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Mark C. Chappell PhD

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentSurgery, Hypertension
Address
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentTranslational Neuroscience


    Collapse Research 
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    R29HL056973     (CHAPPELL, MARK C)Aug 15, 1996 - Jun 30, 2001
    NIH
    REGULATION AND FUNCTION OF ANGIOTENSIN (1-7)
    Role: Principal Investigator
    R01HL056973     (CHAPPELL, MARK C)Aug 15, 1996 - Jun 30, 2010
    NIH
    Estrogen, ACE2 and Salt-Sensitivity
    Role: Principal Investigator
    S10RR021164     (CHAPPELL, MARK C)Apr 1, 2005 - Mar 31, 2006
    NIH
    Robotics Extraction System/HPLC for Shared Resource Lab
    Role: Principal Investigator
    R21HL112237     (CHAPPELL, MARK C)Dec 1, 2011 - Feb 28, 2014
    NIH
    Establishment of a model for diabetic cardiorenal syndrome in female mRen2.Lewis
    Role: Principal Investigator
    R21HD084227     (CHAPPELL, MARK C)Dec 1, 2015 - Nov 30, 2018
    NIH
    Novel Angiotensin-(1-7) Endopeptidase in Fetal Programming
    Role: Principal Investigator
    R01HL146818     (CHAPPELL, MARK C)Aug 15, 2019 - Jul 31, 2024
    NIH
    Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chappell M.C. The Angiotensin-(1-7) Axis: Formation and Metabolism Pathways. In: Santos R. (eds) Angiotensin-(1-7). Springer, Cham. 2019. View Publication.
    2. Yogasundaram H, Chappell MC, Braam B, Oudit GY. Cardiorenal Syndrome and Heart Failure-Challenges and Opportunities. Can J Cardiol. 2019 09; 35(9):1208-1219. PMID: 31300181.
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    3. Hendricks AS, Lawson MJ, Figueroa JP, Chappell MC, Diz DI, Shaltout HA. Central ANG-(1-7) infusion improves blood pressure regulation in antenatal betamethasone-exposed sheep and reveals sex-dependent effects on oxidative stress. . 2019 06 01; 316(6):H1458-H1467. PMID: 30951367.
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    4. Nautiyal M, Shaltout HA, Chappell MC, Diz DI. Comparison of Candesartan and Angiotensin-(1-7) Combination to Mito-TEMPO Treatment for Normalizing Blood Pressure and Sympathovagal Balance in (mREN2)27 Rats. J Cardiovasc Pharmacol. 2019 03; 73(3):143-148. PMID: 30540685.
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    5. South AM, Shaltout HA, Washburn LK, Hendricks AS, Diz DI, Chappell MC. Fetal programming and the angiotensin-(1-7) axis: a review of the experimental and clinical data. Clin Sci (Lond). 2019 01 15; 133(1):55-74. PMID: 30622158.
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    6. South AM, Nixon PA, Chappell MC, Diz DI, Russell GB, Shaltout HA, O'Shea TM, Washburn LK. Obesity is Associated with Higher Blood Pressure and Higher Levels of Angiotensin II but Lower Angiotensin-(1-7) in Adolescents Born Preterm. J Pediatr. 2019 02; 205:55-60.e1. PMID: 30404738.
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    7. South AM, Nixon PA, Chappell MC, Diz DI, Russell GB, Jensen ET, Shaltout HA, O'Shea TM, Washburn LK. Association between preterm birth and the renin-angiotensin system in adolescence: influence of sex and obesity. J Hypertens. 2018 10; 36(10):2092-2101. PMID: 29846325.
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    8. Hendricks AS, Shaltout HA, Westwood BM, Chappell MC, Diz DI. Sex-dependent expression of brain medullary MAP and PI3 kinases in adult sheep with antenatal betamethasone exposure. Clin Sci (Lond). 2018 09 14; 132(17):1953-1962. PMID: 30026259.
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    9. South AM, Nixon PA, Chappell MC, Diz DI, Russell GB, Jensen ET, Shaltout HA, O'Shea TM, Washburn LK. Renal function and blood pressure are altered in adolescents born preterm. Pediatr Nephrol. 2019 01; 34(1):137-144. PMID: 30112655.
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    10. Chappell MC. Hydrogen sulfide, then nitric oxide and vasoprotection. J Hypertens. 2018 03; 36(3):493-494. PMID: 29384987.
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    11. Sodhi CP, Wohlford-Lenane C, Yamaguchi Y, Prindle T, Fulton WB, Wang S, McCray PB, Chappell M, Hackam DJ, Jia H. Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg9 bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration. . 2018 01 01; 314(1):L17-L31. PMID: 28935640.
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    12. Wester A, Devocelle M, Tallant EA, Chappell MC, Gallagher PE, Paradisi F. Stabilization of Angiotensin-(1-7) by key substitution with a cyclic non-natural amino acid. Amino Acids. 2017 10; 49(10):1733-1742. PMID: 28744580.
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    13. Sigmund CD, Diz DI, Chappell MC. No Brain Renin-Angiotensin System: Déjà vu All Over Again? Hypertension. 2017 06; 69(6):1007-1010. PMID: 28396531.
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    14. Nildris Cruz-Diaz, Bryan A. Wilson, Mark C. Chappell. Peptidases and the Renin-Angiotensin System: The Alternative Angiotensin-(1-7) Cascade. In: “Enzyme Inhibitors and Activators”. Chapter 1, 1-24. (Editors, M Senturk) InTech (Rijeda Croatia). 2017. View Publication.
    15. Su Y, Bi J, Pulgar VM, Chappell MC, Rose JC. Antenatal betamethasone attenuates the angiotensin-(1-7)-Mas receptor-nitric oxide axis in isolated proximal tubule cells. Am J Physiol Renal Physiol. 2017 06 01; 312(6):F1056-F1062. PMID: 28228403.
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    16. Yousif MHM, Benter IF, Diz DI, Chappell MC. Angiotensin-(1-7)-dependent vasorelaxation of the renal artery exhibits unique angiotensin and bradykinin receptor selectivity. Peptides. 2017 04; 90:10-16. PMID: 28192151.
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    17. Chappell MC, Al Zayadneh EM. Angiotensin-(1-7) and the Regulation of Anti-Fibrotic Signaling Pathways. J Cell Signal. 2017 Mar; 2(1). PMID: 28691117.
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    18. Brosnihan KB, Chappell MC. Measurement of Angiotensin Peptides: HPLC-RIA. Methods Mol Biol. 2017; 1527:81-99. PMID: 28116709.
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    19. Wilson BA, Chappell MC. Assessment of the Renin-Angiotensin System in Cellular Organelle: New Arenas for Study in the Mitochondria. Methods Mol Biol. 2017; 1614:99-121. PMID: 28500599.
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    20. Wilson BA, Cruz-Diaz N, Su Y, Rose JC, Gwathmey TM, Chappell MC. Angiotensinogen import in isolated proximal tubules: evidence for mitochondrial trafficking and uptake. Am J Physiol Renal Physiol. 2017 05 01; 312(5):F879-F886. PMID: 27903492.
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    21. South AM, Nixon PA, Chappell MC, Diz DI, Russell GB, Snively BM, Shaltout HA, Rose JC, O'Shea TM, Washburn LK. Antenatal corticosteroids and the renin-angiotensin-aldosterone system in adolescents born preterm. Pediatr Res. 2017 01; 81(1-1):88-93. PMID: 27636897.
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    22. Koch A, Gulani J, King G, Hieber K, Chappell M, Ossetrova N. Establishment of Early Endpoints in Mouse Total-Body Irradiation Model. PLoS One. 2016; 11(8):e0161079. PMID: 27579862.
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    23. Chappell MC. Amiloride and the diabetic kidney. J Hypertens. 2016 08; 34(8):1500-1. PMID: 27355999.
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    24. Moroni M, Port M, Gulani J, Chappell M, Abend M. Significance of Bioindicators for Early Predictions on Diagnosis and Therapy of Irradiated Minipigs. Health Phys. 2016 08; 111(2):160-8. PMID: 27356060.
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    25. Cruz-Diaz N, Wilson BA, Pirro NT, Brosnihan KB, Marshall AC, Chappell MC. Identification of dipeptidyl peptidase 3 as the Angiotensin-(1-7) degrading peptidase in human HK-2 renal epithelial cells. Peptides. 2016 09; 83:29-37. PMID: 27315786.
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    26. Chappell MC, Wilson BA, Marshall AC, Alzayadneh E, Rose JC, Diz DI, Shaltout HA. The ACE2 – Angiotensin (1-7)-Mas Receptor Axis in the Kidney. In: New Aspects Of The Renin Angiotensin System In Cardiovascular And Renal Diseases. Bentham Science Publishers. 2016; 194-216. View Publication.
    27. Ferrara AN, Luck JB, Chappell MC. Twostriped Walkingstick Targets Human Eye With Chemical Defense Spray. Wilderness Environ Med. 2016 Jun; 27(2):259-61. PMID: 26961847.
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    28. Liu L, Kashyap S, Murphy B, Hutson DD, Budish RA, Trimmer EH, Zimmerman MA, Trask AJ, Miller KS, Chappell MC, Lindsey SH. GPER activation ameliorates aortic remodeling induced by salt-sensitive hypertension. . 2016 Apr 15; 310(8):H953-61. PMID: 26873963.
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    29. Chappell MC. Reply to "Letter to the editor: Angiotensin quantification by mass spectrometry". . 2016 Feb 01; 310(3):H454. PMID: 26830340.
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    30. Sunwook K, Nussbaum MA, Quandt SA, Laurienti PJ, Arcury TA. Effects of Lifetime Occupational Pesticide Exposure on Postural Control Among Farmworkers and Non-Farmworkers. J Occup Environ Med. 2016 Feb; 58(2):133-9. PMID: 18456730.
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    31. Wilson BA, Nautiyal M, Gwathmey TM, Rose JC, Chappell MC. Evidence for a mitochondrial angiotensin-(1-7) system in the kidney. Am J Physiol Renal Physiol. 2016 04 01; 310(7):F637-F645. PMID: 26697984.
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    32. Chappell MC. Biochemical evaluation of the renin-angiotensin system: the good, bad, and absolute? . 2016 Jan 15; 310(2):H137-52. PMID: 26475588.
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    33. Yamaleyeva LM, Chappell MC, Brosnihan KB, Anton L, Caudell DL, Shi S, McGee C, Pirro N, Gallagher PE, Taylor RN, Merrill DC, Mertz HL. Downregulation of apelin in the human placental chorionic villi from preeclamptic pregnancies. Am J Physiol Endocrinol Metab. 2015 Nov 15; 309(10):E852-60. PMID: 26394665.
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    34. Chen K, Bi J, Su Y, Chappell MC, Rose JC. Sex-Specific Changes in Renal Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 Gene Expression and Enzyme Activity at Birth and Over the First Year of Life. Reprod Sci. 2016 Feb; 23(2):200-10. PMID: 26243544.
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    35. Su Y, Bi J, Pulgar VM, Figueroa J, Chappell M, Rose JC. Antenatal glucocorticoid treatment alters Na+ uptake in renal proximal tubule cells from adult offspring in a sex-specific manner. Am J Physiol Renal Physiol. 2015 Jun 01; 308(11):F1268-75. PMID: 25834069.
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    36. Wilson BA, Cruz-Diaz N, Marshall AC, Pirro NT, Su Y, Gwathmey TM, Rose JC, Chappell MC. An angiotensin-(1-7) peptidase in the kidney cortex, proximal tubules, and human HK-2 epithelial cells that is distinct from insulin-degrading enzyme. Am J Physiol Renal Physiol. 2015 Mar 15; 308(6):F594-601. PMID: 25568136.
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    37. Alzayadneh EM, Chappell MC. Angiotensin-(1-7) abolishes AGE-induced cellular hypertrophy and myofibroblast transformation via inhibition of ERK1/2. Cell Signal. 2014 Dec; 26(12):3027-35. PMID: 25246357.
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    38. Bi J, Contag SA, Chen K, Su Y, Figueroa JP, Chappell MC, Rose JC. Sex-specific effect of antenatal betamethasone exposure on renal oxidative stress induced by angiotensins in adult sheep. Am J Physiol Renal Physiol. 2014 Nov 01; 307(9):F1013-22. PMID: 25209867.
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    39. Alzayadneh EM, Chappell MC. Nuclear expression of renin-angiotensin system components in NRK-52E renal epithelial cells. J Renin Angiotensin Aldosterone Syst. 2015 Dec; 16(4):1135-48. PMID: 24961503.
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    40. Wilson BA, Marshall AC, Alzayadneh EM, Chappell MC. The ins and outs of angiotensin processing within the kidney. . 2014 Sep 01; 307(5):R487-9. PMID: 24944244.
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    41. Marshall AC, Pirro NT, Rose JC, Diz DI, Chappell MC. Evidence for an angiotensin-(1-7) neuropeptidase expressed in the brain medulla and CSF of sheep. J Neurochem. 2014 Jul; 130(2):313-23. PMID: 24661079.
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    42. Washburn LK, Brosnihan KB, Chappell MC, Diz DI, Gwathmey TM, Nixon PA, Russell GB, Snively BM, O'Shea TM. The renin-angiotensin-aldosterone system in adolescent offspring born prematurely to mothers with preeclampsia. J Renin Angiotensin Aldosterone Syst. 2015 Sep; 16(3):529-38. PMID: 24737639.
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    43. Zhao Z, Wang H, Jessup JA, Lindsey SH, Chappell MC, Groban L. Role of estrogen in diastolic dysfunction. . 2014 Mar 01; 306(5):H628-40. PMID: 24414072.
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    44. Chappell MC, Marshall AC, Alzayadneh EM, Shaltout HA, Diz DI. Update on the Angiotensin converting enzyme 2-Angiotensin (1-7)-MAS receptor axis: fetal programing, sex differences, and intracellular pathways. Front Endocrinol (Lausanne). 2014 Jan 09; 4:201. PMID: 24409169.
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    45. Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC. Enhanced activity of an angiotensin-(1-7) neuropeptidase in glucocorticoid-induced fetal programming. Peptides. 2014 Feb; 52:74-81. PMID: 24355101.
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    46. Lindsey SH, Liu L, Chappell MC. Vasodilation by GPER in mesenteric arteries involves both endothelial nitric oxide and smooth muscle cAMP signaling. Steroids. 2014 Mar; 81:99-102. PMID: 24246735.
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    47. Wang H, Jessup JA, Zhao Z, Da Silva J, Lin M, MacNamara LM, Ahmad S, Chappell MC, Ferrario CM, Groban L. Characterization of the cardiac renin angiotensin system in oophorectomized and estrogen-replete mRen2.Lewis rats. PLoS One. 2013; 8(10):e76992. PMID: 24204720.
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    48. Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC. Antenatal betamethasone exposure is associated with lower ANG-(1-7) and increased ACE in the CSF of adult sheep. . 2013 Oct 01; 305(7):R679-88. PMID: 23948771.
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    49. Chappell MC. Of diabetic mice and ACE2: a new biomarker of renal disease? Am J Physiol Renal Physiol. 2013 Oct 01; 305(7):F970-2. PMID: 23863471.
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    50. Lindsey SH, da Silva AS, Silva MS, Chappell MC. Reduced vasorelaxation to estradiol and G-1 in aged female and adult male rats is associated with GPR30 downregulation. Am J Physiol Endocrinol Metab. 2013 Jul 01; 305(1):E113-8. PMID: 23673155.
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    51. Marshall AC, Shaltout HA, Nautiyal M, Rose JC, Chappell MC, Diz DI. Fetal betamethasone exposure attenuates angiotensin-(1-7)-Mas receptor expression in the dorsal medulla of adult sheep. Peptides. 2013 Jun; 44:25-31. PMID: 23538211.
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    52. Nautiyal M, Shaltout HA, de Lima DC, do Nascimento K, Chappell MC, Diz DI. Response to Angiotensin-(1-7) and Bradykinin in Baroreceptor Reflex Sensitivity in Hypertension. Hypertension. 2013 Feb; 61(2):e20. PMID: 23444463.
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    53. Nautiyal M, Arnold AC, Chappell MC, Diz DI. The brain Renin-Angiotensin system and mitochondrial function: influence on blood pressure and baroreflex in transgenic rat strains. Int J Hypertens. 2013; 2013:136028. PMID: 23401750.
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    54. Bi J, Contag SA, Carey LC, Tang L, Valego NK, Chappell MC, Rose JC. Antenatal betamethasone exposure alters renal responses to angiotensin-(1-7) in uninephrectomized adult male sheep. J Renin Angiotensin Aldosterone Syst. 2013 Dec; 14(4):290-8. PMID: 23161144.
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    55. Nautiyal M, Shaltout HA, de Lima DC, do Nascimento K, Chappell MC, Diz DI. Central angiotensin-(1-7) improves vagal function independent of blood pressure in hypertensive (mRen2)27 rats. Hypertension. 2012 Nov; 60(5):1257-65. PMID: 23045456.
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    56. Chappell MC. Nonclassical renin-angiotensin system and renal function. Compr Physiol. 2012 Oct; 2(4):2733-52. PMID: 23720263.
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    57. Nautiyal M, Katakam PV, Busija DW, Gallagher PE, Tallant EA, Chappell MC, Diz DI. Differences in oxidative stress status and expression of MKP-1 in dorsal medulla of transgenic rats with altered brain renin-angiotensin system. . 2012 Oct 15; 303(8):R799-806. PMID: 22914751.
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    58. Garcia-Espinosa MA, Shaltout HA, Gallagher PE, Chappell MC, Diz DI. In vivo expression of angiotensin-(1-7) lowers blood pressure and improves baroreflex function in transgenic (mRen2)27 rats. J Cardiovasc Pharmacol. 2012 Aug; 60(2):150-7. PMID: 22526299.
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    59. Yamaleyeva LM, Lindsey SH, Varagic J, Zhang LL, Gallagher PE, Chen AF, Chappell MC. Amelioration of renal injury and oxidative stress by the nNOS inhibitor L-VNIO in the salt-sensitive mRen2.Lewis congenic rat. J Cardiovasc Pharmacol. 2012 Jun; 59(6):529-38. PMID: 22370956.
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    60. Harrison-Bernard LM, Chappell MC. Unraveling the glomerular RAS: one peptidase at a time. Am J Physiol Renal Physiol. 2012 Aug 01; 303(3):F373-4. PMID: 22573374.
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    61. Westwood BM, Chappell MC. Divergent pathways for the angiotensin-(1-12) metabolism in the rat circulation and kidney. Peptides. 2012 Jun; 35(2):190-5. PMID: 22490446.
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    62. Yamaleyeva LM, Gilliam-Davis S, Almeida I, Brosnihan KB, Lindsey SH, Chappell MC. Differential regulation of circulating and renal ACE2 and ACE in hypertensive mRen2.Lewis rats with early-onset diabetes. Am J Physiol Renal Physiol. 2012 Jun 01; 302(11):F1374-84. PMID: 22378820.
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    63. Shaltout HA, Rose JC, Chappell MC, Diz DI. Angiotensin-(1-7) deficiency and baroreflex impairment precede the antenatal Betamethasone exposure-induced elevation in blood pressure. Hypertension. 2012 Feb; 59(2):453-8. PMID: 22215705.
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    64. Gwathmey TM, Alzayadneh EM, Pendergrass KD, Chappell MC. Novel roles of nuclear angiotensin receptors and signaling mechanisms. . 2012 Mar 01; 302(5):R518-30. PMID: 22170620.
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    65. Ahmad S, Simmons T, Varagic J, Moniwa N, Chappell MC, Ferrario CM. Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue. PLoS One. 2011; 6(12):e28501. PMID: 22180785.
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    66. Lindsey SH, Chappell MC. Evidence that the G protein-coupled membrane receptor GPR30 contributes to the cardiovascular actions of estrogen. Gend Med. 2011 Dec; 8(6):343-54. PMID: 22153880.
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    67. Bharadwaj MS, Strawn WB, Groban L, Yamaleyeva LM, Chappell MC, Horta C, Atkins K, Firmes L, Gurley SB, Brosnihan KB. Angiotensin-converting enzyme 2 deficiency is associated with impaired gestational weight gain and fetal growth restriction. Hypertension. 2011 Nov; 58(5):852-8. PMID: 21968754.
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    68. Isa K, Arnold AC, Westwood BM, Chappell MC, Diz DI. Angiotensin-converting enzyme inhibition, but not AT(1) receptor blockade, in the solitary tract nucleus improves baroreflex sensitivity in anesthetized transgenic hypertensive (mRen2)27 rats. Hypertens Res. 2011 Dec; 34(12):1257-62. PMID: 21937997.
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    69. Lindsey SH, Yamaleyeva LM, Brosnihan KB, Gallagher PE, Chappell MC. Estrogen receptor GPR30 reduces oxidative stress and proteinuria in the salt-sensitive female mRen2.Lewis rat. Hypertension. 2011 Oct; 58(4):665-71. PMID: 21844484.
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    70. Jessup JA, Zhang L, Chen AF, Presley TD, Kim-Shapiro DB, Chappell MC, Wang H, Groban L. Neuronal nitric oxide synthase inhibition improves diastolic function and reduces oxidative stress in ovariectomized mRen2.Lewis rats. Menopause. 2011 Jun; 18(6):698-708. PMID: 21293310.
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    71. Gilliam-Davis S, Gallagher PE, Payne VS, Kasper SO, Tommasi EN, Westwood BM, Robbins ME, Chappell MC, Diz DI. Long-term systemic angiotensin II type 1 receptor blockade regulates mRNA expression of dorsomedial medulla renin-angiotensin system components. Physiol Genomics. 2011 Jul 14; 43(13):829-35. PMID: 21540301.
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    72. Benter IF, Yousif MH, Al-Saleh FM, Raghupathy R, Chappell MC, Diz DI. Angiotensin-(1-7) blockade attenuates captopril- or hydralazine-induced cardiovascular protection in spontaneously hypertensive rats treated with NG-nitro-L-arginine methyl ester. J Cardiovasc Pharmacol. 2011 May; 57(5):559-67. PMID: 21326110.
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    73. Lindsey SH, Carver KA, Prossnitz ER, Chappell MC. Vasodilation in response to the GPR30 agonist G-1 is not different from estradiol in the mRen2.Lewis female rat. J Cardiovasc Pharmacol. 2011 May; 57(5):598-603. PMID: 21326105.
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    74. Shaltout HA, Chappell MC, Rose JC, Diz DI. Exaggerated sympathetic mediated responses to behavioral or pharmacological challenges following antenatal betamethasone exposure. Am J Physiol Endocrinol Metab. 2011 Jun; 300(6):E979-85. PMID: 21386063.
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    75. Ahmad S, Varagic J, Westwood BM, Chappell MC, Ferrario CM. Uptake and metabolism of the novel peptide angiotensin-(1-12) by neonatal cardiac myocytes. PLoS One. 2011 Jan 10; 6(1):e15759. PMID: 21249217.
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    76. Gwathmey TM, Shaltout HA, Rose JC, Diz DI, Chappell MC. Glucocorticoid-induced fetal programming alters the functional complement of angiotensin receptor subtypes within the kidney. Hypertension. 2011 Mar; 57(3):620-6. PMID: 21220702.
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    77. Jessup JA, Lindsey SH, Wang H, Chappell MC, Groban L. Attenuation of salt-induced cardiac remodeling and diastolic dysfunction by the GPER agonist G-1 in female mRen2.Lewis rats. PLoS One. 2010 Nov 03; 5(11):e15433. PMID: 21082029.
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    78. Gwathmey TM, Westwood BM, Pirro NT, Tang L, Rose JC, Diz DI, Chappell MC. Nuclear angiotensin-(1-7) receptor is functionally coupled to the formation of nitric oxide. Am J Physiol Renal Physiol. 2010 Nov; 299(5):F983-90. PMID: 20810609.
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    79. Embers ME, Doyle LA, Whitehouse CA, Selby EB, Chappell M, Philipp MT. Characterization of a Moraxella species that causes epistaxis in macaques. Vet Microbiol. 2011 Jan 27; 147(3-4):367-75. PMID: 20667430.
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    80. Chappell MC. Angiotensin-converting enzyme 2 autoantibodies: further evidence for a role of the renin-angiotensin system in inflammation. Arthritis Res Ther. 2010; 12(3):128. PMID: 20602809.
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    81. Arnold AC, Isa K, Shaltout HA, Nautiyal M, Ferrario CM, Chappell MC, Diz DI. Angiotensin-(1-12) requires angiotensin converting enzyme and AT1 receptors for cardiovascular actions within the solitary tract nucleus. . 2010 Sep; 299(3):H763-71. PMID: 20562338.
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    82. Tang L, Bi J, Valego N, Carey L, Figueroa J, Chappell M, Rose JC. Prenatal betamethasone exposure alters renal function in immature sheep: sex differences in effects. . 2010 Sep; 299(3):R793-803. PMID: 20554936.
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    83. Shaltout HA, Rose JC, Figueroa JP, Chappell MC, Diz DI, Averill DB. Acute AT(1)-receptor blockade reverses the hemodynamic and baroreflex impairment in adult sheep exposed to antenatal betamethasone. . 2010 Aug; 299(2):H541-7. PMID: 20543085.
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    84. Cohen JA, Lindsey SH, Pirro NT, Brosnihan KB, Gallagher PE, Chappell MC. Influence of estrogen depletion and salt loading on renal angiotensinogen expression in the mRen(2).Lewis strain. Am J Physiol Renal Physiol. 2010 Jul; 299(1):F35-42. PMID: 20462965.
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    85. Dhaunsi GS, Yousif MH, Akhtar S, Chappell MC, Diz DI, Benter IF. Angiotensin-(1-7) prevents diabetes-induced attenuation in PPAR-gamma and catalase activities. Eur J Pharmacol. 2010 Jul 25; 638(1-3):108-14. PMID: 20447391.
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    86. Trask AJ, Groban L, Westwood BM, Varagic J, Ganten D, Gallagher PE, Chappell MC, Ferrario CM. Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats. Am J Hypertens. 2010 Jun; 23(6):687-93. PMID: 20300067.
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    87. Contag SA, Bi J, Chappell MC, Rose JC. Developmental effect of antenatal exposure to betamethasone on renal angiotensin II activity in the young adult sheep. Am J Physiol Renal Physiol. 2010 Apr; 298(4):F847-56. PMID: 20071463.
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    88. Brosnihan KB, Hering L, Dechend R, Chappell MC, Herse F. Increased angiotensin II in the mesometrial triangle of a transgenic rat model of preeclampsia. Hypertension. 2010 Feb; 55(2):562-6. PMID: 20038747.
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    89. Chappell MC. Does ACE2 contribute to the development of hypertension? Hypertens Res. 2010 Feb; 33(2):107-9. PMID: 20019704.
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    90. Gwathmey TM, Pendergrass KD, Reid SD, Rose JC, Diz DI, Chappell MC. Angiotensin-(1-7)-angiotensin-converting enzyme 2 attenuates reactive oxygen species formation to angiotensin II within the cell nucleus. Hypertension. 2010 Jan; 55(1):166-71. PMID: 19948986.
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    91. Varagic J, Ahmad S, Brosnihan KB, Groban L, Chappell MC, Tallant EA, Gallagher PE, Ferrario CM. Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction. Ther Adv Cardiovasc Dis. 2010 Feb; 4(1):17-25. PMID: 19946038.
      Citations:    
    92. Silberman Y, Bajo M, Chappell AM, Christian DT, Cruz M, Diaz MR, Kash T, Lack AK, Messing RO, Siggins GR, Winder D, Roberto M, McCool BA, Weiner JL. Neurobiological mechanisms contributing to alcohol-stress-anxiety interactions. Alcohol. 2009 Nov; 43(7):509-19. PMID: 19913194.
      Citations:    
    93. Park S, Bivona BJ, Kobori H, Seth DM, Chappell MC, Lazartigues E, Harrison-Bernard LM. Major role for ACE-independent intrarenal ANG II formation in type II diabetes. Am J Physiol Renal Physiol. 2010 Jan; 298(1):F37-48. PMID: 19846569.
      Citations:    
    94. Jessup JA, Westwood BM, Chappell MC, Groban L. Dual ACE-inhibition and AT1 receptor antagonism improves ventricular lusitropy without affecting cardiac fibrosis in the congenic mRen2.Lewis rat. Ther Adv Cardiovasc Dis. 2009 Aug; 3(4):245-57. PMID: 19531557.
      Citations:    
    95. Pendergrass KD, Gwathmey TM, Michalek RD, Grayson JM, Chappell MC. The angiotensin II-AT1 receptor stimulates reactive oxygen species within the cell nucleus. Biochem Biophys Res Commun. 2009 Jun 26; 384(2):149-54. PMID: 19409874.
      Citations:    
    96. Jia HP, Look DC, Tan P, Shi L, Hickey M, Gakhar L, Chappell MC, Wohlford-Lenane C, McCray PB. Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia. . 2009 Jul; 297(1):L84-96. PMID: 19411314.
      Citations:    
    97. Isa K, García-Espinosa MA, Arnold AC, Pirro NT, Tommasi EN, Ganten D, Chappell MC, Ferrario CM, Diz DI. Chronic immunoneutralization of brain angiotensin-(1-12) lowers blood pressure in transgenic (mRen2)27 hypertensive rats. . 2009 Jul; 297(1):R111-5. PMID: 19403863.
      Citations:    
    98. Lindsey SH, Cohen JA, Brosnihan KB, Gallagher PE, Chappell MC. Chronic treatment with the G protein-coupled receptor 30 agonist G-1 decreases blood pressure in ovariectomized mRen2.Lewis rats. Endocrinology. 2009 Aug; 150(8):3753-8. PMID: 19372194.
      Citations:    
    99. Gwathmey TM, Shaltout HA, Pendergrass KD, Pirro NT, Figueroa JP, Rose JC, Diz DI, Chappell MC. Nuclear angiotensin II type 2 (AT2) receptors are functionally linked to nitric oxide production. Am J Physiol Renal Physiol. 2009 Jun; 296(6):F1484-93. PMID: 19244399.
      Citations:    
    100. Ferrario CM, Varagic J, Habibi J, Nagata S, Kato J, Chappell MC, Trask AJ, Kitamura K, Whaley-Connell A, Sowers JR. Differential regulation of angiotensin-(1-12) in plasma and cardiac tissue in response to bilateral nephrectomy. . 2009 Apr; 296(4):H1184-92. PMID: 19218503.
      Citations:    
    101. Shaltout HA, Figueroa JP, Rose JC, Diz DI, Chappell MC. Alterations in circulatory and renal angiotensin-converting enzyme and angiotensin-converting enzyme 2 in fetal programmed hypertension. Hypertension. 2009 Feb; 53(2):404-8. PMID: 19047579.
      Citations:    
    102. Tang L, Carey LC, Bi J, Valego N, Sun X, Deibel P, Perrott J, Figueroa JP, Chappell MC, Rose JC. Gender differences in the effects of antenatal betamethasone exposure on renal function in adult sheep. . 2009 Feb; 296(2):R309-17. PMID: 19036827.
      Citations:    
    103. Kantorowicz L, Valego NK, Tang L, Figueroa JP, Chappell MC, Carey LC, Rose JC. Plasma and renal renin concentrations in adult sheep after prenatal betamethasone exposure. Reprod Sci. 2008 Oct; 15(8):831-8. PMID: 19017818.
      Citations:    
    104. Varagic J, Trask AJ, Jessup JA, Chappell MC, Ferrario CM. New angiotensins. J Mol Med (Berl). 2008 Jun; 86(6):663-71. PMID: 18437333.
      Citations:    
    105. Jessup JA, Trask AJ, Chappell MC, Nagata S, Kato J, Kitamura K, Ferrario CM. Localization of the novel angiotensin peptide, angiotensin-(1-12), in heart and kidney of hypertensive and normotensive rats. . 2008 Jun; 294(6):H2614-8. PMID: 18408132.
      Citations:    
    106. Trask AJ, Jessup JA, Chappell MC, Ferrario CM. Angiotensin-(1-12) is an alternate substrate for angiotensin peptide production in the heart. . 2008 May; 294(5):H2242-7. PMID: 18359898.
      Citations:    
    107. Diz DI, Garcia-Espinosa MA, Gegick S, Tommasi EN, Ferrario CM, Ann Tallant E, Chappell MC, Gallagher PE. Injections of angiotensin-converting enzyme 2 inhibitor MLN4760 into nucleus tractus solitarii reduce baroreceptor reflex sensitivity for heart rate control in rats. Exp Physiol. 2008 May; 93(5):694-700. PMID: 18356558.
      Citations:    
    108. Garabelli PJ, Modrall JG, Penninger JM, Ferrario CM, Chappell MC. Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heart. Exp Physiol. 2008 May; 93(5):613-21. PMID: 18356559.
      Citations:    
    109. Jessup JA, Brosnihan KB, Gallagher PE, Chappell MC, Ferrario CM. Differential effect of low dose thiazides on the Renin Angiotensin system in genetically hypertensive and normotensive rats. J Am Soc Hypertens. 2008 Mar-Apr; 2(2):106-15. PMID: 19343087.
      Citations:    
    110. Groban L, Yamaleyeva LM, Westwood BM, Houle TT, Lin M, Kitzman DW, Chappell MC. Progressive diastolic dysfunction in the female mRen(2). Lewis rat: influence of salt and ovarian hormones. J Gerontol A Biol Sci Med Sci. 2008 Jan; 63(1):3-11. PMID: 18245755.
      Citations:    
    111. Chappell MC, Westwood BM, Yamaleyeva LM. Differential effects of sex steroids in young and aged female mRen2.Lewis rats: a model of estrogen and salt-sensitive hypertension. Gend Med. 2008; 5 Suppl A:S65-75. PMID: 18395684.
      Citations:    
    112. Benter IF, Yousif MH, Dhaunsi GS, Kaur J, Chappell MC, Diz DI. Angiotensin-(1-7) prevents activation of NADPH oxidase and renal vascular dysfunction in diabetic hypertensive rats. Am J Nephrol. 2008; 28(1):25-33. PMID: 17890855.
      Citations:    
    113. Chappell MC. Emerging evidence for a functional angiotensin-converting enzyme 2-angiotensin-(1-7)-MAS receptor axis: more than regulation of blood pressure? Hypertension. 2007 Oct; 50(4):596-9. PMID: 17785634.
      Citations:    
    114. Yamaleyeva LM, Pendergrass KD, Pirro NT, Gallagher PE, Groban L, Chappell MC. Ovariectomy is protective against renal injury in the high-salt-fed older mRen2. Lewis rat. . 2007 Oct; 293(4):H2064-71. PMID: 17630347.
      Citations:    
    115. Chappell MC. Role of ACE, ACE2 and Neprilysin in the Kidney. In: Leung P.S. (eds) Frontiers in Research of the Renin-Angiotensin System on Human Disease. Proteases in Biology and Disease, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6372-5_1. 2007; 1-20. View Publication.
    116. Carlos M. Ferrario, David B. Averill, K. Bridget Brosnihan, Mark C. Chappell, Debra I. Diz, Patricia E. Gallagher, Liomar Neves, E. Ann Tallant. Regulation of Cardiovascular Control Mechanisms by Angiotensin-(1–7) and Angiotensin-Converting Enzyme 2. In: Carey R.M. (eds) Hypertension and Hormone Mechanisms. Contemporary Endocrinology. Humana Press. https://doi.org/10.1007/978-1-59259-987-5_3. 2007; 43-59. View Publication.
    117. Oudit GY, Kassiri Z, Patel MP, Chappell M, Butany J, Backx PH, Tsushima RG, Scholey JW, Khokha R, Penninger JM. Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice. Cardiovasc Res. 2007 Jul 01; 75(1):29-39. PMID: 17499227.
      Citations:    
    118. Trask AJ, Averill DB, Ganten D, Chappell MC, Ferrario CM. Primary role of angiotensin-converting enzyme-2 in cardiac production of angiotensin-(1-7) in transgenic Ren-2 hypertensive rats. . 2007 Jun; 292(6):H3019-24. PMID: 17308000.
      Citations:    
    119. Yamaleyeva LM, Gallagher PE, Vinsant S, Chappell MC. Discoordinate regulation of renal nitric oxide synthase isoforms in ovariectomized mRen2. Lewis rats. . 2007 Feb; 292(2):R819-26. PMID: 17023669.
      Citations:    
    120. Shaltout HA, Westwood BM, Averill DB, Ferrario CM, Figueroa JP, Diz DI, Rose JC, Chappell MC. Angiotensin metabolism in renal proximal tubules, urine, and serum of sheep: evidence for ACE2-dependent processing of angiotensin II. Am J Physiol Renal Physiol. 2007 Jan; 292(1):F82-91. PMID: 16896185.
      Citations:    
    121. Chappell MC, Yamaleyeva LM, Westwood BM. Estrogen and salt sensitivity in the female mRen(2). Lewis rat. . 2006 Nov; 291(5):R1557-63. PMID: 16825422.
      Citations:    
    122. Jessup JA, Gallagher PE, Averill DB, Brosnihan KB, Tallant EA, Chappell MC, Ferrario CM. Effect of angiotensin II blockade on a new congenic model of hypertension derived from transgenic Ren-2 rats. . 2006 Nov; 291(5):H2166-72. PMID: 16766648.
      Citations:    
    123. Pendergrass KD, Averill DB, Ferrario CM, Diz DI, Chappell MC. Differential expression of nuclear AT1 receptors and angiotensin II within the kidney of the male congenic mRen2. Lewis rat. Am J Physiol Renal Physiol. 2006 Jun; 290(6):F1497-506. PMID: 16403834.
      Citations:    
    124. Groban L, Pailes NA, Bennett CD, Carter CS, Chappell MC, Kitzman DW, Sonntag WE. Growth hormone replacement attenuates diastolic dysfunction and cardiac angiotensin II expression in senescent rats. J Gerontol A Biol Sci Med Sci. 2006 Jan; 61(1):28-35. PMID: 16456192.
      Citations:    
    125. Chen Y, Chen H, Hoffmann A, Cool DR, Diz DI, Chappell MC, Chen AF, Chen A, Morris M. Adenovirus-mediated small-interference RNA for in vivo silencing of angiotensin AT1a receptors in mouse brain. Hypertension. 2006 Feb; 47(2):230-7. PMID: 16380517.
      Citations:    
    126. Ferrario CM, Jessup J, Gallagher PE, Averill DB, Brosnihan KB, Ann Tallant E, Smith RD, Chappell MC. Effects of renin-angiotensin system blockade on renal angiotensin-(1-7) forming enzymes and receptors. Kidney Int. 2005 Nov; 68(5):2189-96. PMID: 16221218.
      Citations:    
    127. Brosnihan KB, Neves LA, Chappell MC. Does the angiotensin-converting enzyme (ACE)/ACE2 balance contribute to the fate of angiotensin peptides in programmed hypertension? Hypertension. 2005 Nov; 46(5):1097-9. PMID: 16216992.
      Citations:    
    128. Gallagher PE, Chappell MC, Ferrario CM, Tallant EA. Distinct roles for ANG II and ANG-(1-7) in the regulation of angiotensin-converting enzyme 2 in rat astrocytes. . 2006 Feb; 290(2):C420-6. PMID: 16176966.
      Citations:    
    129. Sadjadi J, Kramer GL, Yu CH, Burress Welborn M, Chappell MC, Gregory Modrall J. Angiotensin converting enzyme-independent angiotensin ii production by chymase is up-regulated in the ischemic kidney in renovascular hypertension. J Surg Res. 2005 Aug; 127(2):65-9. PMID: 15869764.
      Citations:    
    130. Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, Huan Y, Yang P, Zhang Y, Deng W, Bao L, Zhang B, Liu G, Wang Z, Chappell M, Liu Y, Zheng D, Leibbrandt A, Wada T, Slutsky AS, Liu D, Qin C, Jiang C, Penninger JM. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med. 2005 Aug; 11(8):875-9. PMID: 16007097.
      Citations:    
    131. Ferrario CM, Jessup J, Chappell MC, Averill DB, Brosnihan KB, Tallant EA, Diz DI, Gallagher PE. Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2. Circulation. 2005 May 24; 111(20):2605-10. PMID: 15897343.
      Citations:    
    132. Chappell, MC, Modrall JG, Diz DI, Ferrario CM. Novel aspects of the renal renin-angiotensin system: Angiotensin-(1-7), ACE2 and blood pressure regulation. In: Kidney and Blood Pressure Regulation. (Contrib. Nephrol. Basel), Karger, ;143. 2004; 77-89. View Publication.
    133. C. M. Ferrario, D. B. Averill, K. B. Brosnihan, M. C. Chappell, D. I. Diz, P. E. Gallagher, E. A. Tallant. Angiotensin-(1–7). Its Contribution to Arterial Pressure Control Mechanisms. In: Unger T., Schölkens B.A. (eds) Angiotensin Vol. I. Handbook of Experimental Pharmacology, vol 163 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18495-6_21. 2004; 477-518. View Publication.
    134. Modrall JG, Sadjadi J, Brosnihan KB, Gallagher PE, Yu CH, Kramer GL, Bernstein KE, Chappell MC. Depletion of tissue angiotensin-converting enzyme differentially influences the intrarenal and urinary expression of angiotensin peptides. Hypertension. 2004 Apr; 43(4):849-53. PMID: 14981053.
      Citations:    
    135. Chappell MC, Modrall JG, Diz DI, Ferrario CM. Novel aspects of the renal renin-angiotensin system: angiotensin-(1-7), ACE2 and blood pressure regulation. Contrib Nephrol. 2004; 143:77-89. PMID: 15248357.
      Citations:    
    136. Averill DB, Ishiyama Y, Chappell MC, Ferrario CM. Cardiac angiotensin-(1-7) in ischemic cardiomyopathy. Circulation. 2003 Oct 28; 108(17):2141-6. PMID: 14517166.
      Citations:    
    137. Brosnihan KB, Neves LA, Joyner J, Averill DB, Chappell MC, Sarao R, Penninger J, Ferrario CM. Enhanced renal immunocytochemical expression of ANG-(1-7) and ACE2 during pregnancy. Hypertension. 2003 Oct; 42(4):749-53. PMID: 12874086.
      Citations:    
    138. Chappell MC, Gallagher PE, Averill DB, Ferrario CM, Brosnihan KB. Estrogen or the AT1 antagonist olmesartan reverses the development of profound hypertension in the congenic mRen2. Lewis rat. Hypertension. 2003 Oct; 42(4):781-6. PMID: 12874087.
      Citations:    
    139. Leung PS, Chappell MC. A local pancreatic renin-angiotensin system: endocrine and exocrine roles. Int J Biochem Cell Biol. 2003 Jun; 35(6):838-46. PMID: 12676170.
      Citations:    
    140. Neves LA, Averill DB, Ferrario CM, Chappell MC, Aschner JL, Walkup MP, Brosnihan KB. Characterization of angiotensin-(1-7) receptor subtype in mesenteric arteries. Peptides. 2003 Mar; 24(3):455-62. PMID: 12732345.
      Citations:    
    141. Nakamura S, Averill DB, Chappell MC, Diz DI, Brosnihan KB, Ferrario CM. Angiotensin receptors contribute to blood pressure homeostasis in salt-depleted SHR. . 2003 Jan; 284(1):R164-73. PMID: 12482748.
      Citations:    
    142. Ferrario CM, Averill DB, Brosnihan KB, Chappell MC, Iskandar SS, Dean RH, Diz DI. Vasopeptidase inhibition and Ang-(1-7) in the spontaneously hypertensive rat. Kidney Int. 2002 Oct; 62(4):1349-57. PMID: 12234305.
      Citations:    
    143. Crackower MA, Sarao R, Oudit GY, Yagil C, Kozieradzki I, Scanga SE, Oliveira-dos-Santos AJ, da Costa J, Zhang L, Pei Y, Scholey J, Ferrario CM, Manoukian AS, Chappell MC, Backx PH, Yagil Y, Penninger JM. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature. 2002 Jun 20; 417(6891):822-8. PMID: 12075344.
      Citations:    
    144. Ferrario CM, Smith RD, Brosnihan B, Chappell MC, Campese VM, Vesterqvist O, Liao WC, Ruddy MC, Grim CE. Effects of omapatrilat on the renin-angiotensin system in salt-sensitive hypertension. Am J Hypertens. 2002 Jun; 15(6):557-64. PMID: 12074359.
      Citations:    
    145. Chappell MC, Tallant EA, Diz DI, Ferrario CM. The renin-angiotensin system and cardiovascular homeostasis. In: Drugs, enzymes and receptors of the renin-angiotensin system: celebrating a century of discovery. (Husain A, Graham RM, Eds.) Harwood Academic Publishers, Amsterdam (Victor Chang molecular cardiology series), 2000:3-22. 2000. View Publication.
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