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Clinical and Translational Science Institute

Keywords
Last Name

Victor Enrique Ortega, M.D.

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine - Pulmonary
Address
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    Collapse Biography 
    Collapse education and training
    Wake Forest University Graduate School of Arts and Sciences, Winston-Salem, NCPhD06/2016Molecular Medicine and Translational Science

    Collapse Research 
    Collapse research activities and funding
    K08HL118128     (ORTEGA, VICTOR E)Jul 1, 2015 - Mar 31, 2018
    NIH/NHLBI
    Effects of Rare Variants and Ancestry on Beta Agonist Response In Asthma
    Role: Principal Investigator

    R01HL142992     (ORTEGA, VICTOR E)Feb 1, 2019 - Dec 31, 2023
    NIH/NHLBI
    Effects of Rare Variants and Ancestry on Beta Agonist Response in Asthma and COPD
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Allen R, Ortega VE. Resequencing to Fine Map Known Idiopathic Pulmonary Fibrosis Risk Genes: Honing in on Causal Variants. Am J Respir Crit Care Med. 2019 May 21. PMID: 31113211.
      View in: PubMed
    2. Oelsner EC, Ortega VE, Smith BM, Nguyen JN, Manichaikul AW, Hoffman EA, Guo X, Taylor KD, Woodruff PG, Couper DJ, Hansel NN, Martinez FJ, Paine Iii R, Han MK, Cooper C, Dransfield MT, Criner G, Krishnan JA, Bowler R, Bleecker ER, Peters S, Rich SS, Meyers DA, Rotter JI, Barr RG. A Genetic Risk Score Associated with COPD Susceptibility and Lung Structure on Computed Tomography. Am J Respir Crit Care Med. 2019 Mar 29. PMID: 30925230.
      View in: PubMed
    3. Cardet JC, Jiang X, Lu Q, Gerard N, McIntire K, Boushey HA, Castro M, Chinchilli VM, Codispoti CD, Dyer AM, Holguin F, Kraft M, Lazarus S, Lemanske RF, Lugogo N, Mauger D, Moore WC, Moy J, Ortega VE, Peters SP, Smith LJ, Solway J, Sorkness CA, Sumino K, Wechsler ME, Wenzel S, Israel E. Loss of bronchoprotection with ICS plus LABA treatment, ß-receptor dynamics, and the effect of alendronate. J Allergy Clin Immunol. 2019 Mar 11. PMID: 30872116.
      View in: PubMed
    4. Daya M, Rafaels N, Brunetti TM, Chavan S, Levin AM, Shetty A, Gignoux CR, Boorgula MP, Wojcik G, Campbell M, Vergara C, Torgerson DG, Ortega VE, Doumatey A, Johnston HR, Acevedo N, Araujo MI, Avila PC, Belbin G, Bleecker E, Bustamante C, Caraballo L, Cruz A, Dunston GM, Eng C, Faruque MU, Ferguson TS, Figueiredo C, Ford JG, Gan W, Gourraud PA, Hansel NN, Hernandez RD, Herrera-Paz EF, Jiménez S, Kenny EE, Knight-Madden J, Kumar R, Lange LA, Lange EM, Lizee A, Maul P, Maul T, Mayorga A, Meyers D, Nicolae DL, O'Connor TD, Oliveira RR, Olopade CO, Olopade O, Qin ZS, Rotimi C, Vince N, Watson H, Wilks RJ, Wilson JG, Salzberg S, Ober C, Burchard EG, Williams LK, Beaty TH, Taub MA, Ruczinski I, Mathias RA, Barnes KC. Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations. Nat Commun. 2019 02 20; 10(1):880. PMID: 30787307.
      View in: PubMed
    5. Sherman RM, Forman J, Antonescu V, Puiu D, Daya M, Rafaels N, Boorgula MP, Chavan S, Vergara C, Ortega VE, Levin AM, Eng C, Yazdanbakhsh M, Wilson JG, Marrugo J, Lange LA, Williams LK, Watson H, Ware LB, Olopade CO, Olopade O, Oliveira RR, Ober C, Nicolae DL, Meyers DA, Mayorga A, Knight-Madden J, Hartert T, Hansel NN, Foreman MG, Ford JG, Faruque MU, Dunston GM, Caraballo L, Burchard EG, Bleecker ER, Araujo MI, Herrera-Paz EF, Campbell M, Foster C, Taub MA, Beaty TH, Ruczinski I, Mathias RA, Barnes KC, Salzberg SL. Author Correction: Assembly of a pan-genome from deep sequencing of 910 humans of African descent. Nat Genet. 2019 02; 51(2):364. PMID: 30647471.
      View in: PubMed
    6. Fitzpatrick AM, Gillespie SE, Mauger DT, Phillips BR, Bleecker ER, Israel E, Meyers DA, Moore WC, Sorkness RL, Wenzel SE, Bacharier LB, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston BM, Jarjour NN, Larkin A, Levy BD, Ly NP, Ortega VE, Peters SP, Phipatanakul W, Ramratnam S, Teague WG. Racial disparities in asthma-related health care use in the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol. 2019 Jun; 143(6):2052-2061. PMID: 30635198.
      View in: PubMed
    7. Pirozzi CS, Gu T, Quibrera PM, Carretta EE, Han MK, Murray S, Cooper CB, Tashkin DP, Kleerup EC, Barjaktarevic I, Hoffman EA, Martinez CH, Christenson SA, Hansel NN, Graham Barr R, Bleecker ER, Ortega VE, Martinez FJ, Kanner RE, Paine R. Heterogeneous burden of lung disease in smokers with borderline airflow obstruction. Respir Res. 2018 Nov 20; 19(1):223. PMID: 30454050.
      View in: PubMed
    8. Sherman RM, Forman J, Antonescu V, Puiu D, Daya M, Rafaels N, Boorgula MP, Chavan S, Vergara C, Ortega VE, Levin AM, Eng C, Yazdanbakhsh M, Wilson JG, Marrugo J, Lange LA, Williams LK, Watson H, Ware LB, Olopade CO, Olopade O, Oliveira RR, Ober C, Nicolae DL, Meyers DA, Mayorga A, Knight-Madden J, Hartert T, Hansel NN, Foreman MG, Ford JG, Faruque MU, Dunston GM, Caraballo L, Burchard EG, Bleecker ER, Araujo MI, Herrera-Paz EF, Campbell M, Foster C, Taub MA, Beaty TH, Ruczinski I, Mathias RA, Barnes KC, Salzberg SL. Assembly of a pan-genome from deep sequencing of 910 humans of African descent. Nat Genet. 2019 01; 51(1):30-35. PMID: 30455414.
      View in: PubMed
    9. Li X, Ortega VE, Ampleford EJ, Graham Barr R, Christenson SA, Cooper CB, Couper D, Dransfield MT, Han MLK, Hansel NN, Hoffman EA, Kanner RE, Kleerup EC, Martinez FJ, Paine R, Woodruff PG, Hawkins GA, Bleecker ER, Meyers DA. Genome-wide association study of lung function and clinical implication in heavy smokers. BMC Med Genet. 2018 Aug 01; 19(1):134. PMID: 30068317.
      View in: PubMed
    10. Lima JJ, Castro M, King TS, Lang JE, Ortega VE, Peters SP, Denlinger LC, Israel E, Sorkness CA, Wechsler ME, Wenzel SE, Smith LJ. Association of free vitamin D3 concentrations and asthma treatment failures in the VIDA Trial. Ann Allergy Asthma Immunol. 2018 10; 121(4):444-450.e1. PMID: 29908319.
      View in: PubMed
    11. Labaki WW, Xia M, Murray S, Curtis JL, Barr RG, Bhatt SP, Bleecker ER, Hansel NN, Cooper CB, Dransfield MT, Wells JM, Hoffman EA, Kanner RE, Paine R, Ortega VE, Peters SP, Krishnan JA, Bowler RP, Couper DJ, Woodruff PG, Martinez FJ, Martinez CH, Han MK. NT-proBNP in stable COPD and future exacerbation risk: Analysis of the SPIROMICS cohort. Respir Med. 2018 07; 140:87-93. PMID: 29957287.
      View in: PubMed
    12. Ortega VE. Picking the Right Fruit: Intersecting Chronic Obstructive Pulmonary Disease Genome-Wide Association Study Discoveries with Epigenetics. Am J Respir Crit Care Med. 2018 05 15; 197(10):1237-1239. PMID: 29425467.
      View in: PubMed
    13. Khoury O, Barrios C, Ortega V, Atala A, Murphy SV. Immunomodulatory Cell Therapy to Target Cystic Fibrosis Inflammation. Am J Respir Cell Mol Biol. 2018 Jan; 58(1):12-20. PMID: 28707978.
      View in: PubMed
    14. Hastie AT, Martinez FJ, Curtis JL, Doerschuk CM, Hansel NN, Christenson S, Putcha N, Ortega VE, Li X, Barr RG, Carretta EE, Couper DJ, Cooper CB, Hoffman EA, Kanner RE, Kleerup E, O'Neal WK, Paine R, Peters SP, Alexis NE, Woodruff PG, Han MK, Meyers DA, Bleecker ER. Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort. Lancet Respir Med. 2017 12; 5(12):956-967. PMID: 29146301.
      View in: PubMed
    15. Cardet JC, Louisias M, King TS, Castro M, Codispoti CD, Dunn R, Engle L, Giles BL, Holguin F, Lima JJ, Long D, Lugogo N, Nyenhuis S, Ortega VE, Ramratnam S, Wechsler ME, Israel E, Phipatanakul W. Income is an independent risk factor for worse asthma outcomes. J Allergy Clin Immunol. 2018 02; 141(2):754-760.e3. PMID: 28535964.
      View in: PubMed
    16. Himes BE, Ortega VE. Making progress toward understanding the genetic architecture of asthma in the most affected US ethnic group. Eur Respir J. 2017 05; 49(5). PMID: 28461304.
      View in: PubMed
    17. Celedón JC, Burchard EG, Schraufnagel D, Castillo-Salgado C, Schenker M, Balmes J, Neptune E, Cummings KJ, Holguin F, Riekert KA, Wisnivesky JP, Garcia JGN, Roman J, Kittles R, Ortega VE, Redline S, Mathias R, Thomas A, Samet J, Ford JG. An American Thoracic Society/National Heart, Lung, and Blood Institute Workshop Report: Addressing Respiratory Health Equality in the United States. Ann Am Thorac Soc. 2017 May; 14(5):814-826. PMID: 28459618.
      View in: PubMed
    18. Ortega VE, Pecchiari M. Understanding at-risk subgroups for lung function impairment in life-long nonsmokers with a1-antitrypsin deficiency. Eur Respir J. 2017 03; 49(3). PMID: 28356380.
      View in: PubMed
    19. Ortega VE, Torgerson DG. On a Collision Course: The Electronic Medical Record and Genetic Studies of Asthma. Am J Respir Crit Care Med. 2017 02 15; 195(4):412-414. PMID: 28199158.
      View in: PubMed
    20. Mathias RA, Taub MA, Gignoux CR, Fu W, Musharoff S, O'Connor TD, Vergara C, Torgerson DG, Pino-Yanes M, Shringarpure SS, Huang L, Rafaels N, Boorgula MP, Johnston HR, Ortega VE, Levin AM, Song W, Torres R, Padhukasahasram B, Eng C, Mejia-Mejia DA, Ferguson T, Qin ZS, Scott AF, Yazdanbakhsh M, Wilson JG, Marrugo J, Lange LA, Kumar R, Avila PC, Williams LK, Watson H, Ware LB, Olopade C, Olopade O, Oliveira R, Ober C, Nicolae DL, Meyers D, Mayorga A, Knight-Madden J, Hartert T, Hansel NN, Foreman MG, Ford JG, Faruque MU, Dunston GM, Caraballo L, Burchard EG, Bleecker E, Araujo MI, Herrera-Paz EF, Gietzen K, Grus WE, Bamshad M, Bustamante CD, Kenny EE, Hernandez RD, Beaty TH, Ruczinski I, Akey J, Barnes KC. A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome. Nat Commun. 2016 10 11; 7:12522. PMID: 27725671.
      View in: PubMed
    21. Ortega VE, Celedón JC. The Advent of High-Throughput Sequencing Studies of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2016 06 15; 193(12):1323-4. PMID: 27304235.
      View in: PubMed
    22. Ortega VE, Kumar R. The Effect of Ancestry and Genetic Variation on Lung Function Predictions: What Is "Normal" Lung Function in Diverse Human Populations? Curr Allergy Asthma Rep. 2015 Apr; 15(4):16. PMID: 26130473.
      View in: PubMed
    23. Ortega VE. Predictive genetic profiles for ß-agonist therapy in asthma. A future under construction. Am J Respir Crit Care Med. 2015 Mar 01; 191(5):494-6. PMID: 25723819.
      View in: PubMed
    24. Ortega VE, Meyers DA, Bleecker ER. Asthma pharmacogenetics and the development of genetic profiles for personalized medicine. Pharmgenomics Pers Med. 2015; 8:9-22. PMID: 25691813.
      View in: PubMed
    25. Ortega VE, Meyers DA. Implications of population structure and ancestry on asthma genetic studies. Curr Opin Allergy Clin Immunol. 2014 Oct; 14(5):381-9. PMID: 25153337.
      View in: PubMed
    26. Ortega VE, Hawkins GA, Moore WC, Hastie AT, Ampleford EJ, Busse WW, Castro M, Chardon D, Erzurum SC, Israel E, Montealegre F, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Effect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting ß agonist treatment in a multiethnic asthma population: a genetic study. Lancet Respir Med. 2014 Mar; 2(3):204-13. PMID: 24621682.
      View in: PubMed
    27. Ortega VE, Meyers DA. Pharmacogenetics: implications of race and ethnicity on defining genetic profiles for personalized medicine. J Allergy Clin Immunol. 2014 Jan; 133(1):16-26. PMID: 24369795.
      View in: PubMed
    28. Miller SM, Ortega VE. Pharmacogenetics and the development of personalized approaches for combination therapy in asthma. Curr Allergy Asthma Rep. 2013 Oct; 13(5):443-52. PMID: 23912588.
      View in: PubMed
    29. Ortega VE, Wechsler ME. Asthma pharmacogenetics: responding to the call for a personalized approach. Curr Opin Allergy Clin Immunol. 2013 Aug; 13(4):399-409. PMID: 23799335.
      View in: PubMed
    30. Hastie AT, Moore WC, Li H, Rector BM, Ortega VE, Pascual RM, Peters SP, Meyers DA, Bleecker ER. Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects. J Allergy Clin Immunol. 2013 Jul; 132(1):72-80. PMID: 23706399.
      View in: PubMed
    31. Ortega VE, Peters SP. Beta-2 adrenergic agonists: focus on safety and benefits versus risks. Curr Opin Pharmacol. 2010 Jun; 10(3):246-53. PMID: 20452285.
      View in: PubMed
    32. Ortega VE, Hawkins GA, Peters SP, Bleecker ER. Pharmacogenetics of the beta 2-adrenergic receptor gene. Immunol Allergy Clin North Am. 2007 Nov; 27(4):665-84; vii. PMID: 17996583.
      View in: PubMed
    33. Penn RB, Ortega VE, Bleecker ER. A Roadmap to functional genomics. Physiol Genomics. 2007 Jun 19; 30(1):82-8. PMID: 17327496.
      View in: PubMed
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