DavidSoto PantojaDavid Soto Pantoja PhD36.09032400000000-80.266491000000001771Soto Pantoja, DavidAssociate Professorprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD012867Anatomy822000.853395SkinCancer BiologyDermatologyRadiation OncologyWake Forest School of MedicineDebraDizDebra I. Diz PhD36.09032400000000-80.26649100000000200Diz, DebraProfessorAnthonyAtalaAnthony Atala MD36.08943500000000-80.268632000000003Atala, AnthonyProfessorJamesHolmesJames H. Holmes MD36.08919100000000-80.26677800000000424Holmes, JamesProfessorJamesYooJames J. Yoo MD, PhD36.08943500000000-80.26863200000000500Yoo, JamesProfessorMarkChappellMark C. Chappell PhD36.09032400000000-80.26649100000000616Chappell, MarkProfessorElisabethTallantElisabeth A. Tallant PhD36.09032400000000-80.2664910000000063Tallant, ElisabethProfessor EmeritusPatriciaGallagherPatricia E. Gallagher PhD36.09032400000000-80.26649100000000751Gallagher, PatriciaProfessorStevenFeldmanSteven R. Feldman MD, PhD36.08959100000000-80.26859900000000884Feldman, StevenProfessorKatherineCookKatherine L. Cook PhD36.09032400000000-80.266491000000001763Cook, KatherineAssistant Professor0.5050210.020755159research areas0.3119160.3119161coauthor of9.414260.91292549similar to1140selected publications24840925Soto-Pantoja DR, Shih HB, Maxhimer JB, Cook KL, Ghosh A, Isenberg JS, Roberts DDMatrix biology : journal of the International Society for Matrix BiologySoto-Pantoja DR, Shih HB, Maxhimer JB, Cook KL, Ghosh A, Isenberg JS, Roberts DD. Thrombospondin-1 and CD47 signaling regulate healing of thermal injury in mice. Matrix Biol. 2014 Jul; 37:25-34.Matrix Biol2014-05-17T00:00:002014Thrombospondin-1 and CD47 signaling regulate healing of thermal injury in mice.26799652Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et alAutophagyKlionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222.Autophagy2016-01-01T00:00:002016Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).27698188Cook KL, Soto-Pantoja DR, Clarke PA, Cruz MI, Zwart A, Wärri A, Hilakivi-Clarke L, Roberts DD, Clarke RCancer researchCook KL, Soto-Pantoja DR, Clarke PA, Cruz MI, Zwart A, Wärri A, Hilakivi-Clarke L, Roberts DD, Clarke R. Endoplasmic Reticulum Stress Protein GRP78 Modulates Lipid Metabolism to Control Drug Sensitivity and Antitumor Immunity in Breast Cancer. Cancer Res. 2016 10 01; 76(19):5657-5670.Cancer Res2016-10-01T00:00:002016Endoplasmic Reticulum Stress Protein GRP78 Modulates Lipid Metabolism to Control Drug Sensitivity and Antitumor Immunity in Breast Cancer.Authorship 531141Authorship 531151802Authorship 531162Authorship 53117226311851Miller TW, Soto-Pantoja DR, Schwartz AL, Sipes JM, DeGraff WG, Ridnour LA, Wink DA, Roberts DDThe Journal of biological chemistryMiller TW, Soto-Pantoja DR, Schwartz AL, Sipes JM, DeGraff WG, Ridnour LA, Wink DA, Roberts DD. CD47 Receptor Globally Regulates Metabolic Pathways That Control Resistance to Ionizing Radiation. J Biol Chem. 2015 Oct 09; 290(41):24858-74.J Biol Chem2015-08-26T00:00:002015CD47 Receptor Globally Regulates Metabolic Pathways That Control Resistance to Ionizing Radiation.27239962Soto-Pantoja DR, Sipes JM, Martin-Manso G, Westwood B, Morris NL, Ghosh A, Emenaker NJ, Roberts DDOncogenesisSoto-Pantoja DR, Sipes JM, Martin-Manso G, Westwood B, Morris NL, Ghosh A, Emenaker NJ, Roberts DD. Dietary fat overcomes the protective activity of thrombospondin-1 signaling in the Apc(Min/+) model of colon cancer. Oncogenesis. 2016 May 30; 5(5):e230.Oncogenesis2016-05-30T00:00:002016Dietary fat overcomes the protective activity of thrombospondin-1 signaling in the Apc(Min/+) model of colon cancer.ChristopherSchaichChristopher L. Schaich PhD36.09032400000000-80.266491000000002062Schaich, ChristopherAssistant ProfessorAuthorship 542255Authorship 542262Authorship 54227125510468Priya MK, Sahu G, Soto-Pantoja DR, Goldy N, Sundaresan AM, Jadhav V, Barathkumar TR, Saran U, Jaffar Ali BM, Roberts DD, Bera AK, Chatterjee SAngiogenesisPriya MK, Sahu G, Soto-Pantoja DR, Goldy N, Sundaresan AM, Jadhav V, Barathkumar TR, Saran U, Jaffar Ali BM, Roberts DD, Bera AK, Chatterjee S. Tipping off endothelial tubes: nitric oxide drives tip cells. Angiogenesis. 2015 Apr; 18(2):175-89.Angiogenesis2014-12-16T00:00:002014Tipping off endothelial tubes: nitric oxide drives tip cells.25990221Ridnour LA, Cheng RY, Weiss JM, Kaur S, Soto-Pantoja DR, Basudhar D, Heinecke JL, Stewart CA, DeGraff W, Sowers AL, Thetford A, Kesarwala AH, Roberts DD, Young HA, Mitchell JB, Trinchieri G, Wiltrout RH, Wink DACancer researchRidnour LA, Cheng RY, Weiss JM, Kaur S, Soto-Pantoja DR, Basudhar D, Heinecke JL, Stewart CA, DeGraff W, Sowers AL, Thetford A, Kesarwala AH, Roberts DD, Young HA, Mitchell JB, Trinchieri G, Wiltrout RH, Wink DA. NOS Inhibition Modulates Immune Polarization and Improves Radiation-Induced Tumor Growth Delay. Cancer Res. 2015 Jul 15; 75(14):2788-99.Cancer Res2015-05-19T00:00:002015NOS Inhibition Modulates Immune Polarization and Improves Radiation-Induced Tumor Growth Delay.2019-08-31NIHSOTO PANTOJA, DAVID R2015-09-01Therapeutic targeting of CD47 regulates tumor cell bioenergetics and mitophagyK22CA181274Principal Investigator24Assistant ProfessorAuthorship 67549Authorship 67550David R. Soto-Pantoja, Elisabeth A. Tallant, Patricia E. Gallagher
HypertensionDavid R. Soto-Pantoja, Elisabeth A. Tallant, Patricia E. Gallagher
. Muscadine Grape Extract Prevents Cardiac Cell Cytotoxicity Due to Oxidative Stress by Enhancing Mitochondrial Function. Hypertension. 2019; 74(Suppl_1):AP2007.2019-09-14T00:00:002019Muscadine Grape Extract Prevents Cardiac Cell Cytotoxicity Due to Oxidative Stress by Enhancing Mitochondrial FunctionElizabeth Stirling, Adam Wilson, Mitra Kooshki, Liliya Yamaleyeva, Guanxu Jin, Wei Zhang, Lance Miller, Pierre Triozzi, David Soto-PantojaJournal for ImmunoTherapy of CancerElizabeth Stirling, Adam Wilson, Mitra Kooshki, Liliya Yamaleyeva, Guanxu Jin, Wei Zhang, Lance Miller, Pierre Triozzi, David Soto-Pantoja. The Thrombospondin-1/CD47 signaling axis serve as potential
markers of immune checkpoint blockade response modulating
immune cell bioenergetics in the tumor microenvironment. Journal for ImmunoTherapy of Cancer. 2019; 7(Suppl 1):190:O8.2019-11-06T00:00:002019The Thrombospondin-1/CD47 signaling axis serve as potential
markers of immune checkpoint blockade response modulating
immune cell bioenergetics in the tumor microenvironmentAuthorship 67552Authorship 67553Authorship 67554Authorship 67555Authorship 67556Authorship 67558Authorship 67559Authorship 67560Authorship 67561Authorship 67562Authorship 67563Authorship 67564Authorship 67565Patricia E. Gallagher, Alison L. Arter, David R. Soto-Pantoja, and E. Ann TallantAACR; Cancer Res 2013Patricia E. Gallagher, Alison L. Arter, David R. Soto-Pantoja, and E. Ann Tallant. Angiotensin-(1-7) attenuates triple-negative breast cancer growth and progression through regulation of protein phosphatases. AACR; Cancer Res 2013. 2013; 73(3 Suppl):Abstract nr C66.2013-02-01T00:00:002013Angiotensin-(1-7) attenuates triple-negative breast cancer growth and progression through regulation of protein phosphatasesDavid R. Soto-Pantoja, John M. Sipes, Nicole Morris, Nancy J. Emmenaker, and David D. RobertsAACR; Cancer Res David R. Soto-Pantoja, John M. Sipes, Nicole Morris, Nancy J. Emmenaker, and David D. Roberts. Thrombospondin-1 regulates energy metabolism to increase carcinogenesis in an in vivo model of colorectal cancer. AACR; Cancer Res. 2015; 75(15 Suppl):Abstract nr 1202.2015-08-01T00:00:002015Thrombospondin-1 regulates energy metabolism to increase carcinogenesis in an in vivo model of colorectal cancerDR Soto-Pantoja, W Petty, PE Gallagher, and E TallantCancer Res DR Soto-Pantoja, W Petty, PE Gallagher, and E Tallant. Angiotensin-(1-7) inhibits triple negative tumor growth through the inhibition of angiogenesis and a reduction in placental growth factor PlGF. Cancer Res. 2009; 69(2 Suppl):Abstract nr 901.2009-01-01T00:00:002009Angiotensin-(1-7) inhibits triple negative tumor growth through the inhibition of angiogenesis and a reduction in placental growth factor PlGFKatherine L. Cook, Anni Warri, Rong Hu, Lu Jin, Alan Zwart, David R. Soto Pantoja, Jie Liu, Toren Finkel, and Robert ClarkeAACR; Cancer Res Katherine L. Cook, Anni Warri, Rong Hu, Lu Jin, Alan Zwart, David R. Soto Pantoja, Jie Liu, Toren Finkel, and Robert Clarke. Autophagy and unfolded protein response (UPR) signaling regulates progression of apoptosis in mammary gland involution. AACR; Cancer Res. 2013; 73(8 Suppl):Abstract nr 1667.2013-04-01T00:00:002013Autophagy and unfolded protein response (UPR) signaling regulates progression of apoptosis in mammary gland involutionDavid R. Soto Pantoja, E. Ann Tallant, and Patricia E. GallagherProc Amer Assoc Cancer ResDavid R. Soto Pantoja, E. Ann Tallant, and Patricia E. Gallagher. Inhibition of human breast cancer cell growth by angiotensin-(1–7). Proc Amer Assoc Cancer Res. 2004; 45:Abstr 3824.2004-04-01T00:00:002004Inhibition of human breast cancer cell growth by angiotensin-(1–7)Ashley A. Smith, Adam S. Wilson, and David R. Soto-PantojaAACR; Cancer Res Ashley A. Smith, Adam S. Wilson, and David R. Soto-Pantoja. Targeting CD47 expression on macrophages regulates immunometabolism enhancing tumoricidal activity against cancer cells. AACR; Cancer Res. 2017; 77(13 Suppl):Abstract nr 5661.2017-07-01T00:00:002017Targeting CD47 expression on macrophages regulates immunometabolism enhancing tumoricidal activity against cancer cellsKL Cook, A Wilson, B Westwood, and DR Soto-PantojaAACR; Cancer Res KL Cook, A Wilson, B Westwood, and DR Soto-Pantoja. Targeting of the unfolded protein response signaling arms differentially regulates macrophage proliferation, plasticity, and breast cancer cell clearance. AACR; Cancer Res. 2017; 77(4 Suppl):Abstract nr P2-04-06.2017-02-01T00:00:002017Targeting of the unfolded protein response signaling arms differentially regulates macrophage proliferation, plasticity, and breast cancer cell clearanceDavid D. Roberts, Ashley Smith, John M. Sipes, Adam Wilson, Lesley Mathews-Griner, Rajarshi Guha, Craig J. Thomas, Marc Ferrer, and David R. Soto-PantojaAACR; Cancer Res David D. Roberts, Ashley Smith, John M. Sipes, Adam Wilson, Lesley Mathews-Griner, Rajarshi Guha, Craig J. Thomas, Marc Ferrer, and David R. Soto-Pantoja. High-throughput matrix screening reveals synergistic chemotherapeutic combinations with blockade of CD47 to enhance cytotoxicity in breast cancer. AACR; Cancer Res. 2016; 76(14 Suppl):Abstract nr 1352.2016-07-01T00:00:002016High-throughput matrix screening reveals synergistic chemotherapeutic combinations with blockade of CD47 to enhance cytotoxicity in breast cancerDavid R. Soto-Pantoja, John M. Sipes, Arunima Ghosh, Maria J. Merino, and David D. RobertsAACR; Cancer Res David R. Soto-Pantoja, John M. Sipes, Arunima Ghosh, Maria J. Merino, and David D. Roberts. Therapeutic targeting of CD47 regulates cell bioenergetics and autophagy to reduce breast tumor growth and protect against anthracycline-mediated cardiac toxicity. AACR; Cancer Res. 2014; 74(19 Suppl):Abstract nr 2434.2014-04-01T00:00:002014Therapeutic targeting of CD47 regulates cell bioenergetics and autophagy to reduce breast tumor growth and protect against anthracycline-mediated cardiac toxicityYismelin R. Feliz-Mosquea, Elizabeth Stirling, Katherine L. Cook, Adam Wilson, Manish Bharadwaj, Anthony J. Molina, Liliya Yamaleyeva, Pierre L. Triozzi, and David R. Soto-PantojaAACR; Cancer ResYismelin R. Feliz-Mosquea, Elizabeth Stirling, Katherine L. Cook, Adam Wilson, Manish Bharadwaj, Anthony J. Molina, Liliya Yamaleyeva, Pierre L. Triozzi, and David R. Soto-Pantoja. Anti-CD47 immunotherapy regulates T cell metabolism and hypoxia in the tumor microenvironment. AACR; Cancer Res. 2018; 78(13 Suppl):Abstract nr 3528.2018-07-01T00:00:002018Anti-CD47 immunotherapy regulates T cell metabolism and hypoxia in the tumor microenvironmentDavid R. Soto-Pantoja, Yismeilin R. Feliz-Mosquea, Kenysha YJ Clear, Adam S. Wilson, and Katherine L. CookAACR; Cancer Res David R. Soto-Pantoja, Yismeilin R. Feliz-Mosquea, Kenysha YJ Clear, Adam S. Wilson, and Katherine L. Cook. Targeting PKR-like endoplasmic reticulum kinase modulates metabolism to promote T-cell effector function and PD1 immunotherapy responsiveness. AACR; Cancer Res. 2018; 78(13 Suppl):Abstract nr 449.2018-07-01T00:00:002018Targeting PKR-like endoplasmic reticulum kinase modulates metabolism to promote T-cell effector function and PD1 immunotherapy responsivenessDavid R. Soto-Pantoja, Patricia E. Gallagher, and E. Ann TallantProc Amer Assoc Cancer ResDavid R. Soto-Pantoja, Patricia E. Gallagher, and E. Ann Tallant. Inhibition of angiogenesis by angiotensin-(1-7). Proc Amer Assoc Cancer Res. 2006; 47:Abstr 950.2006-04-01T00:00:002006Inhibition of angiogenesis by angiotensin-(1-7)David R. Soto-Pantoja, John M. Sipes, Brian Westwood, Nicole Morris, Nancy J. Emenaker, and David D. RobertsAACR; Cancer Res David R. Soto-Pantoja, John M. Sipes, Brian Westwood, Nicole Morris, Nancy J. Emenaker, and David D. Roberts. Thrombospondin-1 regulates intestinal microbiota and bile acid metabolism in a murine model of colorectal cancer. AACR; Cancer Res. 2017; 77(13 Suppl):Abstract nr LB-213.2017-07-01T00:00:002017Thrombospondin-1 regulates intestinal microbiota and bile acid metabolism in a murine model of colorectal cancerAuthorship 67567Authorship 67568Authorship 67569Authorship 67570Authorship 67571Authorship 67572Authorship 67573Authorship 67574Authorship 67575David R. Soto Pantoja, Terabe Masaki, Lisa A. Ridnour, William DeGraff, Jay A. Berzofsky, and David D. RobertsAACR; Cancer Res David R. Soto Pantoja, Terabe Masaki, Lisa A. Ridnour, William DeGraff, Jay A. Berzofsky, and David D. Roberts. Lack of CD47 in the tumor microenvironment enhances anti-tumor adaptive immune responses when combined with ionizing radiation. AACR; Cancer Res. 2012; 72(8 Suppl):Abstract nr 3451.2012-04-01T00:00:002012Lack of CD47 in the tumor microenvironment enhances anti-tumor adaptive immune responses when combined with ionizing radiationNancy J. Emenaker, David R. Soto Pantoja, David D. Roberts
FASEB JNancy J. Emenaker, David R. Soto Pantoja, David D. Roberts
. Lack of thrombospondin-1 increases tumorigenesis and decreases survival of in a new mouse model of colorectal cancer. FASEB J. 2012; 26(1).2012-04-01T00:00:002012Lack of thrombospondin-1 increases tumorigenesis and decreases survival of in a new mouse model of colorectal cancerNancy Emenaker, David Soto Pantoja, Michael Snipes, Niccole Morris, David Roberts
FASEB JNancy Emenaker, David Soto Pantoja, Michael Snipes, Niccole Morris, David Roberts
. Thrombospondin-1 Regulates Hepatic Lipid and Energy Metabolism to Increase Carcinogenesis in an In Vivo Model of Colorectal Cancer. FASEB J. 2015; 29(1):394.1.2015-04-01T00:00:002015Thrombospondin-1 Regulates Hepatic Lipid and Energy Metabolism to Increase Carcinogenesis in an In Vivo Model of Colorectal CancerDavid Soto-Pantoja, Nildris Cruz-Diaz, Mark C Chappell
HypertensionDavid Soto-Pantoja, Nildris Cruz-Diaz, Mark C Chappell
. Angiotensin-(1-7) Preserves Mitochondrial Function in Doxorubicin-exposed Renal Epithelial Cells. Hypertension. 2017; 70(Suppl_1):AP411.2017-09-14T00:00:002017Angiotensin-(1-7) Preserves Mitochondrial Function in Doxorubicin-exposed Renal Epithelial CellsJyotsana Menon, Mark Miller, David Soto-Pantoja, Michael Callahan, E. Ann Tallant, and Patricia GallagherAACR Jyotsana Menon, Mark Miller, David Soto-Pantoja, Michael Callahan, E. Ann Tallant, and Patricia Gallagher. Angiotensin-(1-7) reduces lung tumor incidence in a novel bitransgenic Ki-rasG12C mouse model of lung tumorigenesis through a reduction in cyclooxygenase-2. AACR. 2008; 68(9 Suppl):Abstract 4654 .2008-05-01T00:00:002008Angiotensin-(1-7) reduces lung tumor incidence in a novel bitransgenic Ki-rasG12C mouse model of lung tumorigenesis through a reduction in cyclooxygenase-2David Soto-Pantoja, Jyotsana Menon, Patricia Gallagher, and E. Ann TallantProceedings of the 99th Annual Meeting of the American Association for Cancer Research; AACRDavid Soto-Pantoja, Jyotsana Menon, Patricia Gallagher, and E. Ann Tallant. Angiotensin-(1-7) inhibits the growth of human triple negative breast tumors in an orthotopic model. Proceedings of the 99th Annual Meeting of the American Association for Cancer Research; AACR. 2008; 68(9 Suppl):Abstract 2416.2008-05-01T00:00:002008Angiotensin-(1-7) inhibits the growth of human triple negative breast tumors in an orthotopic modelYismeilin R. Feliz Mosquea, David R. Soto Pantoja, Adam Wilson, Pierre L. Triozzi, and Katherine L. CookAACR; Cancer Res Yismeilin R. Feliz Mosquea, David R. Soto Pantoja, Adam Wilson, Pierre L. Triozzi, and Katherine L. Cook. UPR signaling promotes T-cell dysfunction to prevent immune-mediated cancer cell killing and immune checkpoint therapy resistance. AACR; Cancer Res. 2017; 77(13 Suppl):Abstract nr 1704.2017-07-01T00:00:002017UPR signaling promotes T-cell dysfunction to prevent immune-mediated cancer cell killing and immune checkpoint therapy resistanceKL Cook, D Soto Pantoja, P Gallagher, and E TallantCancer Res KL Cook, D Soto Pantoja, P Gallagher, and E Tallant. Angiotensin-(1-7) inhibition of human breast tumors with distinct hormone receptor expression results in a differential regulation of Akt. Cancer Res. 2009; 69(2 Suppl):Abstract nr 3127.2009-01-01T00:00:002009Angiotensin-(1-7) inhibition of human breast tumors with distinct hormone receptor expression results in a differential regulation of AktPatricia E. Gallagher, David R. Soto-Pantoja, E. Ann TallantHypertensionPatricia E. Gallagher, David R. Soto-Pantoja, E. Ann Tallant. Angiotensin-(1–7) Reduces Endothelial Cell Growth and Migration and Increases VEGI to Inhibit Angiogenesis. Hypertension. 2008; 52(4):e72;P080.2008-10-01T00:00:002008Angiotensin-(1–7) Reduces Endothelial Cell Growth and Migration and Increases VEGI to Inhibit Angiogenesis2022-03-31NIHSOTO PANTOJA, DAVID R2020-04-01Combinatorial Strategies for the Treatment of Brain MetastasesR21CA249349Principal InvestigatorAuthorship 68077David Soto-Pantoja, Kenysha Clear, Katherine Loree CookCancer ResDavid Soto-Pantoja, Kenysha Clear, Katherine Loree Cook. Targeting the unfolded protein response components differentially sensitizes breast tumors to doxorubicin while modulating chemotherapy-induced cardiotoxicities. Cancer Res. 2020; 80(4 Suppl):P5-14-19.2020-02-01T00:00:002020Targeting the unfolded protein response components differentially sensitizes breast tumors to doxorubicin while modulating chemotherapy-induced cardiotoxicitiesAuthorship 68531David R.Soto-Pantoja, Kenysha Y.J. Clear, Adam S. Wilson, Greg Kucera, Edward Levine, Akiko Chiba, Katherine L. CookAACR;Cancer ResDavid R.Soto-Pantoja, Kenysha Y.J. Clear, Adam S. Wilson, Greg Kucera, Edward Levine, Akiko Chiba, Katherine L. Cook. Entero-mammary microbiota signaling axis regulates dietary influences on breast cancer risk. AACR;Cancer Res. 2020; 80(8 Suppl):31: PR11.2020-04-01T00:00:002020Entero-mammary microbiota signaling axis regulates dietary influences on breast cancer riskAuthorship 68662Authorship 68663Authorship 68664Soto-Pantoja DR, Isenberg JS, Roberts DD. Therapeutic applications of morpholino oligonucleotides. In Templeton, N. S. (Ed) Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, 4th Edition, CRC PressSoto-Pantoja DR, Isenberg JS, Roberts DD. . Therapeutic applications of morpholino oligonucleotides. In Templeton, N. S. (Ed) Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, 4th Edition, CRC Press. 2017.2017-06-01T00:00:002017Therapeutic applications of morpholino oligonucleotides. In Templeton, N. S. (Ed) Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, 4th Edition, CRC PressRoberts D.D., Isenberg J.S., Soto-Pantoja D.R CD47. In: Choi S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_573Roberts D.D., Isenberg J.S., Soto-Pantoja D.R . CD47. In: Choi S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_573. 2018.2018-06-01T00:00:002018CD47. In: Choi S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_573Roberts D.D., Kaur S., Soto-Pantoja D.RThrombospondin-1. In: Choi S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_637Roberts D.D., Kaur S., Soto-Pantoja D.R. Thrombospondin-1. In: Choi S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_637. 2018.2018-06-01T00:00:002018Thrombospondin-1. In: Choi S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_637Authorship 68866Qianqian Song, Elizabeth Forbes, Lance D. Miller, Pierre L. Triozzi, Liang Liu, Wei Zhang and David R. Soto-PantojaAACR; Cancer Res Qianqian Song, Elizabeth Forbes, Lance D. Miller, Pierre L. Triozzi, Liang Liu, Wei Zhang and David R. Soto-Pantoja. Single-cell liquid biopsy reveals circulating heterogeneity and converging subpopulations in relation to immunotherapy response in melanoma. AACR; Cancer Res. 2020; 80(21_Suppl):Abstract nr PO-127.2020-11-01T00:00:002020Single-cell liquid biopsy reveals circulating heterogeneity and converging subpopulations in relation to immunotherapy response in melanomaInternal Medicine, RheumatologySurgery, HypertensionSurgery, TraumaUrologyWake Forest Institute for Regenerative Medicinehttp://www.wfirm.orgWFIRMAuthorship 73737Authorship 73738Authorship 73766Katherine L. Cook; Adam S Wilson; David R Soto-Pantoja; Bruce F. Kimler; Shahid Umar; Carol J. FabianOmega-3 polyunsaturated fatty acid supplementation shifts the gut and breast microbiome to influence inflammation. Cancer ResKatherine L. Cook; Adam S Wilson; David R Soto-Pantoja; Bruce F. Kimler; Shahid Umar; Carol J. Fabian. Omega-3 polyunsaturated fatty acid supplementation shifts the gut and breast microbiome to influence inflammation. Cancer Res. 2022; 82(4_Suppl):P1-09-03.2022-02-15T00:00:002022Omega-3 polyunsaturated fatty acid supplementation shifts the gut and breast microbiome to influence inflammation. Cancer ResStirling ER, Bronson SM, Crowe WN, Wilson A, Kooshki M, Zhao D, Triozzi PL, Lesser GJ, Soto-Pantoja DR.BSCI-17. Targeting SIRPa as a therapeutic strategy for the treatment of breast cancer brain metastasis. Neurooncol Adv.Stirling ER, Bronson SM, Crowe WN, Wilson A, Kooshki M, Zhao D, Triozzi PL, Lesser GJ, Soto-Pantoja DR. BSCI-17. Targeting SIRPa as a therapeutic strategy for the treatment of breast cancer brain metastasis. Neurooncol Adv. 2021; v.3(Suppl_3):iii4. doi: 10.1093/noajnl/vdab.2021-08-09T00:00:002021BSCI-17. Targeting SIRPa as a therapeutic strategy for the treatment of breast cancer brain metastasis. Neurooncol AdvStirling, E.R., Soto-Pantoja, D.RIn Vitro Cell Impedance Assay to Examine Antigen-Specific T-Cell-Mediated Melanoma Cell Killing to Support Cancer Immunotherapy Drug Discovery. In: Deep, G. (eds) Cancer Biomarkers. Methods in Molecular Biology, vol 2413. Humana, New York, NY. Stirling, E.R., Soto-Pantoja, D.R. In Vitro Cell Impedance Assay to Examine Antigen-Specific T-Cell-Mediated Melanoma Cell Killing to Support Cancer Immunotherapy Drug Discovery. In: Deep, G. (eds) Cancer Biomarkers. Methods in Molecular Biology, vol 2413. Humana, New York, NY. 2022.2022-01-19T00:00:002022In Vitro Cell Impedance Assay to Examine Antigen-Specific T-Cell-Mediated Melanoma Cell Killing to Support Cancer Immunotherapy Drug Discovery. In: Deep, G. (eds) Cancer Biomarkers. Methods in Molecular Biology, vol 2413. Humana, New York, NY2Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professor3Associate ProfessorAssociate Professortrue1Professor EmeritusProfessor Emeritustrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessorD019700Chemicals & Drugs660.995296Thrombospondin 1D014945Physiology821800.889939Wound HealingD002056Disorders39970.902393BurnsD015398Physiology1676070.76081Signal Transduction