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Clinical and Translational Science Institute

Keywords
Last Name

Wei Zhang

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentCancer Biology
Address
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    Collapse Research 
    Collapse research activities and funding
    R29CA067987     (ZHANG, WEI)Sep 1, 1996 - Aug 31, 2002
    NIH/NCI
    REGULATION OF TUMOR SUPPRESSOR P53 BY PHOSPHORYLATION
    Role: Principal Investigator

    R01CA098503     (ZHANG, WEI)Dec 1, 2002 - Jul 31, 2016
    NIH/NCI
    Dissecting Glioma Genesis through a Glial-Specific Mouse Model
    Role: Principal Investigator

    R01CA098570     (ZHANG, WEI)Jul 1, 2003 - Jun 30, 2009
    NIH/NCI
    Characterization of Leiomyosarcoma and GIST by Genomics
    Role: Principal Investigator

    R56CA098503     (ZHANG, WEI)Jun 1, 2004 - Aug 31, 2010
    NIH/NCI
    Dissecting Glioma Genesis through a Glial-Specific Mouse Model
    Role: Principal Investigator

    R01CA141432     (ZHANG, WEI)Aug 1, 2010 - Jun 30, 2015
    NIH/NCI
    Oncogene cooperation in glioma genesis
    Role: Principal Investigator

    R21CA150654     (ZHANG, WEI)Apr 1, 2011 - Mar 31, 2013
    NIH/NCI
    Identification of microRNAs as blood-based markers for colorectal cancer
    Role: Principal Investigator

    R01CA183153     (ZHANG, WEI)Dec 9, 2013 - Nov 30, 2019
    NIH/NCI
    Characterization of oncogenic FGFR3-TACC3 fusion gene in glioblastoma
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Li X, Pasche B, Zhang W, Chen K. Association of MUC16 Mutation With Tumor Mutation Load and Outcomes in Patients With Gastric Cancer. JAMA Oncol. 2018 Dec 01; 4(12):1691-1698. PMID: 30098163.
      View in: PubMed
    2. Su W, Hong L, Xu X, Huang S, Herpai D, Li L, Xu Y, Truong L, Hu WY, Wu X, Xiao C, Zhang W, Han J, Debinski W, Xiang R, Sun P. miR-30 disrupts senescence and promotes cancer by targeting both p16INK4A and DNA damage pathways. Oncogene. 2018 10; 37(42):5618-5632. PMID: 29907771.
      View in: PubMed
    3. Kim G, Kurnit KC, Djordjevic B, Singh C, Munsell MF, Wang WL, Lazar AJ, Zhang W, Broaddus R. Nuclear ß-catenin localization and mutation of the CTNNB1 gene: a context-dependent association. Mod Pathol. 2018 Oct; 31(10):1553-1559. PMID: 29795437.
      View in: PubMed
    4. Liu L, Ruiz J, O'Neill SS, Grant SC, Petty WJ, Yang M, Chen K, Topaloglu U, Pasche B, Zhang W. Favorable outcome of patients with lung adenocarcinoma harboring POLE mutations and expressing high PD-L1. Mol Cancer. 2018 Apr 12; 17(1):81. PMID: 29650000.
      View in: PubMed
    5. Huang KL, Mashl RJ, Wu Y, Ritter DI, Wang J, Oh C, Paczkowska M, Reynolds S, Wyczalkowski MA, Oak N, Scott AD, Krassowski M, Cherniack AD, Houlahan KE, Jayasinghe R, Wang LB, Zhou DC, Liu D, Cao S, Kim YW, Koire A, McMichael JF, Hucthagowder V, Kim TB, Hahn A, Wang C, McLellan MD, Al-Mulla F, Johnson KJ, Lichtarge O, Boutros PC, Raphael B, Lazar AJ, Zhang W, Wendl MC, Govindan R, Jain S, Wheeler D, Kulkarni S, Dipersio JF, Reimand J, Meric-Bernstam F, Chen K, Shmulevich I, Plon SE, Chen F, Ding L. Pathogenic Germline Variants in 10,389 Adult Cancers. Cell. 2018 04 05; 173(2):355-370.e14. PMID: 29625052.
      View in: PubMed
    6. Li XC, Wang MY, Yang M, Dai HJ, Zhang BF, Wang W, Chu XL, Wang X, Zheng H, Niu RF, Zhang W, Chen KX. A mutational signature associated with alcohol consumption and prognostically significantly mutated driver genes in esophageal squamous cell carcinoma. Ann Oncol. 2018 Apr 01; 29(4):938-944. PMID: 29351612.
      View in: PubMed
    7. Pardee TS, Anderson RG, Pladna KM, Isom S, Ghiraldeli LP, Miller LD, Chou JW, Jin G, Zhang W, Ellis LR, Berenzon D, Howard DS, Hurd DD, Manuel M, Dralle S, Lyerly S, Powell BL. A Phase I Study of CPI-613 in Combination with High-Dose Cytarabine and Mitoxantrone for Relapsed or Refractory Acute Myeloid Leukemia. Clin Cancer Res. 2018 May 01; 24(9):2060-2073. PMID: 29437791.
      View in: PubMed
    8. Yang M, Forbes ME, Bitting RL, O'Neill SS, Chou PC, Topaloglu U, Miller LD, Hawkins GA, Grant SC, DeYoung BR, Petty WJ, Chen K, Pasche BC, Zhang W. Incorporating blood-based liquid biopsy information into cancer staging: time for a TNMB system? Ann Oncol. 2018 02 01; 29(2):311-323. PMID: 29216340.
      View in: PubMed
    9. Chen T, Li J, Xu M, Zhao Q, Hou Y, Yao L, Zhong Y, Chou PC, Zhang W, Zhou P, Jiang Y. PKCe phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation. Nat Commun. 2017 10 16; 8(1):939. PMID: 29038521.
      View in: PubMed
    10. Granberg KJ, Annala M, Lehtinen B, Kesseli J, Haapasalo J, Ruusuvuori P, Yli-Harja O, Visakorpi T, Haapasalo H, Nykter M, Zhang W. Strong FGFR3 staining is a marker for FGFR3 fusions in diffuse gliomas. Neuro Oncol. 2017 Sep 01; 19(9):1206-1216. PMID: 28379477.
      View in: PubMed
    11. Li L, Zheng H, Huang Y, Huang C, Zhang S, Tian J, Li P, Sood AK, Zhang W, Chen K. DNA methylation signatures and coagulation factors in the peripheral blood leucocytes of epithelial ovarian cancer. Carcinogenesis. 2017 08 01; 38(8):797-805. PMID: 28637314.
      View in: PubMed
    12. Kytola V, Topaloglu U, Miller LD, Bitting RL, Goodman MM, D Agostino RB, Desnoyers RJ, Albright C, Yacoub G, Qasem SA, DeYoung B, Thorsson V, Shmulevich I, Yang M, Shcherban A, Pagni M, Liu L, Nykter M, Chen K, Hawkins GA, Grant SC, Petty WJ, Alistar AT, Levine EA, Staren ED, Langefeld CD, Miller V, Singal G, Petro RM, Robinson M, Blackstock W, Powell BL, Wagner LI, Foley KL, Abraham E, Pasche B, Zhang W. Mutational Landscapes of Smoking-Related Cancers in Caucasians and African Americans: Precision Oncology Perspectives at Wake Forest Baptist Comprehensive Cancer Center. Theranostics. 2017; 7(11):2914-2923. PMID: 28824725.
      View in: PubMed
    13. Alistar A, Morris BB, Desnoyer R, Klepin HD, Hosseinzadeh K, Clark C, Cameron A, Leyendecker J, D'Agostino R, Topaloglu U, Boteju LW, Boteju AR, Shorr R, Zachar Z, Bingham PM, Ahmed T, Crane S, Shah R, Migliano JJ, Pardee TS, Miller L, Hawkins G, Jin G, Zhang W, Pasche B. Safety and tolerability of the first-in-class agent CPI-613 in combination with modified FOLFIRINOX in patients with metastatic pancreatic cancer: a single-centre, open-label, dose-escalation, phase 1 trial. Lancet Oncol. 2017 06; 18(6):770-778. PMID: 28495639.
      View in: PubMed
    14. Yang M, Topaloglu U, Petty WJ, Pagni M, Foley KL, Grant SC, Robinson M, Bitting RL, Thomas A, Alistar AT, Desnoyers RJ, Goodman M, Albright C, Porosnicu M, Vatca M, Qasem SA, DeYoung B, Kytola V, Nykter M, Chen K, Levine EA, Staren ED, D'Agostino RB, Petro RM, Blackstock W, Powell BL, Abraham E, Pasche B, Zhang W. Circulating mutational portrait of cancer: manifestation of aggressive clonal events in both early and late stages. J Hematol Oncol. 2017 05 04; 10(1):100. PMID: 28472989.
      View in: PubMed
    15. Sun L, Hu L, Cogdell D, Lu L, Gao C, Tian W, Zhang Z, Kang Y, Fleming JB, Zhang W. MIR506 induces autophagy-related cell death in pancreatic cancer cells by targeting the STAT3 pathway. Autophagy. 2017 Apr 03; 13(4):703-714. PMID: 28121485.
      View in: PubMed
    16. Sun Y, Ji P, Chen T, Zhou X, Yang D, Guo Y, Liu Y, Hu L, Xia D, Liu Y, Multani AS, Shmulevich I, Kucherlapati R, Kopetz S, Sood AK, Hamilton SR, Sun B, Zhang W. MIIP haploinsufficiency induces chromosomal instability and promotes tumour progression in colorectal cancer. J Pathol. 2017 Jan; 241(1):67-79. PMID: 27741356.
      View in: PubMed
    17. Wang Y, Hu L, Ji P, Teng F, Tian W, Liu Y, Cogdell D, Liu J, Sood AK, Broaddus R, Xue F, Zhang W. MIIP remodels Rac1-mediated cytoskeleton structure in suppression of endometrial cancer metastasis. J Hematol Oncol. 2016 10 19; 9(1):112. PMID: 27760566.
      View in: PubMed
    18. Zheng LS, Yang JP, Cao Y, Peng LX, Sun R, Xie P, Wang MY, Meng DF, Luo DH, Zou X, Chen MY, Mai HQ, Guo L, Guo X, Shao JY, Huang BJ, Zhang W, Qian CN. SPINK6 Promotes Metastasis of Nasopharyngeal Carcinoma via Binding and Activation of Epithelial Growth Factor Receptor. Cancer Res. 2017 01 15; 77(2):579-589. PMID: 27671677.
      View in: PubMed
    19. Gao S, Sun Y, Zhang X, Hu L, Liu Y, Chua CY, Phillips LM, Ren H, Fleming JB, Wang H, Chiao PJ, Hao J, Zhang W. IGFBP2 Activates the NF-?B Pathway to Drive Epithelial-Mesenchymal Transition and Invasive Character in Pancreatic Ductal Adenocarcinoma. Cancer Res. 2016 11 15; 76(22):6543-6554. PMID: 27659045.
      View in: PubMed
    20. Phillips LM, Zhou X, Cogdell DE, Chua CY, Huisinga A, R Hess K, Fuller GN, Zhang W. Glioma progression is mediated by an addiction to aberrant IGFBP2 expression and can be blocked using anti-IGFBP2 strategies. J Pathol. 2016 07; 239(3):355-64. PMID: 27125842; PMCID: PMC4915980 [Available on 07/01/17].
    21. Liu B, Zhang X, Song F, Liu Q, Dai H, Zheng H, Cui P, Zhang L, Zhang W, Chen K. A functional single nucleotide polymorphism of SET8 is prognostic for breast cancer. Oncotarget. 2016 Jun 07; 7(23):34277-87. PMID: 27144429.
      View in: PubMed
    22. Liu B, Zhang X, Song F, Zheng H, Zhao Y, Li H, Zhang L, Yang M, Zhang W, Chen K. MiR-502/SET8 regulatory circuit in pathobiology of breast cancer. Cancer Lett. 2016 07 01; 376(2):259-67. PMID: 27080302.
      View in: PubMed
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