TieLiuTie F. Liu MD, PhD36.09032400000000-80.26649100000000981Liu, TieFuInstructorprns:coAuthorOfcoauthor ofFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson25001863Vachharajani VT, Liu T, Brown CM, Wang X, Buechler NL, Wells JD, Yoza BK, McCall CEJournal of leukocyte biologyVachharajani VT, Liu T, Brown CM, Wang X, Buechler NL, Wells JD, Yoza BK, McCall CE. SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome. J Leukoc Biol. 2014 Nov; 96(5):785-96.J Leukoc Biol2014-07-07T00:00:002014SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome.25088223Vachharajani V, Liu T, McCall CEExpert review of clinical immunologyVachharajani V, Liu T, McCall CE. Epigenetic coordination of acute systemic inflammation: potential therapeutic targets. Expert Rev Clin Immunol. 2014 Sep; 10(9):1141-50.Expert Rev Clin Immunol2014-08-04T00:00:002014Epigenetic coordination of acute systemic inflammation: potential therapeutic targets.25404738Liu TF, Vachharajani V, Millet P, Bharadwaj MS, Molina AJ, McCall CEThe Journal of biological chemistryLiu TF, Vachharajani V, Millet P, Bharadwaj MS, Molina AJ, McCall CE. Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis. J Biol Chem. 2015 Jan 02; 290(1):396-408.J Biol Chem2014-11-17T00:00:002014Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis.AnesthesiologyCancer BiologyWake Forest School of MedicineWilliamPettyWilliam J. Petty MD36.09032400000000-80.266491000000001044Petty, WilliamProfessorBarbaraYozaBarbara K. Yoza PhD36.08959100000000-80.26859900000000113Yoza, BarbaraProfessorXueweiZhuXuewei Zhu PhD36.08943500000000-80.268632000000001224Zhu, XueweiAssociate ProfessorCharlesMcCallCharles E. McCall MD36.09032400000000-80.26649100000000144McCall, CharlesProfessorWaldemarDebinskiWaldemar Debinski MD, PhD36.08959100000000-80.26859900000000201Debinski, WaldemarProfessorKonstantinosVotanopoulosKonstantinos Votanopoulos MD, PhD, FACS36.09032400000000-80.26649100000000555Votanopoulos, KonstantinosProfessorLanceMillerLance D. Miller PhD, MS36.09032400000000-80.26649100000000574Miller, LanceAssistant ProfessorPatriciaGallagherPatricia E. Gallagher PhD36.09032400000000-80.26649100000000751Gallagher, PatriciaProfessorStevenKridelSteven J. Kridel PhD36.09032400000000-80.26649100000000902Kridel, StevenAssociate Professor1.824780.0125307184research areas3.283090.033826710coauthor of1126selected publications25898983Reynolds LM, Ding J, Taylor JR, Lohman K, Soranzo N, de la Fuente A, Liu TF, Johnson C, Barr RG, Register TC, Donohue KM, Talor MV, Cihakova D, Gu C, Divers J, Siscovick D, Burke G, Post W, Shea S, Jacobs DR, Hoeschele I, McCall CE, Kritchevsky SB, Herrington D, Tracy RP, Liu YBMC genomicsReynolds LM, Ding J, Taylor JR, Lohman K, Soranzo N, de la Fuente A, Liu TF, Johnson C, Barr RG, Register TC, Donohue KM, Talor MV, Cihakova D, Gu C, Divers J, Siscovick D, Burke G, Post W, Shea S, Jacobs DR, Hoeschele I, McCall CE, Kritchevsky SB, Herrington D, Tracy RP, Liu Y. Transcriptomic profiles of aging in purified human immune cells. BMC Genomics. 2015 Apr 22; 16:333.BMC Genomics2015-04-22T00:00:002015Transcriptomic profiles of aging in purified human immune cells.Authorship 431582Authorship 431622Authorship 431691Authorship 431847LindsayReynoldsLindsay M. Reynolds PhD1856Reynolds, LindsayAssistant Professor26904696Vachharajani VT, Liu T, Wang X, Hoth JJ, Yoza BK, McCall CEJournal of immunology researchVachharajani VT, Liu T, Wang X, Hoth JJ, Yoza BK, McCall CE. Sirtuins Link Inflammation and Metabolism. J Immunol Res. 2016; 2016:8167273.J Immunol Res2016-01-20T00:00:002016Sirtuins Link Inflammation and Metabolism.Authorship 51379224020005Liu TF, McCall CEGenes & cancerLiu TF, McCall CE. Deacetylation by SIRT1 Reprograms Inflammation and Cancer. Genes Cancer. 2013 Mar; 4(3-4):135-47.Genes Cancer2013-03-01T00:00:002013Deacetylation by SIRT1 Reprograms Inflammation and Cancer.Authorship 352241Authorship 352262Authorship 352281Authorship 352291Authorship 352311Authorship 352342Authorship 352382Authorship 352841Authorship 352951Authorship 352992Authorship 35308112702570Liu TF, Cohen KA, Ramage JG, Willingham MC, Thorburn AM, Frankel AECancer researchLiu TF, Cohen KA, Ramage JG, Willingham MC, Thorburn AM, Frankel AE. A diphtheria toxin-epidermal growth factor fusion protein is cytotoxic to human glioblastoma multiforme cells. Cancer Res. 2003 Apr 15; 63(8):1834-7.Cancer Res2003-04-15T00:00:002003A diphtheria toxin-epidermal growth factor fusion protein is cytotoxic to human glioblastoma multiforme cells.14680969Urieto JO, Liu T, Black JH, Cohen KA, Hall PD, Willingham MC, Pennell LK, Hogge DE, Kreitman RJ, Frankel AEProtein expression and purificationUrieto JO, Liu T, Black JH, Cohen KA, Hall PD, Willingham MC, Pennell LK, Hogge DE, Kreitman RJ, Frankel AE. Expression and purification of the recombinant diphtheria fusion toxin DT388IL3 for phase I clinical trials. Protein Expr Purif. 2004 Jan; 33(1):123-33.Protein Expr Purif2004-01-01T00:00:002004Expression and purification of the recombinant diphtheria fusion toxin DT388IL3 for phase I clinical trials.15671563Liu TF, Hall PD, Cohen KA, Willingham MC, Cai J, Thorburn A, Frankel AEClinical cancer research : an official journal of the American Association for Cancer ResearchLiu TF, Hall PD, Cohen KA, Willingham MC, Cai J, Thorburn A, Frankel AE. Interstitial diphtheria toxin-epidermal growth factor fusion protein therapy produces regressions of subcutaneous human glioblastoma multiforme tumors in athymic nude mice. Clin Cancer Res. 2005 Jan 01; 11(1):329-34.Clin Cancer Res2005-01-01T00:00:002005Interstitial diphtheria toxin-epidermal growth factor fusion protein therapy produces regressions of subcutaneous human glioblastoma multiforme tumors in athymic nude mice.30633362Zhu X, Meyers A, Long D, Ingram B, Liu T, Yoza BK, Vachharajani V, McCall CEJournal of leukocyte biologyZhu X, Meyers A, Long D, Ingram B, Liu T, Yoza BK, Vachharajani V, McCall CE. Frontline Science: Monocytes sequentially rewire metabolism and bioenergetics during an acute inflammatory response. J Leukoc Biol. 2019 02; 105(2):215-228.J Leukoc Biol2019-01-11T00:00:002019Frontline Science: Monocytes sequentially rewire metabolism and bioenergetics during an acute inflammatory response.Authorship 35457212570681Cohen KA, Liu T, Bissonette R, Puri RK, Frankel AECurrent pharmaceutical biotechnologyCohen KA, Liu T, Bissonette R, Puri RK, Frankel AE. DAB389EGF fusion protein therapy of refractory glioblastoma multiforme. Curr Pharm Biotechnol. 2003 Feb; 4(1):39-49.Curr Pharm Biotechnol2003-02-01T00:00:002003DAB389EGF fusion protein therapy of refractory glioblastoma multiforme.Authorship 66551524Assistant ProfessorEpidemiology & Prevention (Public Health Sciences)Internal Medicine, Hematology & OncologyInternal Medicine, Molecular MedicineSurgery, HypertensionSurgery, OncologyAuthorship 148112true1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1InstructorInstructorAuthorship 195033Authorship 221521Authorship 232891Authorship 233723Authorship 252411Authorship 333391Authorship 9172312939468Liu TF, Tatter SB, Willingham MC, Yang M, Hu JJ, Frankel AEMolecular cancer therapeuticsLiu TF, Tatter SB, Willingham MC, Yang M, Hu JJ, Frankel AE. Growth factor receptor expression varies among high-grade gliomas and normal brain: epidermal growth factor receptor has excellent properties for interstitial fusion protein therapy. . 2003 Aug; 2(8):783-7.2003-08-01T00:00:002003Growth factor receptor expression varies among high-grade gliomas and normal brain: epidermal growth factor receptor has excellent properties for interstitial fusion protein therapy.14519080Mishra G, Liu TF, Frankel AEExpert opinion on biological therapyMishra G, Liu TF, Frankel AE. Recombinant toxin DAB389EGF is cytotoxic to human pancreatic cancer cells. Expert Opin Biol Ther. 2003 Oct; 3(7):1173-80.Expert Opin Biol Ther2003-10-01T00:00:002003Recombinant toxin DAB389EGF is cytotoxic to human pancreatic cancer cells.14624623Liu TF, Willingham MC, Tatter SB, Cohen KA, Lowe AC, Thorburn A, Frankel AEBioconjugate chemistryLiu TF, Willingham MC, Tatter SB, Cohen KA, Lowe AC, Thorburn A, Frankel AE. Diphtheria toxin-epidermal growth factor fusion protein and Pseudomonas exotoxin-interleukin 13 fusion protein exert synergistic toxicity against human glioblastoma multiforme cells. Bioconjug Chem. 2003 Nov-Dec; 14(6):1107-14.Bioconjug Chem2003-11-01T00:00:002003Diphtheria toxin-epidermal growth factor fusion protein and Pseudomonas exotoxin-interleukin 13 fusion protein exert synergistic toxicity against human glioblastoma multiforme cells.15614527Cohen KA, Liu TF, Cline JM, Wagner JD, Hall PD, Frankel AECancer immunology, immunotherapy : CIICohen KA, Liu TF, Cline JM, Wagner JD, Hall PD, Frankel AE. Safety evaluation of DT388IL3, a diphtheria toxin/interleukin 3 fusion protein, in the cynomolgus monkey. Cancer Immunol Immunother. 2005 Aug; 54(8):799-806.Cancer Immunol Immunother2004-12-22T00:00:002004Safety evaluation of DT388IL3, a diphtheria toxin/interleukin 3 fusion protein, in the cynomolgus monkey.19118043Liu TF, Cai J, Gibo DM, Debinski WClinical cancer research : an official journal of the American Association for Cancer ResearchLiu TF, Cai J, Gibo DM, Debinski W. Reoxygenation of hypoxic glioblastoma multiforme cells potentiates the killing effect of an interleukin-13-based cytotoxin. Clin Cancer Res. 2009 Jan 01; 15(1):160-8.Clin Cancer Res2009-01-01T00:00:002009Reoxygenation of hypoxic glioblastoma multiforme cells potentiates the killing effect of an interleukin-13-based cytotoxin.22700961Liu TF, Vachharajani VT, Yoza BK, McCall CEThe Journal of biological chemistryLiu TF, Vachharajani VT, Yoza BK, McCall CE. NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response. J Biol Chem. 2012 Jul 27; 287(31):25758-69.J Biol Chem2012-06-14T00:00:002012NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response.14649887Liu TF, Cohen KA, Willingham MC, Tatter SB, Puri RK, Frankel AEJournal of neuro-oncologyLiu TF, Cohen KA, Willingham MC, Tatter SB, Puri RK, Frankel AE. Combination fusion protein therapy of refractory brain tumors: demonstration of efficacy in cell culture. J Neurooncol. 2003 Oct; 65(1):77-85.J Neurooncol2003-10-01T00:00:002003Combination fusion protein therapy of refractory brain tumors: demonstration of efficacy in cell culture.15003313Liu TF, Urieto JO, Moore JE, Miller MS, Lowe AC, Thorburn A, Frankel AEExperimental hematologyLiu TF, Urieto JO, Moore JE, Miller MS, Lowe AC, Thorburn A, Frankel AE. Diphtheria toxin fused to variant interleukin-3 provides enhanced binding to the interleukin-3 receptor and more potent leukemia cell cytotoxicity. Exp Hematol. 2004 Mar; 32(3):277-81.Exp Hematol2004-03-01T00:00:002004Diphtheria toxin fused to variant interleukin-3 provides enhanced binding to the interleukin-3 receptor and more potent leukemia cell cytotoxicity.15370220Cohen KA, Liu TF, Cline JM, Wagner JD, Hall PD, Frankel AELeukemia & lymphomaCohen KA, Liu TF, Cline JM, Wagner JD, Hall PD, Frankel AE. Toxicology and pharmacokinetics of DT388IL3, a fusion toxin consisting of a truncated diphtheria toxin (DT388) linked to human interleukin 3 (IL3), in cynomolgus monkeys. Leuk Lymphoma. 2004 Aug; 45(8):1647-56.Leuk Lymphoma2004-08-01T00:00:002004Toxicology and pharmacokinetics of DT388IL3, a fusion toxin consisting of a truncated diphtheria toxin (DT388) linked to human interleukin 3 (IL3), in cynomolgus monkeys.19901031El Gazzar M, Liu T, Yoza BK, McCall CEThe Journal of biological chemistryEl Gazzar M, Liu T, Yoza BK, McCall CE. Dynamic and selective nucleosome repositioning during endotoxin tolerance. J Biol Chem. 2010 Jan 08; 285(2):1259-71.J Biol Chem2009-11-09T00:00:002009Dynamic and selective nucleosome repositioning during endotoxin tolerance.20733328McCall CE, Yoza B, Liu T, El Gazzar MJournal of innate immunityMcCall CE, Yoza B, Liu T, El Gazzar M. Gene-specific epigenetic regulation in serious infections with systemic inflammation. J Innate Immun. 2010; 2(5):395-405.J Innate Immun2010-04-27T00:00:002010Gene-specific epigenetic regulation in serious infections with systemic inflammation.21245135Liu TF, Yoza BK, El Gazzar M, Vachharajani VT, McCall CEThe Journal of biological chemistryLiu TF, Yoza BK, El Gazzar M, Vachharajani VT, McCall CE. NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance. J Biol Chem. 2011 Mar 18; 286(11):9856-64.J Biol Chem2011-01-18T00:00:002011NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance.21562054El Gazzar M, Church A, Liu T, McCall CEJournal of leukocyte biologyEl Gazzar M, Church A, Liu T, McCall CE. MicroRNA-146a regulates both transcription silencing and translation disruption of TNF-a during TLR4-induced gene reprogramming. J Leukoc Biol. 2011 Sep; 90(3):509-19.J Leukoc Biol2011-05-11T00:00:002011MicroRNA-146a regulates both transcription silencing and translation disruption of TNF-a during TLR4-induced gene reprogramming.21610199McCall CE, El Gazzar M, Liu T, Vachharajani V, Yoza BJournal of leukocyte biologyMcCall CE, El Gazzar M, Liu T, Vachharajani V, Yoza B. Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprogramming during acute systemic inflammation. J Leukoc Biol. 2011 Sep; 90(3):439-46.J Leukoc Biol2011-05-24T00:00:002011Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprogramming during acute systemic inflammation.22571857Liu TF, Brown CM, El Gazzar M, McPhail L, Millet P, Rao A, Vachharajani VT, Yoza BK, McCall CEJournal of leukocyte biologyLiu TF, Brown CM, El Gazzar M, McPhail L, Millet P, Rao A, Vachharajani VT, Yoza BK, McCall CE. Fueling the flame: bioenergy couples metabolism and inflammation. J Leukoc Biol. 2012 Sep; 92(3):499-507.J Leukoc Biol2012-05-09T00:00:002012Fueling the flame: bioenergy couples metabolism and inflammation.D056564Chemicals & Drugs9360.958772Sirtuin 1D018805Disorders611450.873946SepsisD011993Chemicals & Drugs53880.956539Recombinant Fusion ProteinsD004734Physiology661390.902514Energy MetabolismD004167Chemicals & Drugs7210.984898Diphtheria Toxin