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Steven J. Kridel PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentAnesthesiology
Address
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    Other Positions
    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentNeurological Surgery

    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentUrology

    TitleChair
    InstitutionWake Forest School of Medicine
    DepartmentCancer Biology

    TitleVice Chair
    InstitutionWake Forest School of Medicine
    DepartmentCancer Biology


    Collapse Research 
    Collapse research activities and funding
    F32AR008508     (KRIDEL, STEVEN J)Mar 29, 1998
    NIH
    BIOCHEMICAL ANALYSIS OF MELTRIN ALPHA IN MYOGENESIS
    Role: Principal Investigator
    T32CA079448     (KRIDEL, STEVEN J.)Mar 15, 2000 - Aug 31, 2016
    NIH
    Training Program in Cancer Biology
    Role: Principal Investigator
    R01CA114104     (KRIDEL, STEVEN J)Sep 1, 2006 - Jul 31, 2011
    NIH
    Fatty acid synthase inhibitors and prostate cancer
    Role: Principal Investigator
    R01CA161503     (KRIDEL, STEVEN J.)Jul 11, 2012 - Apr 30, 2018
    NIH
    NAD+ metabolism in prostate cancer
    Role: Principal Investigator
    R25CA229105     (WATABE, KOUNOSUKE)Sep 20, 2018 - Aug 31, 2024
    NIH
    Training program to promote diversity in cancer research
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Naczki C, John B, Patel C, Lafferty A, Ghoneum A, Afify H, White M, Davis A, Jin G, Kridel S, Said N. SPARC Inhibits Metabolic Plasticity in Ovarian Cancer. Cancers (Basel). 2018 Oct 16; 10(10). PMID: 30332737.
      Citations:    
    2. Chmielewski JP, Bowlby SC, Wheeler FB, Shi L, Sui G, Davis AL, Howard TD, D'Agostino RB, Miller LD, Sirintrapun SJ, Cramer SD, Kridel SJ. CD38 Inhibits Prostate Cancer Metabolism and Proliferation by Reducing Cellular NAD+ Pools. Mol Cancer Res. 2018 11; 16(11):1687-1700. PMID: 30076241.
      Citations:    
    3. Jin G, Xu C, Zhang X, Long J, Rezaeian AH, Liu C, Furth ME, Kridel S, Pasche B, Bian XW, Lin HK. Atad3a suppresses Pink1-dependent mitophagy to maintain homeostasis of hematopoietic progenitor cells. Nat Immunol. 2018 Jan; 19(1):29-40. PMID: 29242539.
      Citations:    
    4. Souchek JJ, Davis AL, Hill TK, Holmes MB, Qi B, Singh PK, Kridel SJ, Mohs AM. Combination Treatment with Orlistat-Containing Nanoparticles and Taxanes Is Synergistic and Enhances Microtubule Stability in Taxane-Resistant Prostate Cancer Cells. . 2017 09; 16(9):1819-1830. PMID: 28615298.
      Citations:    
    5. Wang J, Zhang X, Shi J, Cao P, Wan M, Zhang Q, Wang Y, Kridel SJ, Liu W, Xu J, Zhang Q, Sui G. Fatty acid synthase is a primary target of MiR-15a and MiR-16-1 in breast cancer. Oncotarget. 2016 Nov 29; 7(48):78566-78576. PMID: 27713175.
      Citations:    
    6. Coleman DT, Gray AL, Kridel SJ, Cardelli JA. Palmitoylation regulates the intracellular trafficking and stability of c-Met. Oncotarget. 2016 May 31; 7(22):32664-77. PMID: 27081699.
      Citations:    
    7. Hill TK, Davis AL, Wheeler FB, Kelkar SS, Freund EC, Lowther WT, Kridel SJ, Mohs AM. Development of a Self-Assembled Nanoparticle Formulation of Orlistat, Nano-ORL, with Increased Cytotoxicity against Human Tumor Cell Lines. Mol Pharm. 2016 Mar 07; 13(3):720-8. PMID: 26824142.
      Citations:    
    8. Zhang Q, Wan M, Shi J, Horita DA, Miller LD, Kute TE, Kridel SJ, Kulik G, Sui G. Yin Yang 1 promotes mTORC2-mediated AKT phosphorylation. J Mol Cell Biol. 2016 06; 8(3):232-43. PMID: 26762111.
      Citations:    
    9. Ritchie MK, Johnson LC, Clodfelter JE, Pemble CW, Fulp BE, Furdui CM, Kridel SJ, Lowther WT. Crystal Structure and Substrate Specificity of Human Thioesterase 2: INSIGHTS INTO THE MOLECULAR BASIS FOR THE MODULATION OF FATTY ACID SYNTHASE. J Biol Chem. 2016 Feb 12; 291(7):3520-30. PMID: 26663084.
      Citations:    
    10. Gao C, Wang N, Guo X, Ziegler JT, Taylor KD, Xiang AH, Hai Y, Kridel SJ, Nadler JL, Kandeel F, Raffel LJ, Chen YD, Norris JM, Rotter JI, Watanabe RM, Wagenknecht LE, Bowden DW, Speliotes EK, Goodarzi MO, Langefeld CD, Palmer ND. A Comprehensive Analysis of Common and Rare Variants to Identify Adiposity Loci in Hispanic Americans: The IRAS Family Study (IRASFS). PLoS One. 2015; 10(11):e0134649. PMID: 26599207.
      Citations:    
    11. Suburu J, Shi L, Wu J, Wang S, Samuel M, Thomas MJ, Kock ND, Yang G, Kridel S, Chen YQ. Fatty acid synthase is required for mammary gland development and milk production during lactation. Am J Physiol Endocrinol Metab. 2014 May 15; 306(10):E1132-43. PMID: 24668799.
      Citations:    
    12. Odens H, Lowther T, Kridel S, Watts L, Filipponi L, Schmitt J. Inhibition of the thioesterase activity of human fatty acid synthase by 1,4- and 9,10-diones. Chem Pharm Bull (Tokyo). 2014; 62(9):933-6. PMID: 25177021.
      Citations:    
    13. Deford-Watts LM, Mintz A, Kridel SJ. The potential of ¹¹C-acetate PET for monitoring the Fatty acid synthesis pathway in Tumors. Curr Pharm Biotechnol. 2013; 14(3):300-12. PMID: 23597406.
      Citations:    
    14. Bowlby SC, Thomas MJ, D'Agostino RB, Kridel SJ. Nicotinamide phosphoribosyl transferase (Nampt) is required for de novo lipogenesis in tumor cells. PLoS One. 2012; 7(6):e40195. PMID: 22768255.
      Citations:    
    15. Scott KE, Wheeler FB, Davis AL, Thomas MJ, Ntambi JM, Seals DF, Kridel SJ. Metabolic regulation of invadopodia and invasion by acetyl-CoA carboxylase 1 and de novo lipogenesis. PLoS One. 2012; 7(1):e29761. PMID: 22238651.
      Citations:    
    16. Berquin IM, Edwards IJ, Kridel SJ, Chen YQ. Polyunsaturated fatty acid metabolism in prostate cancer. Cancer Metastasis Rev. 2011 Dec; 30(3-4):295-309. PMID: 22015690.
      Citations:    
    17. Pandya H, Gibo DM, Garg S, Kridel S, Debinski W. An interleukin 13 receptor a 2-specific peptide homes to human Glioblastoma multiforme xenografts. Neuro Oncol. 2012 Jan; 14(1):6-18. PMID: 21946118.
      Citations:    
    18. Little JL, Wheeler FB, Koumenis C, Kridel SJ. Disruption of crosstalk between the fatty acid synthesis and proteasome pathways enhances unfolded protein response signaling and cell death. . 2008 Dec; 7(12):3816-24. PMID: 19074856.
      Citations:    
    19. Fels DR, Ye J, Segan AT, Kridel SJ, Spiotto M, Olson M, Koong AC, Koumenis C. Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways. Cancer Res. 2008 Nov 15; 68(22):9323-30. PMID: 19010906.
      Citations:    
    20. Vavere AL, Kridel SJ, Wheeler FB, Lewis JS. 1-11C-acetate as a PET radiopharmaceutical for imaging fatty acid synthase expression in prostate cancer. J Nucl Med. 2008 Feb; 49(2):327-34. PMID: 18199615.
      Citations:    
    21. Little JL, Kridel SJ. Fatty acid synthase activity in tumor cells. Subcell Biochem. 2008; 49:169-94. PMID: 18751912.
      Citations:    
    22. Chen YQ, Edwards IJ, Kridel SJ, Thornburg T, Berquin IM. Dietary fat-gene interactions in cancer. Cancer Metastasis Rev. 2007 Dec; 26(3-4):535-51. PMID: 17849170.
      Citations:    
    23. Kridel SJ, Lowther WT, Pemble CW. Fatty acid synthase inhibitors: new directions for oncology. Expert Opin Investig Drugs. 2007 Nov; 16(11):1817-29. PMID: 17970640.
      Citations:    
    24. Lally BE, Geiger GA, Kridel S, Arcury-Quandt AE, Robbins ME, Kock ND, Wheeler K, Peddi P, Georgakilas A, Kao GD, Koumenis C. Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library. Cancer Res. 2007 Sep 15; 67(18):8791-9. PMID: 17875720.
      Citations:    
    25. Pemble CW, Johnson LC, Kridel SJ, Lowther WT. Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat. Nat Struct Mol Biol. 2007 Aug; 14(8):704-9. PMID: 17618296.
      Citations:    
    26. Little JL, Wheeler FB, Fels DR, Koumenis C, Kridel SJ. Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells. Cancer Res. 2007 Feb 01; 67(3):1262-9. PMID: 17283163.
      Citations:    
    27. Zhao W, Kridel S, Thorburn A, Kooshki M, Little J, Hebbar S, Robbins M. Fatty acid synthase: a novel target for antiglioma therapy. Br J Cancer. 2006 Oct 09; 95(7):869-78. PMID: 16969344.
      Citations:    
    28. Kridel SJ, Axelrod F, Rozenkrantz N, Smith JW. Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity. Cancer Res. 2004 Mar 15; 64(6):2070-5. PMID: 15026345.
      Citations:    
    29. Gu Z, Kaul M, Yan B, Kridel SJ, Cui J, Strongin A, Smith JW, Liddington RC, Lipton SA. S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death. Science. 2002 Aug 16; 297(5584):1186-90. PMID: 12183632.
      Citations:    
    30. Kridel SJ, Sawai H, Ratnikov BI, Chen EI, Li W, Godzik A, Strongin AY, Smith JW. A unique substrate binding mode discriminates membrane type-1 matrix metalloproteinase from other matrix metalloproteinases. J Biol Chem. 2002 Jun 28; 277(26):23788-93. PMID: 11959855.
      Citations:    
    31. Chen EI, Kridel SJ, Howard EW, Li W, Godzik A, Smith JW. A unique substrate recognition profile for matrix metalloproteinase-2. J Biol Chem. 2002 Feb 08; 277(6):4485-91. PMID: 11694539.
      Citations:    
    32. Kridel SJ, Chen E, Smith JW. A substrate phage enzyme-linked immunosorbent assay to profile panels of proteases. Anal Biochem. 2001 Jul 15; 294(2):176-84. PMID: 11444814.
      Citations:    
    33. Kridel SJ, Chen E, Kotra LP, Howard EW, Mobashery S, Smith JW. Substrate hydrolysis by matrix metalloproteinase-9. J Biol Chem. 2001 Jun 08; 276(23):20572-8. PMID: 11279151.
      Citations:    
    34. Kridel SJ, Knauer DJ. Lysine residue 114 in human antithrombin III is required for heparin pentasaccharide-mediated activation. J Biol Chem. 1997 Mar 21; 272(12):7656-60. PMID: 9065421.
      Citations:    
    35. Kridel SJ, Chan WW, Knauer DJ. Requirement of lysine residues outside of the proposed pentasaccharide binding region for high affinity heparin binding and activation of human antithrombin III. J Biol Chem. 1996 Aug 23; 271(34):20935-41. PMID: 8702852.
      Citations:    
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