RaghunathaYammaniRaghunatha Yammani PhD36.08977400000000-80.26684000000000853Yammani, RaghunathaAssociate Professorprns:coAuthorOfcoauthor ofprns:endDateend dateprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 39313124497499Yammani RR, Loeser RFArthritis & rheumatology (Hoboken, N.J.)Yammani RR, Loeser RF. Brief report: stress-inducible nuclear protein 1 regulates matrix metalloproteinase 13 expression in human articular chondrocytes. Arthritis Rheumatol. 2014 May; 66(5):1266-71.Arthritis Rheumatol2014-05-01T00:00:002014Brief report: stress-inducible nuclear protein 1 regulates matrix metalloproteinase 13 expression in human articular chondrocytes.AnesthesiologyBiochemistryWake Forest School of MedicineDanielFilesDaniel C. Files MD36.08959100000000-80.268599000000001099Files, DanielAssistant ProfessorMatthewMilesMatthew C. Miles MD, MEd36.08977400000000-80.266840000000001297Miles, MatthewAssociate ProfessorCristinaFurduiCristina M. Furdui PhD36.09032400000000-80.26649100000000135Furdui, CristinaProfessorChuanyaoTongChuanyao Tong MD36.08977400000000-80.26684000000000180Tong, ChuanyaoProfessorAnthonyAtalaAnthony Atala MD36.08943500000000-80.268632000000003Atala, AnthonyProfessorJamesYooJames J. Yoo MD, PhD36.08943500000000-80.26863200000000500Yoo, JamesProfessorKevinHighKevin P. High MD36.08977400000000-80.26684000000000524High, KevinProfessorKimberlyNelsonKimberly J. Nelson PhD36.13393700000000-80.25477800000000526Nelson, KimberlyInstructorLesliePooleLeslie B. Poole PhD36.08919100000000-80.26677800000000567Poole, LeslieProfessorOsvaldoDelbonoOsvaldo Delbono MD, PhD36.08977400000000-80.26684000000000730Delbono, OsvaldoProfessorBarryFreedmanBarry I. Freedman MD36.08959100000000-80.2685990000000078Freedman, BarryProfessor2.983020.0106186191research areas0.1709780.03355818coauthor of31.24782.5658949similar to1120selected publicationsThomasMartinThomas J. Martin PhD36.08977400000000-80.26684000000000977Martin, ThomasProfessorThomasPerraultThomas J. Perrault PhD36.08977400000000-80.26684000000000990Perrault, ThomasProfessorAuthorship 416331125761888Files DC, Liu C, Pereyra A, Wang ZM, Aggarwal NR, D'Alessio FR, Garibaldi BT, Mock JR, Singer BD, Feng X, Yammani RR, Zhang T, Lee AL, Philpott S, Lussier S, Purcell L, Chou J, Seeds M, King LS, Morris PE, Delbono OScience translational medicineFiles DC, Liu C, Pereyra A, Wang ZM, Aggarwal NR, D'Alessio FR, Garibaldi BT, Mock JR, Singer BD, Feng X, Yammani RR, Zhang T, Lee AL, Philpott S, Lussier S, Purcell L, Chou J, Seeds M, King LS, Morris PE, Delbono O. Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting. Sci Transl Med. 2015 Mar 11; 7(278):278ra32.Sci Transl Med2015-03-11T00:00:002015Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting.Authorship 47441426314228Wood ST, Long DL, Reisz JA, Yammani RR, Burke EA, Klomsiri C, Poole LB, Furdui CM, Loeser RFArthritis & rheumatology (Hoboken, N.J.)Wood ST, Long DL, Reisz JA, Yammani RR, Burke EA, Klomsiri C, Poole LB, Furdui CM, Loeser RF. Cysteine-Mediated Redox Regulation of Cell Signaling in Chondrocytes Stimulated With Fibronectin Fragments. Arthritis Rheumatol. 2016 Jan; 68(1):117-26.Arthritis Rheumatol2016-01-01T00:00:002016Cysteine-Mediated Redox Regulation of Cell Signaling in Chondrocytes Stimulated With Fibronectin Fragments.2017-06-30NIHYAMMANI, RAGHUNATHA R2013-07-25ER Stress: Role in OAR21AR0638352014-06-30NIHYAMMANI, RAGHUNATHA R2011-04-01Invivo role of S100A4 in OA pathophysiologyR03AR0610502020-05-31NIHYAMMANI, RAGHUNATHA R2014-06-01Diet , ER stress and OAR01AR066105Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorAuthorship 59646229852167Mallik A, Yammani RRBiochemical and biophysical research communicationsMallik A, Yammani RR. Saturated fatty acid palmitate negatively regulates autophagy by promoting ATG5 protein degradation in meniscus cells. Biochem Biophys Res Commun. 2018 07 20; 502(3):370-374.Biochem Biophys Res Commun2018-05-30T00:00:002018Saturated fatty acid palmitate negatively regulates autophagy by promoting ATG5 protein degradation in meniscus cells.Authorship 640739Authorship 66844230674641Tan L, Yammani RRBioscience reportsTan L, Yammani RR. Nupr1 regulates palmitate-induced apoptosis in human articular chondrocytes. Biosci Rep. 2019 02 28; 39(2).Biosci Rep2019-02-15T00:00:002019Nupr1 regulates palmitate-induced apoptosis in human articular chondrocytes.30190325Nelson KJ, Bolduc JA, Wu H, Collins JA, Burke EA, Reisz JA, Klomsiri C, Wood ST, Yammani RR, Poole LB, Furdui CM, Loeser RFThe Journal of biological chemistryNelson KJ, Bolduc JA, Wu H, Collins JA, Burke EA, Reisz JA, Klomsiri C, Wood ST, Yammani RR, Poole LB, Furdui CM, Loeser RF. H2O2 oxidation of cysteine residues in c-Jun N-terminal kinase 2 (JNK2) contributes to redox regulation in human articular chondrocytes. J Biol Chem. 2018 10 19; 293(42):16376-16389.J Biol Chem2018-09-06T00:00:002018H2O2 oxidation of cysteine residues in c-Jun N-terminal kinase 2 (JNK2) contributes to redox regulation in human articular chondrocytes.Family & Community MedicineInternal Medicine, Infectious DiseasesInternal Medicine, Molecular MedicineInternal Medicine, NephrologyInternal Medicine, Pulmonary, Critical Care, Allergy and Immunologic DiseasesOrthopedic Surgery Pediatrics, EndocrinologyPhysiology & PharmacologyUrologyWake Forest Institute for Regenerative Medicinehttp://www.wfirm.orgWFIRMAuthorship 116611Authorship 136212Authorship 161961true1ProfessorProfessortrue1ProfessorProfessortrue1InstructorInstructortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professor2Associate ProfessorAssociate Professortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessorAuthorship 231613Authorship 23574Authorship 242121Authorship 262131Authorship 280673Authorship 296103Authorship 307442Authorship 335851Authorship 335923Authorship 86983Authorship 9026214585166Seetharam B, Yammani RRExpert reviews in molecular medicineSeetharam B, Yammani RR. Cobalamin transport proteins and their cell-surface receptors. Expert Rev Mol Med. 2003 Jun 13; 5(18):1-18.Expert Rev Mol Med2003-06-13T00:00:002003Cobalamin transport proteins and their cell-surface receptors.17990981Ahuja R, Yammani R, Bauer JA, Kalra S, Seetharam S, Seetharam BThe Biochemical journalAhuja R, Yammani R, Bauer JA, Kalra S, Seetharam S, Seetharam B. Interactions of cubilin with megalin and the product of the amnionless gene (AMN): effect on its stability. Biochem J. 2008 Mar 01; 410(2):301-8.Biochem J2008-03-01T00:00:002008Interactions of cubilin with megalin and the product of the amnionless gene (AMN): effect on its stability.12121845Yammani RR, Sharma M, Seetharam S, Moulder JE, Dahms NM, Seetharam BAmerican journal of physiology. Regulatory, integrative and comparative physiologyYammani RR, Sharma M, Seetharam S, Moulder JE, Dahms NM, Seetharam B. Loss of albumin and megalin binding to renal cubilin in rats results in albuminuria after total body irradiation. . 2002 Aug; 283(2):R339-46.2002-08-01T00:00:002002Loss of albumin and megalin binding to renal cubilin in rats results in albuminuria after total body irradiation.12623069Vanamala SK, Seetharam S, Yammani RR, Seetharam BArchives of biochemistry and biophysicsVanamala SK, Seetharam S, Yammani RR, Seetharam B. Human transcobalamin II receptor binds to Staphylococcus aureus protein A: implications as to its structure and function. Arch Biochem Biophys. 2003 Mar 15; 411(2):204-14.Arch Biochem Biophys2003-03-15T00:00:002003Human transcobalamin II receptor binds to Staphylococcus aureus protein A: implications as to its structure and function.14724191Kalra S, Seetharam S, Yammani RR, Seetharam BThe Journal of physiologyKalra S, Seetharam S, Yammani RR, Seetharam B. Rat transcobalamin: cloning and regulation of mRNA expression. J Physiol. 2004 Apr 15; 556(Pt 2):623-35.J Physiol2004-01-14T00:00:002004Rat transcobalamin: cloning and regulation of mRNA expression.15488467Kalra S, Li N, Yammani RR, Seetharam S, Seetharam BArchives of biochemistry and biophysicsKalra S, Li N, Yammani RR, Seetharam S, Seetharam B. Cobalamin (vitamin B12) binding, phylogeny, and synteny of human transcobalamin. Arch Biochem Biophys. 2004 Nov 15; 431(2):189-96.Arch Biochem Biophys2004-11-15T00:00:002004Cobalamin (vitamin B12) binding, phylogeny, and synteny of human transcobalamin.16052547Loeser RF, Yammani RR, Carlson CS, Chen H, Cole A, Im HJ, Bursch LS, Yan SDArthritis and rheumatismLoeser RF, Yammani RR, Carlson CS, Chen H, Cole A, Im HJ, Bursch LS, Yan SD. Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis. Arthritis Rheum. 2005 Aug; 52(8):2376-85.Arthritis Rheum2005-08-01T00:00:002005Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis.16948116Yammani RR, Carlson CS, Bresnick AR, Loeser RFArthritis and rheumatismYammani RR, Carlson CS, Bresnick AR, Loeser RF. Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products. Arthritis Rheum. 2006 Sep; 54(9):2901-11.Arthritis Rheum2006-09-01T00:00:002006Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products.17347267Bose S, Kalra S, Yammani RR, Ahuja R, Seetharam BThe Journal of physiologyBose S, Kalra S, Yammani RR, Ahuja R, Seetharam B. Plasma membrane delivery, endocytosis and turnover of transcobalamin receptor in polarized human intestinal epithelial cells. J Physiol. 2007 Jun 01; 581(Pt 2):457-66.J Physiol2007-03-08T00:00:002007Plasma membrane delivery, endocytosis and turnover of transcobalamin receptor in polarized human intestinal epithelial cells.19180501Cravero JD, Carlson CS, Im HJ, Yammani RR, Long D, Loeser RFArthritis and rheumatismCravero JD, Carlson CS, Im HJ, Yammani RR, Long D, Loeser RF. Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis. Arthritis Rheum. 2009 Feb; 60(2):492-500.Arthritis Rheum2009-02-01T00:00:002009Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis.19248116Yammani RR, Long D, Loeser RFArthritis and rheumatismYammani RR, Long D, Loeser RF. Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes. Arthritis Rheum. 2009 Mar; 60(3):792-800.Arthritis Rheum2009-03-01T00:00:002009Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes.20685652Miranda KJ, Loeser RF, Yammani RRThe Journal of biological chemistryMiranda KJ, Loeser RF, Yammani RR. Sumoylation and nuclear translocation of S100A4 regulate IL-1beta-mediated production of matrix metalloproteinase-13. J Biol Chem. 2010 Oct 08; 285(41):31517-24.J Biol Chem2010-08-04T00:00:002010Sumoylation and nuclear translocation of S100A4 regulate IL-1beta-mediated production of matrix metalloproteinase-13.22266138Yammani RRBiochimica et biophysica actaYammani RR. S100 proteins in cartilage: role in arthritis. Biochim Biophys Acta. 2012 Apr; 1822(4):600-6.Biochim Biophys Acta2012-01-12T00:00:002012S100 proteins in cartilage: role in arthritis.22289259Yammani RR, Loeser RFArthritis research & therapyYammani RR, Loeser RF. Extracellular nicotinamide phosphoribosyltransferase (NAMPT/visfatin) inhibits insulin-like growth factor-1 signaling and proteoglycan synthesis in human articular chondrocytes. Arthritis Res Ther. 2012 Jan 30; 14(1):R23.Arthritis Res Ther2012-01-30T00:00:002012Extracellular nicotinamide phosphoribosyltransferase (NAMPT/visfatin) inhibits insulin-like growth factor-1 signaling and proteoglycan synthesis in human articular chondrocytes.D009418Chemicals & Drugs10180.988551S100 ProteinsD002358Anatomy29680.934481Cartilage, ArticularD053509Chemicals & Drugs5100.992711Matrix Metalloproteinase 13D051792Chemicals & Drugs27380.962502Basic Helix-Loop-Helix Transcription FactorsD019902Anatomy26710.945437Chondrocytes