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Clinical and Translational Science Institute

Keywords
Last Name

Sara Jones, Ph.D.

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentPhysiology and Pharmacology
Address
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentInstitute for Regenerative Medicine


    Collapse Research 
    Collapse research activities and funding
    F32DA005749     (JONES, SARA R)Mar 6, 1996
    NIH/NIDA
    MOLECULAR MECHANISM OF AMPHETAMINE ACTION
    Role: Principal Investigator

    R01DA014030     (JONES, SARA R)Apr 1, 2001 - Mar 31, 2016
    NIH/NIDA
    Animal Models of Cocaine Addiction
    Role: Principal Investigator

    U01AA014091     (JONES, SARA RAULERSON)Feb 1, 2003 - Jan 31, 2022
    NIH/NIAAA
    Role of Kappa Opioid Receptors in Maladaptive Catecholamine Responses to Stress and Alcohol Exposure
    Role: Principal Investigator

    R21AA013900     (JONES, SARA R)Jun 1, 2004 - May 31, 2009
    NIH/NIAAA
    Ethanol, NMDA Receptor and Dopamine Interactions
    Role: Principal Investigator

    R21DA018815     (JONES, SARA R)Sep 25, 2004 - Jul 31, 2007
    NIH/NIDA
    Voltammetry in Freely Moving Mice
    Role: Principal Investigator

    R01DA021325     (JONES, SARA R)Jul 20, 2007 - Jun 30, 2013
    NIH/NIDA
    Dopamine Transporter Changes Following Cocaine Self-Administration
    Role: Principal Investigator

    R01DA030161     (JONES, SARA R)Sep 15, 2010 - Jun 30, 2015
    NIH/NIDA
    Methylphenidate, Serotonin and Dopamine Interactions
    Role: Principal Investigator

    R01AA023999     (JONES, SARA RAULERSON)Aug 5, 2015 - Jun 30, 2020
    NIH/NIAAA
    Ethanol Dependence Induced Changes in Dopamine Signaling in Basolateral Amygdala
    Role: Principal Investigator

    T32DA041349     (JONES, SARA RAULERSON)Jul 1, 2017 - Jun 30, 2022
    NIH/NIDA
    The Neurobiology of Drug Abuse
    Role: Principal Investigator

    R01DA048490     (MARTIN, THOMAS JEFFREY)Apr 15, 2019 - Feb 29, 2024
    NIH/NIDA
    Biased Kappa Opioid Agonists as Non-addictive Analgesics
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Karkhanis AN, Leach AC, Yorgason JT, Uneri A, Barth S, Niere F, Alexander NJ, Weiner JL, McCool BA, Raab-Graham KF, Ferris MJ, Jones SR. Chronic Social Isolation Stress during Peri-Adolescence Alters Presynaptic Dopamine Terminal Dynamics via Augmentation in Accumbal Dopamine Availability. ACS Chem Neurosci. 2018 Oct 16. PMID: 30284806.
      View in: PubMed
    2. McGuier NS, Rinker JA, Cannady R, Fulmer DB, Jones SR, Hoffman M, Mulholland PJ. Identification and validation of midbrain Kcnq4 regulation of heavy alcohol consumption in rodents. Neuropharmacology. 2018 08; 138:10-19. PMID: 29775679.
      View in: PubMed
    3. Siciliano CA, Karkhanis AN, Holleran KM, Melchior JR, Jones SR. Cross-Species Alterations in Synaptic Dopamine Regulation After Chronic Alcohol Exposure. Handb Exp Pharmacol. 2018; 248:213-238. PMID: 29675581.
      View in: PubMed
    4. Siciliano CA, Saha K, Calipari ES, Fordahl SC, Chen R, Khoshbouei H, Jones SR. Amphetamine Reverses Escalated Cocaine Intake via Restoration of Dopamine Transporter Conformation. J Neurosci. 2018 01 10; 38(2):484-497. PMID: 29175958.
      View in: PubMed
    5. Melchior JR, Jones SR. Chronic ethanol exposure increases inhibition of optically targeted phasic dopamine release in the nucleus accumbens core and medial shell ex vivo. Mol Cell Neurosci. 2017 12; 85:93-104. PMID: 28942046.
      View in: PubMed
    6. Karkhanis A, Holleran KM, Jones SR. Dynorphin/Kappa Opioid Receptor Signaling in Preclinical Models of Alcohol, Drug, and Food Addiction. Int Rev Neurobiol. 2017; 136:53-88. PMID: 29056156.
      View in: PubMed
    7. Siciliano CA, McIntosh JM, Jones SR, Ferris MJ. a6ß2 subunit containing nicotinic acetylcholine receptors exert opposing actions on rapid dopamine signaling in the nucleus accumbens of rats with high-versus low-response to novelty. Neuropharmacology. 2017 Nov; 126:281-291. PMID: 28666811.
      View in: PubMed
    8. Siciliano CA, Jones SR. Cocaine Potency at the Dopamine Transporter Tracks Discrete Motivational States During Cocaine Self-Administration. Neuropsychopharmacology. 2017 Aug; 42(9):1893-1904. PMID: 28139678.
      View in: PubMed
    9. Fordahl SC, Jones SR. High-Fat-Diet-Induced Deficits in Dopamine Terminal Function Are Reversed by Restoring Insulin Signaling. ACS Chem Neurosci. 2017 02 15; 8(2):290-299. PMID: 27966885.
      View in: PubMed
    10. Brodnik ZD, Ferris MJ, Jones SR, España RA. Reinforcing Doses of Intravenous Cocaine Produce Only Modest Dopamine Uptake Inhibition. ACS Chem Neurosci. 2017 02 15; 8(2):281-289. PMID: 27936579.
      View in: PubMed
    11. Brust TF, Morgenweck J, Kim SA, Rose JH, Locke JL, Schmid CL, Zhou L, Stahl EL, Cameron MD, Scarry SM, Aubé J, Jones SR, Martin TJ, Bohn LM. Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria. Sci Signal. 2016 11 29; 9(456):ra117. PMID: 27899527.
      View in: PubMed
    12. McGinnis MM, Siciliano CA, Jones SR. Dopamine D3 autoreceptor inhibition enhances cocaine potency at the dopamine transporter. J Neurochem. 2016 09; 138(6):821-9. PMID: 27393374.
      View in: PubMed
    13. Shaw JK, Ferris MJ, Locke JL, Brodnik ZD, Jones SR, España RA. Hypocretin/orexin knock-out mice display disrupted behavioral and dopamine responses to cocaine. Addict Biol. 2017 Nov; 22(6):1695-1705. PMID: 27480648.
      View in: PubMed
    14. Rose JH, Karkhanis AN, Steiniger-Brach B, Jones SR. Distinct Effects of Nalmefene on Dopamine Uptake Rates and Kappa Opioid Receptor Activity in the Nucleus Accumbens Following Chronic Intermittent Ethanol Exposure. Int J Mol Sci. 2016 Jul 27; 17(8). PMID: 27472317.
      View in: PubMed
    15. Siciliano CA, Fordahl SC, Jones SR. Cocaine Self-Administration Produces Long-Lasting Alterations in Dopamine Transporter Responses to Cocaine. J Neurosci. 2016 07 27; 36(30):7807-16. PMID: 27466327.
      View in: PubMed
    16. Karkhanis AN, Huggins KN, Rose JH, Jones SR. Switch from excitatory to inhibitory actions of ethanol on dopamine levels after chronic exposure: Role of kappa opioid receptors. Neuropharmacology. 2016 11; 110(Pt A):190-197. PMID: 27450094.
      View in: PubMed
    17. Karkhanis AN, Beveridge TJ, Blough BE, Jones SR, Ferris MJ. The individual and combined effects of phenmetrazine and mgluR2/3 agonist LY379268 on the motivation to self-administer cocaine. Drug Alcohol Depend. 2016 Sep 01; 166:51-60. PMID: 27394931.
      View in: PubMed
    18. Siciliano CA, Locke JL, Mathews TA, Lopez MF, Becker HC, Jones SR. Dopamine synthesis in alcohol drinking-prone and -resistant mouse strains. Alcohol. 2017 Feb; 58:25-32. PMID: 27425261.
      View in: PubMed
    19. Fordahl SC, Locke JL, Jones SR. High fat diet augments amphetamine sensitization in mice: Role of feeding pattern, obesity, and dopamine terminal changes. Neuropharmacology. 2016 10; 109:170-182. PMID: 27267686.
      View in: PubMed
    20. Salvatore MF, Calipari ES, Jones SR. Regulation of Tyrosine Hydroxylase Expression and Phosphorylation in Dopamine Transporter-Deficient Mice. ACS Chem Neurosci. 2016 07 20; 7(7):941-51. PMID: 27124386.
      View in: PubMed
    21. Butler TR, Karkhanis AN, Jones SR, Weiner JL. Adolescent Social Isolation as a Model of Heightened Vulnerability to Comorbid Alcoholism and Anxiety Disorders. Alcohol Clin Exp Res. 2016 06; 40(6):1202-14. PMID: 27154240.
      View in: PubMed
    22. Rose JH, Karkhanis AN, Chen R, Gioia D, Lopez MF, Becker HC, McCool BA, Jones SR. Supersensitive Kappa Opioid Receptors Promotes Ethanol Withdrawal-Related Behaviors and Reduce Dopamine Signaling in the Nucleus Accumbens. Int J Neuropsychopharmacol. 2016 05; 19(5). PMID: 26625893.
      View in: PubMed
    23. Silverstein-Metzler MG, Shively CA, Clarkson TB, Appt SE, Carr JJ, Kritchevsky SB, Jones SR, Register TC. Sertraline inhibits increases in body fat and carbohydrate dysregulation in adult female cynomolgus monkeys. Psychoneuroendocrinology. 2016 06; 68:29-38. PMID: 26939086.
      View in: PubMed
    24. Siciliano CA, Calipari ES, Yorgason JT, Lovinger DM, Mateo Y, Jimenez VA, Helms CM, Grant KA, Jones SR. Increased presynaptic regulation of dopamine neurotransmission in the nucleus accumbens core following chronic ethanol self-administration in female macaques. Psychopharmacology (Berl). 2016 Apr; 233(8):1435-43. PMID: 26892380.
      View in: PubMed
    25. Karkhanis AN, Rose JH, Weiner JL, Jones SR. Early-Life Social Isolation Stress Increases Kappa Opioid Receptor Responsiveness and Downregulates the Dopamine System. Neuropsychopharmacology. 2016 08; 41(9):2263-74. PMID: 26860203.
      View in: PubMed
    26. Siciliano CA, Calipari ES, Yorgason JT, Mateo Y, Helms CM, Lovinger DM, Grant KA, Jones SR. Chronic ethanol self-administration in macaques shifts dopamine feedback inhibition to predominantly D2 receptors in nucleus accumbens core. Drug Alcohol Depend. 2016 Jan 01; 158:159-63. PMID: 26627912.
      View in: PubMed
    27. Yorgason JT, Calipari ES, Ferris MJ, Karkhanis AN, Fordahl SC, Weiner JL, Jones SR. Social isolation rearing increases dopamine uptake and psychostimulant potency in the striatum. Neuropharmacology. 2016 Feb; 101:471-9. PMID: 26525189.
      View in: PubMed
    28. Sun H, Calipari ES, Beveridge TJ, Jones SR, Chen R. The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration. Neuroscience. 2015 Oct 29; 307:253-61. PMID: 26321241.
      View in: PubMed
    29. Cervera-Juanes R, Wilhem LJ, Park B, Lee R, Locke J, Helms C, Gonzales S, Wand G, Jones SR, Grant KA, Ferguson B. MAOA expression predicts vulnerability for alcohol use. Mol Psychiatry. 2016 Apr; 21(4):472-9. PMID: 26148813.
      View in: PubMed
    30. Siciliano CA, Ferris MJ, Jones SR. Cocaine self-administration disrupts mesolimbic dopamine circuit function and attenuates dopaminergic responsiveness to cocaine. Eur J Neurosci. 2015 Aug; 42(4):2091-6. PMID: 26037018.
      View in: PubMed
    31. Melchior JR, Ferris MJ, Stuber GD, Riddle DR, Jones SR. Optogenetic versus electrical stimulation of dopamine terminals in the nucleus accumbens reveals local modulation of presynaptic release. J Neurochem. 2015 09; 134(5):833-44. PMID: 26011081.
      View in: PubMed
    32. Karkhanis AN, Alexander NJ, McCool BA, Weiner JL, Jones SR. Chronic social isolation during adolescence augments catecholamine response to acute ethanol in the basolateral amygdala. Synapse. 2015 Aug; 69(8):385-95. PMID: 25963724.
      View in: PubMed
    33. Siciliano CA, Calipari ES, Cuzon Carlson VC, Helms CM, Lovinger DM, Grant KA, Jones SR. Voluntary ethanol intake predicts ?-opioid receptor supersensitivity and regionally distinct dopaminergic adaptations in macaques. J Neurosci. 2015 Apr 15; 35(15):5959-68. PMID: 25878269.
      View in: PubMed
    34. Ferris MJ, Calipari ES, Rose JH, Siciliano CA, Sun H, Chen R, Jones SR. A Single Amphetamine Infusion Reverses Deficits in Dopamine Nerve-Terminal Function Caused by a History of Cocaine Self-Administration. Neuropsychopharmacology. 2015 Jul; 40(8):1826-36. PMID: 25689882.
      View in: PubMed
    35. Karkhanis AN, Rose JH, Huggins KN, Konstantopoulos JK, Jones SR. Chronic intermittent ethanol exposure reduces presynaptic dopamine neurotransmission in the mouse nucleus accumbens. Drug Alcohol Depend. 2015 May 01; 150:24-30. PMID: 25765483.
      View in: PubMed
    36. Luderman KD, Chen R, Ferris MJ, Jones SR, Gnegy ME. Protein kinase C beta regulates the D2-like dopamine autoreceptor. Neuropharmacology. 2015 Feb; 89:335-41. PMID: 25446677.
      View in: PubMed
    37. Richardson JR, Taylor MM, Shalat SL, Guillot TS, Caudle WM, Hossain MM, Mathews TA, Jones SR, Cory-Slechta DA, Miller GW. Developmental pesticide exposure reproduces features of attention deficit hyperactivity disorder. FASEB J. 2015 May; 29(5):1960-72. PMID: 25630971.
      View in: PubMed
    38. Siciliano CA, Calipari ES, Ferris MJ, Jones SR. Adaptations of presynaptic dopamine terminals induced by psychostimulant self-administration. ACS Chem Neurosci. 2015 Jan 21; 6(1):27-36. PMID: 25491345.
      View in: PubMed
    39. Calipari ES, Ferris MJ, Siciliano CA, Jones SR. Differential influence of dopamine transport rate on the potencies of cocaine, amphetamine, and methylphenidate. ACS Chem Neurosci. 2015 Jan 21; 6(1):155-62. PMID: 25474655.
      View in: PubMed
    40. Yorgason JT, Rose JH, McIntosh JM, Ferris MJ, Jones SR. Greater ethanol inhibition of presynaptic dopamine release in C57BL/6J than DBA/2J mice: Role of nicotinic acetylcholine receptors. Neuroscience. 2015 Jan 22; 284:854-64. PMID: 25451295.
      View in: PubMed
    41. Karkhanis AN, Locke JL, McCool BA, Weiner JL, Jones SR. Social isolation rearing increases nucleus accumbens dopamine and norepinephrine responses to acute ethanol in adulthood. Alcohol Clin Exp Res. 2014 Nov; 38(11):2770-9. PMID: 25421514.
      View in: PubMed
    42. Calipari ES, Siciliano CA, Zimmer BA, Jones SR. Brief intermittent cocaine self-administration and abstinence sensitizes cocaine effects on the dopamine transporter and increases drug seeking. Neuropsychopharmacology. 2015 Feb; 40(3):728-35. PMID: 25212486.
      View in: PubMed
    43. Siciliano CA, Calipari ES, Jones SR. Amphetamine potency varies with dopamine uptake rate across striatal subregions. J Neurochem. 2014 Nov; 131(3):348-55. PMID: 24988947.
      View in: PubMed
    44. Ferris MJ, España RA, Locke JL, Konstantopoulos JK, Rose JH, Chen R, Jones SR. Dopamine transporters govern diurnal variation in extracellular dopamine tone. Proc Natl Acad Sci U S A. 2014 Jul 01; 111(26):E2751-9. PMID: 24979798.
      View in: PubMed
    45. Diaz MR, Jotty K, Locke JL, Jones SR, Valenzuela CF. Moderate Alcohol Exposure during the Rat Equivalent to the Third Trimester of Human Pregnancy Alters Regulation of GABAA Receptor-Mediated Synaptic Transmission by Dopamine in the Basolateral Amygdala. Front Pediatr. 2014; 2:46. PMID: 24904907.
      View in: PubMed
    46. Daigle TL, Ferris MJ, Gainetdinov RR, Sotnikova TD, Urs NM, Jones SR, Caron MG. Selective deletion of GRK2 alters psychostimulant-induced behaviors and dopamine neurotransmission. Neuropsychopharmacology. 2014 Sep; 39(10):2450-62. PMID: 24776686.
      View in: PubMed
    47. Ferris MJ, Milenkovic M, Liu S, Mielnik CA, Beerepoot P, John CE, España RA, Sotnikova TD, Gainetdinov RR, Borgland SL, Jones SR, Ramsey AJ. Sustained N-methyl-d-aspartate receptor hypofunction remodels the dopamine system and impairs phasic signaling. Eur J Neurosci. 2014 Jul; 40(1):2255-63. PMID: 24754704.
      View in: PubMed
    48. Siciliano CA, Calipari ES, Ferris MJ, Jones SR. Biphasic mechanisms of amphetamine action at the dopamine terminal. J Neurosci. 2014 Apr 16; 34(16):5575-82. PMID: 24741047.
      View in: PubMed
    49. Calipari ES, Jones SR. Sensitized nucleus accumbens dopamine terminal responses to methylphenidate and dopamine transporter releasers after intermittent-access self-administration. Neuropharmacology. 2014 Jul; 82:1-10. PMID: 24632529.
      View in: PubMed
    50. Calipari ES, Ferris MJ, Siciliano CA, Zimmer BA, Jones SR. Intermittent cocaine self-administration produces sensitization of stimulant effects at the dopamine transporter. J Pharmacol Exp Ther. 2014 May; 349(2):192-8. PMID: 24566123.
      View in: PubMed
    51. Calipari ES, Sun H, Eldeeb K, Luessen DJ, Feng X, Howlett AC, Jones SR, Chen R. Amphetamine self-administration attenuates dopamine D2 autoreceptor function. Neuropsychopharmacology. 2014 Jul; 39(8):1833-42. PMID: 24513972.
      View in: PubMed
    52. Rose JH, Calipari ES, Mathews TA, Jones SR. Greater ethanol-induced locomotor activation in DBA/2J versus C57BL/6J mice is not predicted by presynaptic striatal dopamine dynamics. PLoS One. 2013; 8(12):e83852. PMID: 24349553.
      View in: PubMed
    53. Calipari ES, Ferris MJ, Jones SR. Extended access of cocaine self-administration results in tolerance to the dopamine-elevating and locomotor-stimulating effects of cocaine. J Neurochem. 2014 Jan; 128(2):224-32. PMID: 24102293.
      View in: PubMed
    54. Calipari ES, Beveridge TJ, Jones SR, Porrino LJ. Withdrawal from extended-access cocaine self-administration results in dysregulated functional activity and altered locomotor activity in rats. Eur J Neurosci. 2013 Dec; 38(12):3749-57. PMID: 24118121.
      View in: PubMed
    55. Yorgason JT, Ferris MJ, Steffensen SC, Jones SR. Frequency-dependent effects of ethanol on dopamine release in the nucleus accumbens. Alcohol Clin Exp Res. 2014 Feb; 38(2):438-47. PMID: 24117706.
      View in: PubMed
    56. Ferris MJ, Calipari ES, Melchior JR, Roberts DC, España RA, Jones SR. Paradoxical tolerance to cocaine after initial supersensitivity in drug-use-prone animals. Eur J Neurosci. 2013 Aug; 38(4):2628-36. PMID: 23725404.
      View in: PubMed
    57. Calipari ES, Ferris MJ, Zimmer BA, Roberts DC, Jones SR. Temporal pattern of cocaine intake determines tolerance vs sensitization of cocaine effects at the dopamine transporter. Neuropsychopharmacology. 2013 Nov; 38(12):2385-92. PMID: 23719505.
      View in: PubMed
    58. Ferris MJ, Calipari ES, Yorgason JT, Jones SR. Examining the complex regulation and drug-induced plasticity of dopamine release and uptake using voltammetry in brain slices. ACS Chem Neurosci. 2013 May 15; 4(5):693-703. PMID: 23581570.
      View in: PubMed
    59. Yorgason JT, España RA, Konstantopoulos JK, Weiner JL, Jones SR. Enduring increases in anxiety-like behavior and rapid nucleus accumbens dopamine signaling in socially isolated rats. Eur J Neurosci. 2013 Mar; 37(6):1022-31. PMID: 23294165.
      View in: PubMed
    60. Calipari ES, Ferris MJ, Salahpour A, Caron MG, Jones SR. Methylphenidate amplifies the potency and reinforcing effects of amphetamines by increasing dopamine transporter expression. Nat Commun. 2013; 4:2720. PMID: 24193139.
      View in: PubMed
    61. Espana RA, Jones SR. Presynaptic dopamine modulation by stimulant self-administration. Front Biosci (Schol Ed). 2013 Jan 01; 5:261-76. PMID: 23277050.
      View in: PubMed
    62. Calipari ES, Huggins KN, Mathews TA, Jones SR. Conserved dorsal-ventral gradient of dopamine release and uptake rate in mice, rats and rhesus macaques. Neurochem Int. 2012 Dec; 61(7):986-91. PMID: 22819794.
      View in: PubMed
    63. Brookshire BR, Jones SR. Chronic methylphenidate administration in mice produces depressive-like behaviors and altered responses to fluoxetine. Synapse. 2012 Sep; 66(9):844-7. PMID: 22588965.
      View in: PubMed
    64. Calipari ES, Ferris MJ, Melchior JR, Bermejo K, Salahpour A, Roberts DC, Jones SR. Methylphenidate and cocaine self-administration produce distinct dopamine terminal alterations. Addict Biol. 2014 Mar; 19(2):145-55. PMID: 22458761.
      View in: PubMed
    65. Huggins KN, Mathews TA, Locke JL, Szeliga KT, Friedman DP, Bennett AJ, Jones SR. Effects of early life stress on drinking and serotonin system activity in rhesus macaques: 5-hydroxyindoleacetic acid in cerebrospinal fluid predicts brain tissue levels. Alcohol. 2012 Jun; 46(4):371-6. PMID: 22445804.
      View in: PubMed
    66. Oleson EB, Ferris MJ, España RA, Harp J, Jones SR. Effects of the histamine H1 receptor antagonist and benztropine analog diphenylpyraline on dopamine uptake, locomotion and reward. Eur J Pharmacol. 2012 May 15; 683(1-3):161-5. PMID: 22445882.
      View in: PubMed
    67. Ferris MJ, Calipari ES, Mateo Y, Melchior JR, Roberts DC, Jones SR. Cocaine self-administration produces pharmacodynamic tolerance: differential effects on the potency of dopamine transporter blockers, releasers, and methylphenidate. Neuropsychopharmacology. 2012 Jun; 37(7):1708-16. PMID: 22395730.
      View in: PubMed
    68. Yorgason JT, Jones SR, España RA. Low and high affinity dopamine transporter inhibitors block dopamine uptake within 5 sec of intravenous injection. Neuroscience. 2011 May 19; 182:125-32. PMID: 21402130.
      View in: PubMed
    69. Yorgason JT, España RA, Jones SR. Demon voltammetry and analysis software: analysis of cocaine-induced alterations in dopamine signaling using multiple kinetic measures. J Neurosci Methods. 2011 Nov 15; 202(2):158-64. PMID: 21392532.
      View in: PubMed
    70. Ferris MJ, Mateo Y, Roberts DC, Jones SR. Cocaine-insensitive dopamine transporters with intact substrate transport produced by self-administration. Biol Psychiatry. 2011 Feb 01; 69(3):201-7. PMID: 20801429.
      View in: PubMed
    71. España RA, Melchior JR, Roberts DC, Jones SR. Hypocretin 1/orexin A in the ventral tegmental area enhances dopamine responses to cocaine and promotes cocaine self-administration. Psychopharmacology (Berl). 2011 Mar; 214(2):415-26. PMID: 20959967.
      View in: PubMed
    72. España RA, Oleson EB, Locke JL, Brookshire BR, Roberts DC, Jones SR. The hypocretin-orexin system regulates cocaine self-administration via actions on the mesolimbic dopamine system. Eur J Neurosci. 2010 Jan; 31(2):336-48. PMID: 20039943.
      View in: PubMed
    73. Oleson EB, Salek J, Bonin KD, Jones SR, Budygin EA. Real-time voltammetric detection of cocaine-induced dopamine changes in the striatum of freely moving mice. Neurosci Lett. 2009 Dec 25; 467(2):144-6. PMID: 19822192.
      View in: PubMed
    74. Mathews TA, Brookshire BR, Budygin EA, Hamre K, Goldowitz D, Jones SR. Ethanol-induced hyperactivity is associated with hypodopaminergia in the 22-TNJ ENU-mutated mouse. Alcohol. 2009 Sep; 43(6):421-31. PMID: 19801272.
      View in: PubMed
    75. Brookshire BR, Jones SR. Direct and indirect 5-HT receptor agonists produce gender-specific effects on locomotor and vertical activities in C57 BL/6J mice. Pharmacol Biochem Behav. 2009 Nov; 94(1):194-203. PMID: 19698737.
      View in: PubMed
    76. España RA, Roberts DC, Jones SR. Short-acting cocaine and long-acting GBR-12909 both elicit rapid dopamine uptake inhibition following intravenous delivery. Neuroscience. 2008 Jul 31; 155(1):250-7. PMID: 18597947.
      View in: PubMed
    77. Schroeder FA, Penta KL, Matevossian A, Jones SR, Konradi C, Tapper AR, Akbarian S. Drug-induced activation of dopamine D(1) receptor signaling and inhibition of class I/II histone deacetylase induce chromatin remodeling in reward circuitry and modulate cocaine-related behaviors. Neuropsychopharmacology. 2008 Nov; 33(12):2981-92. PMID: 18288092.
      View in: PubMed
    78. Lack CM, Jones SR, Roberts DC. Increased breakpoints on a progressive ratio schedule reinforced by IV cocaine are associated with reduced locomotor activation and reduced dopamine efflux in nucleus accumbens shell in rats. Psychopharmacology (Berl). 2008 Jan; 195(4):517-25. PMID: 17879088.
      View in: PubMed
    79. Budygin EA, Oleson EB, Mathews TA, Läck AK, Diaz MR, McCool BA, Jones SR. Effects of chronic alcohol exposure on dopamine uptake in rat nucleus accumbens and caudate putamen. Psychopharmacology (Berl). 2007 Sep; 193(4):495-501. PMID: 17492432.
      View in: PubMed
    80. John CE, Jones SR. Voltammetric characterization of the effect of monoamine uptake inhibitors and releasers on dopamine and serotonin uptake in mouse caudate-putamen and substantia nigra slices. Neuropharmacology. 2007 Jun; 52(8):1596-605. PMID: 17459426.
      View in: PubMed
    81. Mathews TA, John CE, Lapa GB, Budygin EA, Jones SR. No role of the dopamine transporter in acute ethanol effects on striatal dopamine dynamics. Synapse. 2006 Sep 15; 60(4):288-94. PMID: 16786536.
      View in: PubMed
    82. Jones SR, Mathews TA, Budygin EA. Effect of moderate ethanol dose on dopamine uptake in rat nucleus accumbens in vivo. Synapse. 2006 Sep 01; 60(3):251-5. PMID: 16752364.
      View in: PubMed
    83. John CE, Jones SR. Exocytotic release of dopamine in ventral tegmental area slices from C57BL/6 and dopamine transporter knockout mice. Neurochem Int. 2006 Dec; 49(8):737-45. PMID: 16901588.
      View in: PubMed
    84. Goldowitz D, Matthews DB, Hamre KM, Mittleman G, Chesler EJ, Becker HC, Lopez MF, Jones SR, Mathews TA, Miles MF, Kerns R, Grant KA. Progress in using mouse inbred strains, consomics, and mutants to identify genes related to stress, anxiety, and alcohol phenotypes. Alcohol Clin Exp Res. 2006 Jun; 30(6):1066-78. PMID: 16737467.
      View in: PubMed
    85. John CE, Budygin EA, Mateo Y, Jones SR. Neurochemical characterization of the release and uptake of dopamine in ventral tegmental area and serotonin in substantia nigra of the mouse. J Neurochem. 2006 Jan; 96(1):267-82. PMID: 16300629.
      View in: PubMed
    86. Lapa GB, Byrd GD, Lapa AA, Budygin EA, Childers SR, Jones SR, Harp JJ. The synthesis and biological evaluation of dopamine transporter inhibiting activity of substituted diphenylmethoxypiperidines. Bioorg Med Chem Lett. 2005 Nov 15; 15(22):4915-8. PMID: 16165350.
      View in: PubMed
    87. Erikson KM, John CE, Jones SR, Aschner M. Manganese accumulation in striatum of mice exposed to toxic doses is dependent upon a functional dopamine transporter. Environ Toxicol Pharmacol. 2005 Nov; 20(3):390-4. PMID: 21783617.
      View in: PubMed
    88. Budygin EA, Mathews TA, Lapa GB, Jones SR. Local effects of acute ethanol on dopamine neurotransmission in the ventral striatum in C57BL/6 mice. Eur J Pharmacol. 2005 Oct 31; 523(1-3):40-5. PMID: 16226738.
      View in: PubMed
    89. Mateo Y, Lack CM, Morgan D, Roberts DC, Jones SR. Reduced dopamine terminal function and insensitivity to cocaine following cocaine binge self-administration and deprivation. Neuropsychopharmacology. 2005 Aug; 30(8):1455-63. PMID: 15702135.
      View in: PubMed
    90. Mateo Y, Budygin EA, John CE, Banks ML, Jones SR. Voltammetric assessment of dopamine clearance in the absence of the dopamine transporter: no contribution of other transporters in core or shell of nucleus accumbens. J Neurosci Methods. 2004 Dec 30; 140(1-2):183-7. PMID: 15589348.
      View in: PubMed
    91. Lapa GB, Mathews TA, Harp J, Budygin EA, Jones SR. Diphenylpyraline, a histamine H1 receptor antagonist, has psychostimulant properties. Eur J Pharmacol. 2005 Jan 04; 506(3):237-40. PMID: 15627433.
      View in: PubMed
    92. Mateo Y, Budygin EA, Morgan D, Roberts DC, Jones SR. Fast onset of dopamine uptake inhibition by intravenous cocaine. Eur J Neurosci. 2004 Nov; 20(10):2838-42. PMID: 15548229.
      View in: PubMed
    93. Sotnikova TD, Budygin EA, Jones SR, Dykstra LA, Caron MG, Gainetdinov RR. Dopamine transporter-dependent and -independent actions of trace amine beta-phenylethylamine. J Neurochem. 2004 Oct; 91(2):362-73. PMID: 15447669.
      View in: PubMed
    94. Budygin EA, Brodie MS, Sotnikova TD, Mateo Y, John CE, Cyr M, Gainetdinov RR, Jones SR. Dissociation of rewarding and dopamine transporter-mediated properties of amphetamine. Proc Natl Acad Sci U S A. 2004 May 18; 101(20):7781-6. PMID: 15136721.
      View in: PubMed
    95. Mateo Y, Budygin EA, John CE, Jones SR. Role of serotonin in cocaine effects in mice with reduced dopamine transporter function. Proc Natl Acad Sci U S A. 2004 Jan 06; 101(1):372-7. PMID: 14691264.
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    96. Budygin EA, John CE, Mateo Y, Daunais JB, Friedman DP, Grant KA, Jones SR. Chronic ethanol exposure alters presynaptic dopamine function in the striatum of monkeys: a preliminary study. Synapse. 2003 Dec 01; 50(3):266-8. PMID: 14515345.
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    97. Mottola DM, Kilts JD, Lewis MM, Connery HS, Walker QD, Jones SR, Booth RG, Hyslop DK, Piercey M, Wightman RM, Lawler CP, Nichols DE, Mailman RB. Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase. J Pharmacol Exp Ther. 2002 Jun; 301(3):1166-78. PMID: 12023552.
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    98. Budygin EA, John CE, Mateo Y, Jones SR. Lack of cocaine effect on dopamine clearance in the core and shell of the nucleus accumbens of dopamine transporter knock-out mice. J Neurosci. 2002 May 15; 22(10):RC222. PMID: 12006604.
      View in: PubMed
    99. Budygin EA, Phillips PE, Wightman RM, Jones SR. Terminal effects of ethanol on dopamine dynamics in rat nucleus accumbens: an in vitro voltammetric study. Synapse. 2001 Nov; 42(2):77-9. PMID: 11574942.
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    100. Zhuang X, Oosting RS, Jones SR, Gainetdinov RR, Miller GW, Caron MG, Hen R. Hyperactivity and impaired response habituation in hyperdopaminergic mice. Proc Natl Acad Sci U S A. 2001 Feb 13; 98(4):1982-7. PMID: 11172062.
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    101. Xu F, Gainetdinov RR, Wetsel WC, Jones SR, Bohn LM, Miller GW, Wang YM, Caron MG. Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. Nat Neurosci. 2000 May; 3(5):465-71. PMID: 10769386.
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    102. Bliziotes M, McLoughlin S, Gunness M, Fumagalli F, Jones SR, Caron MG. Bone histomorphometric and biomechanical abnormalities in mice homozygous for deletion of the dopamine transporter gene. Bone. 2000 Jan; 26(1):15-9. PMID: 10617152.
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