EdgarRomero-SandovalEdgar A. Romero-Sandoval MD, PhD36.08977400000000-80.266840000000002050Romero-Sandoval, EdgarAlfonsoAssociate Professorplugins:TwitterTwitterprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD000700Chemicals & Drugs341010.916189AnalgesicsAnesthesiologyDermatologyNeurologyPediatricsWake Forest School of MedicineWesleyHsuWesley Hsu MD, FAACS36.08959100000000-80.268599000000001154Hsu, WesleyAssociate ProfessorChristopherPetersChristopher M. Peters PhD36.08977400000000-80.266840000000001228Peters, ChristopherAssociate ProfessorChuanyaoTongChuanyao Tong MD36.08977400000000-80.26684000000000180Tong, ChuanyaoProfessorDouglasRirieDouglas G. Ririe MD, PhD, MHA36.08977400000000-80.26684000000000246Ririe, DouglasProfessorJamesEisenachJames C. Eisenach MD36.09003100000000-80.26802800000000269Eisenach, JamesProfessorAnthonyAtalaAnthony Atala MD36.08943500000000-80.268632000000003Atala, AnthonyProfessorAllenTsangAllen W. Tsang PhD36.08977400000000-80.2668400000000066Tsang, AllenAssistant ProfessorMedgeOwenMedge D. Owen MD36.08977400000000-80.26684000000000677Owen, MedgeProfessorScottMillerScott A. Miller MD36.08977400000000-80.26684000000000874Miller, ScottAssociate ProfessorStevenFeldmanSteven R. Feldman MD, PhD36.08959100000000-80.26859900000000884Feldman, StevenProfessorThomasMartinThomas J. Martin PhD36.08977400000000-80.26684000000000977Martin, ThomasProfessorRoyStrowd39Kx9JuN9juVSqDBwREVbE232ngcdw==Roy E. Strowd MD, MEd, MS36.09003100000000-80.268028000000001858Strowd, RoyAssociate Professor2.23040.0132641247research areas1.573730.047321210coauthor of180.6166.736145similar to1164selected publicationsAuthorship 533804Authorship 534171Authorship 536142Authorship 536831Authorship 536944Authorship 53698319476641Romero-Sandoval EA, Horvath R, Landry RP, DeLeo JAMolecular painRomero-Sandoval EA, Horvath R, Landry RP, DeLeo JA. Cannabinoid receptor type 2 activation induces a microglial anti-inflammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation. Mol Pain. 2009 May 28; 5:25.Mol Pain2009-05-28T00:00:002009Cannabinoid receptor type 2 activation induces a microglial anti-inflammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation.22119425Landry RP, Jacobs VL, Romero-Sandoval EA, DeLeo JAExperimental neurologyLandry RP, Jacobs VL, Romero-Sandoval EA, DeLeo JA. Propentofylline, a CNS glial modulator does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages. Exp Neurol. 2012 Apr; 234(2):340-50.Exp Neurol2011-11-15T00:00:002011Propentofylline, a CNS glial modulator does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages.17590515Summer GJ, Romero-Sandoval EA, Bogen O, Dina OA, Khasar SG, Levine JDPainSummer GJ, Romero-Sandoval EA, Bogen O, Dina OA, Khasar SG, Levine JD. Proinflammatory cytokines mediating burn-injury pain. Pain. 2008 Mar; 135(1-2):98-107.Pain2007-06-27T00:00:002007Proinflammatory cytokines mediating burn-injury pain.22540262Ndong C, Landry RP, DeLeo JA, Romero-Sandoval EAMolecular painNdong C, Landry RP, DeLeo JA, Romero-Sandoval EA. Mitogen activated protein kinase phosphatase-1 prevents the development of tactile sensitivity in a rodent model of neuropathic pain. Mol Pain. 2012 Apr 27; 8:34.Mol Pain2012-04-27T00:00:002012Mitogen activated protein kinase phosphatase-1 prevents the development of tactile sensitivity in a rodent model of neuropathic pain.22086978Jacobs VL, Landry RP, Liu Y, Romero-Sandoval EA, De Leo JANeuro-oncologyJacobs VL, Landry RP, Liu Y, Romero-Sandoval EA, De Leo JA. Propentofylline decreases tumor growth in a rodent model of glioblastoma multiforme by a direct mechanism on microglia. Neuro Oncol. 2012 Feb; 14(2):119-31.Neuro Oncol2011-11-15T00:00:002011Propentofylline decreases tumor growth in a rodent model of glioblastoma multiforme by a direct mechanism on microglia.18600578Romero-Sandoval EA, Horvath RJ, DeLeo JACurrent opinion in investigational drugs (London, England : 2000)Romero-Sandoval EA, Horvath RJ, DeLeo JA. Neuroimmune interactions and pain: focus on glial-modulating targets. Curr Opin Investig Drugs. 2008 Jul; 9(7):726-34.Curr Opin Investig Drugs2008-07-01T00:00:002008Neuroimmune interactions and pain: focus on glial-modulating targets.Authorship 537336Authorship 537348Authorship 537351Authorship 537365Authorship 537374Authorship 537386Authorship 537391Authorship 537404Authorship 537411Authorship 537422Authorship 537436Authorship 537443Authorship 537451Authorship 537461Authorship 537471Authorship 537481Authorship 537492Authorship 537501Authorship 537516Authorship 537522Authorship 537534Authorship 537544Authorship 537551Authorship 537561Authorship 53764Authorship 537651Authorship 537661Authorship 537671Authorship 537681Authorship 53769Authorship 5377014530796Herrero JF, Romero-Sandoval EA, Gaitan G, Mazario JCNS drug reviewsHerrero JF, Romero-Sandoval EA, Gaitan G, Mazario J. Antinociception and the new COX inhibitors: research approaches and clinical perspectives. CNS Drug Rev. 2003; 9(3):227-52.CNS Drug Rev2003-01-01T00:00:002003Antinociception and the new COX inhibitors: research approaches and clinical perspectives.16870215Alfonso Romero-Sandoval E, Molina C, Herrero JFNeuropharmacologyAlfonso Romero-Sandoval E, Molina C, Herrero JF. Enhancement of the analgesic activity of paracetamol and nitroparacetamol by the oral administration of all-trans retinoic acid. Neuropharmacology. 2006 Sep; 51(4):858-65.Neuropharmacology2006-07-25T00:00:002006Enhancement of the analgesic activity of paracetamol and nitroparacetamol by the oral administration of all-trans retinoic acid.26497478Romero-Sandoval EA, Asbill S, Paige CA, Byrd-Glover KPharmacotherapyRomero-Sandoval EA, Asbill S, Paige CA, Byrd-Glover K. Peripherally Restricted Cannabinoids for the Treatment of Pain. Pharmacotherapy. 2015 Oct; 35(10):917-25.Pharmacotherapy2015-10-01T00:00:002015Peripherally Restricted Cannabinoids for the Treatment of Pain.28405172Skopelja-Gardner S, Saha M, Alvarado-Vazquez PA, Liponis BS, Martinez E, Romero-Sandoval EAJournal of pain researchSkopelja-Gardner S, Saha M, Alvarado-Vazquez PA, Liponis BS, Martinez E, Romero-Sandoval EA. Mitogen-activated protein kinase phosphatase-3 (MKP-3) in the surgical wound is necessary for the resolution of postoperative pain in mice. J Pain Res. 2017; 10:763-774.J Pain Res2017-03-28T00:00:002017Mitogen-activated protein kinase phosphatase-3 (MKP-3) in the surgical wound is necessary for the resolution of postoperative pain in mice.25508635Asbill S, Sweitzer SM, Spigener S, Romero-Sandoval AInternational journal of pharmaceutical compoundingAsbill S, Sweitzer SM, Spigener S, Romero-Sandoval A. Compounded pain formulations: what is the evidence? Int J Pharm Compd. 2014 Jul-Aug; 18(4):278-86.Int J Pharm Compd2014-07-01T00:00:002014Compounded pain formulations: what is the evidence?20573450Horvath RJ, Romero-Sandoval AE, De Leo JAPainHorvath RJ, Romero-Sandoval AE, De Leo JA. Inhibition of microglial P2X4 receptors attenuates morphine tolerance, Iba1, GFAP and mu opioid receptor protein expression while enhancing perivascular microglial ED2. Pain. 2010 Sep; 150(3):401-413.Pain2010-06-22T00:00:002010Inhibition of microglial P2X4 receptors attenuates morphine tolerance, Iba1, GFAP and mu opioid receptor protein expression while enhancing perivascular microglial ED2.22901764Landry RP, Martinez E, DeLeo JA, Romero-Sandoval EAThe journal of pain : official journal of the American Pain SocietyLandry RP, Martinez E, DeLeo JA, Romero-Sandoval EA. Spinal cannabinoid receptor type 2 agonist reduces mechanical allodynia and induces mitogen-activated protein kinase phosphatases in a rat model of neuropathic pain. J Pain. 2012 Sep; 13(9):836-48.J Pain2012-08-14T00:00:002012Spinal cannabinoid receptor type 2 agonist reduces mechanical allodynia and induces mitogen-activated protein kinase phosphatases in a rat model of neuropathic pain.11906970Romero-Sandoval EA, Mazario J, Howat D, Herrero JFBritish journal of pharmacologyRomero-Sandoval EA, Mazario J, Howat D, Herrero JF. NCX-701 (nitroparacetamol) is an effective antinociceptive agent in rat withdrawal reflexes and wind-up. Br J Pharmacol. 2002 Mar; 135(6):1556-62.Br J Pharmacol2002-03-01T00:00:002002NCX-701 (nitroparacetamol) is an effective antinociceptive agent in rat withdrawal reflexes and wind-up.16847436Romero-Sandoval EA, Molina C, Alique M, Moreno-Manzano V, Lucio FJ, Herrero JFBritish journal of pharmacologyRomero-Sandoval EA, Molina C, Alique M, Moreno-Manzano V, Lucio FJ, Herrero JF. Vitamin A active metabolite, all-trans retinoic acid, induces spinal cord sensitization. I. Effects after oral administration. Br J Pharmacol. 2006 Sep; 149(1):56-64.Br J Pharmacol2006-07-17T00:00:002006Vitamin A active metabolite, all-trans retinoic acid, induces spinal cord sensitization. I. Effects after oral administration.24861519Ndong C, Landry RP, Saha M, Romero-Sandoval EANeuroscience lettersNdong C, Landry RP, Saha M, Romero-Sandoval EA. Mitogen-activated protein kinase (MAPK) phosphatase-3 (MKP-3) displays a p-JNK-MAPK substrate preference in astrocytes in vitro. Neurosci Lett. 2014 Jul 11; 575:13-8.Neurosci Lett2014-05-23T00:00:002014Mitogen-activated protein kinase (MAPK) phosphatase-3 (MKP-3) displays a p-JNK-MAPK substrate preference in astrocytes in vitro.21841467Romero-Sandoval EAAnesthesiologyRomero-Sandoval EA. Depression and pain: does ketamine improve the quality of life of patients in chronic pain by targeting their mood? Anesthesiology. 2011 Oct; 115(4):687-8.Anesthesiology2011-10-01T00:00:002011Depression and pain: does ketamine improve the quality of life of patients in chronic pain by targeting their mood?18362605Romero-Sandoval A, Nutile-McMenemy N, DeLeo JAAnesthesiologyRomero-Sandoval A, Nutile-McMenemy N, DeLeo JA. Spinal microglial and perivascular cell cannabinoid receptor type 2 activation reduces behavioral hypersensitivity without tolerance after peripheral nerve injury. Anesthesiology. 2008 Apr; 108(4):722-34.Anesthesiology2008-04-01T00:00:002008Spinal microglial and perivascular cell cannabinoid receptor type 2 activation reduces behavioral hypersensitivity without tolerance after peripheral nerve injury.26961090Savage SR, Romero-Sandoval A, Schatman M, Wallace M, Fanciullo G, McCarberg B, Ware MThe journal of pain : official journal of the American Pain SocietySavage SR, Romero-Sandoval A, Schatman M, Wallace M, Fanciullo G, McCarberg B, Ware M. Cannabis in Pain Treatment: Clinical and Research Considerations. J Pain. 2016 06; 17(6):654-68.J Pain2016-03-04T00:00:002016Cannabis in Pain Treatment: Clinical and Research Considerations.27615510Bernal L, Alvarado-Vázquez A, Ferreira DW, Paige CA, Ulecia-Morón C, Hill B, Caesar M, Romero-Sandoval EAImmunobiologyBernal L, Alvarado-Vázquez A, Ferreira DW, Paige CA, Ulecia-Morón C, Hill B, Caesar M, Romero-Sandoval EA. Evaluation of a nanotechnology-based approach to induce gene-expression in human THP-1 macrophages under inflammatory conditions. Immunobiology. 2017 02; 222(2):399-408.Immunobiology2016-09-05T00:00:002016Evaluation of a nanotechnology-based approach to induce gene-expression in human THP-1 macrophages under inflammatory conditions.26685497Heustess A, Spigener S, Sweitzer S, Romero-Sandoval A, Asbill SInternational journal of pharmaceutical compoundingHeustess A, Spigener S, Sweitzer S, Romero-Sandoval A, Asbill S. Analgesic Efficacy and Transdermal Penetration of Topical Gabapentin Creams: Finding an Optimal Dose and Pre-treatment Time. Int J Pharm Compd. 2015 Mar-Apr; 19(2):167-73.Int J Pharm Compd2015-03-01T00:00:002015Analgesic Efficacy and Transdermal Penetration of Topical Gabapentin Creams: Finding an Optimal Dose and Pre-treatment Time.23526770Romero-Sandoval EAEuropean journal of pain (London, England)Romero-Sandoval EA. Peripheral benzodiazepine receptors: are they potential biomarkers for glial activation in pain states? Eur J Pain. 2013 May; 17(5):635-7.Eur J Pain2013-05-01T00:00:002013Peripheral benzodiazepine receptors: are they potential biomarkers for glial activation in pain states?18538310Romero-Sandoval A, Chai N, Nutile-McMenemy N, Deleo JABrain researchRomero-Sandoval A, Chai N, Nutile-McMenemy N, Deleo JA. A comparison of spinal Iba1 and GFAP expression in rodent models of acute and chronic pain. Brain Res. 2008 Jul 11; 1219:116-26.Brain Res2008-05-11T00:00:002008A comparison of spinal Iba1 and GFAP expression in rodent models of acute and chronic pain.17894645Romero-Sandoval EA, Curros-Criado MM, Gaitan G, Molina C, Herrero JFCNS drug reviewsRomero-Sandoval EA, Curros-Criado MM, Gaitan G, Molina C, Herrero JF. Nitroparacetamol (NCX-701) and pain: first in a series of novel analgesics. CNS Drug Rev. 2007; 13(3):279-95.CNS Drug Rev2007-01-01T00:00:002007Nitroparacetamol (NCX-701) and pain: first in a series of novel analgesics.12871658Alfonso Romero-Sandoval E, Del Soldato P, Herrero JFNeuropharmacologyAlfonso Romero-Sandoval E, Del Soldato P, Herrero JF. The effects of sham and full spinalization on the antinociceptive effects of NCX-701 (nitroparacetamol) in monoarthritic rats. Neuropharmacology. 2003 Sep; 45(3):412-9.Neuropharmacology2003-09-01T00:00:002003The effects of sham and full spinalization on the antinociceptive effects of NCX-701 (nitroparacetamol) in monoarthritic rats.Romero-Salndoval EA, Sweitzer SM. Nonneuronal central mechanisms of pain. Romero-Salndoval EA, Sweitzer SM. . Molecular and Cell Biology of Pain. Theodore Price, Greg Dussor, eds. Nonneuronal central mechanisms of pain. 2015; 131:325-358.2015-01-01T00:00:002015Molecular and Cell Biology of Pain. Theodore Price, Greg Dussor, eds24155322Saha M, Skopelja S, Martinez E, Alvarez DL, Liponis BS, Romero-Sandoval EAThe Journal of neuroscience : the official journal of the Society for NeuroscienceSaha M, Skopelja S, Martinez E, Alvarez DL, Liponis BS, Romero-Sandoval EA. Spinal mitogen-activated protein kinase phosphatase-3 (MKP-3) is necessary for the normal resolution of mechanical allodynia in a mouse model of acute postoperative pain. J Neurosci. 2013 Oct 23; 33(43):17182-7.J Neurosci2013-10-23T00:00:002013Spinal mitogen-activated protein kinase phosphatase-3 (MKP-3) is necessary for the normal resolution of mechanical allodynia in a mouse model of acute postoperative pain.28326930Bort A, Alvarado-Vazquez PA, Moracho-Vilrriales C, Virga KG, Gumina G, Romero-Sandoval A, Asbill SMolecular painBort A, Alvarado-Vazquez PA, Moracho-Vilrriales C, Virga KG, Gumina G, Romero-Sandoval A, Asbill S. Effects of JWH015 in cytokine secretion in primary human keratinocytes and fibroblasts and its suitability for topical/transdermal delivery. Mol Pain. 2017 01; 13:1744806916688220.Mol Pain2017-01-01T00:00:002017Effects of JWH015 in cytokine secretion in primary human keratinocytes and fibroblasts and its suitability for topical/transdermal delivery.25490519Paige C, Hill B, Canterbury J, Sweitzer S, Romero-Sandoval EAJournal of visualized experiments : JoVEPaige C, Hill B, Canterbury J, Sweitzer S, Romero-Sandoval EA. Construction of an affordable and easy-to-build zebrafish facility. J Vis Exp. 2014 Nov 22; (93):e51989.J Vis Exp2014-11-22T00:00:002014Construction of an affordable and easy-to-build zebrafish facility.20493931Horvath RJ, Landry RP, Romero-Sandoval EA, DeLeo JANeuroscienceHorvath RJ, Landry RP, Romero-Sandoval EA, DeLeo JA. Morphine tolerance attenuates the resolution of postoperative pain and enhances spinal microglial p38 and extracellular receptor kinase phosphorylation. Neuroscience. 2010 Aug 25; 169(2):843-54.Neuroscience2010-05-22T00:00:002010Morphine tolerance attenuates the resolution of postoperative pain and enhances spinal microglial p38 and extracellular receptor kinase phosphorylation.15241564Romero-Sandoval EA, Alique M, Moreno-Manzano V, Molina C, Lucio FJ, Herrero JFInflammation research : official journal of the European Histamine Research Society ... [et al.]Romero-Sandoval EA, Alique M, Moreno-Manzano V, Molina C, Lucio FJ, Herrero JF. The oral administration of retinoic acid enhances nociceptive withdrawal reflexes in rats with soft-tissue inflammation. Inflamm Res. 2004 Jul; 53(7):297-303.Inflamm Res2004-06-25T00:00:002004The oral administration of retinoic acid enhances nociceptive withdrawal reflexes in rats with soft-tissue inflammation.20531936Alkaitis MS, Solorzano C, Landry RP, Piomelli D, DeLeo JA, Romero-Sandoval EAPloS oneAlkaitis MS, Solorzano C, Landry RP, Piomelli D, DeLeo JA, Romero-Sandoval EA. Evidence for a role of endocannabinoids, astrocytes and p38 phosphorylation in the resolution of postoperative pain. PLoS One. 2010 May 28; 5(5):e10891.PLoS One2010-05-28T00:00:002010Evidence for a role of endocannabinoids, astrocytes and p38 phosphorylation in the resolution of postoperative pain.2017-08-31NIH/NIGMSROMERO-SANDOVAL, EDGAR ALFONSO2014-09-01Cell-directed therapy using nanotechnology for the prevention of chronic postoperR15GM1093332012-05-31NIHROMERO-SANDOVAL, EDGAR ALFONSO2009-06-01Cannabinoids and Neuroimmune InteractionsR01DA0252112019-04-30NIHMESSERSMITH, AMY2013-05-15Developing an Office of Sponsored Projects for Presbyterian CollegeG11HD076487Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorAuthorship 55838128983880Romero-Sandoval EA, Kolano AL, Alvarado-Vázquez PACurrent rheumatology reportsRomero-Sandoval EA, Kolano AL, Alvarado-Vázquez PA. Cannabis and Cannabinoids for Chronic Pain. Curr Rheumatol Rep. 2017 Oct 05; 19(11):67.Curr Rheumatol Rep2017-10-05T00:00:002017Cannabis and Cannabinoids for Chronic Pain.KimberlyWagonerKimberly G. Wagoner DrPH, MPH2216Wagoner, KimberlyAssistant ProfessorAuthorship 58964129637590Romero-Sandoval EA, Fincham JE, Kolano AL, Sharpe BN, Alvarado-Vázquez PAPharmacotherapyRomero-Sandoval EA, Fincham JE, Kolano AL, Sharpe BN, Alvarado-Vázquez PA. Cannabis for Chronic Pain: Challenges and Considerations. Pharmacotherapy. 2018 06; 38(6):651-662.Pharmacotherapy2018-05-16T00:00:002018Cannabis for Chronic Pain: Challenges and Considerations.Authorship 66279630588081Alvarado-Vázquez PA, Grosick RL, Moracho-Vilrriales C, Ward E, Threatt T, Romero-Sandoval EAJournal of pain researchAlvarado-Vázquez PA, Grosick RL, Moracho-Vilrriales C, Ward E, Threatt T, Romero-Sandoval EA. Cytokine production capabilities of human primary monocyte-derived macrophages from patients with diabetes mellitus type 2 with and without diabetic peripheral neuropathy. J Pain Res. 2019; 12:69-81.J Pain Res2018-12-19T00:00:002018Cytokine production capabilities of human primary monocyte-derived macrophages from patients with diabetes mellitus type 2 with and without diabetic peripheral neuropathy.31012376Gutierrez S, Alvarado-Vázquez PA, Eisenach JC, Romero-Sandoval EA, Boada MDMolecular painGutierrez S, Alvarado-Vázquez PA, Eisenach JC, Romero-Sandoval EA, Boada MD. Tachykinins modulate nociceptive responsiveness and sensitization: In vivo electrical characterization of primary sensory neurons in tachykinin knockout (Tac1 KO) mice. Mol Pain. 2019 Jan-Dec; 15:1744806919845750.Mol Pain2019-01-01T00:00:002019Tachykinins modulate nociceptive responsiveness and sensitization: In vivo electrical characterization of primary sensory neurons in tachykinin knockout (Tac1 KO) mice.24Assistant Professor22Associate Professor2025-01-31NIHROMERO-SANDOVAL, E. ALFONSO2020-02-15Endoplasmic Reticulum Stress Responses in PainR01NS114653Principal InvestigatorAuthorship 677684Authorship 6776910Authorship 677708Authorship 6777120Authorship 677724Authorship 67773432052458Lycan TW, Hsu FC, Ahn CS, Thomas A, Walker FO, Sangueza OP, Shiozawa Y, Park SH, Peters CM, Romero-Sandoval EA, Melin SA, Sorscher S, Ansley K, Lesser GJ, Cartwright MS, Strowd REMuscle & nerveLycan TW, Hsu FC, Ahn CS, Thomas A, Walker FO, Sangueza OP, Shiozawa Y, Park SH, Peters CM, Romero-Sandoval EA, Melin SA, Sorscher S, Ansley K, Lesser GJ, Cartwright MS, Strowd RE. Neuromuscular ultrasound for taxane peripheral neuropathy in breast cancer. Muscle Nerve. 2020 05; 61(5):587-594.Muscle Nerve2020-02-24T00:00:002020Neuromuscular ultrasound for taxane peripheral neuropathy in breast cancer.30237731Grosick R, Alvarado-Vazquez PA, Messersmith AR, Romero-Sandoval EAJournal of pain researchGrosick R, Alvarado-Vazquez PA, Messersmith AR, Romero-Sandoval EA. High glucose induces a priming effect in macrophages and exacerbates the production of pro-inflammatory cytokines after a challenge. J Pain Res. 2018; 11:1769-1778.J Pain Res2018-09-07T00:00:002018High glucose induces a priming effect in macrophages and exacerbates the production of pro-inflammatory cytokines after a challenge.31320508Chopra S, Giovanelli P, Alvarado-Vazquez PA, Alonso S, Song M, Sandoval TA, Chae CS, Tan C, Fonseca MM, Gutierrez S, Jimenez L, Subbaramaiah K, Iwawaki T, Kingsley PJ, Marnett LJ, Kossenkov AV, Crespo MS, Dannenberg AJ, Glimcher LH, Romero-Sandoval EA, Cubillos-Ruiz JRScience (New York, N.Y.)Chopra S, Giovanelli P, Alvarado-Vazquez PA, Alonso S, Song M, Sandoval TA, Chae CS, Tan C, Fonseca MM, Gutierrez S, Jimenez L, Subbaramaiah K, Iwawaki T, Kingsley PJ, Marnett LJ, Kossenkov AV, Crespo MS, Dannenberg AJ, Glimcher LH, Romero-Sandoval EA, Cubillos-Ruiz JR. IRE1a-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain. Science. 2019 07 19; 365(6450).Science2019-07-19T00:00:002019IRE1a-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain.32097466Kim TE, Townsend RK, Branch CL, Romero-Sandoval EA, Hsu WNeurosurgeryKim TE, Townsend RK, Branch CL, Romero-Sandoval EA, Hsu W. Cannabinoids in the Treatment of Back Pain. Neurosurgery. 2020 08 01; 87(2):166-175.Neurosurgery2020-08-01T00:00:002020Cannabinoids in the Treatment of Back Pain.31711674Ferreira DW, Ulecia-Morón C, Alvarado-Vázquez PA, Cunnane K, Moracho-Vilriales C, Grosick RL, Cunha TM, Romero-Sandoval EAImmunobiologyFerreira DW, Ulecia-Morón C, Alvarado-Vázquez PA, Cunnane K, Moracho-Vilriales C, Grosick RL, Cunha TM, Romero-Sandoval EA. CD163 overexpression using a macrophage-directed gene therapy approach improves wound healing in ex vivo and in vivo human skin models. Immunobiology. 2020 01; 225(1):151862.Immunobiology2019-11-04T00:00:002019CD163 overexpression using a macrophage-directed gene therapy approach improves wound healing in ex vivo and in vivo human skin models.2022-03-31NIHROMERO-SANDOVAL, E. ALFONSO2020-04-01IRE1a-XBP1 Signaling as a Driver of Chemotherapy-Induced Peripheral NeuropathyR21CA248106Principal InvestigatorAuthorship 67906432214334Cash MC, Cunnane K, Fan C, Romero-Sandoval EAPloS oneCash MC, Cunnane K, Fan C, Romero-Sandoval EA. Mapping cannabis potency in medical and recreational programs in the United States. PLoS One. 2020; 15(3):e0230167.PLoS One2020-03-26T00:00:002020Mapping cannabis potency in medical and recreational programs in the United States.Authorship 68879233080058Pennypacker SD, Romero-Sandoval EAPharmacotherapyPennypacker SD, Romero-Sandoval EA. CBD and THC: Do They Complement Each Other Like Yin and Yang? Pharmacotherapy. 2020 11; 40(11):1152-1165.Pharmacotherapy2020-11-01T00:00:002020CBD and THC: Do They Complement Each Other Like Yin and Yang?Authorship 699291333741328Park SH, Eber MR, Fonseca MM, Patel CM, Cunnane KA, Ding H, Hsu FC, Peters CM, Ko MC, Strowd RE, Wilson JA, Hsu W, Romero-Sandoval EA, Shiozawa YBiochemical pharmacologyPark SH, Eber MR, Fonseca MM, Patel CM, Cunnane KA, Ding H, Hsu FC, Peters CM, Ko MC, Strowd RE, Wilson JA, Hsu W, Romero-Sandoval EA, Shiozawa Y. Usefulness of the measurement of neurite outgrowth of primary sensory neurons to study cancer-related painful complications. Biochem Pharmacol. 2021 Jun; 188:114520.Biochem Pharmacol2021-03-17T00:00:002021Usefulness of the measurement of neurite outgrowth of primary sensory neurons to study cancer-related painful complications.Authorship 703888Authorship 70389433829907Arora V, Morado-Urbina CE, Gwak YS, Parker RA, Kittel CA, Munoz-Islas E, Miguel Jimenez-Andrade J, Romero-Sandoval EA, Eisenach JC, Peters CMMolecular painArora V, Morado-Urbina CE, Gwak YS, Parker RA, Kittel CA, Munoz-Islas E, Miguel Jimenez-Andrade J, Romero-Sandoval EA, Eisenach JC, Peters CM. Systemic administration of a ß2-adrenergic receptor agonist reduces mechanical allodynia and suppresses the immune response to surgery in a rat model of persistent post-incisional hypersensitivity. Mol Pain. 2021 Jan-Dec; 17:1744806921997206.Mol Pain2021-01-01T00:00:002021Systemic administration of a ß2-adrenergic receptor agonist reduces mechanical allodynia and suppresses the immune response to surgery in a rat model of persistent post-incisional hypersensitivity.33961945Uhelski ML, Li Y, Fonseca MM, Romero-Snadoval EA, Dougherty PMNeuroscience lettersUhelski ML, Li Y, Fonseca MM, Romero-Snadoval EA, Dougherty PM. Role of innate immunity in chemotherapy-induced peripheral neuropathy. Neurosci Lett. 2021 Jun 11; 755:135941.Neurosci Lett2021-05-04T00:00:002021Role of innate immunity in chemotherapy-induced peripheral neuropathy.Authorship 705083Authorship 70509834142863Wagoner KG, Lazard AJ, Romero-Sandoval EA, Reboussin BACannabis and cannabinoid researchWagoner KG, Lazard AJ, Romero-Sandoval EA, Reboussin BA. Health Claims About Cannabidiol Products: A Retrospective Analysis of U.S. Food and Drug Administration Warning Letters from 2015 to 2019. Cannabis Cannabinoid Res. 2021 Jun 17.Cannabis Cannabinoid Res2021-06-17T00:00:002021Health Claims About Cannabidiol Products: A Retrospective Analysis of U.S. Food and Drug Administration Warning Letters from 2015 to 2019.34103982Munoz-Islas E, Elizondo-Martinez CE, Gutierrez-Lopez M, Acosta-Gonzalez RI, Zaga-Clavellina V, Helguera-Repetto AC, Ramirez-Rosas MB, Romero-Sandoval EA, Jimenez-Andrade JMJournal of pain researchMunoz-Islas E, Elizondo-Martinez CE, Gutierrez-Lopez M, Acosta-Gonzalez RI, Zaga-Clavellina V, Helguera-Repetto AC, Ramirez-Rosas MB, Romero-Sandoval EA, Jimenez-Andrade JM. Effect of Experimental Gestational Diabetes Mellitus on Mechanical Sensitivity, Capsaicin-Induced Pain Behaviors and Hind Paw Glabrous Skin Innervation of Male and Female Mouse Offspring. J Pain Res. 2021; 14:1573-1585.J Pain Res2021-06-02T00:00:002021Effect of Experimental Gestational Diabetes Mellitus on Mechanical Sensitivity, Capsaicin-Induced Pain Behaviors and Hind Paw Glabrous Skin Innervation of Male and Female Mouse Offspring.Internal Medicine, General Internal MedicineInternal Medicine, Molecular MedicineNeurological SurgerySocial Sciences & Health Policy (Public Health Sciences)UrologyAuthorship 7144912Authorship 71450334711765Casadei M, Fiore E, Rubione J, Domínguez LM, Coronel MF, Leiguarda C, García M, Mazzolini G, Villar MJ, Montaner A, Constandil L, Romero-Sandoval EA, Brumovsky PRPainCasadei M, Fiore E, Rubione J, Domínguez LM, Coronel MF, Leiguarda C, García M, Mazzolini G, Villar MJ, Montaner A, Constandil L, Romero-Sandoval EA, Brumovsky PR. IMT504 blocks allodynia in rats with spared nerve injury by promoting the migration of mesenchymal stem cells and by favoring an anti-inflammatory milieu at the injured nerve. Pain. 2021 Sep 15.Pain2021-09-15T00:00:002021IMT504 blocks allodynia in rats with spared nerve injury by promoting the migration of mesenchymal stem cells and by favoring an anti-inflammatory milieu at the injured nerve.34690791Caudle RM, Smith MT, Romero-Sandoval EAFrontiers in pharmacologyCaudle RM, Smith MT, Romero-Sandoval EA. Editorial: Verification of Animal Pain Models by Reverse Translation. Front Pharmacol. 2021; 12:778880.Front Pharmacol2021-10-08T00:00:002021Editorial: Verification of Animal Pain Models by Reverse Translation.Twitter Tweets Harvard Tweetshttp://www.wfirm.orgWFIRMAuthorship 7215935189108Kiguchi N, Ding H, Park SH, Mabry KM, Kishioka S, Shiozawa Y, Alfonso Romero-Sandoval E, Peters CM, Ko MCBiochemical pharmacologyKiguchi N, Ding H, Park SH, Mabry KM, Kishioka S, Shiozawa Y, Alfonso Romero-Sandoval E, Peters CM, Ko MC. Functional roles of neuromedin B and gastrin-releasing peptide in regulating itch and pain in the spinal cord of non-human primates. Biochem Pharmacol. 2022 Feb 18; 114972.Biochem Pharmacol2022-02-18T00:00:002022Functional roles of neuromedin B and gastrin-releasing peptide in regulating itch and pain in the spinal cord of non-human primates.Authorship 728417Authorship 72842335366987Pennypacker SD, Fonseca MM, Morgan JW, Dougherty PM, Cubillos-Ruiz JR, Strowd RE, Romero-Sandoval EAMethods in cell biologyPennypacker SD, Fonseca MM, Morgan JW, Dougherty PM, Cubillos-Ruiz JR, Strowd RE, Romero-Sandoval EA. Methods and protocols for chemotherapy-induced peripheral neuropathy (CIPN) mouse models using paclitaxel. Methods Cell Biol. 2022; 168:277-298.Methods Cell Biol2022-01-10T00:00:002022Methods and protocols for chemotherapy-induced peripheral neuropathy (CIPN) mouse models using paclitaxel.35366986Morgan JW, Pennypacker SD, Romero-Sandoval EA, Fonseca MMMethods in cell biologyMorgan JW, Pennypacker SD, Romero-Sandoval EA, Fonseca MM. Methods and protocols for translatable rodent models of postsurgical pain. Methods Cell Biol. 2022; 168:249-276.Methods Cell Biol2022-01-20T00:00:002022Methods and protocols for translatable rodent models of postsurgical pain.Authorship 73184435734402Pennypacker SD, Cunnane K, Cash MC, Romero-Sandoval EAFrontiers in pharmacologyPennypacker SD, Cunnane K, Cash MC, Romero-Sandoval EA. Potency and Therapeutic THC and CBD Ratios: U.S. Cannabis Markets Overshoot. Front Pharmacol. 2022; 13:921493.Front Pharmacol2022-06-06T00:00:002022Potency and Therapeutic THC and CBD Ratios: U.S. Cannabis Markets Overshoot.Authorship 734271635552618Chae CS, Sandoval TA, Hwang SM, Park ES, Giovanelli P, Awasthi D, Salvagno C, Emmanuelli A, Tan C, Chaudhary V, Casado J, Kossenkov AV, Song M, Barrat FJ, Holcomb K, Romero-Sandoval EA, Zamarin D, Pépin D, D'Andrea AD, Färkkilä A, Cubillos-Ruiz JRCancer discoveryChae CS, Sandoval TA, Hwang SM, Park ES, Giovanelli P, Awasthi D, Salvagno C, Emmanuelli A, Tan C, Chaudhary V, Casado J, Kossenkov AV, Song M, Barrat FJ, Holcomb K, Romero-Sandoval EA, Zamarin D, Pépin D, D'Andrea AD, Färkkilä A, Cubillos-Ruiz JR. Tumor-Derived Lysophosphatidic Acid Blunts Protective Type I Interferon Responses in Ovarian Cancer. Cancer Discov. 2022 Aug 05; 12(8):1904-1921.Cancer Discov2022-08-05T00:00:002022Tumor-Derived Lysophosphatidic Acid Blunts Protective Type I Interferon Responses in Ovarian Cancer.Authorship 740096Authorship 74010736514481Amann L, Kruse E, Lazard AJ, Reboussin BA, Wagoner KG, Romero-Sandoval EAJournal of pain researchAmann L, Kruse E, Lazard AJ, Reboussin BA, Wagoner KG, Romero-Sandoval EA. CBD Retailers in NC Promote CBD Online to Treat Pain Violating FDA Rules About Medical Claims and Offer Low-CBD/High-Price Products. J Pain Res. 2022; 15:3847-3858.J Pain Res2022-12-07T00:00:002022CBD Retailers in NC Promote CBD Online to Treat Pain Violating FDA Rules About Medical Claims and Offer Low-CBD/High-Price Products.35784239Dobbins M, Rakkar M, Cunnane K, Pennypacker SD, Wagoner KG, Reboussin BA, Romero-Sandoval EAFrontiers in public healthDobbins M, Rakkar M, Cunnane K, Pennypacker SD, Wagoner KG, Reboussin BA, Romero-Sandoval EA. Association of Tetrahydrocannabinol Content and Price in Herbal Cannabis Products Offered by Dispensaries in California: A Purview of Consumers/Patients. Front Public Health. 2022; 10:893009.Front Public Health2022-06-17T00:00:002022Association of Tetrahydrocannabinol Content and Price in Herbal Cannabis Products Offered by Dispensaries in California: A Purview of Consumers/Patients.Authorship 7591314Authorship 75914437432737Awasthi D, Chopra S, Cho BA, Emmanuelli A, Sandoval TA, Hwang SM, Chae CS, Salvagno C, Tan C, Vasquez-Urbina L, Fernandez Rodriguez JJ, Santagostino SF, Iwawaki T, Romero-Sandoval EA, Crespo MS, Morales DK, Iliev ID, Hohl TM, Cubillos-Ruiz JRThe Journal of clinical investigationAwasthi D, Chopra S, Cho BA, Emmanuelli A, Sandoval TA, Hwang SM, Chae CS, Salvagno C, Tan C, Vasquez-Urbina L, Fernandez Rodriguez JJ, Santagostino SF, Iwawaki T, Romero-Sandoval EA, Crespo MS, Morales DK, Iliev ID, Hohl TM, Cubillos-Ruiz JR. Inflammatory ER stress responses dictate the immunopathogenic progression of systemic candidiasis. J Clin Invest. 2023 Jul 11.J Clin Invest2023-07-11T00:00:002023Inflammatory ER stress responses dictate the immunopathogenic progression of systemic candidiasis.37209211Ding H, Kiguchi N, Dobbins M, Romero-Sandoval EA, Kishioka S, Ko MCDrugsDing H, Kiguchi N, Dobbins M, Romero-Sandoval EA, Kishioka S, Ko MC. Nociceptin Receptor-Related Agonists as Safe and Non-addictive Analgesics. Drugs. 2023 Jun; 83(9):771-793.Drugs2023-05-20T00:00:002023Nociceptin Receptor-Related Agonists as Safe and Non-addictive Analgesics.true1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Assistant ProfessorAssistant Professortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professor2ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Associate ProfessorAssociate Professor4Associate ProfessorAssociate Professor3ProfessorProfessortrue1ProfessorProfessor16192389Romero-Sandoval EA, McCall C, Eisenach JCThe Journal of neuroscience : the official journal of the Society for NeuroscienceRomero-Sandoval EA, McCall C, Eisenach JC. Alpha2-adrenoceptor stimulation transforms immune responses in neuritis and blocks neuritis-induced pain. J Neurosci. 2005 Sep 28; 25(39):8988-94.J Neurosci2005-09-28T00:00:002005Alpha2-adrenoceptor stimulation transforms immune responses in neuritis and blocks neuritis-induced pain.17079113Romero-Sandoval A, Eisenach JCBrain, behavior, and immunityRomero-Sandoval A, Eisenach JC. Clonidine reduces hypersensitivity and alters the balance of pro- and anti-inflammatory leukocytes after local injection at the site of inflammatory neuritis. Brain Behav Immun. 2007 Jul; 21(5):569-80.Brain Behav Immun2006-10-31T00:00:002006Clonidine reduces hypersensitivity and alters the balance of pro- and anti-inflammatory leukocytes after local injection at the site of inflammatory neuritis.16436856Romero-Sandoval A, Eisenach JCAnesthesiologyRomero-Sandoval A, Eisenach JC. Perineural clonidine reduces mechanical hypersensitivity and cytokine production in established nerve injury. Anesthesiology. 2006 Feb; 104(2):351-5.Anesthesiology2006-02-01T00:00:002006Perineural clonidine reduces mechanical hypersensitivity and cytokine production in established nerve injury.17259863Romero-Sandoval A, Bynum T, Eisenach JCNeuroreportRomero-Sandoval A, Bynum T, Eisenach JC. Analgesia induced by perineural clonidine is enhanced in persistent neuritis. Neuroreport. 2007 Jan 08; 18(1):67-71.Neuroreport2007-01-08T00:00:002007Analgesia induced by perineural clonidine is enhanced in persistent neuritis.17413917Romero-Sandoval A, Eisenach JCAnesthesiologyRomero-Sandoval A, Eisenach JC. Spinal cannabinoid receptor type 2 activation reduces hypersensitivity and spinal cord glial activation after paw incision. Anesthesiology. 2007 Apr; 106(4):787-94.Anesthesiology2007-04-01T00:00:002007Spinal cannabinoid receptor type 2 activation reduces hypersensitivity and spinal cord glial activation after paw incision.D013116Anatomy231130.918566Spinal CordD017628Anatomy27440.959882MicrogliaD010146Disorders1042470.835732PainD009437Disorders19450.945056Neuralgia