CharlesMcCallCharles E. McCall MD36.09032400000000-80.26649100000000144McCall, CharlesEProfessorprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 366875Authorship 403036Authorship 403448Authorship 404653Authorship 4094714Authorship 40954624980967McClure C, Brudecki L, Ferguson DA, Yao ZQ, Moorman JP, McCall CE, El Gazzar MInfection and immunityMcClure C, Brudecki L, Ferguson DA, Yao ZQ, Moorman JP, McCall CE, El Gazzar M. MicroRNA 21 (miR-21) and miR-181b couple with NFI-A to generate myeloid-derived suppressor cells and promote immunosuppression in late sepsis. Infect Immun. 2014 Sep; 82(9):3816-25.Infect Immun2014-06-30T00:00:002014MicroRNA 21 (miR-21) and miR-181b couple with NFI-A to generate myeloid-derived suppressor cells and promote immunosuppression in late sepsis.25001863Vachharajani VT, Liu T, Brown CM, Wang X, Buechler NL, Wells JD, Yoza BK, McCall CEJournal of leukocyte biologyVachharajani VT, Liu T, Brown CM, Wang X, Buechler NL, Wells JD, Yoza BK, McCall CE. SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome. J Leukoc Biol. 2014 Nov; 96(5):785-96.J Leukoc Biol2014-07-07T00:00:002014SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome.25088223Vachharajani V, Liu T, McCall CEExpert review of clinical immunologyVachharajani V, Liu T, McCall CE. Epigenetic coordination of acute systemic inflammation: potential therapeutic targets. Expert Rev Clin Immunol. 2014 Sep; 10(9):1141-50.Expert Rev Clin Immunol2014-08-04T00:00:002014Epigenetic coordination of acute systemic inflammation: potential therapeutic targets.25404168Reynolds LM, Taylor JR, Ding J, Lohman K, Johnson C, Siscovick D, Burke G, Post W, Shea S, Jacobs DR, Stunnenberg H, Kritchevsky SB, Hoeschele I, McCall CE, Herrington D, Tracy RP, Liu YNature communicationsReynolds LM, Taylor JR, Ding J, Lohman K, Johnson C, Siscovick D, Burke G, Post W, Shea S, Jacobs DR, Stunnenberg H, Kritchevsky SB, Hoeschele I, McCall CE, Herrington D, Tracy RP, Liu Y. Age-related variations in the methylome associated with gene expression in human monocytes and T cells. Nat Commun. 2014 Nov 18; 5:5366.Nat Commun2014-11-18T00:00:002014Age-related variations in the methylome associated with gene expression in human monocytes and T cells.25404738Liu TF, Vachharajani V, Millet P, Bharadwaj MS, Molina AJ, McCall CEThe Journal of biological chemistryLiu TF, Vachharajani V, Millet P, Bharadwaj MS, Molina AJ, McCall CE. Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis. J Biol Chem. 2015 Jan 02; 290(1):396-408.J Biol Chem2014-11-17T00:00:002014Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis.AnesthesiologyMicrobiology and ImmunologyWake Forest School of MedicineWernerBischoffWerner E. Bischoff MD, MS, PhD, FSHEA36.09032400000000-80.266491000000001023Bischoff, WernerProfessorBarbaraYozaBarbara K. Yoza PhD36.08959100000000-80.26859900000000113Yoza, BarbaraProfessorXueweiZhuXuewei Zhu PhD36.08943500000000-80.268632000000001224Zhu, XueweiAssociate ProfessorCristinaFurduiCristina M. Furdui PhD36.09032400000000-80.26649100000000135Furdui, CristinaProfessor8.476230.00828711337research areas5.253210.014665429coauthor of110.43915.425653similar to1183selected publicationsAnthonyAtalaAnthony Atala MD36.08943500000000-80.268632000000003Atala, AnthonyProfessorJohnParksJohn S. Parks PhD36.08943500000000-80.26863200000000464Parks, JohnProfessorKonstantinosVotanopoulosKonstantinos Votanopoulos MD, PhD, FACS36.09032400000000-80.26649100000000555Votanopoulos, KonstantinosProfessorLanceMillerLance D. Miller PhD, MS36.09032400000000-80.26649100000000574Miller, LanceAssistant ProfessorStephenKritchevskyStephen Kritchevsky PhD36.08884000000000-80.27016200000000903Kritchevsky, StephenProfessorTieLiuTie F. Liu MD, PhD36.09032400000000-80.26649100000000981Liu, TieInstructorAuthorship 42063525909427Smith LM, Wells JD, Vachharajani VT, Yoza BK, McCall CE, Hoth JJThe journal of trauma and acute care surgerySmith LM, Wells JD, Vachharajani VT, Yoza BK, McCall CE, Hoth JJ. SIRT1 mediates a primed response to immune challenge after traumatic lung injury. J Trauma Acute Care Surg. 2015 May; 78(5):1034-8.J Trauma Acute Care Surg2015-05-01T00:00:002015SIRT1 mediates a primed response to immune challenge after traumatic lung injury.Authorship 421022225898983Reynolds LM, Ding J, Taylor JR, Lohman K, Soranzo N, de la Fuente A, Liu TF, Johnson C, Barr RG, Register TC, Donohue KM, Talor MV, Cihakova D, Gu C, Divers J, Siscovick D, Burke G, Post W, Shea S, Jacobs DR, Hoeschele I, McCall CE, Kritchevsky SB, Herrington D, Tracy RP, Liu YBMC genomicsReynolds LM, Ding J, Taylor JR, Lohman K, Soranzo N, de la Fuente A, Liu TF, Johnson C, Barr RG, Register TC, Donohue KM, Talor MV, Cihakova D, Gu C, Divers J, Siscovick D, Burke G, Post W, Shea S, Jacobs DR, Hoeschele I, McCall CE, Kritchevsky SB, Herrington D, Tracy RP, Liu Y. Transcriptomic profiles of aging in purified human immune cells. BMC Genomics. 2015 Apr 22; 16:333.BMC Genomics2015-04-22T00:00:002015Transcriptomic profiles of aging in purified human immune cells.Authorship 42229425959124Wang X, Buechler NL, Yoza BK, McCall CE, Vachharajani VTObesity (Silver Spring, Md.)Wang X, Buechler NL, Yoza BK, McCall CE, Vachharajani VT. Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice. Obesity (Silver Spring). 2015 Jun; 23(6):1209-17.Obesity (Silver Spring)2015-05-09T00:00:002015Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice.DavidSoto PantojaDavid Soto Pantoja PhD36.09032400000000-80.266491000000001771Soto Pantoja, DavidAssociate ProfessorAuthorship 466642826153245Ding J, Reynolds LM, Zeller T, Müller C, Lohman K, Nicklas BJ, Kritchevsky SB, Huang Z, de la Fuente A, Soranzo N, Settlage RE, Chuang CC, Howard T, Xu N, Goodarzi MO, Chen YD, Rotter JI, Siscovick DS, Parks JS, Murphy S, Jacobs DR, Post W, Tracy RP, Wild PS, Blankenberg S, Hoeschele I, Herrington D, McCall CE, Liu YDiabetesDing J, Reynolds LM, Zeller T, Müller C, Lohman K, Nicklas BJ, Kritchevsky SB, Huang Z, de la Fuente A, Soranzo N, Settlage RE, Chuang CC, Howard T, Xu N, Goodarzi MO, Chen YD, Rotter JI, Siscovick DS, Parks JS, Murphy S, Jacobs DR, Post W, Tracy RP, Wild PS, Blankenberg S, Hoeschele I, Herrington D, McCall CE, Liu Y. Alterations of a Cellular Cholesterol Metabolism Network Are a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease. Diabetes. 2015 Oct; 64(10):3464-74.Diabetes2015-07-07T00:00:002015Alterations of a Cellular Cholesterol Metabolism Network Are a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease.Authorship 46985425998849McClure C, Brudecki L, Yao ZQ, McCall CE, El Gazzar MJournal of innate immunityMcClure C, Brudecki L, Yao ZQ, McCall CE, El Gazzar M. Processing Body Formation Limits Proinflammatory Cytokine Synthesis in Endotoxin-Tolerant Monocytes and Murine Septic Macrophages. J Innate Immun. 2015; 7(6):572-83.J Innate Immun2015-05-19T00:00:002015Processing Body Formation Limits Proinflammatory Cytokine Synthesis in Endotoxin-Tolerant Monocytes and Murine Septic Macrophages.LindsayReynoldsLindsay M. Reynolds PhD1856Reynolds, LindsayAssistant ProfessorAuthorship 47995526259914McClure C, Ali E, Youssef D, Yao ZQ, McCall CE, El Gazzar MJournal of leukocyte biologyMcClure C, Ali E, Youssef D, Yao ZQ, McCall CE, El Gazzar M. NFI-A disrupts myeloid cell differentiation and maturation in septic mice. J Leukoc Biol. 2016 Jan; 99(1):201-11.J Leukoc Biol2015-08-10T00:00:002015NFI-A disrupts myeloid cell differentiation and maturation in septic mice.Authorship 483225Authorship 48396626843329Millet P, Vachharajani V, McPhail L, Yoza B, McCall CEJournal of immunology (Baltimore, Md. : 1950)Millet P, Vachharajani V, McPhail L, Yoza B, McCall CE. GAPDH Binding to TNF-a mRNA Contributes to Posttranscriptional Repression in Monocytes: A Novel Mechanism of Communication between Inflammation and Metabolism. J Immunol. 2016 Mar 15; 196(6):2541-51.J Immunol2016-02-03T00:00:002016GAPDH Binding to TNF-a mRNA Contributes to Posttranscriptional Repression in Monocytes: A Novel Mechanism of Communication between Inflammation and Metabolism.26904696Vachharajani VT, Liu T, Wang X, Hoth JJ, Yoza BK, McCall CEJournal of immunology researchVachharajani VT, Liu T, Wang X, Hoth JJ, Yoza BK, McCall CE. Sirtuins Link Inflammation and Metabolism. J Immunol Res. 2016; 2016:8167273.J Immunol Res2016-01-20T00:00:002016Sirtuins Link Inflammation and Metabolism.Authorship 49655627500833Wang X, Buechler NL, Martin A, Wells J, Yoza B, McCall CE, Vachharajani VPloS oneWang X, Buechler NL, Martin A, Wells J, Yoza B, McCall CE, Vachharajani V. Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice. PLoS One. 2016; 11(8):e0160431.PLoS One2016-08-08T00:00:002016Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice.Authorship 517595Authorship 51868427430527McClure C, McPeak MB, Youssef D, Yao ZQ, McCall CE, El Gazzar MImmunology and cell biologyMcClure C, McPeak MB, Youssef D, Yao ZQ, McCall CE, El Gazzar M. Stat3 and C/EBPß synergize to induce miR-21 and miR-181b expression during sepsis. Immunol Cell Biol. 2017 01; 95(1):42-55.Immunol Cell Biol2016-07-19T00:00:002016Stat3 and C/EBPß synergize to induce miR-21 and miR-181b expression during sepsis.27785087Wang X, Buechler NL, Yoza BK, McCall CE, Vachharajani VJournal of inflammation researchWang X, Buechler NL, Yoza BK, McCall CE, Vachharajani V. Adiponectin treatment attenuates inflammatory response during early sepsis in obese mice. J Inflamm Res. 2016; 9:167-174.J Inflamm Res2016-10-05T00:00:002016Adiponectin treatment attenuates inflammatory response during early sepsis in obese mice.Authorship 52182827903268Chi GC, Liu Y, MacDonald JW, Barr RG, Donohue KM, Hensley MD, Hou L, McCall CE, Reynolds LM, Siscovick DS, Kaufman JDEnvironmental health : a global access science sourceChi GC, Liu Y, MacDonald JW, Barr RG, Donohue KM, Hensley MD, Hou L, McCall CE, Reynolds LM, Siscovick DS, Kaufman JD. Long-term outdoor air pollution and DNA methylation in circulating monocytes: results from the Multi-Ethnic Study of Atherosclerosis (MESA). Environ Health. 2016 12 01; 15(1):119.Environ Health2016-12-01T00:00:002016Long-term outdoor air pollution and DNA methylation in circulating monocytes: results from the Multi-Ethnic Study of Atherosclerosis (MESA).Authorship 52709628167668McPeak MB, Youssef D, Williams DA, Pritchett C, Yao ZQ, McCall CE, El Gazzar MInfection and immunityMcPeak MB, Youssef D, Williams DA, Pritchett C, Yao ZQ, McCall CE, El Gazzar M. Myeloid Cell-Specific Knockout of NFI-A Improves Sepsis Survival. Infect Immun. 2017 04; 85(4).Infect Immun2017-03-23T00:00:002017Myeloid Cell-Specific Knockout of NFI-A Improves Sepsis Survival.Authorship 52965627583522Wang X, Buechler NL, Martin A, Wells J, Yoza B, McCall CE, Vachharajani VPloS oneWang X, Buechler NL, Martin A, Wells J, Yoza B, McCall CE, Vachharajani V. Correction: Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice. PLoS One. 2016; 11(9):e0162560.PLoS One2016-09-01T00:00:002016Correction: Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice.2017-01-03NIHMCCALL, CHARLES EMORY2005-07-01NF-kB and Chromatin Changes in Human SepsisR01AI0657912006-05-31NIHMCCALL, CHARLES EMORY1999-06-01EDUCATION IN PATIENT ORIENTED RESEARCHK30HL0041642015-11-30NIHMCCALL, CHARLES EMORY2009-12-01Epigenetics of Severe Systemic InflammationR01AI0791442007-09-21NIHMCCALL, CHARLES EMORY2006-09-22Planning Grant for Institutional Clinical and Translational Science AwardP20RR0235702009-11-30NIHMCCALL, CHARLES EMORY2009-06-05Epigenetics of Severe Systemic InflammationR56AI0791442004-03-31NIHMCCALL, CHARLES EMORY1974-04-01FUNCTIONAL AND METABOLIC PROPERTIES OF TOXIC NEUTROPHILSR01AI0091692007-03-31NIHMCCALL, CHARLES EMORY1974-04-01Function and Metabolic Properties of Toxic NeutrophilsR21AI0091691997-08-31NIHMCCALL, CHARLES E1982-09-01PATHOGENIC MECHANISMS PRODUCING LUNG INJURYR01HL0292932019-04-30NIHMCCALL, CHARLES EMORY2014-08-05Mitochondrial Biogenesis is Regulated by RelB During InflammationR01GM102497Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorAuthorship 544526Authorship 54520428476751McPeak MB, Youssef D, Williams DA, Pritchett CL, Yao ZQ, McCall CE, El Gazzar MJournal of leukocyte biologyMcPeak MB, Youssef D, Williams DA, Pritchett CL, Yao ZQ, McCall CE, El Gazzar M. Frontline Science: Myeloid cell-specific deletion of Cebpb decreases sepsis-induced immunosuppression in mice. J Leukoc Biol. 2017 08; 102(2):191-200.J Leukoc Biol2017-05-05T00:00:002017Frontline Science: Myeloid cell-specific deletion of Cebpb decreases sepsis-induced immunosuppression in mice.28503576Buechler N, Wang X, Yoza BK, McCall CE, Vachharajani VJournal of immunology researchBuechler N, Wang X, Yoza BK, McCall CE, Vachharajani V. Sirtuin 2 Regulates Microvascular Inflammation during Sepsis. J Immunol Res. 2017; 2017:2648946.J Immunol Res2017-04-19T00:00:002017Sirtuin 2 Regulates Microvascular Inflammation during Sepsis.Authorship 55035728642803Taylor J, Reynolds L, Hou L, Lohman K, Cui W, Kritchevsky S, McCall C, Liu YImmunity & ageing : I & ATaylor J, Reynolds L, Hou L, Lohman K, Cui W, Kritchevsky S, McCall C, Liu Y. Transcriptomic profiles of aging in naïve and memory CD4+ cells from mice. Immun Ageing. 2017; 14:15.Immun Ageing2017-06-20T00:00:002017Transcriptomic profiles of aging in naïve and memory CD4+ cells from mice.Authorship 5546627Authorship 55546928887543Long D, Wu H, Tsang AW, Poole LB, Yoza BK, Wang X, Vachharajani V, Furdui CM, McCall CEScientific reportsLong D, Wu H, Tsang AW, Poole LB, Yoza BK, Wang X, Vachharajani V, Furdui CM, McCall CE. The Oxidative State of Cysteine Thiol 144 Regulates the SIRT6 Glucose Homeostat. Sci Rep. 2017 09 08; 7(1):11005.Sci Rep2017-09-08T00:00:002017The Oxidative State of Cysteine Thiol 144 Regulates the SIRT6 Glucose Homeostat.28855511Liu Y, Reynolds LM, Ding J, Hou L, Lohman K, Young T, Cui W, Huang Z, Grenier C, Wan M, Stunnenberg HG, Siscovick D, Hou L, Psaty BM, Rich SS, Rotter JI, Kaufman JD, Burke GL, Murphy S, Jacobs DR, Post W, Hoeschele I, Bell DA, Herrington D, Parks JS, Tracy RP, McCall CE, Stein JHNature communicationsLiu Y, Reynolds LM, Ding J, Hou L, Lohman K, Young T, Cui W, Huang Z, Grenier C, Wan M, Stunnenberg HG, Siscovick D, Hou L, Psaty BM, Rich SS, Rotter JI, Kaufman JD, Burke GL, Murphy S, Jacobs DR, Post W, Hoeschele I, Bell DA, Herrington D, Parks JS, Tracy RP, McCall CE, Stein JH. Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis. Nat Commun. 2017 08 30; 8(1):393.Nat Commun2017-08-30T00:00:002017Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis.2018-12-31NIHMCCALL, CHARLES EMORY2006-02-01Metabolic and Immune Properties of SepsisR56AI065791Principal InvestigatorAuthorship 55646528934717Dai J, Kumbhare A, Youssef D, Yao ZQ, McCall CE, El Gazzar MMolecular immunologyDai J, Kumbhare A, Youssef D, Yao ZQ, McCall CE, El Gazzar M. Expression of C/EBPß in myeloid progenitors during sepsis promotes immunosuppression. Mol Immunol. 2017 11; 91:165-172.Mol Immunol2017-09-19T00:00:002017Expression of C/EBPß in myeloid progenitors during sepsis promotes immunosuppression.RetoAsmisReto H. Asmis PhD36.09040200000000-80.267005999999992162Asmis, RetoProfessorAuthorship 350503Authorship 350633Authorship 35124223825193Brudecki L, Ferguson DA, McCall CE, El Gazzar MClinical and vaccine immunology : CVIBrudecki L, Ferguson DA, McCall CE, El Gazzar M. Mitogen-activated protein kinase phosphatase 1 disrupts proinflammatory protein synthesis in endotoxin-adapted monocytes. Clin Vaccine Immunol. 2013 Sep; 20(9):1396-404.Clin Vaccine Immunol2013-07-03T00:00:002013Mitogen-activated protein kinase phosphatase 1 disrupts proinflammatory protein synthesis in endotoxin-adapted monocytes.23897118Brudecki L, Ferguson DA, McCall CE, El Gazzar MImmunology and cell biologyBrudecki L, Ferguson DA, McCall CE, El Gazzar M. MicroRNA-146a and RBM4 form a negative feed-forward loop that disrupts cytokine mRNA translation following TLR4 responses in human THP-1 monocytes. Immunol Cell Biol. 2013 Sep; 91(8):532-40.Immunol Cell Biol2013-07-30T00:00:002013MicroRNA-146a and RBM4 form a negative feed-forward loop that disrupts cytokine mRNA translation following TLR4 responses in human THP-1 monocytes.24020005Liu TF, McCall CEGenes & cancerLiu TF, McCall CE. Deacetylation by SIRT1 Reprograms Inflammation and Cancer. Genes Cancer. 2013 Mar; 4(3-4):135-47.Genes Cancer2013-03-01T00:00:002013Deacetylation by SIRT1 Reprograms Inflammation and Cancer.2023-04-30NIHMCCALL, CHARLES EMORY2018-05-01Redox control over metabolism and mitochondrial bioenergetics directs the course of acute inflammation and sepsis.R35GM126922Principal InvestigatorAuthorship 579384Authorship 583466Authorship 585354Authorship 587704Authorship 596196Authorship 599706Authorship 599971Authorship 60077530069485Martin AN, Alexander-Miller M, Yoza BK, Vachharajani V, McCall CEJournal of immunology researchMartin AN, Alexander-Miller M, Yoza BK, Vachharajani V, McCall CE. Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice. J Immunol Res. 2018; 2018:2402593.J Immunol Res2018-07-04T00:00:002018Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice.29593712Tao J, Zhang J, Ling Y, McCall CE, Liu TFFrontiers in immunologyTao J, Zhang J, Ling Y, McCall CE, Liu TF. Mitochondrial Sirtuin 4 Resolves Immune Tolerance in Monocytes by Rebalancing Glycolysis and Glucose Oxidation Homeostasis. Front Immunol. 2018; 9:419.Front Immunol2018-03-09T00:00:002018Mitochondrial Sirtuin 4 Resolves Immune Tolerance in Monocytes by Rebalancing Glycolysis and Glucose Oxidation Homeostasis.29172874Dai J, Kumbhare A, Williams DA, Youssef D, Yao ZQ, McCall CE, El Gazzar MInnate immunityDai J, Kumbhare A, Williams DA, Youssef D, Yao ZQ, McCall CE, El Gazzar M. Nfia deletion in myeloid cells blocks expansion of myeloid-derived suppressor cells during sepsis. Innate Immun. 2018 01; 24(1):54-65.Innate Immun2017-11-27T00:00:002017Nfia deletion in myeloid cells blocks expansion of myeloid-derived suppressor cells during sepsis.30089711McCall CE, Zabalawi M, Liu T, Martin A, Long DL, Buechler NL, Arts RJW, Netea M, Yoza BK, Stacpoole PW, Vachharajani VJCI insightMcCall CE, Zabalawi M, Liu T, Martin A, Long DL, Buechler NL, Arts RJW, Netea M, Yoza BK, Stacpoole PW, Vachharajani V. Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival. JCI Insight. 2018 08 09; 3(15).JCI Insight2018-08-09T00:00:002018Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival.30080782Hoth JJ, Smith LM, Furdui CM, Wells JD, Yoza BK, McCall CEThe journal of trauma and acute care surgeryHoth JJ, Smith LM, Furdui CM, Wells JD, Yoza BK, McCall CE. Antioxidant treatment after injury suppresses second hit immune priming. J Trauma Acute Care Surg. 2018 08; 85(2):367-374.J Trauma Acute Care Surg2018-08-01T00:00:002018Antioxidant treatment after injury suppresses second hit immune priming.30025864Bah I, Kumbhare A, Nguyen L, McCall CE, El Gazzar MCellular immunologyBah I, Kumbhare A, Nguyen L, McCall CE, El Gazzar M. IL-10 induces an immune repressor pathway in sepsis by promoting S100A9 nuclear localization and MDSC development. Cell Immunol. 2018 10; 332:32-38.Cell Immunol2018-07-11T00:00:002018IL-10 induces an immune repressor pathway in sepsis by promoting S100A9 nuclear localization and MDSC development.29204146Dai J, Kumbhare A, Youssef D, McCall CE, El Gazzar MFrontiers in immunologyDai J, Kumbhare A, Youssef D, McCall CE, El Gazzar M. Intracellular S100A9 Promotes Myeloid-Derived Suppressor Cells during Late Sepsis. Front Immunol. 2017; 8:1565.Front Immunol2017-11-17T00:00:002017Intracellular S100A9 Promotes Myeloid-Derived Suppressor Cells during Late Sepsis.29463685McPeak MB, Youssef D, Williams DA, Pritchett C, Yao ZQ, McCall CE, El Gazzar MInfection and immunityMcPeak MB, Youssef D, Williams DA, Pritchett C, Yao ZQ, McCall CE, El Gazzar M. Correction for McPeak et al., "Myeloid Cell-Specific Knockout of NFI-A Improves Sepsis Survival". Infect Immun. 2018 03; 86(3).Infect Immun2018-02-20T00:00:002018Correction for McPeak et al., "Myeloid Cell-Specific Knockout of NFI-A Improves Sepsis Survival".30216989Wang X, Buechler NL, Woodruff AG, Long DL, Zabalawi M, Yoza BK, McCall CE, Vachharajani VInternational journal of molecular sciencesWang X, Buechler NL, Woodruff AG, Long DL, Zabalawi M, Yoza BK, McCall CE, Vachharajani V. Sirtuins and Immuno-Metabolism of Sepsis. Int J Mol Sci. 2018 Sep 13; 19(9).Int J Mol Sci2018-09-13T00:00:002018Sirtuins and Immuno-Metabolism of Sepsis.30633362Zhu X, Meyers A, Long D, Ingram B, Liu T, Yoza BK, Vachharajani V, McCall CEJournal of leukocyte biologyZhu X, Meyers A, Long D, Ingram B, Liu T, Yoza BK, Vachharajani V, McCall CE. Frontline Science: Monocytes sequentially rewire metabolism and bioenergetics during an acute inflammatory response. J Leukoc Biol. 2019 02; 105(2):215-228.J Leukoc Biol2019-01-11T00:00:002019Frontline Science: Monocytes sequentially rewire metabolism and bioenergetics during an acute inflammatory response.20ProfessorAuthorship 640966Authorship 647217Authorship 665508Authorship 667032Authorship 669144Authorship 67076630997862Vachharajani V, McCall CEInnate immunityVachharajani V, McCall CE. Epigenetic and metabolic programming of innate immunity in sepsis. Innate Immun. 2019 07; 25(5):267-279.Innate Immun2019-04-18T00:00:002019Epigenetic and metabolic programming of innate immunity in sepsis.31393272Smith LM, Yoza BK, Hoth JJ, McCall CE, Vachharajani VShock (Augusta, Ga.)Smith LM, Yoza BK, Hoth JJ, McCall CE, Vachharajani V. SIRT1 Mediates Septic Cardiomyopathy in a Murine Model of Polymicrobial Sepsis. Shock. 2020 07; 54(1):96-101.Shock2020-07-01T00:00:002020SIRT1 Mediates Septic Cardiomyopathy in a Murine Model of Polymicrobial Sepsis.30203196Wang X, Buechler NL, Long DL, Furdui CM, Yoza BK, McCall CE, Vachharajani VInflammationWang X, Buechler NL, Long DL, Furdui CM, Yoza BK, McCall CE, Vachharajani V. Cysteine thiol oxidation on SIRT2 regulates inflammation in obese mice with sepsis. Inflammation. 2019 Feb; 42(1):156-169.Inflammation2019-02-01T00:00:002019Cysteine thiol oxidation on SIRT2 regulates inflammation in obese mice with sepsis.31078118Alkhateeb T, Kumbhare A, Bah I, Youssef D, Yao ZQ, McCall CE, El Gazzar MMolecular immunologyAlkhateeb T, Kumbhare A, Bah I, Youssef D, Yao ZQ, McCall CE, El Gazzar M. S100A9 maintains myeloid-derived suppressor cells in chronic sepsis by inducing miR-21 and miR-181b. Mol Immunol. 2019 08; 112:72-81.Mol Immunol2019-05-09T00:00:002019S100A9 maintains myeloid-derived suppressor cells in chronic sepsis by inducing miR-21 and miR-181b.24Assistant ProfessorAuthorship 10443Authorship 105476Clinical and Translational Science InstituteEpidemiology & Prevention (Public Health Sciences)Internal Medicine, Gerontology & Geriatric MedicineInternal Medicine, Hematology & OncologyInternal Medicine, Infectious DiseasesInternal Medicine, Molecular MedicineSurgery, HypertensionSurgery, OncologyUrologyAuthorship 113695http://www.wfirm.orgWFIRMAuthorship 124223Authorship 124235Authorship 127686Authorship 36126223922380Millet P, McCall C, Yoza BJournal of leukocyte biologyMillet P, McCall C, Yoza B. RelB: an outlier in leukocyte biology. J Leukoc Biol. 2013 Nov; 94(5):941-51.J Leukoc Biol2013-08-06T00:00:002013RelB: an outlier in leukocyte biology.Authorship 142881Authorship 147922Authorship 149325Authorship 362551723900078Liu Y, Ding J, Reynolds LM, Lohman K, Register TC, De La Fuente A, Howard TD, Hawkins GA, Cui W, Morris J, Smith SG, Barr RG, Kaufman JD, Burke GL, Post W, Shea S, McCall CE, Siscovick D, Jacobs DR, Tracy RP, Herrington DM, Hoeschele IHuman molecular geneticsLiu Y, Ding J, Reynolds LM, Lohman K, Register TC, De La Fuente A, Howard TD, Hawkins GA, Cui W, Morris J, Smith SG, Barr RG, Kaufman JD, Burke GL, Post W, Shea S, McCall CE, Siscovick D, Jacobs DR, Tracy RP, Herrington DM, Hoeschele I. Methylomics of gene expression in human monocytes. Hum Mol Genet. 2013 Dec 15; 22(24):5065-74.Hum Mol Genet2013-07-29T00:00:002013Methylomics of gene expression in human monocytes.Authorship 166384Authorship 168133Authorship 171407Authorship 171656Authorship 181506true1ProfessorProfessor23Associate DeanAssociate Dean4DirectorDirectortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessor5ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1InstructorInstructortrue1ProfessorProfessorAuthorship 188433Authorship 202986Authorship 216976Authorship 244261Authorship 247377Authorship 248364Authorship 259549Authorship 268024Authorship 274892Authorship 291503Authorship 306724Authorship 314282Authorship 314871Authorship 31897424553525Hoth JJ, Wells JD, Jones SE, Yoza BK, McCall CEThe journal of trauma and acute care surgeryHoth JJ, Wells JD, Jones SE, Yoza BK, McCall CE. Complement mediates a primed inflammatory response after traumatic lung injury. J Trauma Acute Care Surg. 2014 Mar; 76(3):601-8; discussion 608-9.J Trauma Acute Care Surg2014-03-01T00:00:002014Complement mediates a primed inflammatory response after traumatic lung injury.Authorship 320782Authorship 334706Authorship 337835Authorship 43742Authorship 53978Authorship 71813Authorship 77594Authorship 85964Authorship 91134Authorship 9373412028750Yoza BK, Hu JY, McCall CEJournal of endotoxin researchYoza BK, Hu JY, McCall CE. Inhibition of histone deacetylation enhances endotoxin-stimulated transcription but does not reverse endotoxin tolerance. J Endotoxin Res. 2002; 8(2):109-14.J Endotoxin Res2002-01-01T00:00:002002Inhibition of histone deacetylation enhances endotoxin-stimulated transcription but does not reverse endotoxin tolerance.12055225Jacinto R, Hartung T, McCall C, Li LJournal of immunology (Baltimore, Md. : 1950)Jacinto R, Hartung T, McCall C, Li L. Lipopolysaccharide- and lipoteichoic acid-induced tolerance and cross-tolerance: distinct alterations in IL-1 receptor-associated kinase. J Immunol. 2002 Jun 15; 168(12):6136-41.J Immunol2002-06-15T00:00:002002Lipopolysaccharide- and lipoteichoic acid-induced tolerance and cross-tolerance: distinct alterations in IL-1 receptor-associated kinase.12631337Bensen JT, Langefeld CD, Li L, McCall CE, Cousart SL, Dryman BN, Freedman BI, Bowden DWKidney internationalBensen JT, Langefeld CD, Li L, McCall CE, Cousart SL, Dryman BN, Freedman BI, Bowden DW. Association of an IL-1A 3'UTR polymorphism with end-stage renal disease and IL-1 alpha expression. Kidney Int. 2003 Apr; 63(4):1211-9.Kidney Int2003-04-01T00:00:002003Association of an IL-1A 3'UTR polymorphism with end-stage renal disease and IL-1 alpha expression.12691617Li L, Jacinto R, Yoza B, McCall CEJournal of endotoxin researchLi L, Jacinto R, Yoza B, McCall CE. Distinct post-receptor alterations generate gene- and signal-selective adaptation and cross-adaptation of TLR4 and TLR2 in human leukocytes. J Endotoxin Res. 2003; 9(1):39-44.J Endotoxin Res2003-01-01T00:00:002003Distinct post-receptor alterations generate gene- and signal-selective adaptation and cross-adaptation of TLR4 and TLR2 in human leukocytes.15972680Chan C, Li L, McCall CE, Yoza BKJournal of immunology (Baltimore, Md. : 1950)Chan C, Li L, McCall CE, Yoza BK. Endotoxin tolerance disrupts chromatin remodeling and NF-kappaB transactivation at the IL-1beta promoter. J Immunol. 2005 Jul 01; 175(1):461-8.J Immunol2005-07-01T00:00:002005Endotoxin tolerance disrupts chromatin remodeling and NF-kappaB transactivation at the IL-1beta promoter.16192389Romero-Sandoval EA, McCall C, Eisenach JCThe Journal of neuroscience : the official journal of the Society for NeuroscienceRomero-Sandoval EA, McCall C, Eisenach JC. Alpha2-adrenoceptor stimulation transforms immune responses in neuritis and blocks neuritis-induced pain. J Neurosci. 2005 Sep 28; 25(39):8988-94.J Neurosci2005-09-28T00:00:002005Alpha2-adrenoceptor stimulation transforms immune responses in neuritis and blocks neuritis-induced pain.16951372Yoza BK, Hu JY, Cousart SL, Forrest LM, McCall CEJournal of immunology (Baltimore, Md. : 1950)Yoza BK, Hu JY, Cousart SL, Forrest LM, McCall CE. Induction of RelB participates in endotoxin tolerance. J Immunol. 2006 Sep 15; 177(6):4080-5.J Immunol2006-09-15T00:00:002006Induction of RelB participates in endotoxin tolerance.17940599Loza MJ, McCall CE, Li L, Isaacs WB, Xu J, Chang BLPloS oneLoza MJ, McCall CE, Li L, Isaacs WB, Xu J, Chang BL. Assembly of inflammation-related genes for pathway-focused genetic analysis. PLoS One. 2007 Oct 17; 2(10):e1035.PLoS One2007-10-17T00:00:002007Assembly of inflammation-related genes for pathway-focused genetic analysis.18665044Hoth JJ, Wells JD, Brownlee NA, Hiltbold EM, Meredith JW, McCall CE, Yoza BKShock (Augusta, Ga.)Hoth JJ, Wells JD, Brownlee NA, Hiltbold EM, Meredith JW, McCall CE, Yoza BK. Toll-like receptor 4-dependent responses to lung injury in a murine model of pulmonary contusion. Shock. 2009 Apr; 31(4):376-81.Shock2009-04-01T00:00:002009Toll-like receptor 4-dependent responses to lung injury in a murine model of pulmonary contusion.18809684El Gazzar M, Yoza BK, Chen X, Hu J, Hawkins GA, McCall CEThe Journal of biological chemistryEl Gazzar M, Yoza BK, Chen X, Hu J, Hawkins GA, McCall CE. G9a and HP1 couple histone and DNA methylation to TNFalpha transcription silencing during endotoxin tolerance. J Biol Chem. 2008 Nov 21; 283(47):32198-208.J Biol Chem2008-09-22T00:00:002008G9a and HP1 couple histone and DNA methylation to TNFalpha transcription silencing during endotoxin tolerance.19020113Chen X, Yoza BK, El Gazzar M, Hu JY, Cousart SL, McCall CEClinical and vaccine immunology : CVIChen X, Yoza BK, El Gazzar M, Hu JY, Cousart SL, McCall CE. RelB sustains IkappaBalpha expression during endotoxin tolerance. Clin Vaccine Immunol. 2009 Jan; 16(1):104-10.Clin Vaccine Immunol2008-11-19T00:00:002008RelB sustains IkappaBalpha expression during endotoxin tolerance.19158276El Gazzar M, Yoza BK, Chen X, Garcia BA, Young NL, McCall CEMolecular and cellular biologyEl Gazzar M, Yoza BK, Chen X, Garcia BA, Young NL, McCall CE. Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance. Mol Cell Biol. 2009 Apr; 29(7):1959-71.Mol Cell Biol2009-01-21T00:00:002009Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance.19590302Hoth JJ, Martin RS, Yoza BK, Wells JD, Meredith JW, McCall CEThe Journal of traumaHoth JJ, Martin RS, Yoza BK, Wells JD, Meredith JW, McCall CE. Pulmonary contusion primes systemic innate immunity responses. J Trauma. 2009 Jul; 67(1):14-21; discussion 21-2.J Trauma2009-07-01T00:00:002009Pulmonary contusion primes systemic innate immunity responses.19690169Chen X, El Gazzar M, Yoza BK, McCall CEThe Journal of biological chemistryChen X, El Gazzar M, Yoza BK, McCall CE. The NF-kappaB factor RelB and histone H3 lysine methyltransferase G9a directly interact to generate epigenetic silencing in endotoxin tolerance. J Biol Chem. 2009 Oct 09; 284(41):27857-27865.J Biol Chem2009-08-18T00:00:002009The NF-kappaB factor RelB and histone H3 lysine methyltransferase G9a directly interact to generate epigenetic silencing in endotoxin tolerance.20690979Vachharajani V, Wang SW, Mishra N, El Gazzar M, Yoza B, McCall CMicrocirculation (New York, N.Y. : 1994)Vachharajani V, Wang SW, Mishra N, El Gazzar M, Yoza B, McCall C. Curcumin modulates leukocyte and platelet adhesion in murine sepsis. Microcirculation. 2010 Aug; 17(6):407-16.Microcirculation2010-08-01T00:00:002010Curcumin modulates leukocyte and platelet adhesion in murine sepsis.21078560Yoza BK, McCall CECytokineYoza BK, McCall CE. Facultative heterochromatin formation at the IL-1 beta promoter in LPS tolerance and sepsis. Cytokine. 2011 Feb; 53(2):145-52.Cytokine2011-02-01T00:00:002011Facultative heterochromatin formation at the IL-1 beta promoter in LPS tolerance and sepsis.21330942Hoth JJ, Wells JD, Hiltbold EM, McCall CE, Yoza BKShock (Augusta, Ga.)Hoth JJ, Wells JD, Hiltbold EM, McCall CE, Yoza BK. Mechanism of neutrophil recruitment to the lung after pulmonary contusion. Shock. 2011 Jun; 35(6):604-9.Shock2011-06-01T00:00:002011Mechanism of neutrophil recruitment to the lung after pulmonary contusion.21912420El Gazzar M, McCall CEImmunology and cell biologyEl Gazzar M, McCall CE. MicroRNAs regulatory networks in myeloid lineage development and differentiation: regulators of the regulators. Immunol Cell Biol. 2012 Jul; 90(6):587-93.Immunol Cell Biol2011-09-13T00:00:002011MicroRNAs regulatory networks in myeloid lineage development and differentiation: regulators of the regulators.22293596Hoth JJ, Wells JD, Yoza BK, McCall CEShock (Augusta, Ga.)Hoth JJ, Wells JD, Yoza BK, McCall CE. Innate immune response to pulmonary contusion: identification of cell type-specific inflammatory responses. Shock. 2012 Apr; 37(4):385-91.Shock2012-04-01T00:00:002012Innate immune response to pulmonary contusion: identification of cell type-specific inflammatory responses.22403054Kavanagh K, Wylie AT, Chavanne TJ, Jorgensen MJ, Voruganti VS, Comuzzie AG, Kaplan JR, McCall CE, Kritchevsky SBThe journals of gerontology. Series A, Biological sciences and medical sciencesKavanagh K, Wylie AT, Chavanne TJ, Jorgensen MJ, Voruganti VS, Comuzzie AG, Kaplan JR, McCall CE, Kritchevsky SB. Aging does not reduce heat shock protein 70 in the absence of chronic insulin resistance. J Gerontol A Biol Sci Med Sci. 2012 Oct; 67(10):1014-21.J Gerontol A Biol Sci Med Sci2012-03-08T00:00:002012Aging does not reduce heat shock protein 70 in the absence of chronic insulin resistance.22700961Liu TF, Vachharajani VT, Yoza BK, McCall CEThe Journal of biological chemistryLiu TF, Vachharajani VT, Yoza BK, McCall CE. NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response. J Biol Chem. 2012 Jul 27; 287(31):25758-69.J Biol Chem2012-06-14T00:00:002012NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response.22732898Brudecki L, Ferguson DA, McCall CE, El Gazzar MImmunology and cell biologyBrudecki L, Ferguson DA, McCall CE, El Gazzar M. Adoptive transfer of CD34(+) cells during murine sepsis rebalances macrophage lipopolysaccharide responses. Immunol Cell Biol. 2012 Nov; 90(10):925-34.Immunol Cell Biol2012-06-26T00:00:002012Adoptive transfer of CD34(+) cells during murine sepsis rebalances macrophage lipopolysaccharide responses.11937546Hu J, Jacinto R, McCall C, Li LJournal of immunology (Baltimore, Md. : 1950)Hu J, Jacinto R, McCall C, Li L. Regulation of IL-1 receptor-associated kinases by lipopolysaccharide. J Immunol. 2002 Apr 15; 168(8):3910-4.J Immunol2002-04-15T00:00:002002Regulation of IL-1 receptor-associated kinases by lipopolysaccharide.16832247Hoth JJ, Stitzel JD, Gayzik FS, Brownlee NA, Miller PR, Yoza BK, McCall CE, Meredith JW, Payne RMThe Journal of traumaHoth JJ, Stitzel JD, Gayzik FS, Brownlee NA, Miller PR, Yoza BK, McCall CE, Meredith JW, Payne RM. The pathogenesis of pulmonary contusion: an open chest model in the rat. J Trauma. 2006 Jul; 61(1):32-44; discussion 44-5.J Trauma2006-07-01T00:00:002006The pathogenesis of pulmonary contusion: an open chest model in the rat.17255558McCall CE, Yoza BKAmerican journal of respiratory and critical care medicineMcCall CE, Yoza BK. Gene silencing in severe systemic inflammation. Am J Respir Crit Care Med. 2007 Apr 15; 175(8):763-7.Am J Respir Crit Care Med2007-01-25T00:00:002007Gene silencing in severe systemic inflammation.17558351Hoth JJ, Hudson WP, Brownlee NA, Yoza BK, Hiltbold EM, Meredith JW, McCall CEShock (Augusta, Ga.)Hoth JJ, Hudson WP, Brownlee NA, Yoza BK, Hiltbold EM, Meredith JW, McCall CE. Toll-like receptor 2 participates in the response to lung injury in a murine model of pulmonary contusion. Shock. 2007 Oct; 28(4):447-52.Shock2007-10-01T00:00:002007Toll-like receptor 2 participates in the response to lung injury in a murine model of pulmonary contusion.17568691El Mezayen R, El Gazzar M, Seeds MC, McCall CE, Dreskin SC, Nicolls MRImmunology lettersEl Mezayen R, El Gazzar M, Seeds MC, McCall CE, Dreskin SC, Nicolls MR. Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin. Immunol Lett. 2007 Jul 31; 111(1):36-44.Immunol Lett2007-05-25T00:00:002007Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin.17646159El Gazzar M, Yoza BK, Hu JY, Cousart SL, McCall CEThe Journal of biological chemistryEl Gazzar M, Yoza BK, Hu JY, Cousart SL, McCall CE. Epigenetic silencing of tumor necrosis factor alpha during endotoxin tolerance. J Biol Chem. 2007 Sep 14; 282(37):26857-26864.J Biol Chem2007-07-23T00:00:002007Epigenetic silencing of tumor necrosis factor alpha during endotoxin tolerance.19901031El Gazzar M, Liu T, Yoza BK, McCall CEThe Journal of biological chemistryEl Gazzar M, Liu T, Yoza BK, McCall CE. Dynamic and selective nucleosome repositioning during endotoxin tolerance. J Biol Chem. 2010 Jan 08; 285(2):1259-71.J Biol Chem2009-11-09T00:00:002009Dynamic and selective nucleosome repositioning during endotoxin tolerance.20435889El Gazzar M, McCall CEThe Journal of biological chemistryEl Gazzar M, McCall CE. MicroRNAs distinguish translational from transcriptional silencing during endotoxin tolerance. J Biol Chem. 2010 Jul 02; 285(27):20940-51.J Biol Chem2010-04-30T00:00:002010MicroRNAs distinguish translational from transcriptional silencing during endotoxin tolerance.20733328McCall CE, Yoza B, Liu T, El Gazzar MJournal of innate immunityMcCall CE, Yoza B, Liu T, El Gazzar M. Gene-specific epigenetic regulation in serious infections with systemic inflammation. J Innate Immun. 2010; 2(5):395-405.J Innate Immun2010-04-27T00:00:002010Gene-specific epigenetic regulation in serious infections with systemic inflammation.21245135Liu TF, Yoza BK, El Gazzar M, Vachharajani VT, McCall CEThe Journal of biological chemistryLiu TF, Yoza BK, El Gazzar M, Vachharajani VT, McCall CE. NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance. J Biol Chem. 2011 Mar 18; 286(11):9856-64.J Biol Chem2011-01-18T00:00:002011NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance.21562054El Gazzar M, Church A, Liu T, McCall CEJournal of leukocyte biologyEl Gazzar M, Church A, Liu T, McCall CE. MicroRNA-146a regulates both transcription silencing and translation disruption of TNF-a during TLR4-induced gene reprogramming. J Leukoc Biol. 2011 Sep; 90(3):509-19.J Leukoc Biol2011-05-11T00:00:002011MicroRNA-146a regulates both transcription silencing and translation disruption of TNF-a during TLR4-induced gene reprogramming.21610199McCall CE, El Gazzar M, Liu T, Vachharajani V, Yoza BJournal of leukocyte biologyMcCall CE, El Gazzar M, Liu T, Vachharajani V, Yoza B. Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprogramming during acute systemic inflammation. J Leukoc Biol. 2011 Sep; 90(3):439-46.J Leukoc Biol2011-05-24T00:00:002011Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprogramming during acute systemic inflammation.21996662Vachharajani V, Cunningham C, Yoza B, Carson J, Vachharajani TJ, McCall CObesity (Silver Spring, Md.)Vachharajani V, Cunningham C, Yoza B, Carson J, Vachharajani TJ, McCall C. Adiponectin-deficiency exaggerates sepsis-induced microvascular dysfunction in the mouse brain. Obesity (Silver Spring). 2012 Mar; 20(3):498-504.Obesity (Silver Spring)2011-10-13T00:00:002011Adiponectin-deficiency exaggerates sepsis-induced microvascular dysfunction in the mouse brain.22144495Brudecki L, Ferguson DA, Yin D, Lesage GD, McCall CE, El Gazzar MInfection and immunityBrudecki L, Ferguson DA, Yin D, Lesage GD, McCall CE, El Gazzar M. Hematopoietic stem-progenitor cells restore immunoreactivity and improve survival in late sepsis. Infect Immun. 2012 Feb; 80(2):602-11.Infect Immun2011-12-05T00:00:002011Hematopoietic stem-progenitor cells restore immunoreactivity and improve survival in late sepsis.22451518Brudecki L, Ferguson DA, McCall CE, El Gazzar MInfection and immunityBrudecki L, Ferguson DA, McCall CE, El Gazzar M. Myeloid-derived suppressor cells evolve during sepsis and can enhance or attenuate the systemic inflammatory response. Infect Immun. 2012 Jun; 80(6):2026-34.Infect Immun2012-03-26T00:00:002012Myeloid-derived suppressor cells evolve during sepsis and can enhance or attenuate the systemic inflammatory response.22571857Liu TF, Brown CM, El Gazzar M, McPhail L, Millet P, Rao A, Vachharajani VT, Yoza BK, McCall CEJournal of leukocyte biologyLiu TF, Brown CM, El Gazzar M, McPhail L, Millet P, Rao A, Vachharajani VT, Yoza BK, McCall CE. Fueling the flame: bioenergy couples metabolism and inflammation. J Leukoc Biol. 2012 Sep; 92(3):499-507.J Leukoc Biol2012-05-09T00:00:002012Fueling the flame: bioenergy couples metabolism and inflammation.D056564Chemicals & Drugs9360.958772Sirtuin 1D018805Disorders611450.873946SepsisD007249Disorders1785010.762055InflammationD004731Chemicals & Drugs12360.975371EndotoxinsD009000Anatomy371190.893763Monocytes