ThomasShupeThomas D. Shupe PhD36.08943500000000-80.26863200000000995Shupe, ThomasDAssociate Professorprns:coAuthorOfcoauthor ofFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonHerbertBonkovskyHerbert L. Bonkovsky MD36.09032400000000-80.266491000000001707Bonkovsky, HerbertProfessorAuthorship 409911025433603Ko IK, Peng L, Peloso A, Smith CJ, Dhal A, Deegan DB, Zimmerman C, Clouse C, Zhao W, Shupe TD, Soker S, Yoo JJ, Atala ABiomaterialsKo IK, Peng L, Peloso A, Smith CJ, Dhal A, Deegan DB, Zimmerman C, Clouse C, Zhao W, Shupe TD, Soker S, Yoo JJ, Atala A. Bioengineered transplantable porcine livers with re-endothelialized vasculature. Biomaterials. 2015 Feb; 40:72-9.Biomaterials2014-11-26T00:00:002014Bioengineered transplantable porcine livers with re-endothelialized vasculature.Wake Forest School of MedicineYuanyuanZhangYuanyuan Zhang MD, PhD36.08943500000000-80.268632000000001063Zhang, YuanyuanAssociate ProfessorColinBishopColin E. Bishop PhD36.08943500000000-80.26863200000000122Bishop, ColinProfessorGiuseppeOrlandoGiuseppe Orlando MD, PhD36.08959100000000-80.268599000000001226Orlando, GiuseppeAssociate ProfessorJohnJacksonJohn D. Jackson PhD, MS36.08943500000000-80.268632000000001267Jackson, JohnProfessorAnthonyAtalaAnthony Atala MD36.08943500000000-80.268632000000003Atala, AnthonyProfessorJamesYooJames J. Yoo MD, PhD36.08943500000000-80.26863200000000500Yoo, JamesProfessorShaySokerShay Soker PhD36.08943500000000-80.26863200000000939Soker, ShayProfessor2.370190.0134143192research areas1.292550.02699912coauthor of130.1993.1297550similar to1132selected publicationsIckheeKimIckhee Kim MD, PhD36.08943500000000-80.268632000000001734Kim, IckheeInstructorAuthorship 34827423747949Mirmalek-Sani SH, Sullivan DC, Zimmerman C, Shupe TD, Petersen BEThe American journal of pathologyMirmalek-Sani SH, Sullivan DC, Zimmerman C, Shupe TD, Petersen BE. Immunogenicity of decellularized porcine liver for bioengineered hepatic tissue. Am J Pathol. 2013 Aug; 183(2):558-65.Am J Pathol2013-06-07T00:00:002013Immunogenicity of decellularized porcine liver for bioengineered hepatic tissue.Young MinJuYoung Min Ju PhD36.08943500000000-80.268632000000001787Ju, Young MinAssistant ProfessorAuthorship 42646125953495Shupe TD, Petersen BEHepatology (Baltimore, Md.)Shupe TD, Petersen BE. Liver regeneration: A consequence of complex, well-orchestrated signals. Hepatology. 2015 Aug; 62(2):644-5.Hepatology2015-06-19T00:00:002015Liver regeneration: A consequence of complex, well-orchestrated signals.Authorship 46493626210285Skardal A, Devarasetty M, Kang HW, Mead I, Bishop C, Shupe T, Lee SJ, Jackson J, Yoo J, Soker S, Atala AActa biomaterialiaSkardal A, Devarasetty M, Kang HW, Mead I, Bishop C, Shupe T, Lee SJ, Jackson J, Yoo J, Soker S, Atala A. A hydrogel bioink toolkit for mimicking native tissue biochemical and mechanical properties in bioprinted tissue constructs. Acta Biomater. 2015 Oct; 25:24-34.Acta Biomater2015-07-22T00:00:002015A hydrogel bioink toolkit for mimicking native tissue biochemical and mechanical properties in bioprinted tissue constructs.SeanMurphySean V. Murphy PhD36.08943500000000-80.268632000000001840Murphy, SeanAssociate ProfessorAuthorship 47489526569044Deegan DB, Zimmerman C, Skardal A, Atala A, Shupe TDJournal of the mechanical behavior of biomedical materialsDeegan DB, Zimmerman C, Skardal A, Atala A, Shupe TD. Stiffness of hyaluronic acid gels containing liver extracellular matrix supports human hepatocyte function and alters cell morphology. J Mech Behav Biomed Mater. 2015 Mar; 55:87-103.J Mech Behav Biomed Mater2015-10-30T00:00:002015Stiffness of hyaluronic acid gels containing liver extracellular matrix supports human hepatocyte function and alters cell morphology.Authorship 481991226756674Bhise NS, Manoharan V, Massa S, Tamayol A, Ghaderi M, Miscuglio M, Lang Q, Shrike Zhang Y, Shin SR, Calzone G, Annabi N, Shupe TD, Bishop CE, Atala A, Dokmeci MR, Khademhosseini ABiofabricationBhise NS, Manoharan V, Massa S, Tamayol A, Ghaderi M, Miscuglio M, Lang Q, Shrike Zhang Y, Shin SR, Calzone G, Annabi N, Shupe TD, Bishop CE, Atala A, Dokmeci MR, Khademhosseini A. A liver-on-a-chip platform with bioprinted hepatic spheroids. Biofabrication. 2016 Jan 12; 8(1):014101.Biofabrication2016-01-12T00:00:002016A liver-on-a-chip platform with bioprinted hepatic spheroids.Authorship 49003727166839Skardal A, Devarasetty M, Kang HW, Seol YJ, Forsythe SD, Bishop C, Shupe T, Soker S, Atala AJournal of visualized experiments : JoVESkardal A, Devarasetty M, Kang HW, Seol YJ, Forsythe SD, Bishop C, Shupe T, Soker S, Atala A. Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink. J Vis Exp. 2016 Apr 21; (110):e53606.J Vis Exp2016-04-21T00:00:002016Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink.Authorship 50074227422270Skardal A, Shupe T, Atala ADrug discovery todaySkardal A, Shupe T, Atala A. Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling. Drug Discov Today. 2016 09; 21(9):1399-1411.Drug Discov Today2016-07-12T00:00:002016Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling.Authorship 504711227710832Zhang YS, Arneri A, Bersini S, Shin SR, Zhu K, Goli-Malekabadi Z, Aleman J, Colosi C, Busignani F, Dell'Erba V, Bishop C, Shupe T, Demarchi D, Moretti M, Rasponi M, Dokmeci MR, Atala A, Khademhosseini ABiomaterialsZhang YS, Arneri A, Bersini S, Shin SR, Zhu K, Goli-Malekabadi Z, Aleman J, Colosi C, Busignani F, Dell'Erba V, Bishop C, Shupe T, Demarchi D, Moretti M, Rasponi M, Dokmeci MR, Atala A, Khademhosseini A. Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip. Biomaterials. 2016 12; 110:45-59.Biomaterials2016-09-05T00:00:002016Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip.Authorship 51503621927552Darwiche H, Oh SH, Steiger-Luther NC, Williams JM, Pintilie DG, Shupe TD, Petersen BEHepatic medicine : evidence and researchDarwiche H, Oh SH, Steiger-Luther NC, Williams JM, Pintilie DG, Shupe TD, Petersen BE. Inhibition of Notch signaling affects hepatic oval cell response in rat model of 2AAF-PH. Hepat Med. 2011 Sep 01; 3:89-98.Hepat Med2011-09-01T00:00:002011Inhibition of Notch signaling affects hepatic oval cell response in rat model of 2AAF-PH.Authorship 532552728265064Zhang YS, Aleman J, Shin SR, Kilic T, Kim D, Mousavi Shaegh SA, Massa S, Riahi R, Chae S, Hu N, Avci H, Zhang W, Silvestri A, Sanati Nezhad A, Manbohi A, De Ferrari F, Polini A, Calzone G, Shaikh N, Alerasool P, Budina E, Kang J, Bhise N, Ribas J, Pourmand A, Skardal A, Shupe T, Bishop CE, Dokmeci MR, Atala A, Khademhosseini AProceedings of the National Academy of Sciences of the United States of AmericaZhang YS, Aleman J, Shin SR, Kilic T, Kim D, Mousavi Shaegh SA, Massa S, Riahi R, Chae S, Hu N, Avci H, Zhang W, Silvestri A, Sanati Nezhad A, Manbohi A, De Ferrari F, Polini A, Calzone G, Shaikh N, Alerasool P, Budina E, Kang J, Bhise N, Ribas J, Pourmand A, Skardal A, Shupe T, Bishop CE, Dokmeci MR, Atala A, Khademhosseini A. Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors. Proc Natl Acad Sci U S A. 2017 03 21; 114(12):E2293-E2302.Proc Natl Acad Sci U S A2017-03-06T00:00:002017Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors.Authorship 553331228821762Skardal A, Murphy SV, Devarasetty M, Mead I, Kang HW, Seol YJ, Shrike Zhang Y, Shin SR, Zhao L, Aleman J, Hall AR, Shupe TD, Kleensang A, Dokmeci MR, Jin Lee S, Jackson JD, Yoo JJ, Hartung T, Khademhosseini A, Soker S, Bishop CE, Atala AScientific reportsSkardal A, Murphy SV, Devarasetty M, Mead I, Kang HW, Seol YJ, Shrike Zhang Y, Shin SR, Zhao L, Aleman J, Hall AR, Shupe TD, Kleensang A, Dokmeci MR, Jin Lee S, Jackson JD, Yoo JJ, Hartung T, Khademhosseini A, Soker S, Bishop CE, Atala A. Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform. Sci Rep. 2017 08 18; 7(1):8837.Sci Rep2017-08-18T00:00:002017Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform.Authorship 55816328644395Devarasetty M, Forsythe S, Shupe TD, Soker S, Bishop CE, Atala A, Skardal ABiosensorsDevarasetty M, Forsythe S, Shupe TD, Soker S, Bishop CE, Atala A, Skardal A. Optical Tracking and Digital Quantification of Beating Behavior in Bioengineered Human Cardiac Organoids. Biosensors (Basel). 2017 Jun 23; 7(3).Biosensors (Basel)2017-06-23T00:00:002017Optical Tracking and Digital Quantification of Beating Behavior in Bioengineered Human Cardiac Organoids.Authorship 584912Authorship 58817330009571Hunsberger JG, Shupe T, Atala AStem cells translational medicineHunsberger JG, Shupe T, Atala A. An Industry-Driven Roadmap for Manufacturing in Regenerative Medicine. Stem Cells Transl Med. 2018 08; 7(8):564-568.Stem Cells Transl Med2018-07-15T00:00:002018An Industry-Driven Roadmap for Manufacturing in Regenerative Medicine.29755963Forsythe SD, Devarasetty M, Shupe T, Bishop C, Atala A, Soker S, Skardal AFrontiers in public healthForsythe SD, Devarasetty M, Shupe T, Bishop C, Atala A, Soker S, Skardal A. Environmental Toxin Screening Using Human-Derived 3D Bioengineered Liver and Cardiac Organoids. Front Public Health. 2018; 6:103.Front Public Health2018-04-16T00:00:002018Environmental Toxin Screening Using Human-Derived 3D Bioengineered Liver and Cardiac Organoids.20ProfessorAuthorship 64683430409188Wan Q, Xiong G, Liu G, Shupe TD, Wei G, Zhang D, Liang D, Lu X, Atala A, Zhang YStem cell research & therapyWan Q, Xiong G, Liu G, Shupe TD, Wei G, Zhang D, Liang D, Lu X, Atala A, Zhang Y. Urothelium with barrier function differentiated from human urine-derived stem cells for potential use in urinary tract reconstruction. Stem Cell Res Ther. 2018 11 08; 9(1):304.Stem Cell Res Ther2018-11-08T00:00:002018Urothelium with barrier function differentiated from human urine-derived stem cells for potential use in urinary tract reconstruction.24Assistant Professor26InstructorInternal Medicine, GastroenterologySurgery, TransplantUrologyWake Forest Institute for Regenerative Medicinehttp://www.wfirm.orgWFIRMAuthorship 118412Authorship 150431Authorship 178233true1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Assistant ProfessorAssistant Professortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1InstructorInstructortrue1ProfessorProfessorAuthorship 205692Authorship 23641Authorship 245154Authorship 263802Authorship 265756Authorship 273703Authorship 279902Authorship 298703Authorship 323381Authorship 36381Authorship 66444Authorship 86692Authorship 9044115940639Pi L, Oh SH, Shupe T, Petersen BEGastroenterologyPi L, Oh SH, Shupe T, Petersen BE. Role of connective tissue growth factor in oval cell response during liver regeneration after 2-AAF/PHx in rats. Gastroenterology. 2005 Jun; 128(7):2077-88.Gastroenterology2005-06-01T00:00:002005Role of connective tissue growth factor in oval cell response during liver regeneration after 2-AAF/PHx in rats.16534498Jung Y, Oh SH, Zheng D, Shupe TD, Witek RP, Petersen BELaboratory investigation; a journal of technical methods and pathologyJung Y, Oh SH, Zheng D, Shupe TD, Witek RP, Petersen BE. A potential role of somatostatin and its receptor SSTR4 in the migration of hepatic oval cells. Lab Invest. 2006 May; 86(5):477-89.Lab Invest2006-05-01T00:00:002006A potential role of somatostatin and its receptor SSTR4 in the migration of hepatic oval cells.17681181Piscaglia AC, Shupe TD, Oh SH, Gasbarrini A, Petersen BEGastroenterologyPiscaglia AC, Shupe TD, Oh SH, Gasbarrini A, Petersen BE. Granulocyte-colony stimulating factor promotes liver repair and induces oval cell migration and proliferation in rats. Gastroenterology. 2007 Aug; 133(2):619-31.Gastroenterology2007-05-21T00:00:002007Granulocyte-colony stimulating factor promotes liver repair and induces oval cell migration and proliferation in rats.18375039Ellor S, Shupe T, Petersen BExperimental hematologyEllor S, Shupe T, Petersen B. Stem cell therapy for inherited metabolic disorders of the liver. Exp Hematol. 2008 Jun; 36(6):716-725.Exp Hematol2008-04-02T00:00:002008Stem cell therapy for inherited metabolic disorders of the liver.19089369Shupe TD, Piscaglia AC, Oh SH, Gasbarrini A, Petersen BEMethods in molecular biology (Clifton, N.J.)Shupe TD, Piscaglia AC, Oh SH, Gasbarrini A, Petersen BE. Isolation and characterization of hepatic stem cells, or "oval cells," from rat livers. Methods Mol Biol. 2009; 482:387-405.Methods Mol Biol2009-01-01T00:00:002009Isolation and characterization of hepatic stem cells, or "oval cells," from rat livers.19446912Piscaglia AC, Shupe TD, Pani G, Tesori V, Gasbarrini A, Petersen BEJournal of hepatologyPiscaglia AC, Shupe TD, Pani G, Tesori V, Gasbarrini A, Petersen BE. Establishment of cancer cell lines from rat hepatocholangiocarcinoma and assessment of the role of granulocyte-colony stimulating factor and hepatocyte growth factor in their growth, motility and survival. J Hepatol. 2009 Jul; 51(1):77-92.J Hepatol2009-04-05T00:00:002009Establishment of cancer cell lines from rat hepatocholangiocarcinoma and assessment of the role of granulocyte-colony stimulating factor and hepatocyte growth factor in their growth, motility and survival.20440274Pintilie DG, Shupe TD, Oh SH, Salganik SV, Darwiche H, Petersen BELaboratory investigation; a journal of technical methods and pathologyPintilie DG, Shupe TD, Oh SH, Salganik SV, Darwiche H, Petersen BE. Hepatic stellate cells' involvement in progenitor-mediated liver regeneration. Lab Invest. 2010 Aug; 90(8):1199-208.Lab Invest2010-05-03T00:00:002010Hepatic stellate cells' involvement in progenitor-mediated liver regeneration.20885860Shupe T, Williams M, Brown A, Willenberg B, Petersen BEOrganogenesisShupe T, Williams M, Brown A, Willenberg B, Petersen BE. Method for the decellularization of intact rat liver. Organogenesis. 2010 Apr-Jun; 6(2):134-6.Organogenesis2010-04-01T00:00:002010Method for the decellularization of intact rat liver.22143342Oh SH, Darwiche H, Cho JH, Shupe T, Petersen BEPancreasOh SH, Darwiche H, Cho JH, Shupe T, Petersen BE. Characterization of a novel functional protein in the pancreatic islet: islet homeostasis protein regulation of glucagon synthesis in a cells. Pancreas. 2012 Jan; 41(1):22-30.Pancreas2012-01-01T00:00:002012Characterization of a novel functional protein in the pancreatic islet: islet homeostasis protein regulation of glucagon synthesis in a cells.22267591Orlando G, DomÃnguez-Bendala J, Shupe T, Bergman C, Bitar KN, Booth C, Carbone M, Koch KL, Lerut JP, Neuberger JM, Petersen B, Ricordi C, Atala A, Stratta RJ, Soker SGutOrlando G, DomÃnguez-Bendala J, Shupe T, Bergman C, Bitar KN, Booth C, Carbone M, Koch KL, Lerut JP, Neuberger JM, Petersen B, Ricordi C, Atala A, Stratta RJ, Soker S. Cell and organ bioengineering technology as applied to gastrointestinal diseases. Gut. 2013 May; 62(5):774-86.Gut2012-01-20T00:00:002012Cell and organ bioengineering technology as applied to gastrointestinal diseases.15019083Shupe T, Sell SToxicology lettersShupe T, Sell S. Low hepatic glutathione S-transferase and increased hepatic DNA adduction contribute to increased tumorigenicity of aflatoxin B1 in newborn and partially hepatectomized mice. Toxicol Lett. 2004 Mar 14; 148(1-2):1-9.Toxicol Lett2004-03-14T00:00:002004Low hepatic glutathione S-transferase and increased hepatic DNA adduction contribute to increased tumorigenicity of aflatoxin B1 in newborn and partially hepatectomized mice.17142863Shupe T, Petersen BEStem cell reviewsShupe T, Petersen BE. Evidence regarding a stem cell origin of hepatocellular carcinoma. Stem Cell Rev. 2005; 1(3):261-4.Stem Cell Rev2005-01-01T00:00:002005Evidence regarding a stem cell origin of hepatocellular carcinoma.18506878Petersen B, Shupe THepatology (Baltimore, Md.)Petersen B, Shupe T. Location is everything: the liver stem cell niche. Hepatology. 2008 Jun; 47(6):1810-2.Hepatology2008-06-01T00:00:002008Location is everything: the liver stem cell niche.19581879Salganik SV, Weinstein DA, Shupe TD, Salganik M, Pintilie DG, Petersen BELaboratory investigation; a journal of technical methods and pathologySalganik SV, Weinstein DA, Shupe TD, Salganik M, Pintilie DG, Petersen BE. A detailed characterization of the adult mouse model of glycogen storage disease Ia. Lab Invest. 2009 Sep; 89(9):1032-42.Lab Invest2009-07-06T00:00:002009A detailed characterization of the adult mouse model of glycogen storage disease Ia.20413689Williams JM, Oh SH, Jorgensen M, Steiger N, Darwiche H, Shupe T, Petersen BEThe American journal of pathologyWilliams JM, Oh SH, Jorgensen M, Steiger N, Darwiche H, Shupe T, Petersen BE. The role of the Wnt family of secreted proteins in rat oval "stem" cell-based liver regeneration: Wnt1 drives differentiation. Am J Pathol. 2010 Jun; 176(6):2732-42.Am J Pathol2010-04-22T00:00:002010The role of the Wnt family of secreted proteins in rat oval "stem" cell-based liver regeneration: Wnt1 drives differentiation.20851776Shupe T, Petersen BEThe international journal of biochemistry & cell biologyShupe T, Petersen BE. Potential applications for cell regulatory factors in liver progenitor cell therapy. Int J Biochem Cell Biol. 2011 Feb; 43(2):214-21.Int J Biochem Cell Biol2010-09-21T00:00:002010Potential applications for cell regulatory factors in liver progenitor cell therapy.D008099Anatomy1134660.776585LiverD022781Anatomy24740.936494HepatocytesD023822Procedures556070.660534Tissue EngineeringD013234Anatomy542920.803961Stem CellsD008115Physiology11230.985899Liver Regeneration