cardiothoracic Surgery Internal Medicine, Cardiovascular MedicineInternal Medicine, Gerontology & Geriatric MedicineInternal Medicine, Infectious DiseasesSurgery, GeneralSurgery, General AdministrationSurgery, Hypertension34933010Ferrario CM, VonCannon JL, Zhang J, Figueroa JP, Wright KN, Groban L, Saha A, Meredith JW, Ahmad SPeptidesFerrario CM, VonCannon JL, Zhang J, Figueroa JP, Wright KN, Groban L, Saha A, Meredith JW, Ahmad S. Immunoneutralization of human angiotensin-(1-12) with a monoclonal antibody in a humanized model of hypertension. Peptides. 2022 Mar; 149:170714.Peptides2021-12-18T00:00:002021Immunoneutralization of human angiotensin-(1-12) with a monoclonal antibody in a humanized model of hypertension.35529089Ferrario CM, Groban L, Wang H, Sun X, VonCannon JL, Wright KN, Ahmad SKidney international supplementsFerrario CM, Groban L, Wang H, Sun X, VonCannon JL, Wright KN, Ahmad S. The renin-angiotensin system biomolecular cascade: a 2022 update of newer insights and concepts. Kidney Int Suppl (2011). 2022 Apr; 12(1):36-47.Kidney Int Suppl (2011)2022-03-18T00:00:002022The renin-angiotensin system biomolecular cascade: a 2022 update of newer insights and concepts.36272015Ferrario CM, Saha A, VonCannon JL, Meredith WJ, Ahmad SCurrent hypertension reportsFerrario CM, Saha A, VonCannon JL, Meredith WJ, Ahmad S. Does the Naked Emperor Parable Apply to Current Perceptions of the Contribution of Renin Angiotensin System Inhibition in Hypertension? Curr Hypertens Rep. 2022 Oct 22.Curr Hypertens Rep2022-10-22T00:00:002022Does the Naked Emperor Parable Apply to Current Perceptions of the Contribution of Renin Angiotensin System Inhibition in Hypertension?24204720Wang H, Jessup JA, Zhao Z, Da Silva J, Lin M, MacNamara LM, Ahmad S, Chappell MC, Ferrario CM, Groban LPloS oneWang H, Jessup JA, Zhao Z, Da Silva J, Lin M, MacNamara LM, Ahmad S, Chappell MC, Ferrario CM, Groban L. Characterization of the cardiac renin angiotensin system in oophorectomized and estrogen-replete mRen2.Lewis rats. PLoS One. 2013; 8(10):e76992.PLoS One2013-10-25T00:00:002013Characterization of the cardiac renin angiotensin system in oophorectomized and estrogen-replete mRen2.Lewis rats.Authorship 745441Authorship 745455Authorship 745467Authorship 74547936944130Ahmad S, Wright KN, VonCannon JL, Ferrario CM, Ola MS, Choudhary M, Malek G, Gustafson JR, Sappington RMJournal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and TherapeuticsAhmad S, Wright KN, VonCannon JL, Ferrario CM, Ola MS, Choudhary M, Malek G, Gustafson JR, Sappington RM. Internalization of Angiotensin-(1-12) in Adult Retinal Pigment Epithelial-19 Cells. J Ocul Pharmacol Ther. 2023 May; 39(4):290-299.J Ocul Pharmacol Ther2023-03-21T00:00:002023Internalization of Angiotensin-(1-12) in Adult Retinal Pigment Epithelial-19 Cells.true1Associate ProfessorAssociate Professortrue1Associate ProfessorAssociate Professortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Professor EmeritusProfessor Emeritustrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessor17509623Kushman ME, Kabler SL, Ahmad S, Doehmer J, Morrow CS, Townsend AJMutation researchKushman ME, Kabler SL, Ahmad S, Doehmer J, Morrow CS, Townsend AJ. Cytotoxicity and mutagenicity of dibenzo[a,l]pyrene and (+/-)-dibenzo[a,l]pyrene-11,12-dihydrodiol in V79MZ cells co-expressing either hCYP1A1 or hCYP1B1 together with human glutathione-S-transferase A1. Mutat Res. 2007 Nov 01; 624(1-2):80-7.Mutat Res2007-04-19T00:00:002007Cytotoxicity and mutagenicity of dibenzo[a,l]pyrene and (+/-)-dibenzo[a,l]pyrene-11,12-dihydrodiol in V79MZ cells co-expressing either hCYP1A1 or hCYP1B1 together with human glutathione-S-transferase A1.19946038Varagic J, Ahmad S, Brosnihan KB, Groban L, Chappell MC, Tallant EA, Gallagher PE, Ferrario CMTherapeutic advances in cardiovascular diseaseVaragic J, Ahmad S, Brosnihan KB, Groban L, Chappell MC, Tallant EA, Gallagher PE, Ferrario CM. Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction. Ther Adv Cardiovasc Dis. 2010 Feb; 4(1):17-25.Ther Adv Cardiovasc Dis2009-11-27T00:00:002009Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction.21249217Ahmad S, Varagic J, Westwood BM, Chappell MC, Ferrario CMPloS oneAhmad S, Varagic J, Westwood BM, Chappell MC, Ferrario CM. Uptake and metabolism of the novel peptide angiotensin-(1-12) by neonatal cardiac myocytes. PLoS One. 2011 Jan 10; 6(1):e15759.PLoS One2011-01-10T00:00:002011Uptake and metabolism of the novel peptide angiotensin-(1-12) by neonatal cardiac myocytes.22180785Ahmad S, Simmons T, Varagic J, Moniwa N, Chappell MC, Ferrario CMPloS oneAhmad S, Simmons T, Varagic J, Moniwa N, Chappell MC, Ferrario CM. Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue. PLoS One. 2011; 6(12):e28501.PLoS One2011-12-13T00:00:002011Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue.22222314Moniwa N, Varagic J, Ahmad S, VonCannon JL, Ferrario CMTherapeutic advances in cardiovascular diseaseMoniwa N, Varagic J, Ahmad S, VonCannon JL, Ferrario CM. Restoration of the blood pressure circadian rhythm by direct renin inhibition and blockade of angiotensin II receptors in mRen2.Lewis hypertensive rats. Ther Adv Cardiovasc Dis. 2012 Feb; 6(1):15-29.Ther Adv Cardiovasc Dis2012-01-05T00:00:002012Restoration of the blood pressure circadian rhythm by direct renin inhibition and blockade of angiotensin II receptors in mRen2.Lewis hypertensive rats.23459599Varagic J, Ahmad S, VonCannon JL, Moniwa N, Brosnihan KB, Wysocki J, Batlle D, Ferrario CMAmerican journal of hypertensionVaragic J, Ahmad S, VonCannon JL, Moniwa N, Brosnihan KB, Wysocki J, Batlle D, Ferrario CM. Predominance of AT(1) blockade over mas-mediated angiotensin-(1-7) mechanisms in the regulation of blood pressure and renin-angiotensin system in mRen2.Lewis rats. Am J Hypertens. 2013 May; 26(5):583-90.Am J Hypertens2013-03-04T00:00:002013Predominance of AT(1) blockade over mas-mediated angiotensin-(1-7) mechanisms in the regulation of blood pressure and renin-angiotensin system in mRen2.Lewis rats.KatherineSchaferKatherine R. Schafer MD, FACP36.09032400000000-80.266491000000001585Schafer, KatherineAssociate Professor5.758170.0160974262research areas5.504720.02326657coauthor of250.4175.6060748similar to1161selected publications17525473Kushman ME, Kabler SL, Ahmad S, Doehmer J, Morrow CS, Townsend AJToxicological sciences : an official journal of the Society of ToxicologyKushman ME, Kabler SL, Ahmad S, Doehmer J, Morrow CS, Townsend AJ. Protective efficacy of hGSTM1-1 against B[a]P and (+)- or (-)-B[a]P-7,8-dihydrodiol cytotoxicity, mutagenicity, and macromolecular adducts in V79 cells coexpressing hCYP1A1. Toxicol Sci. 2007 Sep; 99(1):51-7.Toxicol Sci2007-05-24T00:00:002007Protective efficacy of hGSTM1-1 against B[a]P and (+)- or (-)-B[a]P-7,8-dihydrodiol cytotoxicity, mutagenicity, and macromolecular adducts in V79 cells coexpressing hCYP1A1.18992797Ahmad S, Kabler SL, Rudd L, Amin S, Doehmer J, Morrow CS, Townsend AJToxicology lettersAhmad S, Kabler SL, Rudd L, Amin S, Doehmer J, Morrow CS, Townsend AJ. Cytotoxicity and mutagenicity of 5-methylchrysene and its 1,2-dihydrodiol in V79MZ cells modified to express human CYP1A1 or CYP1B1, in the presence or absence of human GSTP1 coexpression. Toxicol Lett. 2008 Dec 15; 183(1-3):99-104.Toxicol Lett2008-10-22T00:00:002008Cytotoxicity and mutagenicity of 5-methylchrysene and its 1,2-dihydrodiol in V79MZ cells modified to express human CYP1A1 or CYP1B1, in the presence or absence of human GSTP1 coexpression.20933203Ferrario CM, Ahmad S, Joyner J, Varagic JAdvances in pharmacology (San Diego, Calif.)Ferrario CM, Ahmad S, Joyner J, Varagic J. Advances in the renin angiotensin system focus on angiotensin-converting enzyme 2 and angiotensin-(1-7). Adv Pharmacol. 2010; 59:197-233.Adv Pharmacol2010-01-01T00:00:002010Advances in the renin angiotensin system focus on angiotensin-converting enzyme 2 and angiotensin-(1-7).21042014Varagic J, Ahmad S, Brosnihan KB, Habibi J, Tilmon RD, Sowers JR, Ferrario CMAmerican journal of nephrologyVaragic J, Ahmad S, Brosnihan KB, Habibi J, Tilmon RD, Sowers JR, Ferrario CM. Salt-induced renal injury in spontaneously hypertensive rats: effects of nebivolol. Am J Nephrol. 2010; 32(6):557-66.Am J Nephrol2010-11-02T00:00:002010Salt-induced renal injury in spontaneously hypertensive rats: effects of nebivolol.22768235Wei CC, Chen Y, Powell LC, Zheng J, Shi K, Bradley WE, Powell PC, Ahmad S, Ferrario CM, Dell'Italia LJPloS oneWei CC, Chen Y, Powell LC, Zheng J, Shi K, Bradley WE, Powell PC, Ahmad S, Ferrario CM, Dell'Italia LJ. Cardiac kallikrein-kinin system is upregulated in chronic volume overload and mediates an inflammatory induced collagen loss. PLoS One. 2012; 7(6):e40110.PLoS One2012-06-29T00:00:002012Cardiac kallikrein-kinin system is upregulated in chronic volume overload and mediates an inflammatory induced collagen loss.22895019Varagic J, Ahmad S, Voncannon JL, Moniwa N, Simington SW, Brosnihan BK, Gallagher PE, Habibi J, Sowers JR, Ferrario CMJournal of hypertensionVaragic J, Ahmad S, Voncannon JL, Moniwa N, Simington SW, Brosnihan BK, Gallagher PE, Habibi J, Sowers JR, Ferrario CM. Nebivolol reduces cardiac angiotensin II, associated oxidative stress and fibrosis but not arterial pressure in salt-loaded spontaneously hypertensive rats. J Hypertens. 2012 Sep; 30(9):1766-74.J Hypertens2012-09-01T00:00:002012Nebivolol reduces cardiac angiotensin II, associated oxidative stress and fibrosis but not arterial pressure in salt-loaded spontaneously hypertensive rats.23232645Moniwa N, Varagic J, Ahmad S, VonCannon JL, Simington SW, Wang H, Groban L, Brosnihan KB, Nagata S, Kato J, Kitamura K, Gomez RA, Lopez ML, Ferrario CMHypertension (Dallas, Tex. : 1979)Moniwa N, Varagic J, Ahmad S, VonCannon JL, Simington SW, Wang H, Groban L, Brosnihan KB, Nagata S, Kato J, Kitamura K, Gomez RA, Lopez ML, Ferrario CM. Hemodynamic and hormonal changes to dual renin-angiotensin system inhibition in experimental hypertension. Hypertension. 2013 Feb; 61(2):417-24.Hypertension2012-12-10T00:00:002012Hemodynamic and hormonal changes to dual renin-angiotensin system inhibition in experimental hypertension.23312967Ahmad S, Wei CC, Tallaj J, Dell'Italia LJ, Moniwa N, Varagic J, Ferrario CMJournal of the American Society of Hypertension : JASHAhmad S, Wei CC, Tallaj J, Dell'Italia LJ, Moniwa N, Varagic J, Ferrario CM. Chymase mediates angiotensin-(1-12) metabolism in normal human hearts. J Am Soc Hypertens. 2013 Mar-Apr; 7(2):128-36.J Am Soc Hypertens2013-01-10T00:00:002013Chymase mediates angiotensin-(1-12) metabolism in normal human hearts.D053818Chemicals & Drugs5480.939736ChymasesD000808Chemicals & Drugs201000.923941AngiotensinogenD000804Chemicals & Drugs333590.82479Angiotensin IID010446Chemicals & Drugs914800.745563Peptide Fragments