GregoryKuceraGregory L. Kucera PhD36.08919100000000-80.26677800000000312Kucera, GregoryLProfessorprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD003841Chemicals & Drugs20630.963796DeoxycytidineKounosukeWatabeKounosuke Watabe PhD36.09032400000000-80.266491000000001727Watabe, KounosukeProfessorAuthorship 391104Authorship 408296Authorship 40830324407462Qiao X, Ding S, Liu F, Kucera GL, Bierbach UJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic ChemistryQiao X, Ding S, Liu F, Kucera GL, Bierbach U. Investigating the cellular fate of a DNA-targeted platinum-based anticancer agent by orthogonal double-click chemistry. J Biol Inorg Chem. 2014 Mar; 19(3):415-26.J Biol Inorg Chem2014-01-10T00:00:002014Investigating the cellular fate of a DNA-targeted platinum-based anticancer agent by orthogonal double-click chemistry.25302716Pickard AJ, Liu F, Bartenstein TF, Haines LG, Levine KE, Kucera GL, Bierbach UChemistry (Weinheim an der Bergstrasse, Germany)Pickard AJ, Liu F, Bartenstein TF, Haines LG, Levine KE, Kucera GL, Bierbach U. Redesigning the DNA-targeted chromophore in platinum-acridine anticancer agents: a structure-activity relationship study. Chemistry. 2014 Dec 01; 20(49):16174-87.Chemistry2014-10-10T00:00:002014Redesigning the DNA-targeted chromophore in platinum-acridine anticancer agents: a structure-activity relationship study.25303639Ding S, Pickard AJ, Kucera GL, Bierbach UChemistry (Weinheim an der Bergstrasse, Germany)Ding S, Pickard AJ, Kucera GL, Bierbach U. Design of enzymatically cleavable prodrugs of a potent platinum-containing anticancer agent. Chemistry. 2014 Dec 01; 20(49):16164-73.Chemistry2014-10-10T00:00:002014Design of enzymatically cleavable prodrugs of a potent platinum-containing anticancer agent.AnesthesiologyBiochemistryCancer BiologyWake Forest School of MedicineTimothyPardeeTimothy S. Pardee MD, PhD36.08959100000000-80.268599000000001000Pardee, TimothyAssistant ProfessorCarolAlbrightCarol A. Albright PhD36.08919100000000-80.266778000000001092Albright, CarolAssistant ProfessorEdwardLevineEdward A. Levine MD36.08959100000000-80.26859900000000273Levine, EdwardProfessorAnnetteGrefeAnnette E. Grefe MD36.08919100000000-80.2667780000000029Grefe, AnnetteAssociate ProfessorAnthonyAtalaAnthony Atala MD36.08943500000000-80.268632000000003Atala, AnthonyProfessorGregoryFietsGregory L. Fiets MD36.08919100000000-80.26677800000000306Fiets, GregoryAssociate ProfessorGregoryHawkinsGregory A. Hawkins PhD36.09040200000000-80.26700599999999308Hawkins, GregoryProfessor1.651860.0072216175research areas0.299810.039320311coauthor of22.43442.4026649similar to1133selected publicationsKonstantinosVotanopoulosKonstantinos Votanopoulos MD, PhD, FACS36.09032400000000-80.26649100000000555Votanopoulos, KonstantinosProfessorAimeeWilkinAimee M. Wilkin MD, MPH36.08919100000000-80.2667780000000068Wilkin, AimeeProfessorWilliamGmeinerWilliam H. Gmeiner PhD36.09032400000000-80.2664910000000080Gmeiner, WilliamProfessorSamuelLentzSamuel S. Lentz MD36.08959100000000-80.26859900000000907Lentz, SamuelProfessorAuthorship 41911625793564Yang M, Pickard AJ, Qiao X, Gueble MJ, Day CS, Kucera GL, Bierbach UInorganic chemistryYang M, Pickard AJ, Qiao X, Gueble MJ, Day CS, Kucera GL, Bierbach U. Synthesis, reactivity, and biological activity of gold(I) complexes modified with thiourea-functionalized tyrosine kinase inhibitors. Inorg Chem. 2015 Apr 06; 54(7):3316-24.Inorg Chem2015-03-20T00:00:002015Synthesis, reactivity, and biological activity of gold(I) complexes modified with thiourea-functionalized tyrosine kinase inhibitors.Authorship 48303226829896Alexander P, Kucera G, Pardee TSCritical reviews in oncology/hematologyAlexander P, Kucera G, Pardee TS. Improving nucleoside analogs via lipid conjugation: Is fatter any better? Crit Rev Oncol Hematol. 2016 Apr; 100:46-56.Crit Rev Oncol Hematol2016-01-21T00:00:002016Improving nucleoside analogs via lipid conjugation: Is fatter any better?Authorship 514824Authorship 51504522328962Smyre CL, Saluta G, Kute TE, Kucera GL, Bierbach UACS medicinal chemistry lettersSmyre CL, Saluta G, Kute TE, Kucera GL, Bierbach U. Inhibition of DNA Synthesis by a Platinum-Acridine Hybrid Agent Leads to Potent Cell Kill in Non-Small Cell Lung Cancer. ACS Med Chem Lett. 2011 Aug 31; 2(11):870-874.ACS Med Chem Lett2011-08-31T00:00:002011Inhibition of DNA Synthesis by a Platinum-Acridine Hybrid Agent Leads to Potent Cell Kill in Non-Small Cell Lung Cancer.21927647Graham LA, Wilson GM, West TK, Day CS, Kucera GL, Bierbach UACS medicinal chemistry lettersGraham LA, Wilson GM, West TK, Day CS, Kucera GL, Bierbach U. Unusual Reactivity of a Potent Platinum-Acridine Hybrid Antitumor Agent. ACS Med Chem Lett. 2011 Sep 08; 2(9):687-691.ACS Med Chem Lett2011-09-08T00:00:002011Unusual Reactivity of a Potent Platinum-Acridine Hybrid Antitumor Agent.2000-01-31NIHKUCERA, GREGORY L1994-02-15DEOXYCYTIDINE ANALOG EFFECTS ON PHOSPHOLIPID METABOLISMR29CA058944Principal InvestigatorAuthorship 55045328644853Alexander PM, Caudell DL, Kucera GL, Pladna KM, Pardee TSPloS oneAlexander PM, Caudell DL, Kucera GL, Pladna KM, Pardee TS. The novel phospholipid mimetic KPC34 is highly active against preclinical models of Philadelphia chromosome positive acute lymphoblastic leukemia. PLoS One. 2017; 12(6):e0179798.PLoS One2017-06-23T00:00:002017The novel phospholipid mimetic KPC34 is highly active against preclinical models of Philadelphia chromosome positive acute lymphoblastic leukemia.Caio MaxRocha LimaCaio Max S. Rocha Lima MD, MS2211Rocha Lima, Caio MaxProfessor31033233Song Q, Hawkins GA, Wudel L, Chou PC, Forbes E, Pullikuth AK, Liu L, Jin G, Craddock L, Topaloglu U, Kucera G, O'Neill S, Levine EA, Sun P, Watabe K, Lu Y, Alexander-Miller MA, Pasche B, Miller LD, Zhang WCancer medicineSong Q, Hawkins GA, Wudel L, Chou PC, Forbes E, Pullikuth AK, Liu L, Jin G, Craddock L, Topaloglu U, Kucera G, O'Neill S, Levine EA, Sun P, Watabe K, Lu Y, Alexander-Miller MA, Pasche B, Miller LD, Zhang W. Dissecting intratumoral myeloid cell plasticity by single cell RNA-seq. Cancer Med. 2019 06; 8(6):3072-3085.Cancer Med2019-04-29T00:00:002019Dissecting intratumoral myeloid cell plasticity by single cell RNA-seq.20ProfessorAuthorship 658302Authorship 669701131194582Sexton T, Kucera GL, Levine EA, Watabe K, O'Neill SSBiopreservation and biobankingSexton T, Kucera GL, Levine EA, Watabe K, O'Neill SS. Optimization of Tissue Microarrays from Banked Human Formalin-Fixed Paraffin Embedded Tissues in the Cancer Research Setting. Biopreserv Biobank. 2019 Oct; 17(5):452-457.Biopreserv Biobank2019-06-13T00:00:002019Optimization of Tissue Microarrays from Banked Human Formalin-Fixed Paraffin Embedded Tissues in the Cancer Research Setting.Comprehensive Cancer Center (CCC)Internal Medicine, Hematology & OncologyInternal Medicine, Infectious DiseasesNeurology, Pediatric NeurologyObstetrics and Gynecology, GYN OncologyOrthopedic Surgery Surgery, OncologyUrologyhttp://www.wfirm.orgWFIRMAuthorship 132456Authorship 1417963ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessor4ProfessorProfessortrue1ProfessorProfessor5ProfessorProfessortrue1ProfessorProfessor2Associate DirectorAssociate Directortrue1Clinical Associate ProfessorClinical Associate Professortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessorAuthorship 198715Authorship 243956Authorship 256205Authorship 259627Authorship 266244Authorship 275934Authorship 30083Authorship 301473Authorship 30953Authorship 311195Authorship 32774Authorship 34652Authorship 48114Authorship 58053Authorship 5945Authorship 67933Authorship 82203Authorship 84813Authorship 8544Authorship 90396Authorship 9198211734304Stadheim TA, Kucera GLLeukemia researchStadheim TA, Kucera GL. c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for mitoxantrone- and anisomycin-induced apoptosis in HL-60 cells. Leuk Res. 2002 Jan; 26(1):55-65.Leuk Res2002-01-01T00:00:002002c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for mitoxantrone- and anisomycin-induced apoptosis in HL-60 cells.12018996Melvin MS, Tomlinson JT, Park G, Day CS, Saluta GR, Kucera GL, Manderville RAChemical research in toxicologyMelvin MS, Tomlinson JT, Park G, Day CS, Saluta GR, Kucera GL, Manderville RA. Influence of the a-ring on the proton affinity and anticancer properties of the prodigiosins. Chem Res Toxicol. 2002 May; 15(5):734-41.Chem Res Toxicol2002-05-01T00:00:002002Influence of the a-ring on the proton affinity and anticancer properties of the prodigiosins.12495358Barry CG, Turney EC, Day CS, Saluta G, Kucera GL, Bierbach UInorganic chemistryBarry CG, Turney EC, Day CS, Saluta G, Kucera GL, Bierbach U. Thermally inert metal ammines as light-inducible DNA-targeted agents. Synthesis, photochemistry, and photobiology of a prototypical rhodium(III)-intercalator conjugate. Inorg Chem. 2002 Dec 30; 41(26):7159-69.Inorg Chem2002-12-30T00:00:002002Thermally inert metal ammines as light-inducible DNA-targeted agents. Synthesis, photochemistry, and photobiology of a prototypical rhodium(III)-intercalator conjugate.12954073Alexander RL, Morris-Natschke SL, Ishaq KS, Fleming RA, Kucera GLJournal of medicinal chemistryAlexander RL, Morris-Natschke SL, Ishaq KS, Fleming RA, Kucera GL. Synthesis and cytotoxic activity of two novel 1-dodecylthio-2-decyloxypropyl-3-phosphatidic acid conjugates with gemcitabine and cytosine arabinoside. J Med Chem. 2003 Sep 11; 46(19):4205-8.J Med Chem2003-09-11T00:00:002003Synthesis and cytotoxic activity of two novel 1-dodecylthio-2-decyloxypropyl-3-phosphatidic acid conjugates with gemcitabine and cytosine arabinoside.14998688Xu M, Floyd HS, Greth SM, Chang WC, Lohman K, Stoyanova R, Kucera GL, Kute TE, Willingham MC, Miller MSToxicology and applied pharmacologyXu M, Floyd HS, Greth SM, Chang WC, Lohman K, Stoyanova R, Kucera GL, Kute TE, Willingham MC, Miller MS. Perillyl alcohol-mediated inhibition of lung cancer cell line proliferation: potential mechanisms for its chemotherapeutic effects. Toxicol Appl Pharmacol. 2004 Mar 01; 195(2):232-46.Toxicol Appl Pharmacol2004-03-01T00:00:002004Perillyl alcohol-mediated inhibition of lung cancer cell line proliferation: potential mechanisms for its chemotherapeutic effects.15789226Alexander RL, Greene BT, Torti SV, Kucera GLCancer chemotherapy and pharmacologyAlexander RL, Greene BT, Torti SV, Kucera GL. A novel phospholipid gemcitabine conjugate is able to bypass three drug-resistance mechanisms. Cancer Chemother Pharmacol. 2005 Jul; 56(1):15-21.Cancer Chemother Pharmacol2005-03-24T00:00:002005A novel phospholipid gemcitabine conjugate is able to bypass three drug-resistance mechanisms.15853657Alexander RL, Kucera GLCurrent pharmaceutical designAlexander RL, Kucera GL. Lipid nucleoside conjugates for the treatment of cancer. Curr Pharm Des. 2005; 11(9):1079-89.Curr Pharm Des2005-01-01T00:00:002005Lipid nucleoside conjugates for the treatment of cancer.16722638Guddneppanavar R, Saluta G, Kucera GL, Bierbach UJournal of medicinal chemistryGuddneppanavar R, Saluta G, Kucera GL, Bierbach U. Synthesis, biological activity, and DNA-damage profile of platinum-threading intercalator conjugates designed to target adenine. J Med Chem. 2006 Jun 01; 49(11):3204-14.J Med Chem2006-06-01T00:00:002006Synthesis, biological activity, and DNA-damage profile of platinum-threading intercalator conjugates designed to target adenine.16996114Barnes AP, Miller BE, Kucera GLGynecologic oncologyBarnes AP, Miller BE, Kucera GL. Cyclooxygenase inhibition and hyperthermia for the potentiation of the cytotoxic response in ovarian cancer cells. Gynecol Oncol. 2007 Feb; 104(2):443-50.Gynecol Oncol2006-09-22T00:00:002006Cyclooxygenase inhibition and hyperthermia for the potentiation of the cytotoxic response in ovarian cancer cells.17020344Tomlinson JT, Park G, Misenheimer JA, Kucera GL, Hesp K, Manderville RAOrganic lettersTomlinson JT, Park G, Misenheimer JA, Kucera GL, Hesp K, Manderville RA. Photoinduced cytotoxicity and thioadduct formation by a prodigiosin analogue. Org Lett. 2006 Oct 12; 8(21):4951-4.Org Lett2006-10-12T00:00:002006Photoinduced cytotoxicity and thioadduct formation by a prodigiosin analogue.17498782Lentz SS, Miller BE, Kucera GL, Levine EAGynecologic oncologyLentz SS, Miller BE, Kucera GL, Levine EA. Intraperitoneal hyperthermic chemotherapy using carboplatin: a phase I analysis in ovarian carcinoma. Gynecol Oncol. 2007 Jul; 106(1):207-10.Gynecol Oncol2007-05-10T00:00:002007Intraperitoneal hyperthermic chemotherapy using carboplatin: a phase I analysis in ovarian carcinoma.19012390Ma Z, Choudhury JR, Wright MW, Day CS, Saluta G, Kucera GL, Bierbach UJournal of medicinal chemistryMa Z, Choudhury JR, Wright MW, Day CS, Saluta G, Kucera GL, Bierbach U. A non-cross-linking platinum-acridine agent with potent activity in non-small-cell lung cancer. J Med Chem. 2008 Dec 11; 51(23):7574-80.J Med Chem2008-12-11T00:00:002008A non-cross-linking platinum-acridine agent with potent activity in non-small-cell lung cancer.23074987Ding S, Qiao X, Kucera GL, Bierbach UJournal of medicinal chemistryDing S, Qiao X, Kucera GL, Bierbach U. Using a build-and-click approach for producing structural and functional diversity in DNA-targeted hybrid anticancer agents. J Med Chem. 2012 Nov 26; 55(22):10198-203.J Med Chem2012-10-25T00:00:002012Using a build-and-click approach for producing structural and functional diversity in DNA-targeted hybrid anticancer agents.23427109Ding S, Qiao X, Suryadi J, Marrs GS, Kucera GL, Bierbach UAngewandte Chemie (International ed. in English)Ding S, Qiao X, Suryadi J, Marrs GS, Kucera GL, Bierbach U. Using fluorescent post-labeling to probe the subcellular localization of DNA-targeted platinum anticancer agents. Angew Chem Int Ed Engl. 2013 Mar 18; 52(12):3350-4.Angew Chem Int Ed Engl2013-02-20T00:00:002013Using fluorescent post-labeling to probe the subcellular localization of DNA-targeted platinum anticancer agents.RakheeVaidyaRakhee Vaidya MBBS36.08919100000000-80.266778000000001641Vaidya, RakheeClinical Associate Professor17408248Guddneppanavar R, Choudhury JR, Kheradi AR, Steen BD, Saluta G, Kucera GL, Day CS, Bierbach UJournal of medicinal chemistryGuddneppanavar R, Choudhury JR, Kheradi AR, Steen BD, Saluta G, Kucera GL, Day CS, Bierbach U. Effect of the diamine nonleaving group in platinum-acridinylthiourea conjugates on DNA damage and cytotoxicity. J Med Chem. 2007 May 03; 50(9):2259-63.J Med Chem2007-04-05T00:00:002007Effect of the diamine nonleaving group in platinum-acridinylthiourea conjugates on DNA damage and cytotoxicity.18457380Choudhury JR, Guddneppanavar R, Saluta G, Kucera GL, Bierbach UJournal of medicinal chemistryChoudhury JR, Guddneppanavar R, Saluta G, Kucera GL, Bierbach U. Tuning the DNA conformational perturbations induced by cytotoxic platinum-acridine bisintercalators: effect of metal cis/trans isomerism and DNA threading groups. J Med Chem. 2008 Jun 12; 51(11):3069-72.J Med Chem2008-05-06T00:00:002008Tuning the DNA conformational perturbations induced by cytotoxic platinum-acridine bisintercalators: effect of metal cis/trans isomerism and DNA threading groups.18515101Ma Z, Saluta G, Kucera GL, Bierbach UBioorganic & medicinal chemistry lettersMa Z, Saluta G, Kucera GL, Bierbach U. Effect of linkage geometry on biological activity in thiourea- and guanidine-substituted acridines and platinum-acridines. Bioorg Med Chem Lett. 2008 Jul 01; 18(13):3799-801.Bioorg Med Chem Lett2008-05-16T00:00:002008Effect of linkage geometry on biological activity in thiourea- and guanidine-substituted acridines and platinum-acridines.19477643Kheradi AR, Saluta G, Kucera GL, Day CS, Bierbach UBioorganic & medicinal chemistry lettersKheradi AR, Saluta G, Kucera GL, Day CS, Bierbach U. Synthesis and biological evaluation of platinum-acridine hybrid agents modified with bipyridine non-leaving groups. Bioorg Med Chem Lett. 2009 Jul 01; 19(13):3423-5.Bioorg Med Chem Lett2009-05-18T00:00:002009Synthesis and biological evaluation of platinum-acridine hybrid agents modified with bipyridine non-leaving groups.19803526Eiter LC, Hall NW, Day CS, Saluta G, Kucera GL, Bierbach UJournal of medicinal chemistryEiter LC, Hall NW, Day CS, Saluta G, Kucera GL, Bierbach U. Gold(I) analogues of a platinum-acridine antitumor agent are only moderately cytotoxic but show potent activity against Mycobacterium tuberculosis. J Med Chem. 2009 Nov 12; 52(21):6519-22.J Med Chem2009-11-12T00:00:002009Gold(I) analogues of a platinum-acridine antitumor agent are only moderately cytotoxic but show potent activity against Mycobacterium tuberculosis.20578739Rao L, West TK, Saluta G, Kucera GL, Bierbach UChemical research in toxicologyRao L, West TK, Saluta G, Kucera GL, Bierbach U. Probing platinum-adenine-n3 adduct formation with DNA minor-groove binding agents. Chem Res Toxicol. 2010 Jul 19; 23(7):1148-50.Chem Res Toxicol2010-07-19T00:00:002010Probing platinum-adenine-n3 adduct formation with DNA minor-groove binding agents.22456976Qiao X, Zeitany AE, Wright MW, Essader AS, Levine KE, Kucera GL, Bierbach UMetallomics : integrated biometal scienceQiao X, Zeitany AE, Wright MW, Essader AS, Levine KE, Kucera GL, Bierbach U. Analysis of the DNA damage produced by a platinum-acridine antitumor agent and its effects in NCI-H460 lung cancer cells. Metallomics. 2012 Jul; 4(7):645-52.Metallomics2012-03-29T00:00:002012Analysis of the DNA damage produced by a platinum-acridine antitumor agent and its effects in NCI-H460 lung cancer cells.22871158Graham LA, Suryadi J, West TK, Kucera GL, Bierbach UJournal of medicinal chemistryGraham LA, Suryadi J, West TK, Kucera GL, Bierbach U. Synthesis, aqueous reactivity, and biological evaluation of carboxylic acid ester-functionalized platinum-acridine hybrid anticancer agents. J Med Chem. 2012 Sep 13; 55(17):7817-27.J Med Chem2012-08-17T00:00:002012Synthesis, aqueous reactivity, and biological evaluation of carboxylic acid ester-functionalized platinum-acridine hybrid anticancer agents.23416453Ding S, Qiao X, Kucera GL, Bierbach UChemical communications (Cambridge, England)Ding S, Qiao X, Kucera GL, Bierbach U. Design of a platinum-acridine-endoxifen conjugate targeted at hormone-dependent breast cancer. Chem Commun (Camb). 2013 Mar 25; 49(24):2415-7.Chem Commun (Camb)2013-03-25T00:00:002013Design of a platinum-acridine-endoxifen conjugate targeted at hormone-dependent breast cancer.D009944Chemicals & Drugs18420.97829Organoplatinum CompoundsD000166Chemicals & Drugs6190.989413AcridinesD000970Chemicals & Drugs1525320.69113Antineoplastic AgentsD010984Chemicals & Drugs8190.984516Platinum