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David A. Ornelles PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentMicrobiology and Immunology
Address
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentClinical and Translational Science Institute

    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentRadiation Oncology

    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentCancer Biology

    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentWake Forest Institute for Regenerative Medicine


    Collapse Research 
    Collapse research activities and funding
    R29AI035589     (ORNELLES, DAVID ARNOLD)Dec 1, 1994 - May 30, 2000
    NIH
    ADENOVIRUS CONTROL OF MRNA TRANSPORT
    Role: Principal Investigator
    R01CA077342     (ORNELLES, DAVID ARNOLD)Apr 1, 1999 - Jan 31, 2011
    NIH
    NOVEL CELL CYCLE REGULATION BY ADENOVIRUS E1B 55K
    Role: Principal Investigator
    R01DC010051     (SWORDS, WILLIAM E)Apr 1, 2009 - Mar 31, 2021
    NIH
    Microbial interactions in otitis media
    Role: Co-Principal Investigator
    R01CA127621     (ORNELLES, DAVID ARNOLD)Apr 20, 2009 - Jan 31, 2016
    NIH
    Prenatal adenovirus infection, inhibition of DNA repair, and childhood leukemia
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bracey DN, Seyler TM, Jinnah AH, Smith TL, Ornelles DA, Deora R, Parks GD, Van Dyke ME, Whitlock PW. A porcine xenograft-derived bone scaffold is a biocompatible bone graft substitute: An assessment of cytocompatibility and the alpha-Gal epitope. Xenotransplantation. 2019 09; 26(5):e12534. PMID: 31342586.
      Citations:    
    2. Kaverina NV, Kadagidze ZG, Borovjagin AV, Karseladze AI, Kim CK, Lesniak MS, Miska J, Zhang P, Baryshnikova MA, Xiao T, Ornelles D, Cobbs C, Khramtsov A, Ulasov IV. Tamoxifen overrides autophagy inhibition in Beclin-1-deficient glioma cells and their resistance to adenovirus-mediated oncolysis via upregulation of PUMA and BAX. Oncogene. 2018 11; 37(46):6069-6082. PMID: 29991800.
      Citations:    
    3. Grayson KM, Blevins LK, Oliver MB, Ornelles DA, Swords WE, Alexander-Miller MA. Activation-dependent modulation of Streptococcus pneumoniae-mediated death in human lymphocytes. Pathog Dis. 2017 03 01; 75(2). PMID: 28158464.
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    4. Yacovone SK, Smelser AM, Macosko JC, Holzwarth G, Ornelles DA, Lyles DS. Migration of Nucleocapsids in Vesicular Stomatitis Virus-Infected Cells Is Dependent on both Microtubules and Actin Filaments. J Virol. 2016 07 01; 90(13):6159-70. PMID: 27122580.
      Citations:    
    5. Sunwook K, Nussbaum MA, Quandt SA, Laurienti PJ, Arcury TA. Effects of Lifetime Occupational Pesticide Exposure on Postural Control Among Farmworkers and Non-Farmworkers. J Occup Environ Med. 2016 Feb; 58(2):133-9. PMID: 19129452.
      Citations:    
    6. Yacovone SK, Ornelles DA, Lyles DS. The border-to-border distribution method for analysis of cytoplasmic particles and organelles. Cell Tissue Res. 2016 Feb; 363(2):351-60. PMID: 26310140.
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    7. Ornelles DA, Gooding LR, Garnett-Benson C. Neonatal infection with species C adenoviruses confirmed in viable cord blood lymphocytes. PLoS One. 2015; 10(3):e0119256. PMID: 25764068.
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    8. Murrah KA, Turner RL, Pang B, Perez AC, Reimche JL, King LB, Wren J, Gandhi U, Swords WE, Ornelles DA. Replication of type 5 adenovirus promotes middle ear infection by Streptococcus pneumoniae in the chinchilla model of otitis media. Pathog Dis. 2015 Mar; 73(2):1-8. PMID: 25251686.
      Citations:    
    9. Turner RL, Groitl P, Dobner T, Ornelles DA. Adenovirus replaces mitotic checkpoint controls. J Virol. 2015 May; 89(9):5083-96. PMID: 25694601.
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    10. Turner RL, Wilkinson JC, Ornelles DA. E1B and E4 oncoproteins of adenovirus antagonize the effect of apoptosis inducing factor. Virology. 2014 May; 456-457:205-19. PMID: 24889240.
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    11. Furuse Y, Ornelles DA, Cullen BR. Persistently adenovirus-infected lymphoid cells express microRNAs derived from the viral VAI and especially VAII RNA. Virology. 2013 Dec; 447(1-2):140-5. PMID: 24210108.
      Citations:    
    12. Divers J, Núñez M, High KP, Murea M, Rocco MV, Ma L, Bowden DW, Hicks PJ, Spainhour M, Ornelles DA, Kleiboeker SB, Duncan K, Langefeld CD, Turner J, Freedman BI. JC polyoma virus interacts with APOL1 in African Americans with nondiabetic nephropathy. Kidney Int. 2013 Dec; 84(6):1207-13. PMID: 23677244.
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    13. Kute T, Stehle JR, Ornelles D, Walker N, Delbono O, Vaughn JP. Understanding key assay parameters that affect measurements of trastuzumab-mediated ADCC against Her2 positive breast cancer cells. Oncoimmunology. 2012 Sep 01; 1(6):810-821. PMID: 23162748.
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    14. Whitlock PW, Seyler TM, Parks GD, Ornelles DA, Smith TL, Van Dyke ME, Poehling GG. A novel process for optimizing musculoskeletal allograft tissue to improve safety, ultrastructural properties, and cell infiltration. J Bone Joint Surg Am. 2012 Aug 15; 94(16):1458-67. PMID: 22786867.
      Citations:    
    15. Murphy AM, Besmer DM, Moerdyk-Schauwecker M, Moestl N, Ornelles DA, Mukherjee P, Grdzelishvili VZ. Vesicular stomatitis virus as an oncolytic agent against pancreatic ductal adenocarcinoma. J Virol. 2012 Mar; 86(6):3073-87. PMID: 22238308.
      Citations:    
    16. Zhang Y, Huang W, Ornelles DA, Gooding LR. Modeling adenovirus latency in human lymphocyte cell lines. J Virol. 2010 Sep; 84(17):8799-810. PMID: 20573817.
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    17. Spurgeon ME, Ornelles DA. The adenovirus E1B 55-kilodalton and E4 open reading frame 6 proteins limit phosphorylation of eIF2alpha during the late phase of infection. J Virol. 2009 Oct; 83(19):9970-82. PMID: 19605483.
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    18. Nichols GJ, Schaack J, Ornelles DA. Widespread phosphorylation of histone H2AX by species C adenovirus infection requires viral DNA replication. J Virol. 2009 Jun; 83(12):5987-98. PMID: 19321613.
      Citations:    
    19. Henry CJ, Ornelles DA, Mitchell LM, Brzoza-Lewis KL, Hiltbold EM. IL-12 produced by dendritic cells augments CD8+ T cell activation through the production of the chemokines CCL1 and CCL17. J Immunol. 2008 Dec 15; 181(12):8576-84. PMID: 19050277.
      Citations:    
    20. Marshall LJ, Moore AC, Ohki M, Kitabayashi I, Patterson D, Ornelles DA. RUNX1 permits E4orf6-directed nuclear localization of the adenovirus E1B-55K protein and associates with centers of viral DNA and RNA synthesis. J Virol. 2008 Jul; 82(13):6395-408. PMID: 18417565.
      Citations:    
    21. Ornelles DA, Broughton-Shepard RN, Goodrum FD. Analysis of adenovirus infections in synchronized cells. Methods Mol Med. 2007; 131:83-101. PMID: 17656777.
      Citations:    
    22. Hart LS, Ornelles D, Koumenis C. The adenoviral E4orf6 protein induces atypical apoptosis in response to DNA damage. J Biol Chem. 2007 Mar 02; 282(9):6061-7. PMID: 17172468.
      Citations:    
    23. Shapiro GS, Van Peursem C, Ornelles DA, Schaack J, DeGregori J. Recombinant adenoviral vectors can induce expression of p73 via the E4-orf6/7 protein. J Virol. 2006 Jun; 80(11):5349-60. PMID: 16699015.
      Citations:    
    24. Weitzman MD, Ornelles DA. Inactivating intracellular antiviral responses during adenovirus infection. Oncogene. 2005 Nov 21; 24(52):7686-96. PMID: 16299529.
      Citations:    
    25. Stracker TH, Lee DV, Carson CT, Araujo FD, Ornelles DA, Weitzman MD. Serotype-specific reorganization of the Mre11 complex by adenoviral E4orf3 proteins. J Virol. 2005 Jun; 79(11):6664-73. PMID: 15890904.
      Citations:    
    26. Xue Y, Johnson JS, Ornelles DA, Lieberman J, Engel DA. Adenovirus protein VII functions throughout early phase and interacts with cellular proteins SET and pp32. J Virol. 2005 Feb; 79(4):2474-83. PMID: 15681448.
      Citations:    
    27. Blanchette P, Cheng CY, Yan Q, Ketner G, Ornelles DA, Dobner T, Conaway RC, Conaway JW, Branton PE. Both BC-box motifs of adenovirus protein E4orf6 are required to efficiently assemble an E3 ligase complex that degrades p53. Mol Cell Biol. 2004 Nov; 24(21):9619-29. PMID: 15485928.
      Citations:    
    28. Hart LS, Yannone SM, Naczki C, Orlando JS, Waters SB, Akman SA, Chen DJ, Ornelles D, Koumenis C. The adenovirus E4orf6 protein inhibits DNA double strand break repair and radiosensitizes human tumor cells in an E1B-55K-independent manner. J Biol Chem. 2005 Jan 14; 280(2):1474-81. PMID: 15507430.
      Citations:    
    29. Shepard RN, Ornelles DA. Diverse roles for E4orf3 at late times of infection revealed in an E1B 55-kilodalton protein mutant background. J Virol. 2004 Sep; 78(18):9924-35. PMID: 15331726.
      Citations:    
    30. McNees AL, Mahr JA, Ornelles D, Gooding LR. Postinternalization inhibition of adenovirus gene expression and infectious virus production in human T-cell lines. J Virol. 2004 Jul; 78(13):6955-66. PMID: 15194772.
      Citations:    
    31. Schaack J, Bennett ML, Colbert JD, Torres AV, Clayton GH, Ornelles D, Moorhead J. E1A and E1B proteins inhibit inflammation induced by adenovirus. Proc Natl Acad Sci U S A. 2004 Mar 02; 101(9):3124-9. PMID: 14976240.
      Citations:    
    32. Shepard RN, Ornelles DA. E4orf3 is necessary for enhanced S-phase replication of cell cycle-restricted subgroup C adenoviruses. J Virol. 2003 Aug; 77(15):8593-5. PMID: 12857931.
      Citations:    
    33. Chastain-Moore AM, Roberts T, Trott DA, Newbold RF, Ornelles DA. An activity associated with human chromosome 21 permits nuclear colocalization of the adenovirus E1B-55K and E4orf6 proteins and promotes viral late gene expression. J Virol. 2003 Jul; 77(14):8087-98. PMID: 12829847.
      Citations:    
    34. Orlando JS, Ornelles DA. E4orf6 variants with separate abilities to augment adenovirus replication and direct nuclear localization of the E1B 55-kilodalton protein. J Virol. 2002 Feb; 76(3):1475-87. PMID: 11773420.
      Citations:    
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